Scientific Commons: M. Delarue

Determination of Dihedral psi Angles in Large Proteins by Combining NHN/CαHα Dipole/Dipole Cross Correlation and Chemical Shifts. (2006)

Loth, K., Abergel, D., Pelupessy, P., Delarue, M., Lopes, P., Ouazzani, J., ...

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase - New insights into the phosphoryl transfer mechanism (2003)

HAOUZ, A, Vanheusden, Veerle, MUNIER-LEHMANN, H, FROEYEN, M, HERDEWIJN, P, Van Calenbergh, Serge, ...

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase - New insights into the phosphoryl transfer mechanism (2003)

Vanheusden, V, Munier-Lehmann, H, Van Calenbergh, S, ...

The chemical synthesis of new compounds designed as inhibitors of Mycobacterium tuberculosis TMP kinase (TMPK) is reported. The synthesis concerns TMP analogues modified at the 5-position of the...

Database searching for thymidine and thymidylate kinase inhibitors using 3-dimensional structure based methods (2002)

Manallack, D, Pitt, W, Herdewijn, P, Balzarini, J, De Clecq, E, Sanderson, MR, ...

Superroot, a recessive mutation in Arabidopsis, confers auxin overproduction. (1995)

Boerjan, Wout, CERVERA, MT, DELARUE, M, Beeckman, Tom, DEWITTE, W, BELLINI, C, ...

Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase

Delarue, M., Boulé, J.B., Lescar, J., Expert-Bezançon, N., Jourdan, N., Sukumar, N., ...

The crystal structure of the catalytic core of murine terminal deoxynucleotidyltransferase (TdT) at 2.35 Å resolution reveals a typical DNA polymerase β-like fold locked in a closed form. In...

Superroot, a recessive mutation in Arabidopsis, confers auxin overproduction.

Boerjan, W, Cervera, M T, Delarue, M, Beeckman, T, Dewitte, W, Bellini, C, ...

We have isolated seven allelic recessive Arabidopsis mutants, designated superroot (sur1-1 to sur1-7), displaying several abnormalities reminiscent of auxin effects. These characteristics include...

Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides.

Asseline, U, Delarue, M, Lancelot, G, Toulmé, F, Thuong, N T, Montenay-Garestier, T, ...

Oligodeoxyribonucleotides covalently linked to an intercalating agent via a polymethylene linker were synthesized. Oligothymidylates attached to an acridine dye (Acr) through the 3'-phosphate group...

Crystal structure of a prokaryotic aspartyl tRNA-synthetase.

Delarue, M, Poterszman, A, Nikonov, S, Garber, M, Moras, D, Thierry, J C

The crystal structure of Thermus thermophilus aspartyl tRNA-synthetase (AspRS) refined at 2.5 A resolution is described. This molecular structure is a textbook illustration of the modular...

Identification of four conserved motifs among the RNA-dependent polymerase encoding elements.

Poch, O, Sauvaget, I, Delarue, M, Tordo, N

Four consensus sequences are conserved with the same linear arrangement in RNA-dependent DNA polymerases encoded by retroid elements and in RNA-dependent RNA polymerases encoded by plus-, minus- and...

Oligodeoxynucleotides covalently linked to intercalating dyes as base sequence-specific ligands. Influence of dye attachment site.

Asseline, U, Toulme, F, Thuong, N T, Delarue, M, Montenay-Garestier, T, Hélène, C

New molecules with high and specific affinity for nucleic acid base sequences have been synthesized. They involve an oligodeoxynucleotide covalently attached to an intercalating dye. Visible...