M. Hill

Contents (2009)

M. Behrens, M. Hill, M. J. Hopkins, M. Mahowald

Abstract. Let M(1) be the mod 2 Moore spectrum. J.F. Adams proved that M(1) admits a minimal v1-self map v4 1: Σ8M(1) → M(1). Let M(1, 4) be the cofiber of this self-map. The purpose of this paper...

ADHD and DAT1: further evidence of paternal over-transmission of risk alleles and haplotype (2009)

Hawi, Z., Kent, L., Hill, M., Anney, R.J.L., Brookes, K.J., Barry, E., ...

We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3-UTR VNTR....

Achieving blood pressure goals globally: five core actions for health-care professionals. A worldwide call to action (2008)

Hill, M, Mancia, G, Steyn, K, Black, H. R, Pickering, T, ...

The prevalence of hypertension continues to rise across the world, and most patients who receive medical intervention are not adequately treated to goal. A Working Group including representatives of...

Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression (2005)

Royer, PJ, Hill, M, Tanguy-Royer, S, Hubert, FX, ...

Heme oxygenase-1 (HO-1) is an intracellular enzyme that degrades heme and inhibits immune responses and inflammation in vivo. In most cell types, HO-1 is inducible by inflammatory stimuli and...

Heme oxygenase-1 expression inhibits dendritic cell maturation and function with conserved IL-10 expression (2005)

Hill, M, Tanguy-Royer, S, Hubert, FX, Royer, PJ, ...

Metabolic syndrome in young Czech women with polycystic ovary syndrome (2005)

Vrbíková, J., Vondra, K., Cibula, D., Dvoráková, K., Stanická, S., Srámková, D., ...

METHODS: Sixty-nine young women with polycystic ovary syndrome (PCOS) [age 25.2 6 4.7 years, with body mass index (BMI) 24.3 6 4.8 kg/m2; mean 6 SD] and 73 age-matched healthy females (BMI 22.3 6 3.3...

The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients (2005)

Cibula, D., Fanta, M., Vrbikova, J., Stanicka, S., Dvorakova, K., Hill, M., ...

BACKGROUND: Neither oral contraceptives (COC) nor metformin are an optimal modality for the long-term treatment of polycystic ovary syndrome (PCOS). The aim of this study was to evaluate whether a...

Metabolic syndrome in young Czech women with polycystic ovary syndrome (2005)

Vrbíková, J., Vondra, K., Cibula, D., Dvoáková, K., Stanická, S., Rámková, D., ...

METHODS: Sixty-nine young women with polycystic ovary syndrome (PCOS) [age 25.2 ± 4.7 years, with body mass index (BMI) 24.3 ± 4.8 kg/m2; mean ± SD] and 73 age-matched healthy females (BMI 22.3 ±...

A randomised comparison between 6 months of bolus fluorouracil/leucovorin and 12 weeks of protracted venous infusion fluorouracil as adjuvant treatment in colorectal cancer (2005)

Chau, I., Norman, A. R., Cunningham, D., Tait, D., Ross, P. J., Iveson, T., ...

Background: We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of protracted venous infusion (PVI) 5-fluorouracil (5-FU) against the standard bolus monthly...

A randomised comparison between 6 months of bolus fluorouracil/leucovorin and 12 weeks of protracted venous infusion fluorouracil as adjuvant treatment in colorectal cancer (2005)

Chau, I., Norman, A. R., Cunningham, D., Tait, D., Ross, P. J., Iveson, T., ...

Background: We performed a multicentre randomised trial to compare the efficacy and toxicity of 12 weeks of protracted venous infusion (PVI) 5-fluorouracil (5-FU) against the standard bolus monthly...

The effect of combination therapy with metformin and combined oral contraceptives (COC) versus COC alone on insulin sensitivity, hyperandrogenaemia, SHBG and lipids in PCOS patients (2004)

Cibula, D., Fanta, M., Vrbikova, J., Stanicka, S., Dvorakova, K., Hill, M., ...

BACKGROUND: Neither oral contraceptives (COC) nor metformin are an optimal modality for the long-term treatment of polycystic ovary syndrome (PCOS). The aim of this study was to evaluate whether a...

Pregnancy outcome in women with PCOS and in controls matched by age and weight (2003)

Haakova, L., Cibula, D., Rezabek, K., Hill, M., Fanta, M., Zivny, J.

BACKGROUND: The aim of this study was to compare the pregnancy outcome, especially the prevalence of gestational diabetes mellitus (GDM), in a group of patients with polycystic ovary syndrome (PCOS),...

A phase I/II study of oral uracil/tegafur (UFT), leucovorin and irinotecan in patients with advanced colorectal cancer (2003)

Mackay, H. J., Hill, M., Twelves, C., Glasspool, R., Price, T., Campbell, S., ...

Background: The aim of this study was to determine the maximum tolerated dose (MTD), toxicity profile and response rate of the oral 5-fluorouracil prodrug UFT (tegafur/uracil) and leucovorin (LV) in...

Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin (2002)

Cibula, D., Fanta, M., Hill, M., Sindelka, G., Skrha, J., Zivny, J.

BACKGROUND: Combined oral contraceptives (COC) effectively suppress hyperandrogenism in women with polycystic ovary syndrome (PCOS), though deterioration of insulin sensitivity during treatment is...

A multicentre, randomised phase III trial comparing protracted venous infusion (PVI) 5-fluorouracil (5-FU) with PVI 5-FU plus mitomycin C in patients with inoperable oesophago-gastric cancer (2002)

Tebbutt, N. C., Norman, A., Cunningham, D., Iveson, T., Seymour, M., Hickish, T., ...

Background: This randomised study compared protracted venous infusion (PVI) fluorouracil (5-FU) with PVI 5-FU plus mitomycin C (MMC) in patients with advanced oesophago-gastric cancer. Patients and...

Does obesity diminish the positive effect of oral contraceptive treatment on hyperandrogenism in women with polycystic ovarian syndrome? (2001)

Cibula, D., Hill, M., Fanta, M., Sindelka, G., Zivny, J.

Polycystic ovarian syndrome (PCOS) is an obvious indication for long-term treatment. Combined oral contraceptives (COC) remain the first choice for the treatment of hyperandrogenism in most patients....

Young people's understanding of mental illness (1999)

Secker, J., Armstrong, C., Hill, M.

Research exploring young people's perspectives on mental health is at an early stage of development and few studies have focused in detail on mental distress or illness. This paper reports findings...

Bacterially catalysed N-nitrosation reactions and their relative importance in the human stomach (1987)

Leach, S.A., Thompson, M., Hill, M.

Human exposure to endogenously formed N-nitroso compounds has frequently been suggested as a causative factor in carcinogenesis where this is related to chronic bacterial infection such as is seen in...

A comparison of the endocrine effects of low dose aminoglutethimide with and without hydrocortisone in postmenopausal breast cancer patients.

Dowsett, M., Harris, A. L., Stuart-Harris, R., Hill, M., Cantwell, B. M., Smith, I. E., ...

The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with...

Adjuvant chemotherapy for oesophagogastric cancer with epirubicin, cisplatin and infusional 5-fluorouracil (ECF): a Royal Marsden pilot study.

Bamias, A., Cunningham, D., Nicolson, V., Norman, A., Hill, M., Nicolson, M., ...

Previous trials of adjuvant chemotherapy for oesophagogastric cancer have shown only modest or no improvement in survival. However, the regimens used in these studies produce low response rates in...

High-dose chemotherapy and autologous bone marrow transplant in relapsed Hodgkin's disease--a pragmatic prognostic index.

O'Brien, M. E., Milan, S., Cunningham, D., Jones, A. L., Nicolson, M., Selby, P., ...

High-dose chemotherapy with autologous bone marrow transplantation is used in the treatment of relapsed or high-risk Hodgkin's disease. As prospective randomised studies have proved difficult to...

A phase I/II study of leucovorin, carboplatin and 5-fluorouracil (LCF) in patients with carcinoma of unknown primary site or advanced oesophagogastric/pancreatic adenocarcinomas.

Rigg, A., Cunningham, D., Gore, M., Hill, M., O'Brien, M., Nicolson, M., ...

Carcinoma of unknown primary site (CUPS) accounts for 5-10% of all malignancies. Forty patients with metastatic CUPS or advanced oesophagogastric/pancreatic adenocarcinomas were recruited....

Increased risk of biliary tract cancer following gastric surgery.

Caygill, C., Hill, M., Kirkham, J., Northfield, T. C.

Analysis of 4,466 peptic ulcer patients, who had undergone gastric surgery at least 25 years previously, showed no change in risk from biliary tract cancer within the first 20 years, but a 9.4 fold...

Report of two protocol planned interim analyses in a randomised multicentre phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric cancer receiving ECF

Sumpter, K, Harper-Wynne, C, Cunningham, D, Rao, S, Tebbutt, N, Norman, A R, ...

The purpose of the study was to establish the optimal dose of capecitabine (X) to be used within a multicentre, randomised study evaluating the potential roles of oxaliplatin (O) and X in chemonaive...

Gemcitabine, cisplatin and methylprednisolone (GEM-P) is an effective salvage regimen in patients with relapsed and refractory lymphoma

Ng, M, Waters, J, Cunningham, D, Chau, I, Horwich, A, Hill, M, ...

There is currently no standard salvage chemotherapy regimen in relapsed and refractory lymphoma. Gemcitabine is a novel nucleoside analogue, which acts synergistically with cisplatin both in vitro...

Oxaliplatin and protracted venous infusion of 5-fluorouracil in patients with advanced or relapsed 5-fluorouracil pretreated colorectal cancer

Chau, I, Webb, A, Cunningham, D, Hill, M, Waters, J S, Norman, A, ...

The purpose of this study was to evaluate the activity and safety of oxaliplatin and protracted venous infusion of 5-fluorouracil (PVI 5-FU) in patients with advanced or relapsed 5-FU pretreated...

Neoadjuvant systemic fluorouracil and mitomycin C prior to synchronous chemoradiation is an effective strategy in locally advanced rectal cancer

Chau, I, Allen, M, Cunningham, D, Tait, D, Brown, G, Hill, M, ...

Analysis of the time course and prognostic factors determining toxicity due to infused fluorouracil

Tebbutt, N C, Norman, A R, Cunningham, D, Allen, M, Chau, I, Oates, J, ...

Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy

Chau, I, Norman, A R, Cunningham, D, Waters, J S, Topham, C, Middleton, G, ...

Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer

Saini, A, Norman, A R, Cunningham, D, Chau, I, Hill, M, Tait, D, ...