M. Kobayashi

Details der Publikationsliste

Zeitraum

1951 - 9999

Anzahl

484

Co-Autoren

Change in Undrained Shear Strength of Saturated Clay Due to Rebound (9999)

Nakase,A., Kobayashi,M.

In order to examine the possibility of applying phi = 0 analysis of stability to the long term type problem, a series of triaxial compression tests is carried out on normally- and over-consolidated...

Stable Fractional Vortices in the Cyclic States of Bose-Einstein Condensates (2009)

Huhtamäki, J. A. M., Simula, T. P., Kobayashi, M., Machida, K.

We propose methods to create fractional vortices in the cyclic state of an F = 2 spinor Bose-Einstein condensate by manipulating its internal spin structure using pulsed microwave and laser fields....

Design of a Superferric Dipole for the Superconducting Supercollider (2009)

H. Bingham; Texas Accelerator Center, R. Carcagno; Texas Accelerator Center, M. Davidson; Texas Accelerator Center, H. Hinterberger; Texas Accelerator Center, F. R. Huson; Texas Accelerator Center, M. Kobayashi; Texas Accelerator Center, ...

The Superconducting Supercollider (SSC) is a 20TeV on 20Tev dual beam proton accelerator, which will use superconducting magnets and whose construction is expected to begin in 1987. The Texas...

Cosmic Ray Tests of the Prototype TPC for the ILC Experiment (2009)

Ackermann, K., Arai, S., Arogancia, D. C., Bacala, A. M., Ball, M., Behnke, T., ...

A time projection chamber (TPC) is a strong candidate for the central tracker of the international linear collider (ILC) experiment and we have been conducting a series of cosmic ray experiments...

Evidence for $\pi K$-atoms with DIRAC (2009)

Adeva, B., Afanasyev, L., Allkofer, Y., Amsler, C., Anania, A., Benelli, A., ...

We present evidence for the first observation of electromagnetically bound $\pi^\pm K^\mp$-pairs ($\pi K$-atoms) with the DIRAC experiment at the CERN-PS. The $\pi K$-atoms are produced by the 24...

Electronic structure and magnetism of the diluted magnetic semiconductor Fe-doped ZnO nano-particles (2009)

Kataoka, T., Kobayashi, M., Sakamoto, Y., Song, G. S., Fujimori, A., ...

We have studied the electronic structure of Zn$_{0.9}$Fe$_{0.1}$O nano-particles, which have been reported to show ferromagnetism at room temperature, by x-ray photoemission spectroscopy (XPS),...

Study of the decay K+ => pi+,nu,nubar in the momentum region 140 (2009)

Bassalleck, B., Bhuyan, B., Blackmore, E. W., Bryman, D. A., Chen, S., ...

Experiment E949 at Brookhaven National Laboratory has observed three new events consistent with the decay K+ => pi+,nu,nubar in the pion momentum region 140 < P_pi < 199 MeV/c in an exposure of...

Impact of CSI on Distributed Space-Time Coding in Wireless Relay Networks (2008)

M. Kobayashi, X. Mestre, Tx Rx, Relay M, Mari Kobayashi, Xavier Mestre

c°2007 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for...

Electronic structure of Ga$_{1-x}$Cr$_{x}$N and Si-doping effects studied by photoemission and X-ray absorption spectroscopy (2008)

Song, G. S., Kobayashi, M., Hwang, J. I., Kataoka, T., Takizawa, M., Fujimori, A., ...

The electronic structure of the magnetic semiconductor Ga$_{1-x}$Cr$_{x}$N and the effect of Si doping on it have been investigated by photoemission and soft x-ray absorption spectroscopy. We have...

Compton Imaging of MeV Gamma-Rays with the Liquid Xenon Gamma-Ray Imaging Telescope (LXeGRIT) (2008)

Aprile, E., Curioni, A., Giboni, K. L., Kobayashi, M., Oberlack, U. G., Zhang, S.

The Liquid Xenon Gamma-Ray Imaging Telescope (LXeGRIT) is the first realization of a liquid xenon time projection chamber for Compton imaging of MeV gamma-ray sources in astrophysics. By measuring...

Local electronic structure of Cr in the II-VI diluted ferromagnetic semiconductor Zn$_{1-x}$Cr$_x$Te (2008)

Kobayashi, M., Ishida, Y., Hwang, J. I., Song, G. S., Fujimori, A., ...

The electronic structure of the Cr ions in the diluted ferromagnetic semiconductor Zn$_{1-x}$Cr$_x$Te ($x=0.03$ and 0.15) thin films has been investigated using x-ray magnetic circular dichroism...

Vandermonde Frequency Division Multiplexing for Cognitive Radio (2008)

Cardoso, L. S., Kobayashi, M., Debbah, M., Ryan, O.

We consider a cognitive radio scenario where a primary and a secondary user wish to communicate with their corresponding receivers simultaneously over frequency selective channels. Under realistic...

34. T. Irifune and A. E. Ringwood, Earth Planet. Sci. Lett. (2008)

S. Heinemann, T. G. Sharp, F. Seifert, D. C. Rubie, M. Akaogi, Y. Hamada, ...

41. The infrared reflectance measurements were conducted using a Bruker IFS-66v interferometer with attached microscope; the apparatus was equipped with a globar source, KBr beamsplitter and...

Hybridization between the conduction band and 3d orbitals in the oxide-based diluted magnetic semiconductor In$_{2-x}$V$_x$O$_3$ (2008)

Kobayashi, M., Ishida, Y., Hwang, J. I., Song, G. S., Takizawa, M., Fujimori, A., ...

The electronic structure of In$_{2-x}$V$_x$O$_3$ ($x=0.08$) has been investigated using photoemission spectroscopy (PES) and x-ray absorption spectroscopy (XAS). The V $2p$ core-level PES and XAS...

Nature of magnetic coupling between Mn ions in as-grown Ga$_{1-x}$Mn$_{x}$As studied by x-ray magnetic circular dichroism (2008)

Takeda, Y., Kobayashi, M., Okane, T., Ohkochi, T., Okamoto, J., Saitoh, Y., ...

The magnetic properties of as-grown Ga$_{1-x}$Mn$_{x}$As have been investigated by the systematic measurements of temperature and magnetic field dependent soft x-ray magnetic circular dichroism...

Terbium-activated heavy scintillating glasses (2008)

Fu, J., Kobayashi, M., Parker, J.M.

Tb-activated scintillating glasses with high Ln2O3 (Ln=Gd, Y, Lu) concentration up to 40mol% have been prepared. The effects of Ln3+ ions on the density, thermal properties, transmission and...

Terbium-activated heavy scintillating glasses (2008)

Fu, J., Kobayashi, M., Parker, J.M.

Tb-activated scintillating glasses with high Ln2O3 (Ln=Gd, Y, Lu) concentration up to 40mol% have been prepared. The effects of Ln3+ ions on the density, thermal properties, transmission and...

Systematic changes of the electronic structure of the diluted ferromagnetic oxide Li-doped Ni$_{1-x}$Fe$_x$O with hole doping (2007)

Kobayashi, M., Hwang, J. I., Song, G. S., Ooki, Y., Takizawa, M., Fujimori, A., ...

The electronic structure of Li-doped Ni$_{1-x}$Fe$_x$O has been investigated using photoemission spectroscopy (PES) and x-ray absorption spectroscopy (XAS). The Ni $2p$ core-level PES and XAS spectra...

2 (2007)

M. Tanaka, K. Hara, S. Kim, K. Kondo, H. Takano, M. Kobayashi, ...

We have investigated applications of cerium-doped GSO (Gd 2 SiO 5:Ce, or GSO:Ce) scintillating crystals to high precision electromagnetic calorimeters in high energy physics experiments. Basic...

A New CsI(undoped) Endcap Photon Veto System for BNL E787: A Study of the Decay (2007)

Chiang Garber Inagaki, M. Kobayashi

A new CsI(undoped) calorimeter has been installed for the endcap photon veto system of BNL E787, a search for the decay K + ! + . This new endcap provides substantially more light output than the...

A NEW UNBIASED EQUATION ERROR ALGORITHM FOR IIR ADF AND ITS APPLICATION TO ALE (2007)

J. Okello, Y. Kinugasa, Y. Itoh, Y. Fukui, M. Kobayashi

In this paper, a new online algorithm for updating equation error IIR ADF is proposed. The proposed algorithm, which involves maintaining a constant power of the desired signal, is independent of the...

Depth profile photoemission study of thermally diffused Mn/GaAs (001) interfaces (2007)

Osafune, Y., Song, G. S., Hwang, J. I., Ishida, Y., Kobayashi, M., Ebata, K., ...

We have performed a depth profile study of thermally diffused Mn/GaAs (001) interfaces using photoemission spectroscopy combined with Ar$^+$-ion sputtering. We found that Mn ion was thermally...

Photoemission and x-ray absorption studies of valence states in (Ni,Zn,Fe,Ti)$_{3}$O$_{4}$ thin films exhibiting photo-induced magnetization (2007)

Kobayashi, M., Ooki, Y., Takizawa, M., Song, G. S., Fujimori, A., Takeda, Y., ...

By means of photoemission and x-ray absorption spectroscopy, we have studied the electronic structure of (Ni,Zn,Fe,Ti)$_{3}$O$_{4}$ thin films, which exhibits a cluster glass behavior with a...

An 8-dimensional realization of the Clifford algebra in the 5-dimensional Galilean space-time (2007)

Kobayashi, M., De Montigny, M., Khanna, F. C.

We give an 8-dimensional realization of the Clifford algebra in the 5-dimensional Galilean space-time by using a dimensional reduction from the $(5+1)$ Minkowski space-time to the $(4+1)$ Minkowski...

CPT theorem in a (5+1) Galilean space-time (2007)

Kobayashi, M., De Montigny, M., Khanna, F. C.

We extend the 5-dimensional Galilean space-time to a (5+1) Galilean space-time in order to define a parity transformation in a covariant manner. This allows us to discuss the discrete symmetries in...

X-ray magnetic circular dichroism and photoemission study of the diluted ferromagnetic semiconductor Zn$_{1-x}$Cr$_x$Te (2007)

Ishida, Y., Kobayashi, M., Hwang, J. I., Takeda, Y., Okane, T., ...

We have performed x-ray magnetic circular dichroism (XMCD) and valence-band photoemission studies of the diluted ferromagnetic semiconductor Zn$_{1-x}$Cr$_x$Te. XMCD signals due to ferromagnetism...

A GEM TPC End-Panel Pre-Prototype (2007)

Ishikawa, A., Aoza, A., Higashi, T., Sugiyama, A., Tsuji, H., Kato, Y., ...

A GEM TPC end panel pre-prototype was constructed for a large LC-TPC prototype to test its basic design philosophy and some of its engineering details. Its interim test results are presented.

Usefulness of multi-detector row Computed Tomography for accurate preoperative assessment of pancreatic adenocarcinoma: report of a case (2007)

Maeda, H, Okabayashi, T, Kobayashi, M, Morishita, S, Nishimori, I, Ito, S, ...

A 74-year-old female underwent surgical treatment for adenocarcinoma of the pancreatic head. Preoperative multi-detector row computed tomography (MD-CT) demonstrated tumor invasion into the accessory...

Phase Change Observed in Ultrathin Ba0.5Sr0.5TiO3 Films by in-situ Resonant Photoemission Spectroscopy (2007)

Terai, K., Wadati, H., Kobayashi, M., Takizawa, M., Hwang, J. I., ...

Epitaxial Ba0.5Sr0.5TiO3 thin films were prepared on Nb-doped SrTiO3 (100)substrates by the pulsed laser deposition technique, and were studied by measuring the Ti 2p - 3d resonant photoemission...

Critical test for Altshuler-Aronov theory: Evolution of the density of states singularity in double perovskite Sr$_2$FeMoO$_6$ with controlled disorder (2007)

Kobayashi, M., Tanaka, K., Fujimori, A., Ray, Sugata, Sarma, D. D.

With high-resolution photoemission spectroscopy measurements, the density of states (DOS) near the Fermi level ($E_\mathrm{F}$) of double perovskite Sr$_2$FeMoO$_6$ having different degrees of Fe/Mo...

Intergranular Magnetoresistance in $Sr_2FeMoO_6$ from a Magnetic Tunnel Barrier Mechanism across Grain Boundaries (2007)

Sarma, DD, Ray, Sugata, Tanaka, K, Kobayashi, M, Fujimori, A, Sanyal, P, ...

We present magnetization (M) and magnetoresistance (MR)data for a series of $Sr_2FeMoO_6$ samples with independent control on antisite defect and grain-boundary densities, which reveal several...

X-ray magnetic circular dichroism characterization of GaN/Ga1-xMnxN digital ferromagnetic heterostructure (2007)

Hwang, J. I., Kobayashi, M., Song, G. S., Fujimori, A., Tanaka, A., Yang, Z. S., ...

We have investigated the magnetic properties of a GaN/Ga1-xMnxN (x = 0.1) digital ferromagnetic heterostructure (DFH) showing ferromagnetic behavior using soft x-ray absorption spectroscopy (XAS) and...

Depth profile high-energy spectroscopic study of Mn-doped GaN prepared by thermal diffusion (2007)

Hwang, J. I., Osafune, Y., Kobayashi, M., Ebata, K., Ooki, Y., Ishida, Y., ...

We have performed an $in$-$situ$ depth profile study of Mn-doped GaN prepared by a low temperature thermal diffusion method using photoemission and x-ray absorption spectroscopy. It was revealed from...

A Study of the LXeGRIT Detection Efficiency for MeV Gamma-Rays during the 2000 Balloon Flight Campaign (2007)

Curioni, A., Aprile, E., Doke, T., Giboni, K. L., Kobayashi, M., Oberlack, U. G.

LXeGRIT - Liquid Xenon Gamma-Ray Imaging Telescope - is the first prototype of a Compton telescope for \MeV \g-ray astrophysics based on a LXe time projection chamber. One of the most relevant...

Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist (2007)

Miseki, T., Kawakami, H., Natsuizaka, M., Darmanin, S., Cui, H. Y., Chen, J., ...

We have recently reported that the intra-tumoral injection of adrenomedullin (AM) antagonist (AMA; AM (22-52)) peptides significantly reduced the in vivo growth of a pancreatic cancer cell line in...

Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist. (2007)

Miseki, T., Kawakami, H., Natsuizaka, M., Darmanin, S., Cui, H. Y., Chen, J., ...

We have recently reported that the intra-tumoral injection of adrenomedullin (AM) antagonist (AMA; AM (22-52)) peptides significantly reduced the in vivo growth of a pancreatic cancer cell line in...

Performance of MPGD-based TPC prototypes for the linear collider experiment (2007)

Kobayashi, M., Araki, T., Arogancia, D.C., Bacala, A.M., Boudjemline, K., Burke, D., ...

We conducted a series of beam tests of prototype TPCs for the International Linear Collider (ILC) experiment, equipped with an MWPC, a MicroMEGAS, or GEMs as a readout device. The prototype operated...

Performance of MPGD-based TPC prototypes for the linear collider experiment (2007)

Kobayashi, M., Araki, T., Arogancia, D.C., Bacala, A.M., Boudjemline, K., Burke, D., ...

We conducted a series of beam tests of prototype TPCs for the International Linear Collider (ILC) experiment, equipped with an MWPC, a MicroMEGAS, or GEMs as a readout device. The prototype operated...

Intergranular Magnetoresistance in $Sr_2FeMoO_6$ from a Magnetic Tunnel Barrier Mechanism across Grain Boundaries (2007)

Sarma, DD, Ray, Sugata, Tanaka, K, Kobayashi, M, Fujimori, A, Sanyal, P, ...

We present magnetization (M) and magnetoresistance (MR)data for a series of $Sr_2FeMoO_6$ samples with independent control on antisite defect and grain-boundary densities, which reveal several...

Performance of MPGD-based TPC prototypes for the linear collider experiment (2007)

Kobayashi, M., Araki, T., Arogancia, D.C., Bacala, A.M., Boudjemline, K., Burke, D., ...

We conducted a series of beam tests of prototype TPCs for the International Linear Collider (ILC) experiment, equipped with an MWPC, a MicroMEGAS, or GEMs as a readout device. The prototype operated...

First measurement of the $\pi^+\pi^-$ atom lifetime (2006)

Adeva, B., Afanasyev, L., Benayoun, M., Benelli, A., Berka, Z., Brekhovskikh, V., ...

The goal of the DIRAC experiment at CERN (PS212) is to measure the $\pi^+\pi^-$ atom lifetime with 10% precision. Such a measurement would yield a precision of 5% on the value of the $S$-wave...

Soft x-ray magnetic circular dichroism study of weakly ferromagnetic Zn$_{1-x}$V$_x$O thin film (2006)

Ishida, Y., Hwang, J. I., Kobayashi, M., Takeda, Y., Mamiya, K., Okamoto, J., ...

We performed a soft x-ray magnetic circular dichroism (XMCD) study of a Zn$_{1-x}$V$_x$O thin film which showed small ferromagnetic moment. Field and temperature dependences of V 2$p$ XMCD signals...

Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression (2006)

Inoue, K., Kobayashi, M., Yano, K., Miura, M., Izumi, A., Mataki, C., ...

Objective - Tumor necrosis factor (TNF)-alpha initiates numerous changes in endothelial cell (EC) gene expression that contributes to the pathology of various diseases including inflammation. We...

Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression (2006)

Inoue, K., Kobayashi, M., Yano, K., Miura, M., Izumi, A., Mataki, C., ...

Objective - Tumor necrosis factor (TNF)-alpha initiates numerous changes in endothelial cell (EC) gene expression that contributes to the pathology of various diseases including inflammation. We...

Intranasal lidocaine 8% spray for second-division trigeminal neuralgia (2006)

Kanai, A., Suzuki, A., Kobayashi, M., Hoka, S.

Background. Trigeminal nerve block has been widely used for trigeminal neuralgia. This may induce paraesthesia. The second division of the trigeminal nerve passes through the sphenopalatine ganglion,...

Effect of Reducing Atmosphere on the Magnetism of Zn1-xCoxO Nanoparticles (2005)

Naeem, M., Hasanain, S. K., Kobayashi, M., Ishida, Y., Fujimori, A., Buzby, Scott, ...

We report the crystal structure and magnetic properties of Zn1-xCoxO nanoparticles synthesized by heating metal acetates in organic solvent. The nanoparticles were crystallized in wurtzite ZnO...

Characterization of Magnetic Components in the Diluted Magnetic Semiconductor Zn$_{1-x}$Co$_x$O by X-ray Magnetic Circular Dichroism (2005)

Kobayashi, M., Ishida, Y., Hwang, J. L., Mizokawa, T., Fujimori, A., Mamiya, K., ...

We report on the results of x-ray absorption (XAS), x-ray magnetic circular dichroism (XMCD), and photoemission experiments on {\it n}-type Zn$_{1-x}$Co$_x$O ($x=0.05$) thin film, which shows...

Transport properties of the heavy fermion superconductor PrOs$_{4}$Sb$_{12}$ (2005)

Sugawara, H., Kobayashi, M., Osaki, S., Saha, S. R., Namiki, T., Aoki, Y., ...

We have measured the electrical resistivity, thermoelectric power, Hall coefficient, and magnetoresistance (MR) on single crystals of PrOs$_{4}$Sb$_{12}$, LaOs$_{4}$Sb$_{12}$ and NdOs$_{4}$Sb$_{12}$....

Novel features in the flux-flow resistivity of the heavy fermion superconductor PrOs$_{4}$Sb$_{12}$ (2005)

Kobayashi, M., Sato, H., Sugawara, H., Fujiwara, H., Aoki, Y.

We have investigated the electrical resistivity of the heavy fermion superconductor PrOs$_{4}$Sb$_{12}$ in the mixed state. We found unusual double minima in the flux-flow resistivity as a function...

High-energy spectroscopic study of the III-V nitride-based diluted magnetic semiconductor Ga$_{1-x}$Mn$_{x}$N (2005)

Hwang, J. I., Ishida, Y., Kobayashi, M., Hirata, H., Takubo, K., Mizokawa, T., ...

We have studied the electronic structure of the diluted magnetic semiconductor Ga$_{1-x}$Mn$_{x}$N ($x$ = 0.0, 0.02 and 0.042) grown on Sn-doped $n$-type GaN using photoemission and soft x-ray...

A single-nucleotide polymorphism tagging set for human drug metabolism and transport (2005)

Ahmadi, K.R., Weale, M.E., Xue, Z.Y., Soranzo, N., Yarnall, D.P., Briley, J.D., ...

Interindividual variability in drug response, ranging from no therapeutic benefit to life-threatening adverse reactions, is influenced by variation in genes that control the absorption, distribution,...

A three end-member model for petrologic analysis of lunar prospector gamma-ray spectrometer data (2005)

Berezhnoy, A. A., Hasebe, N., Kobayashi, M., Michael, G. G., Okudaira, O., Yamashita, N.

We analyze preliminary Lunar Prospector gamma-ray spectrometer data. Al-Mg and Fe-Mg petrologic maps of the Moon show that Mg-rich rocks are located in Mare Frigoris, the South Pole Aitken basin, and...

High Performance Materials by the Powder Particle Assemblage (2005)

Kobayashi, M., Miyazaki, H. T., Shinya, N.

The techniques of the particle assemblage have been developed to create intelligent materials by assembling particles. The particle assemblage techniques of particle arrangement, probe manipulation...

Statistical analysis of dangerous goods accidents in Japan (2005)

Ohtani, Hideo, Kobayashi, M., 大谷, 英雄, オオタニ, ヒデオ

Statistical analysis of accident cases concerning dangerous goods was carried out in order to clarify the causes of the accidents. The results of this investigation will be useful for preventing...

Onset of steroid-induced osteonecrosis in rabbits and its relationship to hyperlipaemia and increased free fatty acids (2005)

Kabata, T., Kubo, T., Matsumoto, T., Hirata, T., Fujioka, M., Takahashi, K. A., ...

Objectives. To clarify the initial onset time of osteonecrosis after the start of steroid treatment and its relation to the onset of abnormal lipid metabolism. Methods. Animal models were prepared by...

Transport properties in CeOs$_{4}$Sb$_{12}$: Possibility of the ground state being semiconducting (2004)

Sugawara, H., Osaki, S., Kobayashi, M., Namiki, T., Saha, S. R., Aoki, Y., ...

We have measured both magnetoresistance and Hall effect in CeOs$_4$Sb$_{12}$ to clarify the large resistivity state ascribed to the Kondo insulating one and the origin of the phase transition near...

Kolmogorov spectrum of superfluid turbulence: numerical analysis of the Gross-Pitaevskii equation with the small scale dissipation (2004)

Kobayashi, M., Tsubota, M.

The energy spectrum of superfluid turbulence is studied numerically by solving the Gross-Pitaevskii equation. We introduce the dissipation term which works only in the scale smaller than the healing...

3D numerical transport study of the edge ergodized plasma in TEXTOR-DED (2004)

Kobayashi, M., Feng, Y., Sardei, F., Finken, K. H., Reiser, D., Reiter, D.

This version is available at the following URL: http://dx.doi.org/10.1088/0029-5515/44/6/S07

Improved two-point model for limiter scrape-off layer (2004)

Tokar, M. Z., Kobayashi, M., Feng, Y.

This version is available at the following Publisher URL: http://pop.aip.org

Maximal Bell's Inequality Violation for Non Maximal Entanglement (2003)

Kobayashi, M., Khanna, F., Mann, A., Revzen, M., Santana, A.

Bell's inequality violation (BIQV) for correlations of polarization is studied for a {\it product} state of two two-mode squeezed vacuum (TMSV) states. The violation allowed is shown to attain its...

Overview of magnetic structure induced by the TEXTOR-DED and the related transport (2003)

Abdullaev,S.S., Finken,K.H., Jakubowski,M.W., Kobayashi,M., Reiser,D., Runov,A.M., ...

The Dynamic Ergodic Divertor (DED), a new concept of the ergodic divertor, has been presently installing for the TEXTOR tokamak. Beside the conventional ergodic divertor operation the DED also...

Overview of magnetic structure induced by the TEXTOR-DED and the related transport (2003)

Abdullaev, S.S., Finken, K.H., Jakubowski, M.W., Kobayashi, M., Reiser, D., Runov, A.M., ...

The Dynamic Ergodic Divertor (DED), a new concept of the ergodic divertor, has been presently installing for the TEXTOR tokamak. Beside the conventional ergodic divertor operation the DED also...

The LXeGRIT Compton Telescope Prototype: Current Status and Future Prospects (2002)

Aprile, E., Curioni, A., Giboni, K. L., Kobayashi, M., Oberlack, U. G., Chupp, E. L., ...

LXeGRIT is the first prototype of a novel concept of Compton telescope, based on the complete 3-dimensional reconstruction of the sequence of interactions of individual gamma rays in one position...

On the Background Rate in the LXeGRIT Instrument during the 2000 Balloon Flight (2002)

Curioni, A., Aprile, E., Giboni, K. L., Kobayashi, M., Oberlack, U. G., Chupp, E. L., ...

LXeGRIT is the first prototype of a novel Compton telescope for MeV gamma-ray astrophysics based on a Liquid Xenon Time Projection Chamber (LXeTPC), sensitive in the energy band of 0.15-10 MeV. In...

XENON: a 1 tonne Liquid Xenon Experiment for a Sensitive Dark Matter Search (2002)

Aprile, E., Baltz, E. A., Curioni, A., Giboni, K-L., Hailey, C. J., Hui, L., ...

XENON is a novel liquid xenon experiment concept for a sensitive dark matter search using a 1-tonne active target, distributed in an array of ten independent time projection chambers. The design...

Analysis of Northern Distribution of Aedes albopictus (Diptera: Culicidae) in Japan by Geographical Information System (2002)

M. Kobayashi, N. Nihei, T. Kurihara

Aedes albopictus (Skuse), a mosquito vector of the dengue fever virus, is prevalent in Japan, distributed widely in Honshu Island with its northern limits between latitude 38° to 40°degrees north....

X-Ray Scattering from Poly(thiophene): Crystallinity and Crystollography Structure. (2002)

Mo,Z., Lee,K. B., Moon,Y. B., Kobayashi,M., Heeger,A. J.

X-ray scattering has been used to investigate the crystallinity and crystal structure of chemically coupled polythiophene. Heat treatment at elevated temperatures leads to significant increases in...

Topological properties of the edge ergodic layer in tokamak plasma (2002)

Kobayashi, M., Eich, T., Abdullaev, S. S., Finken, K. H.

This version is available at the following Publisher URL: http://ieeexplore.ieee.org/Xplore/dynhome.jsp

Gonadotropin response to GnRH during sexual ontogeny in the common carp, Cyprinus carpio (2002)

Kandel-Kfir, M, Gur, G, Melamed, P, Zilberstein, Y, Cohen, Y, Zmora, N, ...

This study was designed to reveal whether gonadotropic response to GnRH in the common carp (Cyprinus carpio) changes during sexual ontogeny and whether the response of FSHβ and LHβ subunits is...

Protein kinase C activation by 12-0-tetradecanoylphorbol 13-acetate in CG-4 line oligodendrocytes stimulates turnover of choline and ethanolamine phospholipids by phospholipase D and induces rapid process contraction (2001)

Kobayashi, M., Kidd, D., Hutson, E., Grafton, J., McNulty, S., Rumsby, M.

Treatment of [3H]-choline- or [14C]-ethanolamine-labelled undifferentiated bipolar and differentiated multipolar CG-4 line oligodendrocytes with 12–0-tetradecanoylphorbol 13-acetate (TPA) to...

Plasma rotation induced by the dynamic ergodic divertor (2001)

Finken, K. H., Abdullaev, S. S., Eich, T., Faulconer, D. W., Kobayashi, M., Koch, R., ...

This version is available at the following URL: http://dx.doi.org/10.1088/0029-5515/41/5/303

Lorentz Angle Measurement for CO2/Isobutane Gas Mixtures (2000)

Hoshina, K., Fujii, K., Khalatyan, N., Nitoh, O., Okuno, H., Kato, Y., ...

We have developed a Lorentz angle measurement system for cool gas mixtures in the course of our R&D for a proposed JLC central drift chamber (JLC-CDC). The measurement system is characterized by the...

Search for the Decay K+ -> pi+ pi0 nu nubar (2000)

Aoki, M., Ardebili, M., Atiya, M. S., Bergbusch, P. C., Blackmore, E. W., ...

The first search for the decay K^+ -> pi^+ pi^0 nu nubar has been performed with the E787 detector at BNL. Based on zero events observed in the kinematical search region defined by 90 MeV/c <...

DIRAC Experiment and Test of Low-Energy QCD (2000)

Pentia, M, Adeva, B, Afanasiev, L G, Benayoun, M, Brekhovskikh, V, Caragheorgheopol, G, ...

The low-energy QCD predictions to be tested by the DIRAC experiment are revised. The experimental method, the setup characteristics and capabilities, along with first experimental results are...

Interleukin-4 inhibits interleukin-11 production by rheumatoid synovial cells (2000)

Taki, H., Sugiyama, E., Kuroda, A., Mino, T., Kobayashi, M.

Objective. To examine the effect of interleukin‐4 (IL‐4) on IL‐11 production by rheumatoid synovial cells. Methods. Freshly isolated rheumatoid synovial cells...

FSHβ and LHβ mRNAs in maturing male and female common carp (Cyprinus carpio ) and the response to GnRH (2000)

Kandel-Kfir, M, Gur, G, Melamed, P, Zmora, N, Kobayashi, M, Elizur, A, ...

GnRH is able to stimulate the transcription of both FSH beta and LH beta subunit genes in the common carp. Regulation of FSH beta in carp differs from that of LH beta , and their response to GnRHa...

Gonadotropins - from genes to recombinant proteins (2000)

Elizur, A, Zmora, N, Meiri, I, Kasuto, H, Rosenfeld, H, Kobayashi, M, ...

We have cloned the cDNAs encoding for the LH and FSH beta -subunits from a number of commercially important fish species, including seabream, mullet, tilapia and black carp. The cDNAs were used as...

Prediction of Mechanical Properties and Microstructures in Forged 1050 Aluminum by Numerical Simulation. (1998)

Kobayashi, M., Li, M., Sakuta, H.

Basic experiments were conducted to obtain the fundamental data of hardness distribution and grain size to estimate the mechanical properties and microstructures in forging processes; the...

Crevice Corrosion of Stainless Steels in Chloride Solution. (1998)

Uno, H., Akiyama, S., Wada, S., Kobayashi, M.

The resistance of type 304 stainless steel to crevice corrosion was evaluated by the multiple crevice assembly testing method in chloride-containing solutions; these results were compared with the...

Mechanical Properties of TiAl and (TiAl+Ti3Al) Alloys Produced by Mechanical Alloying. (1998)

Ochiai, S., Kobayashi, M., Michimura, K.

Two representative titanium aluminides containing 48 and 52 at. pct Al were produced by a mechanical alloying (MA) process for the purpose of attaining fine microstructures. For the MA apparatus, an...

Environmental Effects on the Room Temperature Ductility of Polysynthetically Twinned (PST) Crystals of Binary and Some Ternary TiAl Compounds. (1998)

Oh, M. H., Inui, H., Misaki, M., Kobayashi, M., Yamaguchi, M.

Environmental effects on the room temperature ductility of polysynthetically twinned (PST) crystals of binary and some ternary TiAl compounds have been investigated through tensile tests conducted in...

SUPERPLASTIC PHENOMENA OF FINE TIC AND TIN DISPERSED TI-6AL-4V ALLOY COMPOSITES. (1998)

Ochiai, S., Kobayashi, M., Funami, K.

Advanced Materials 93, Part B: Composites, Grain Boundaries and Nanophase Materials; Edited by M. Sakai, et al; Elsevier Science B.V. : The Netherlands

Search for $\nu_\mu \to \nu_\tau$ oscillation using the $\tau$ decay modes into a single charged particle (1998)

Eskut, E, Kayis, A, Onengüt, G, Van Dantzig, R, De Jong, M, Konijn, J, ...

Part of the neutrino events collected in 1994-1995 by the CHORUS experiment has been analysed. A search was performed for $\nu_{\tau}$ charged current interactions followed by the $\tau$ lepton deca...

A Search for $\nu_\mu \to \nu_\tau$ Oscillation (1998)

Eskut, E, Kayis, A, Onengüt, G, Van Dantzig, R, De Jong, M, Konijn, J, ...

CHORUS is an experiment searching for $\numtonut$ oscillation in the CERN wide band neutrino beam with a {\sl hybrid} setup consisting of a nuclear emulsion target followed by electronic detectors....

Genealogical relationships among cultivated avocado as revealed through RFLP analyses (1998)

Davis, J, Henderson, D, Kobayashi, M, Clegg, MT, Clegg, MT

Anonymous DNA fragments from the genome of cultivated avocado (Persea americana Mill.) were cloned into a plasmid vector and used to screen a total of 36 cultivars. There is a high level of...

The CHORUS scintillating fiber tracker and its monitoring systems (1997)

Annis, P, Aoki, S, Brooijmans, G, Brunner, J, Dupraz, J P, Dupont, J, ...

A scintillating fiber tracker system consisting of more than one million fibers has been successfully constructed and made operational for the CERN WA95/CHORUS experiment. The design and construction...

The CHORUS experiment to search for $\nu_{\mu} \rightarrow \nu_{\tau}$ oscillation (1997)

Eskut, E, Kayis, A, Onengüt, G, Van Dantzig, R, Konijn, J, Oldeman, R G C, ...

A new experimental apparatus, designed principally for a high sensitivity search for $\nu_{\mu}~\rightarrow~\nu_{\tau}$ oscillation, has been successfully constructed and made operational by the...

The CHORUS neutrino oscillation search experiment (1997)

Eskut, E, Kayis, A, Onengüt, G, Van Dantzig, R, Konijn, J, Oldeman, R G C, ...

The CHORUS experiment has successfully finished run I (320~000 recorded \numu\ CC in 94/95) and performed half of run II (225~000 \numu\ CC in 96). The analysis chain was exercised on a small data...

A kinematical selection of glueball candidates in central production (1997)

Barberis, D, Beusch, Werner, Binon, Freddy G, Carney, J N, Close, Francis Edwin, Danielsen, K M, ...

A study of central meson production as a function of the difference in transverse momentum ($dP_T$) of the exchanged particles shows that undisputed $q \overline q$ mesons are suppressed at small...

Observation of vertex factorisation breaking in central pp interactions (1996)

Barberis, D, Beusch, Werner, Binon, Freddy G, Carney, J N, Di Bari, D, Dolgopolov, A V, ...

Central \pipi events produced in pp interactions are studied in terms of correlations between the outgoing protons. It is observed there is more $\rho^{0}$(770) and \fmeson production in reactions...

Measurement of B(D_s+ -> mu+ nu_mu)/B(D_s+ -> phi mu+ nu_mu) and Determination of the Decay Constant f_{D_s} (1996)

Kodama, K., Torikai, S., Ushida, N., Mokhtarani, A., Paolone, V. S., Volk, J. T., ...

We have observed $23.2 \pm 6.0_{-0.9}^{+1.0}$ purely-leptonic decays of $D_s^+ -> \mu^+ \nu_\mu$ from a sample of muonic one prong decay events detected in the emulsion target of Fermilab experiment...

Two observers calculate the trace anomaly (1995)

Capri, A. Z., Kobayashi, M., Lamb, D. J.

We adapt a calculation due to Massacand and Schmid to the coordinate independent definition of time and vacuum given by Capri and Roy in order to compute the trace anomaly for a massless scalar field...

Time reversal violation in $K^+ \to \mu^+ \nu \gamma$ decay and three Higgs model (1995)

Kobayashi, M., Okada, Y.

Transverse muon polarization in the $K^+ \rightarrow \mu^+ \nu \gamma$ decay is calculated in the model with scalar and pseudo scalar four-Fermi interactions. Combined with a similar calculation in...

Performance and calibration of the CHORUS scintillating fiber tracker and opto-electronics readout system (1995)

Annis, P, Aoki, S, Brooijmans, G, Brunner, J, De Jong, M, Fabre, Jean-Paul, ...

An essential component of the CERN WA95/CHORUS experiment is a scintillating fiber tracker system for precise track reconstruction of particles. The tracker design, its opto-electronics readout and...

Measurement of inclusive particle spectra and test of MLLA prediction in e+e- annihilation at \Sqrt s = 58 GeV (1995)

Itoh, R, Yamauchi, M, Yamaguchi, A, Abe, K, Abe, T, Adachi, I, ...

Inclusive momentum spectra are measured for all charged particles and for each of \pi^{\pm}, K^{\pm}, K^0/\overline{K^0}, and p/\overline{p} in hadronic events produced via e^+e^- annihilation at...

Finite particle creation in 3+1 de Sitter space (1994)

Lamb, D. J., Capri, A. Z., Kobayashi, M.

In this paper we calculate the particle creation as seen by a stationary observer in 3+1 de Sitter space. This particle creation is calculated using an observer dependent geometrically based...

Discrete spectral shift in an anisotropic universe (1994)

Lamb, D. J., Capri, A. Z., Kobayashi, M.

In this paper we calculate the particle creation as seen by a stationary observer in an anisotropic universe. By using an observer and geometry dependent time to quantise a massive scalar field we...

A COMPRESSION TESTING TECHNIQUE AT HIGH RATES OF STRAIN FOR SHEET METALS (1988)

Sato, Y., Matsui, S., Kobayashi, M., Takahashi, H.

Stress-strain curves of sheet metals at high strain rates, say 700 S-1, are determined. Laminated plates are compressed dynamically by a modified split Hopkinson pressure bar system. Plate specimens...

STRAIN-INDUCED BOUNDARY MIGRATION (SIBM) IN ALUMINUM BICRYSTALS EACH WITH A TILT BOUNDARY (1988)

Inoko, F., Kobayashi, M.

In order to clarify the effect of edge dislocations on the occurrence of the strain-induced boundary migration (SIBM), aluminum bicrystals each with a tilt grain boundary were prepared. The...

A COMPRESSION TESTING TECHNIQUE AT HIGH RATES OF STRAIN FOR SHEET METALS (1988)

Sato, Y., Matsui, S., Kobayashi, M., Takahashi, H.

Stress-strain curves of sheet metals at high strain rates, say 700 S-1, are determined. Laminated plates are compressed dynamically by a modified split Hopkinson pressure bar system. Plate specimens...

STRAIN-INDUCED BOUNDARY MIGRATION (SIBM) IN ALUMINUM BICRYSTALS EACH WITH A TILT BOUNDARY (1988)

Inoko, F., Kobayashi, M.

In order to clarify the effect of edge dislocations on the occurrence of the strain-induced boundary migration (SIBM), aluminum bicrystals each with a tilt grain boundary were prepared. The...

A COMPRESSION TESTING TECHNIQUE AT HIGH RATES OF STRAIN FOR SHEET METALS (1988)

Sato, Y., Matsui, S., Kobayashi, M., Takahashi, H.

Stress-strain curves of sheet metals at high strain rates, say 700 S-1, are determined. Laminated plates are compressed dynamically by a modified split Hopkinson pressure bar system. Plate specimens...

STRAIN-INDUCED BOUNDARY MIGRATION (SIBM) IN ALUMINUM BICRYSTALS EACH WITH A TILT BOUNDARY (1988)

Inoko, F., Kobayashi, M.

In order to clarify the effect of edge dislocations on the occurrence of the strain-induced boundary migration (SIBM), aluminum bicrystals each with a tilt grain boundary were prepared. The...

EXCITON DYNAMICS IN ORGANIC MOLECULAR CRYSTALS (1985)

Matsui, A., Mizuno, K., Kobayashi, M.

Dynamical behavior of Frenkel excitons in aromatic hydrocarbon crystals, pyrene, α-perylene, β-perylene, and tetracene are overviewed based on the published references and in terms of the...

EXCITON DYNAMICS IN ORGANIC MOLECULAR CRYSTALS (1985)

Matsui, A., Mizuno, K., Kobayashi, M.

Dynamical behavior of Frenkel excitons in aromatic hydrocarbon crystals, pyrene, α-perylene, β-perylene, and tetracene are overviewed based on the published references and in terms of the...

EXCITON DYNAMICS IN ORGANIC MOLECULAR CRYSTALS (1985)

Matsui, A., Mizuno, K., Kobayashi, M.

Dynamical behavior of Frenkel excitons in aromatic hydrocarbon crystals, pyrene, α-perylene, β-perylene, and tetracene are overviewed based on the published references and in terms of the...

Rearrangement of the surface antigen gene of hepatitis B virus integrated in the human bepatoma cell lines (1983)

Koike, K., Kobayashi, M., Mizusawa, H., Yoshida, E., Yaginuma, K., Taira, M.

The rearrangement of integrated HBV DNA sequences in three different hepatoma cell lines, huH-1, huH-2, KG-55-T from Japanese patients, were studied by blot hybridization using whole HBV genome or a...

HIGH DAMPING CAPACITY OF Mn-BASE γ-PHASE ALLOYS (1981)

Ito, K., Kobayashi, M., Tsukishima, M.

The damping capacity as well as Young's modulus has been measured by flexural vibration (220-310Hz) as a function of temperature (125 - 370K) for (Mn1- XFeX) 0.95 Cu0. 05 (X = 0-146 - 0.279) and Mn1...

HIGH DAMPING CAPACITY OF Mn-BASE γ-PHASE ALLOYS (1981)

Ito, K., Kobayashi, M., Tsukishima, M.

The damping capacity as well as Young's modulus has been measured by flexural vibration (220-310Hz) as a function of temperature (125 - 370K) for (Mn1- XFeX) 0.95 Cu0. 05 (X = 0-146 - 0.279) and Mn1...

HIGH DAMPING CAPACITY OF Mn-BASE γ-PHASE ALLOYS (1981)

Ito, K., Kobayashi, M., Tsukishima, M.

The damping capacity as well as Young's modulus has been measured by flexural vibration (220-310Hz) as a function of temperature (125 - 370K) for (Mn1- XFeX) 0.95 Cu0. 05 (X = 0-146 - 0.279) and Mn1...

Transcriptional regulation of the Rhodococcus rhodochrous J1 nitA gene encoding a nitrilase.

Komeda, H, Hori, Y, Kobayashi, M, Shimizu, S

The 1.4-kb downstream region from a nitrilase gene (nitA) of an actinomycete Rhodococcus rhodochrous J1, which is industrially in use, was found to be required for the isovaleronitrile-dependent...

The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway.

Spray, C R, Kobayashi, M, Suzuki, Y, Phinney, B O, Gaskin, P, MacMillan, J

In plants, gibberellin (GA)-responding mutants have been used as tools to identify the genes that control specific steps in the GA-biosynthetic pathway. They have also been used to determine which...

Characterization of the gene cluster of high-molecular-mass nitrile hydratase (H-NHase) induced by its reaction product in Rhodococcus rhodochrous J1.

Komeda, H, Kobayashi, M, Shimizu, S

The 4.6-kb region 5'-upstream from the gene encoding a cobalt-containing and amide-induced high molecular mass-nitrile hydratase (H-NHase) from Rhodococcus rhodochrous J1 was found to be required for...

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

Oshima, M, Oshima, H, Kitagawa, K, Kobayashi, M, Itakura, C, Taketo, M

Mutations in the APC (adenomatous polyposis coli) gene appear to be responsible for not only familial adenomatous polyposis but also many sporadic cases of gastrointestinal cancers. Using homologous...

Occurrence of enzymes involved in biosynthesis of indole-3-acetic acid from indole-3-acetonitrile in plant-associated bacteria, Agrobacterium and Rhizobium.

Kobayashi, M, Suzuki, T, Fujita, T, Masuda, M, Shimizu, S

The occurrence of a hitherto unknown pathway involving the action of two enzymes, a nitrile hydratase and an amidase for the biosynthesis of indole-3-acetic acid was discovered in phytopathogenic...

Nitrilase in biosynthesis of the plant hormone indole-3-acetic acid from indole-3-acetonitrile: cloning of the Alcaligenes gene and site-directed mutagenesis of cysteine residues.

Kobayashi, M, Izui, H, Nagasawa, T, Yamada, H

Indole-3-acetic acid is the major auxin in most plants. In Cruciferae, including Brassicaceae, indole-3-acetic acid is synthesized from indole-3-acetonitrile by nitrilase, after indole-3-acetonitrile...

Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter.

Kobayashi, M, Shimomura, A, Hagiwara, M, Kawakami, K

Transcriptional activity of both ATF-1 and CREB is enhanced by protein phosphorylation. While enhancement has been attributed to an increase in binding affinity for a co-activator (CBP), induction of...

Subcutaneous Phaeohyphomycosis Caused by Veronaea botryosa in the People’s Republic of China

Matsushita, A., Jilong, L., Hiruma, M., Kobayashi, M., Matsumoto, T., Ogawa, H., ...

The second case of phaeohyphomycosis caused by Veronaea botryosa in China, in a 12-year-old boy from Jiangsu Province, is presented. Based on direct examination of the scrapings from crusted lesions;...

Gibberellin Metabolism in Maize (The Stepwise Conversion of Gibberellin A12-Aldehyde to Gibberellin A20.

Kobayashi, M., Spray, C. R., Phinney, B. O., Gaskin, P., MacMillan, J.

The stepwise metabolism of gibberellin A12-aldehyde (GA12-aldehyde) to GA20 is demonstrated from seedling shoots of maize (Zea mays L.). The labeled substrates [13C,3H]GA12-aldehyde, [13C,3H]GA12,...

Two Chains of Rhamnogalacturonan II Are Cross-Linked by Borate-Diol Ester Bonds in Higher Plant Cell Walls.

Kobayashi, M., Matoh, T., Azuma, Ji.

Polysaccharide moiety of the boron-polysaccharide complex (T. Matoh, K. Ishigaki, K. Ohno, J. Azuma [1993] Plant Cell Physiol 34: 639-642) isolated from radish (Raphanus sativus) roots has been shown...

Metabolism and Biological Activity of Gibberellin A4 in Vegetative Shoots of Zea mays, Oryza sativa, and Arabidopsis thaliana.

Kobayashi, M., Gaskin, P., Spray, C. R., Suzuki, Y., Phinney, B. O., MacMillan, J.

[17-13C,3H]Gibberellin A4 (GA4) was injected into the shoots of tall (W23/L317), dwarf-1 (d1), and dwarf-5 (d5) Zea mays L. (maize); tall (cv Nipponbare), dwarf-x (dx), and dwarf-y (dy) Oryza sativa...

The Metabolism of Gibberellin A20 to Gibberellin A1 by Tall and Dwarf Mutants of Oryza sativa and Arabidopsis thaliana.

Kobayashi, M., Gaskin, P., Spray, C. R., Phinney, B. O., MacMillan, J.

The purpose of this study was to demonstrate the metabolism of gibberellin A20 (GA20) to gibberellin A1 (GA1) by tall and mutant shoots of rice (Oryza sativa L.) and Arabidopsis thaliana (L.) Heynh....

Phytochrome, Gibberellins, and Hypocotyl Growth (A Study Using the Cucumber (Cucumis sativus L.) long hypocotyl Mutant).

Lopez-Juez, E., Kobayashi, M., Sakurai, A., Kamiya, Y., Kendrick, R. E.

The possible involvement of gibberellins (GAs) in the regulation of hypocotyl elongation by phytochrome was examined. Under white light the tall long hypocotyl (lh) cucumber (Cucumis sativus L.)...

Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus.

Utsunomiya, T, Kobayashi, M, Pollard, R B, Suzuki, F

The antiviral effect of glycyrrhizin (GR), an active component of licorice roots, was investigated in mice infected with influenza virus A2 (H2N2). When mice that had been exposed to 10 50% lethal...

Purification and structural determination of an inhibitor of starfish oocyte maturation from a Bacillus species.

Toraya, T, Maoka, T, Tsuji, H, Kobayashi, M

Inhibitors of bacterial origins of starfish oocyte maturation were sought to obtain biologically active substances which act on either hormonal signal transduction or cell cycle regulation. An oocyte...

Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli.

Nakajima, H, Kobayashi, K, Kobayashi, M, Asako, H, Aono, R

Escherichia coli K-12 OST3410 was isolated previously as a stable cyclohexane-tolerant mutant derived from cyclohexane-sensitive strain JA300. A plasmid which provides cyclohexane tolerance to strain...

Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli.

Asako, H, Nakajima, H, Kobayashi, K, Kobayashi, M, Aono, R

We previously reported that overexpression of the soxS or robA gene causes in several Escherichia coli strains the acquisition of higher organic solvent tolerance and also increased resistance to a...

Construction and characterization of pyocin-colicin chimeric proteins.

Kageyama, M, Kobayashi, M, Sano, Y, Masaki, H

Chimeric proteins were constructed from pyocin S1 or S2 and colicin E3 or E2, and their characteristics were investigated with special reference to the domain structure. The nuclease domains were...

Identification of plasmid partition function in coryneform bacteria.

Kurusu, Y, Satoh, Y, Inui, M, Kohama, K, Kobayashi, M, Terasawa, M, ...

We have identified and characterized a partition function that is required for stable maintenance of plasmids in the coryneform bacteria Brevibacterium flavum MJ233 and Corynebacterium glutamicum...

Intrauterine transmission of human T-cell leukemia virus type I in rats.

Hori, M, Ami, Y, Kushida, S, Kobayashi, M, Uchida, K, Abe, T, ...

To analyze intrauterine transmission, MT-2 cells, a human T-cell line producing human T-cell leukemia virus type I (HTLV-I), were injected into eight pregnant F344 rats, and cesarean section was...

Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa.

Sano, Y, Matsui, H, Kobayashi, M, Kageyama, M

Pyocins S1 and S2 are S-type bacteriocins of Pseudomonas aeruginosa with different receptor recognition specificities. The genetic determinants of these pyocins have been cloned from the chromosomes...

Functional domains of S-type pyocins deduced from chimeric molecules.

Sano, Y, Kobayashi, M, Kageyama, M

Functional domain structures of pyocins AP41, S1, and S2 were assigned by examining the functions of chimeric pyocins and deletion derivatives. Pyocins AP41, S1, and S2 are essentially composed of...

Cloning and characterization of genes responsible for metabolism of nitrile compounds from Pseudomonas chlororaphis B23.

Nishiyama, M, Horinouchi, S, Kobayashi, M, Nagasawa, T, Yamada, H, Beppu, T

The nitrile hydratase (NHase) of Pseudomonas chlororaphis B23, which is composed of two subunits, alpha and beta, catalyzes the hydration of nitrile compounds to the corresponding amides. The NHase...

Purification and characterization of a novel nitrilase of Rhodococcus rhodochrous K22 that acts on aliphatic nitriles.

Kobayashi, M, Yanaka, N, Nagasawa, T, Yamada, H

A novel nitrilase that preferentially catalyzes the hydrolysis of aliphatic nitriles to the corresponding carboxylic acids and ammonia was found in the cells of a facultative crotononitrile-utilizing...

Molecular dissection of influenza virus nucleoprotein: deletion mapping of the RNA binding domain.

Kobayashi, M, Toyoda, T, Adyshev, D M, Azuma, Y, Ishihama, A

Influenza virus nucleoprotein (NP) is associated with the genome RNA, forming ribonucleoprotein cores. To identify the amino acid sequence involved in RNA binding, we performed Northwestern blot...

Integrated structures of duck hepatitis B virus DNA in hepatocellular carcinoma.

Imazeki, F, Yaginuma, K, Omata, M, Okuda, K, Kobayashi, M, Koike, K

The structure of integrated viral DNA in a hepatocellular carcinoma of a duck from Chi-tung county in China was analyzed. Three different clones of integrated viral DNA, lambda DHS 6-1, lambda DHS...

Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children.

Yaginuma, K, Kobayashi, H, Kobayashi, M, Morishima, T, Matsuyama, K, Koike, K

Attention was directed to hepatitis B virus (HBV) integration in tissues obtained from an hepatocellular carcinoma (HCC) of an 11-year-old boy and from the liver of his 6-year-old brother, who had...

Detection of nucleoside triphosphate hydrolase as a circulating antigen in sera of mice infected with Toxoplasma gondii.

Asai, T, Kim, T J, Kobayashi, M, Kojima, S

The nucleoside triphosphate hydrolase, which is present in the tachyzoite form of Toxoplasma gondii, was detected as a circulating antigen in sera of mice infected with a virulent (RH) or an...

Genome variants of human adenovirus types 40 and 41 (subgroup F) in Japan.

Shinozaki, T, Araki, K, Kobayashi, M, Fujita, Y, Abe, T, Ushijima, H

Nineteen strains of fecal adenovirus were typed as adenovirus type 40 (Ad40) by restriction enzyme analysis of the DNA, using SmaI. The DNAs of the strains were further compared by digestion with...

Intravenous infusion of tridocosahexaenoyl-glycerol emulsion into rabbits. Effects on leukotriene B4/5 production and fatty acid composition of plasma and leukocytes.

Nakamura, N, Hamazaki, T, Yamazaki, K, Taki, H, Kobayashi, M, Yazawa, K, ...

Leukotriene (LT) B4 is a major chemical activator of PMN. Inhibitory effects of oral administration of docosahexaenoic acid (DHA) on LTB4 synthesis by PMN are known. We intravenously infused...

Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA.

Yaginuma, K, Shirakata, Y, Kobayashi, M, Koike, K

An in vitro system for the production of hepatitis B virus (HBV) particles was established by the transient expression of transfected HBV DNA using a human hepatocellular carcinoma cell, HuH-7, as a...

ATF-1CREB heterodimer is involved in constitutive expression of the housekeeping Na,K-ATPase alpha 1 subunit gene.

Kobayashi, M, Kawakami, K

Na,K-ATPase alpha 1 subunit is an essential protein for cell growth and homeostasis. The gene coding for the protein is expressed in various types of tissues. We previously demonstrated that the...

A second site specific endonuclease from Thermus thermophilus 111, Tth111II.

Shinomiya, T, Kobayashi, M, Sato, S

A second site specific endonuclease with novel specificity has been purified from Thermus thermophilus strain 111 and named Tth111II. The enzyme is active at temperature up to 80 degrees C and...

Nuclease TT1 from Thermus thermophilus HB8 has an endonuclease activity preferential to circular DNAs.

Takahashi, M, Kobayashi, M, Uchida, T

Homogeneously purified nuclease TT1 from Thermus thermophilus HB8 is known as an exonuclease to produce 5'-mononucleotides. Besides the exonuclease activity, nuclease TT1 also possesses endonuclease...

Tumor-associated mutations of rat mitochondrial transfer RNA genes.

Taira, M, Yoshida, E, Kobayashi, M, Yaginuma, K, Koike, K

Mitochondrial DNA is a sensitive target of chemical carcinogens (Backer and Weinstein (1980) Science 209, 297-299), suggesting that mutations of the mitochondrial genome occur in tumor cells. We...

Rearrangement of the surface antigen gene of hepatitis B virus integrated in the human hepatoma cell lines.

Koike, K, Kobayashi, M, Mizusawa, H, Yoshida, E, Yaginuma, K, Taira, M

The rearrangement of integrated HBV DNA sequences in three different hepatoma cell lines, huH-1, huH-2, KG-55-T from Japanese patients, were studied by blot hybridization using whole HBV genome or a...

A new RNA polymerase and in vitro transcription of the origin of replication from rat mitochondrial DNA.

Yaginuma, K, Kobayashi, M, Taira, M, Koike, K

A new RNA polymerase was found in a rat mitochondrial extract. This enzyme showed strong template preference in vitro for the supercoiled recombinant plasmid consisting of pBR322 and the D-loop...

Promoter selectivity of Escherichia coli RNA polymerase: effect of base substitutions in the promoter -35 region on promoter strength.

Kobayashi, M, Nagata, K, Ishihama, A

A set of 18 variant lac UV5 promoters was constructed, each carrying a single base substitution within the -35 region (nucleotide positions from -36 to -31 relative to the transcription start site)....

A phylogenetically conserved sequence within viral 3' untranslated RNA pseudoknots regulates translation.

Leathers, V, Tanguay, R, Kobayashi, M, Gallie, D R

Both the 68-base 5' leader (omega) and the 205-base 3' untranslated region (UTR) of tobacco mosaic virus (TMV) promote efficient translation. A 35-base region within omega is necessary and sufficient...

Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

Yaginuma, K, Kobayashi, M, Yoshida, E, Koike, K

The integrated form of hepatitis B virus (HBV) in the human hepatoma cell line huH2-2 and its cellular counterpart sequence have been cloned and analyzed. Blot hybridization analysis and nucleotide...

Inversely repeating integrated hepatitis B virus DNA and cellular flanking sequences in the human hepatoma-derived cell line huSP.

Mizusawa, H, Taira, M, Yaginuma, K, Kobayashi, M, Yoshida, E, Koike, K

Among recombinant phages carrying integrated hepatitis B virus (HBV) DNA sequences cloned from the human hepatoma-derived cell line huSP, one clone, lambda hu-489, revealed some unusual features. The...

Simple detection of the 5S ribosomal RNA of Pneumocystis carinii using in situ hybridisation.

Kobayashi, M, Urata, T, Ikezoe, T, Hakoda, E, Uemura, Y, Sonobe, H, ...

AIMS: To investigate the effectiveness of digoxigenin incorporated double stranded DNA probes produced by the polymerase chain reaction (PCR), for the detection of Pneumocystis carinii, using in situ...

The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study.

Hamazaki, T, Sawazaki, S, Itomura, M, Asaoka, E, Nagao, Y, Nishimura, N, ...

41 students took either docosahexaenoic acid (DHA)-rich oil capsules containing 1.5-1.8 grams DHA/day (17 females and 5 males) or control oil capsules containing 97% soybean oil plus 3% fish oil (12...

Characterization of a bacteriophage related to R-type pyocins.

Kageyama, M, Shinomiya, T, Aihara, Y, Kobayashi, M

A bacteriophage with a contractile tail which shows very similar features to R-type pyocins was isolated and characterized. This phage, named PS17,was purified by DEAE-cellulose chromatography and...

An extracellular domain of the beta subunit is essential for processing, transport and kinase activity of insulin receptor.

Haruta, T, Sawa, T, Takata, Y, Imamura, T, Takada, Y, Morioka, H, ...

The extracellular portion of the insulin receptor (IR) beta-subunit has four cysteine and four asparagine residues which are potentially involved in disulphide bond formation between the alpha- and...

Chemical modification of Penicillium 1,2-alpha-D-mannosidase by water-soluble carbodi-imide: identification of a catalytically important aspartic acid residue.

Yoshida, T, Maeda, K, Kobayashi, M, Ichishima, E

1,2-alpha-D-Mannosidase from Penicillium citrinum was inactivated by chemical modification with 1-ethyl-3-(3-dimethylamino-propyl)carbodi-imide (EDC). Most of the activity was lost after modification...

Characterization of [LeuB-24]- and [LeuB-25]-insulin analogues. Receptor binding and biological activity.

Kobayashi, M, Ohgaku, S, Iwasaki, M, Maegawa, H, Shigeta, Y, Inouye, K

Human [LeuB-24]- and [LeuB-25]-insulins were semi-synthesized from porcine insulin by an enzyme-assisted coupling method. The receptor-binding ability of [LeuB-24]- and [LeuB-25]-insulins was 30--48%...

Elongated dermatan sulphate in post-inflammatory healing skin distributes among collagen fibrils separated by enlarged interfibrillar gaps.

Kuwaba, K, Kobayashi, M, Nomura, Y, Irie, S, Koyama , Y

It has been reported that the disaccharide composition of dermatan sulphate shows transient changes after epicutaneous application of the hapten 2,4-dinitrofluorobenzene to mouse skin, and that these...

Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints

KUMAR, P., OKA, M., TOGUCHIDA, J., KOBAYASHI, M., UCHIDA, E., NAKAMURA, T., ...

The uppermost superficial surface layer of articular cartilage, the ‘lamina splendens’ which provides a very low friction lubrication surface in articular joints, was investigated using atomic...

Transcriptional regulation of the Rhodococcus rhodochrous J1 nitA gene encoding a nitrilase.

Komeda, H, Hori, Y, Kobayashi, M, Shimizu, S

The 1.4-kb downstream region from a nitrilase gene (nitA) of an actinomycete Rhodococcus rhodochrous J1, which is industrially in use, was found to be required for the isovaleronitrile-dependent...

The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway.

Spray, C R, Kobayashi, M, Suzuki, Y, Phinney, B O, Gaskin, P, MacMillan, J

In plants, gibberellin (GA)-responding mutants have been used as tools to identify the genes that control specific steps in the GA-biosynthetic pathway. They have also been used to determine which...

Characterization of the gene cluster of high-molecular-mass nitrile hydratase (H-NHase) induced by its reaction product in Rhodococcus rhodochrous J1.

Komeda, H, Kobayashi, M, Shimizu, S

The 4.6-kb region 5'-upstream from the gene encoding a cobalt-containing and amide-induced high molecular mass-nitrile hydratase (H-NHase) from Rhodococcus rhodochrous J1 was found to be required for...

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

Oshima, M, Oshima, H, Kitagawa, K, Kobayashi, M, Itakura, C, Taketo, M

Mutations in the APC (adenomatous polyposis coli) gene appear to be responsible for not only familial adenomatous polyposis but also many sporadic cases of gastrointestinal cancers. Using homologous...

Occurrence of enzymes involved in biosynthesis of indole-3-acetic acid from indole-3-acetonitrile in plant-associated bacteria, Agrobacterium and Rhizobium.

Kobayashi, M, Suzuki, T, Fujita, T, Masuda, M, Shimizu, S

The occurrence of a hitherto unknown pathway involving the action of two enzymes, a nitrile hydratase and an amidase for the biosynthesis of indole-3-acetic acid was discovered in phytopathogenic...

Nitrilase in biosynthesis of the plant hormone indole-3-acetic acid from indole-3-acetonitrile: cloning of the Alcaligenes gene and site-directed mutagenesis of cysteine residues.

Kobayashi, M, Izui, H, Nagasawa, T, Yamada, H

Indole-3-acetic acid is the major auxin in most plants. In Cruciferae, including Brassicaceae, indole-3-acetic acid is synthesized from indole-3-acetonitrile by nitrilase, after indole-3-acetonitrile...

Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na,K-ATPase alpha 1 subunit gene promoter.

Kobayashi, M, Shimomura, A, Hagiwara, M, Kawakami, K

Transcriptional activity of both ATF-1 and CREB is enhanced by protein phosphorylation. While enhancement has been attributed to an increase in binding affinity for a co-activator (CBP), induction of...

Subcutaneous Phaeohyphomycosis Caused by Veronaea botryosa in the People’s Republic of China

Matsushita, A., Jilong, L., Hiruma, M., Kobayashi, M., Matsumoto, T., Ogawa, H., ...

The second case of phaeohyphomycosis caused by Veronaea botryosa in China, in a 12-year-old boy from Jiangsu Province, is presented. Based on direct examination of the scrapings from crusted lesions;...

Gibberellin Metabolism in Maize (The Stepwise Conversion of Gibberellin A12-Aldehyde to Gibberellin A20.

Kobayashi, M., Spray, C. R., Phinney, B. O., Gaskin, P., MacMillan, J.

The stepwise metabolism of gibberellin A12-aldehyde (GA12-aldehyde) to GA20 is demonstrated from seedling shoots of maize (Zea mays L.). The labeled substrates [13C,3H]GA12-aldehyde, [13C,3H]GA12,...

Two Chains of Rhamnogalacturonan II Are Cross-Linked by Borate-Diol Ester Bonds in Higher Plant Cell Walls.

Kobayashi, M., Matoh, T., Azuma, Ji.

Polysaccharide moiety of the boron-polysaccharide complex (T. Matoh, K. Ishigaki, K. Ohno, J. Azuma [1993] Plant Cell Physiol 34: 639-642) isolated from radish (Raphanus sativus) roots has been shown...

Metabolism and Biological Activity of Gibberellin A4 in Vegetative Shoots of Zea mays, Oryza sativa, and Arabidopsis thaliana.

Kobayashi, M., Gaskin, P., Spray, C. R., Suzuki, Y., Phinney, B. O., MacMillan, J.

[17-13C,3H]Gibberellin A4 (GA4) was injected into the shoots of tall (W23/L317), dwarf-1 (d1), and dwarf-5 (d5) Zea mays L. (maize); tall (cv Nipponbare), dwarf-x (dx), and dwarf-y (dy) Oryza sativa...

The Metabolism of Gibberellin A20 to Gibberellin A1 by Tall and Dwarf Mutants of Oryza sativa and Arabidopsis thaliana.

Kobayashi, M., Gaskin, P., Spray, C. R., Phinney, B. O., MacMillan, J.

The purpose of this study was to demonstrate the metabolism of gibberellin A20 (GA20) to gibberellin A1 (GA1) by tall and mutant shoots of rice (Oryza sativa L.) and Arabidopsis thaliana (L.) Heynh....

Phytochrome, Gibberellins, and Hypocotyl Growth (A Study Using the Cucumber (Cucumis sativus L.) long hypocotyl Mutant).

Lopez-Juez, E., Kobayashi, M., Sakurai, A., Kamiya, Y., Kendrick, R. E.

The possible involvement of gibberellins (GAs) in the regulation of hypocotyl elongation by phytochrome was examined. Under white light the tall long hypocotyl (lh) cucumber (Cucumis sativus L.)...

Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus.

Utsunomiya, T, Kobayashi, M, Pollard, R B, Suzuki, F

The antiviral effect of glycyrrhizin (GR), an active component of licorice roots, was investigated in mice infected with influenza virus A2 (H2N2). When mice that had been exposed to 10 50% lethal...

Purification and structural determination of an inhibitor of starfish oocyte maturation from a Bacillus species.

Toraya, T, Maoka, T, Tsuji, H, Kobayashi, M

Inhibitors of bacterial origins of starfish oocyte maturation were sought to obtain biologically active substances which act on either hormonal signal transduction or cell cycle regulation. An oocyte...

Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli.

Nakajima, H, Kobayashi, K, Kobayashi, M, Asako, H, Aono, R

Escherichia coli K-12 OST3410 was isolated previously as a stable cyclohexane-tolerant mutant derived from cyclohexane-sensitive strain JA300. A plasmid which provides cyclohexane tolerance to strain...

Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli.

Asako, H, Nakajima, H, Kobayashi, K, Kobayashi, M, Aono, R

We previously reported that overexpression of the soxS or robA gene causes in several Escherichia coli strains the acquisition of higher organic solvent tolerance and also increased resistance to a...

Construction and characterization of pyocin-colicin chimeric proteins.

Kageyama, M, Kobayashi, M, Sano, Y, Masaki, H

Chimeric proteins were constructed from pyocin S1 or S2 and colicin E3 or E2, and their characteristics were investigated with special reference to the domain structure. The nuclease domains were...

Identification of plasmid partition function in coryneform bacteria.

Kurusu, Y, Satoh, Y, Inui, M, Kohama, K, Kobayashi, M, Terasawa, M, ...

We have identified and characterized a partition function that is required for stable maintenance of plasmids in the coryneform bacteria Brevibacterium flavum MJ233 and Corynebacterium glutamicum...

Intrauterine transmission of human T-cell leukemia virus type I in rats.

Hori, M, Ami, Y, Kushida, S, Kobayashi, M, Uchida, K, Abe, T, ...

To analyze intrauterine transmission, MT-2 cells, a human T-cell line producing human T-cell leukemia virus type I (HTLV-I), were injected into eight pregnant F344 rats, and cesarean section was...

Molecular structures and functions of pyocins S1 and S2 in Pseudomonas aeruginosa.

Sano, Y, Matsui, H, Kobayashi, M, Kageyama, M

Pyocins S1 and S2 are S-type bacteriocins of Pseudomonas aeruginosa with different receptor recognition specificities. The genetic determinants of these pyocins have been cloned from the chromosomes...

Functional domains of S-type pyocins deduced from chimeric molecules.

Sano, Y, Kobayashi, M, Kageyama, M

Functional domain structures of pyocins AP41, S1, and S2 were assigned by examining the functions of chimeric pyocins and deletion derivatives. Pyocins AP41, S1, and S2 are essentially composed of...

Cloning and characterization of genes responsible for metabolism of nitrile compounds from Pseudomonas chlororaphis B23.

Nishiyama, M, Horinouchi, S, Kobayashi, M, Nagasawa, T, Yamada, H, Beppu, T

The nitrile hydratase (NHase) of Pseudomonas chlororaphis B23, which is composed of two subunits, alpha and beta, catalyzes the hydration of nitrile compounds to the corresponding amides. The NHase...

Purification and characterization of a novel nitrilase of Rhodococcus rhodochrous K22 that acts on aliphatic nitriles.

Kobayashi, M, Yanaka, N, Nagasawa, T, Yamada, H

A novel nitrilase that preferentially catalyzes the hydrolysis of aliphatic nitriles to the corresponding carboxylic acids and ammonia was found in the cells of a facultative crotononitrile-utilizing...

Molecular dissection of influenza virus nucleoprotein: deletion mapping of the RNA binding domain.

Kobayashi, M, Toyoda, T, Adyshev, D M, Azuma, Y, Ishihama, A

Influenza virus nucleoprotein (NP) is associated with the genome RNA, forming ribonucleoprotein cores. To identify the amino acid sequence involved in RNA binding, we performed Northwestern blot...

Integrated structures of duck hepatitis B virus DNA in hepatocellular carcinoma.

Imazeki, F, Yaginuma, K, Omata, M, Okuda, K, Kobayashi, M, Koike, K

The structure of integrated viral DNA in a hepatocellular carcinoma of a duck from Chi-tung county in China was analyzed. Three different clones of integrated viral DNA, lambda DHS 6-1, lambda DHS...

Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children.

Yaginuma, K, Kobayashi, H, Kobayashi, M, Morishima, T, Matsuyama, K, Koike, K

Attention was directed to hepatitis B virus (HBV) integration in tissues obtained from an hepatocellular carcinoma (HCC) of an 11-year-old boy and from the liver of his 6-year-old brother, who had...

Detection of nucleoside triphosphate hydrolase as a circulating antigen in sera of mice infected with Toxoplasma gondii.

Asai, T, Kim, T J, Kobayashi, M, Kojima, S

The nucleoside triphosphate hydrolase, which is present in the tachyzoite form of Toxoplasma gondii, was detected as a circulating antigen in sera of mice infected with a virulent (RH) or an...

Genome variants of human adenovirus types 40 and 41 (subgroup F) in Japan.

Shinozaki, T, Araki, K, Kobayashi, M, Fujita, Y, Abe, T, Ushijima, H

Nineteen strains of fecal adenovirus were typed as adenovirus type 40 (Ad40) by restriction enzyme analysis of the DNA, using SmaI. The DNAs of the strains were further compared by digestion with...

Intravenous infusion of tridocosahexaenoyl-glycerol emulsion into rabbits. Effects on leukotriene B4/5 production and fatty acid composition of plasma and leukocytes.

Nakamura, N, Hamazaki, T, Yamazaki, K, Taki, H, Kobayashi, M, Yazawa, K, ...

Leukotriene (LT) B4 is a major chemical activator of PMN. Inhibitory effects of oral administration of docosahexaenoic acid (DHA) on LTB4 synthesis by PMN are known. We intravenously infused...

Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA.

Yaginuma, K, Shirakata, Y, Kobayashi, M, Koike, K

An in vitro system for the production of hepatitis B virus (HBV) particles was established by the transient expression of transfected HBV DNA using a human hepatocellular carcinoma cell, HuH-7, as a...

ATF-1CREB heterodimer is involved in constitutive expression of the housekeeping Na,K-ATPase alpha 1 subunit gene.

Kobayashi, M, Kawakami, K

Na,K-ATPase alpha 1 subunit is an essential protein for cell growth and homeostasis. The gene coding for the protein is expressed in various types of tissues. We previously demonstrated that the...

A second site specific endonuclease from Thermus thermophilus 111, Tth111II.

Shinomiya, T, Kobayashi, M, Sato, S

A second site specific endonuclease with novel specificity has been purified from Thermus thermophilus strain 111 and named Tth111II. The enzyme is active at temperature up to 80 degrees C and...

Nuclease TT1 from Thermus thermophilus HB8 has an endonuclease activity preferential to circular DNAs.

Takahashi, M, Kobayashi, M, Uchida, T

Homogeneously purified nuclease TT1 from Thermus thermophilus HB8 is known as an exonuclease to produce 5'-mononucleotides. Besides the exonuclease activity, nuclease TT1 also possesses endonuclease...

Tumor-associated mutations of rat mitochondrial transfer RNA genes.

Taira, M, Yoshida, E, Kobayashi, M, Yaginuma, K, Koike, K

Mitochondrial DNA is a sensitive target of chemical carcinogens (Backer and Weinstein (1980) Science 209, 297-299), suggesting that mutations of the mitochondrial genome occur in tumor cells. We...

Rearrangement of the surface antigen gene of hepatitis B virus integrated in the human hepatoma cell lines.

Koike, K, Kobayashi, M, Mizusawa, H, Yoshida, E, Yaginuma, K, Taira, M

The rearrangement of integrated HBV DNA sequences in three different hepatoma cell lines, huH-1, huH-2, KG-55-T from Japanese patients, were studied by blot hybridization using whole HBV genome or a...

A new RNA polymerase and in vitro transcription of the origin of replication from rat mitochondrial DNA.

Yaginuma, K, Kobayashi, M, Taira, M, Koike, K

A new RNA polymerase was found in a rat mitochondrial extract. This enzyme showed strong template preference in vitro for the supercoiled recombinant plasmid consisting of pBR322 and the D-loop...

Promoter selectivity of Escherichia coli RNA polymerase: effect of base substitutions in the promoter -35 region on promoter strength.

Kobayashi, M, Nagata, K, Ishihama, A

A set of 18 variant lac UV5 promoters was constructed, each carrying a single base substitution within the -35 region (nucleotide positions from -36 to -31 relative to the transcription start site)....

A phylogenetically conserved sequence within viral 3' untranslated RNA pseudoknots regulates translation.

Leathers, V, Tanguay, R, Kobayashi, M, Gallie, D R

Both the 68-base 5' leader (omega) and the 205-base 3' untranslated region (UTR) of tobacco mosaic virus (TMV) promote efficient translation. A 35-base region within omega is necessary and sufficient...

Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

Yaginuma, K, Kobayashi, M, Yoshida, E, Koike, K

The integrated form of hepatitis B virus (HBV) in the human hepatoma cell line huH2-2 and its cellular counterpart sequence have been cloned and analyzed. Blot hybridization analysis and nucleotide...

Inversely repeating integrated hepatitis B virus DNA and cellular flanking sequences in the human hepatoma-derived cell line huSP.

Mizusawa, H, Taira, M, Yaginuma, K, Kobayashi, M, Yoshida, E, Koike, K

Among recombinant phages carrying integrated hepatitis B virus (HBV) DNA sequences cloned from the human hepatoma-derived cell line huSP, one clone, lambda hu-489, revealed some unusual features. The...

Simple detection of the 5S ribosomal RNA of Pneumocystis carinii using in situ hybridisation.

Kobayashi, M, Urata, T, Ikezoe, T, Hakoda, E, Uemura, Y, Sonobe, H, ...

AIMS: To investigate the effectiveness of digoxigenin incorporated double stranded DNA probes produced by the polymerase chain reaction (PCR), for the detection of Pneumocystis carinii, using in situ...

The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study.

Hamazaki, T, Sawazaki, S, Itomura, M, Asaoka, E, Nagao, Y, Nishimura, N, ...

41 students took either docosahexaenoic acid (DHA)-rich oil capsules containing 1.5-1.8 grams DHA/day (17 females and 5 males) or control oil capsules containing 97% soybean oil plus 3% fish oil (12...

Characterization of a bacteriophage related to R-type pyocins.

Kageyama, M, Shinomiya, T, Aihara, Y, Kobayashi, M

A bacteriophage with a contractile tail which shows very similar features to R-type pyocins was isolated and characterized. This phage, named PS17,was purified by DEAE-cellulose chromatography and...

An extracellular domain of the beta subunit is essential for processing, transport and kinase activity of insulin receptor.

Haruta, T, Sawa, T, Takata, Y, Imamura, T, Takada, Y, Morioka, H, ...

The extracellular portion of the insulin receptor (IR) beta-subunit has four cysteine and four asparagine residues which are potentially involved in disulphide bond formation between the alpha- and...

Chemical modification of Penicillium 1,2-alpha-D-mannosidase by water-soluble carbodi-imide: identification of a catalytically important aspartic acid residue.

Yoshida, T, Maeda, K, Kobayashi, M, Ichishima, E

1,2-alpha-D-Mannosidase from Penicillium citrinum was inactivated by chemical modification with 1-ethyl-3-(3-dimethylamino-propyl)carbodi-imide (EDC). Most of the activity was lost after modification...

Characterization of [LeuB-24]- and [LeuB-25]-insulin analogues. Receptor binding and biological activity.

Kobayashi, M, Ohgaku, S, Iwasaki, M, Maegawa, H, Shigeta, Y, Inouye, K

Human [LeuB-24]- and [LeuB-25]-insulins were semi-synthesized from porcine insulin by an enzyme-assisted coupling method. The receptor-binding ability of [LeuB-24]- and [LeuB-25]-insulins was 30--48%...

Elongated dermatan sulphate in post-inflammatory healing skin distributes among collagen fibrils separated by enlarged interfibrillar gaps.

Kuwaba, K, Kobayashi, M, Nomura, Y, Irie, S, Koyama , Y

It has been reported that the disaccharide composition of dermatan sulphate shows transient changes after epicutaneous application of the hapten 2,4-dinitrofluorobenzene to mouse skin, and that these...

Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints

KUMAR, P., OKA, M., TOGUCHIDA, J., KOBAYASHI, M., UCHIDA, E., NAKAMURA, T., ...

The uppermost superficial surface layer of articular cartilage, the ‘lamina splendens’ which provides a very low friction lubrication surface in articular joints, was investigated using atomic...

Protein kinase C mediates the signal for interferon-gamma mRNA expression in cytotoxic T cells after their adhesion to laminin.

Li, Y Q, Kobayashi, M, Yuan, L, Wang, J, Matsushita, K, Hamada, J I, ...

A cytotoxic T-cell line, CTLL-2 cells, showed spreading after adhering to extracellular matrix proteins such as fibronectin (FN), laminin (LN) and hyarulonic acid (HA). The adhesion of CTLL-2 cells...

Bradykinin stimulates interleukin-8 production by human lung fibroblasts.

Hayashi, R, Yamashita, N, Matsui, S, Maruyama, M, Sugiyama, E, Sugiyama, S, ...

Bradykinin (BK) is a potent inflammatory mediator that is generated from kininogens by the actions of plasma and tissue kallikreins. Lung fibroblasts have the potential to participate in the...

Effect of chemical modification of antigen on characteristics of immune complexes and their glomerular localization in the murine renal tissues.

Koyama, A, Inage, H, Kobayashi, M, Nakamura, H, Narita, M, Tojo, S

In order to investigate the effect of chemical cationization of antigen on the glomerular localization of immune complexes (IC), the glomerular localization was studied in passive serum sickness...

Effect of chemical cationization of antigen on glomerular localization of immune complexes in active models of serum sickness nephritis in rabbits.

Koyama, A, Inage, H, Kobayashi, M, Narita, M, Tojo, S

The effect of chemical cationization of antigen on the glomerular localization and formation of immune complexes (IC) was investigated utilizing the models of acute accelerated and chronic serum...

Characterization studies of suppressor cells in murine bone marrow chimaeras.

Imamura, M, Fujimoto, H, Fukuhara, T, Kobayashi, M, Kasai, M, Sakurada, K, ...

When BALB/c bone marrow cells were transferred to lethally X-irradiated C3H/He mice either intrasplenically (i.s.) or intravenously (i.v.), suppressor cells were detected by means of MLR coculture...

Interleukin-4 inhibits prostaglandin E2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclo-oxygenase II but not of cyclo-oxygenase I.

Sugiyama, E, Taki, H, Kuroda, A, Mino, T, Yamashita, N, Kobayashi, M

OBJECTIVE: To characterise the effect of interleukin-4 (IL-4) on the biosynthesis of cyclo-oxygenases I (COX I) and II (COX II), the rate limiting enzymes of the synthesis of prostaglandin E2 (PGE2),...

Amplification of the c-erbB-2 (HER-2/neu) gene in gastric cancer cells. Detection by fluorescence in situ hybridization.

Ishikawa, T., Kobayashi, M., Mai, M., Suzuki, T., Ooi, A.

Amplification of the c-erbB-2 gene was examined in 120 gastric adenocarcinomas by dual-color fluorescence in situ hybridization (FISH) using probes for centromere 17 and the 17q11.2-12. The results...

Analysis of chromosome 17p13 (p53 locus) alterations in gastric carcinoma cells by dual-color fluorescence in situ hybridization.

Kobayashi, M., Kawashima, A., Mai, M., Ooi, A.

Chromosome 17 and p53 gene locus alterations were determined on 67 gastric carcinomas by dual-color fluorescence in situ hybridization, using probes for centromere 17 and the 17p13.1 (p53 locus). The...

The draft genome of Ciona intestinalis: Insights into chordate and vertebrate origins

Dehal, P, Satou, Y, Campbell, RK, Chapman, J, Degnan, B, De Tomaso, A, ...

The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to these...

Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum

Ajioka, Y, Watanabe, H, Jass, J, Yokota, Y, Kobayashi, M, Nishikura, K

a First Department of Pathology, School of Medicine, Niigata University, Niigata, Japan, b Department of Pathology, Medical School, University of Queensland, Queensland, Australia, c Third...

Systemic and local immune responses against Helicobacter pylori urease in patients with chronic gastritis: distinct IgA and IgG productive sites

Futagami, S, Takahashi, H, Norose, Y, Kobayashi, M

a Third Department of Internal Medicine, b Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan

Upregulation of Reg 1α and GW112 in the epithelium of inflamed colonic mucosa

Shinozaki, S, Nakamura, T, Iimura, M, Kato, Y, Iizuka, B, Kobayashi, M, ...

BACKGROUND AND AIMS—Colonic epithelium is involved in the regulation of intestinal function and mucosal immune responses, and its function is altered in inflammatory bowel disease (IBD). However, a...

Localisation of cyclooxygenase 1 and cyclooxygenase 2 in Helicobacter pylori related gastritis and gastric ulcer tissues in humans

Tatsuguchi, A, Sakamoto, C, Wada, K, Akamatsu, T, Tsukui, T, Miyake, K, ...

BACKGROUND—Prostaglandin endoperoxide synthase/cyclooxygenase (COX) is the key enzyme in gastric mucosal protection and repair but its cellular localisation in the human stomach is still...

Excess purine degradation caused by an imbalance in the supply of adenosine triphosphate in patients with congestive heart failure.

Hisatome, I, Ishiko, R, Miyakoda, H, Saito, M, Kitamura, H, Kinugawa, T, ...

To evaluate purine degradation in patients with congestive heart failure concentrations of serum hypoxanthine, lactate, and noradrenaline were measured before and after submaximal treadmill exercise...

Detection of DNA-bound immunoglobulins in patients with lupus nephritis, using monoclonal anti-DNA antibody.

Koyama, A, Kobayashi, M, Suzuki, S, Suzuki, M, Yamaguchi, N, Narita, M

In order to investigate the relationship between renal histopathology and the characteristics of circulating immune complexes (CICs) in patients with lupus nephritis (LN), we measured the sizes of...

Acute lymphoblastic leukaemia of the B-cell type refractory to intensive chemotherapy.

Kawashima, K, Morishima, Y, Kato, Y, Takeyama, H, Kobayashi, M, Suzuki, K, ...

Four patients, aged 15-50, with acute lymphoblastic leukaemia (ALL) shown to be of the B-cell type, since they formed rosettes with complement-coated sheep erythrocytes (EAC) and had lymphocytes...

Role of antigenic charge and antibody avidity on the glomerular immune complex localization in serum sickness of mice.

Koyama, A, Inage, H, Kobayashi, M, Ohta, Y, Narita, M, Tojo, S, ...

Passive injection of mice with preformed immune complexes (IC) made from cationized bovine serum albumin (BSA) and anti-native BSA antibody gave immune deposits along the glomerular capillary walls...

Immunological control of methicillin-resistant Staphylococcus aureus (MRSA) infection in an immunodeficient murine model of thermal injuries

Katakura, T, Yoshida, T, Kobayashi, M, Herndon, D N, Suzuki, F

Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), is a major cause of sepsis in patients who are immunosuppressed by their burns. In this study, an immunological regulation of...

Differential inhibitory effects of indomethacin, dexamethasone, and interferon-gamma (IFN-γ) on IL-11 production by rheumatoid synovial cells

Taki, H, Sugiyama, E, Mino, T, Kuroda, A, Kobayashi, M

IL-11, a member of the IL-6 type cytokines, has some biological activity related to the joint destruction in rheumatoid arthritis (RA), such as induction of osteoclast differentiation. However, its...

Cytokine-enhanced mixed lymphocyte reaction (MLR) in cord blood

Umemoto, M, Azuma, E, Hirayama, M, Nagai, M, Hiratake, S, Qi, J, ...

Although in cord blood (CB) transplantation graft-versus-host disease (GVHD) is reported to be less severe, GVHD may occur even in patients with HLA-identical sibling donors. This result shows that...

Effects of glycyrrhizin, an active component of licorice roots, on Candida albicans infection in thermally injured mice

Utsunomiya, T, Kobayashi, M, Herndon, D N, Pollard, R B, Suzuki, F

Due to the generation of burn-associated CD8+ CD11b+ TCR γ/δ+ type 2 T cells (burn-associated type 2 T cells), the susceptibility of thermally injured mice to infection with C. albicans has been...

Differential responsiveness of cord and adult blood monocytes to hepatocyte growth factor

Jiang, Qi, Azuma, E, Tanaka, M, Kobayashi, M, Hirayama, M, Kumamoto, T, ...

Monocytes as antigen-presenting cells play an important role in host defence. There are several cytokines affecting monocyte function. We demonstrate that both adult and cord blood monocytes...

Clofibrate enhances the affinity of insulin receptors in non-insulin dependent diabetes mellitus.

Murakami, K, Nambu, S, Koh, H, Kobayashi, M, Shigeta, Y

Glucose-lowering mechanism by clofibrate was studied in non-insulin dependent diabetics managed with dietary therapy alone. Clofibrate 1500 mg was administered for 1 month to 15 patients, and 75 g...

Innate immunity mediated by epidermal keratinocytes promotes acquired immunity involving Langerhans cells and T cells in the skin

Sugita, K, Kabashima, K, Atarashi, K, Shimauchi, T, Kobayashi, M, Tokura, Y

Skin is an immunological organ consisting of epidermal cells, i.e. keratinocytes and Langerhans cells (LCs, antigen-presenting dendritic cells), and both innate and acquired immune systems operate...

Maitotoxin-activated single calcium channels in guinea-pig cardiac cells.

Kobayashi, M., Ochi, R., Ohizumi, Y.

1. In order to clarify the mechanism of Ca-dependent excitatory action of maitotoxin (MTX), the most potent marine toxin known, patch-clamp techniques were used to analyse electrophysiological...

The mechanism of the inotropic action of striatoxin, a novel polypeptide toxin from a marine snail, in isolated cardiac muscle.

Ohizumi, Y., Kobayashi, M., Muroyama, A., Nakamura, H., Kobayashi, J.

1. Striatoxin (StTX), a novel polypeptide from a marine snail, caused a dose-dependent increase in contractility in the isolated atria of guinea-pig and rat in the concentration-range of 2 x 10(-9)...

The mode of inotropic action of ciguatoxin on guinea-pig cardiac muscle.

Seino, A., Kobayashi, M., Momose, K., Yasumoto, T., Ohizumi, Y.

1. Ciguatoxin (CTX) caused a dose-dependent increase in the contractile force of the guinea-pig isolated left atria at concentrations ranging from 0.1 to 10 ng ml-1 with the ED50 value of 0.5 ng...

The mechanism of action of maitotoxin in relation to Ca2+ movements in guinea-pig and rat cardiac muscles.

Kobayashi, M., Ohizumi, Y., Yasumoto, T.

Maitotoxin (MTX), the most potent marine toxin known, produced a dose-dependent positive inotropic effect on guinea-pig isolated left atria and rat ventricle strips at concentrations of 0.1 ng to 4...

The orientation and dynamics of substance P in lipid environments.

Keire, D. A., Kobayashi, M.

The membrane-associated conformation of substance P (RPKPQQFFGLM-NH2) has been previously proposed to be the NK1-receptor-active conformation. In this work, NMR methods are applied to explore the...

Ca(2+)-dependent aggregation of rabbit platelets induced by maitotoxin, a potent marine toxin, isolated from a dinoflagellate.

Watanabe, A., Ishida, Y., Honda, H., Kobayashi, M., Ohizumi, Y.

1. Administration of maitotoxin (MTX), a dinoflagellate toxin, caused aggregation of rabbit washed platelets. The cytosolic Ca2+ concentration ([Ca2+]i), measured by fura-2 fluorescence technique,...

Effects of therapeutic exercise on masticatory function in patients with progressive muscular dystrophy.

Kawazoe, Y, Kobayashi, M, Tasaka, T, Tamamoto, M

The slope of the curve relating integrated electromyographic activity of masseter muscle to biting force, the latency of the jaw-jerk reflex, and masticatory performance wee estimated in patients...

Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I.

Ishihama, H, Suzuki, Y, Muramatsu, K, Nagai, M, Kokubo, M, Shiraya, H, ...

Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I...

Immunotyping of different strains of Japanese encephalitis virus by antibody-absorption, haemagglutination-inhibition and complement-fixation tests*

Okuno, T., Okada, T., Kondo, A., Suzuki, M., Kobayashi, M., Oya, A.

The immunological characteristics of 26 strains of Japanese encephalitis virus (JEV) isolated in Japan and Malaya between 1935 and 1966 have been investigated mainly by the antibody-absorption...

Diuretic response to cyclophosphamide in rats bearing a matrix metalloproteinase-9-producing tumour.

Mizushima, Y., Sassa, K., Hamazaki, T., Fujishita, T., Oosaki, R., Kobayashi, M.

When cyclophosphamide (CY) (100-120 mg kg(-1)) was administered intravenously (i.v.) to normal F-344 rats, oliguria occurred over the 5-day observation period. Conversely, in rats bearing matrix...

Transforming growth factor beta 1 (TGF-beta 1) produced in tumour tissue after chemotherapy acts as a lymphokine-activated killer attractant.

Kuramitsu, Y., Nishibe, M., Kobayashi, M., Togashi, Y., Yuan, L., Takizawa, M., ...

Using an under agarose migration (UAM) assay, we studied lymphokine-activated killer (LAK)-attractant activity in cultured conditioned medium of tumour tissues after chemotherapy as a possible...

Phase II trial of carboplatin plus oral etoposide for elderly patients with small-cell lung cancer.

Matsui, K., Masuda, N., Fukuoka, M., Yana, T., Hirashima, T., Komiya, T., ...

A phase II trial was conducted to evaluate the efficacy and toxicity of the Egorin's carboplatin dosing formula with 14-day oral etoposide in 38 elderly patients with small-cell lung cancer (SCLC)....

Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer

Kato, T, Steers, G, Campo, L, Roberts, H, Leek, R D, Turley, H, ...

The purpose of this study is to investigate the associations of microvessel density (MVD) and other pathological variables with survival, and whether they accounted for survival differences between...

NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines

Yang, Y, Ikezoe, T, Nishioka, C, Bandobashi, K, Takeuchi, T, Adachi, Y, ...

HIV-1 protease inhibitor (PI), nelfinavir (NFV) induced growth arrest and apoptosis of NCI-H460 and -H520, A549, EBC-1 and ABC-1 non-small-cell lung cancer (NSCLC) cells in association with...

Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase

Okada, F, Shionoya, H, Kobayashi, M, Kobayashi, T, Tazawa, H, Onuma, K, ...

Weakly tumorigenic and nonmetastatic QR-32 cells derived from a fibrosarcoma in C57BL6 mouse are converted to malignant cells once they have grown after being coimplanted with a gelatine sponge which...

A quantitative analysis of lymphatic vessels in human breast cancer, based on LYVE-1 immunoreactivity

Kato, T, Prevo, R, Steers, G, Roberts, H, Leek, R D, Kimura, T, ...

This study was undertaken to determine the highly sensitive method for detecting tumour lymphatic vessels in all the fields of each slide (LV), lymphatic microvessel density (LMVD) and lymphatic...

No association between fruit or vegetable consumption and the risk of colorectal cancer in Japan

Tsubono, Y, Otani, T, Kobayashi, M, Yamamoto, S, Sobue, T, Tsugane, S

In a pooled analysis of two prospective studies with 88 658 Japanese men and women, fruit and vegetable consumptions, were not associated with a lower risk of colorectal cancer (705 cases);...

Abnormalities of the FHIT gene in human oral carcinogenesis

Tanimoto, K, Hayashi, S, Tsuchiya, E, Tokuchi, Y, Kobayashi, Y, Yoshiga, K, ...

The abnormalities of the fragile histidine triad (FHIT) gene in tissue samples of oral squamous cell carcinomas (SCCs) along with several leukoplakias and an erythroplakia were examined to determine...

Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse

Vanderkerken, K, Greef, C De, Asosingh, K, Arteta, B, Veerman, M De, Broek, I Vande, ...

One of the main characteristics of multiple myeloma cells is their predominant localization in the bone marrow. It is, however, unclear whether this is due to a selective initial entry, or whether...

Nuclear translocation of beta-catenin in colorectal cancer

Kobayashi, M, Honma, T, Matsuda, Y, Suzuki, Y, Narisawa, R, Ajioka, Y, ...

Post-translational stabilization of beta-catenin through mutation of the adenomatous polyposis coli (APC) gene has been proposed as an early step in colorectal carcinogenesis. Beta-catenin may...

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

Niizeki, H, Kobayashi, M, Horiuchi, I, Akakura, N, Chen, J, Wang, J, ...

The incidence of distant metastases is higher in the tumours with low oxygen pressure than in those with high oxygen pressure. It is well known that hypoxia induces the transcription of various genes...