Authors/writing Members:,, Daemen, Joost, Simoons, Maarten L., Wijns, William, Bagust, Adrian, Bos, Gert, ...
Bots, M.L., Remme, W.J., Lüscher, T.F., Fox, K.M., Bertrand, M., Ferrari, R., ...
Background: ACE inhibition results in secondary prevention of coronary artery disease (CAD) through different mechanisms including improvement of endothelial dysfunction. The Perindopril-Function of...
Long-term outcome after surgery for pulmonary stenosis (a longitudinal study of 22-33 years) (2006)
Roos-Hesselink, J.W., Meijboom, F.J., Spitaels, S.E.C., VanDomburg, R.T., VanRijen, E.H.M., ...
Aims Long-term (>20 years) survival and clinical outcome are only partly documented in patients who underwent surgical repair for isolated pulmonary stenosis. Yet, such data are of critical...
Evaluation of cardioplegia in coronary artery bypass graft surgery (2005)
Brower, R.W., Jong, J.W. De, Simoons, M.L., Bos, A. Van De, Hugenholtz, P.G., Haalebos, M., ...
Chang, W.C., Midodzi, W.K., Westerhout, C.M., Boersma, E., Cooper, J., Barnathan, E.S., ...
STUDY OBJECTIVE: International variation in the outcomes of patients with acute coronary syndromes (ACS) has been well reported. The relative contributions of patient, hospital, and country level...
761 Dynamic 3D echocardiography in virtual reality (2005)
Koning, A.H.J., Meijboom, F.J., McGhie, J.S., Simoons, M.L., Van Der Spek, P.J., ...
Long-term outcome after surgery for pulmonary stenosis (a longitudinal study of 22-33 years) (2005)
Roos-Hesselink, J.W., Meijboom, F.J., Spitaels, S.E.C., VanDomburg, R.T., VanRijen, E.H.M., ...
Aims Long-term (>20 years) survival and clinical outcome are only partly documented in patients who underwent surgical repair for isolated pulmonary stenosis. Yet, such data are of critical...
Mahaffey, K W, Kilaru, R, Alexander, J H, Akkerhuis, K M, Simoons, M L, ...
AIM: To study the relationship between outcomes and peak creatine kinase (CK)-MB levels after percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary...
Prognostic value of placental growth factor in patients with acute chest pain (2004)
Heeschen, C., Dimmeler, S., Fichtlcherer, S., Hamm, C.W., Berger, J., Simoons, M.L., ...
CONTEXT: Experimental data suggest that placental growth factor (PlGF), a member of the vascular endothelial growth factor family, acts as a primary inflammatory instigator of atherosclerotic plaque...
James SK, Lindahl B, Armstrong P, Califf R, Simoons, M.L., Venge P, ...
BACKGROUND: Troponin is a specific marker of myocardial damage. For early prediction of coronary events in patients with suspicion of acute coronary syndromes the assay also needs to be highly...
James SK, Siegbahn A, Armstrong P, Barnathan E, Califf R, Simoons, M.L., ...
BACKGROUND: In acute coronary syndromes, the inflammation and the coagulation systems are activated, implying an impaired outcome. In addition to platelet inhibition, recent evidence suggests that...
S Srichai MB, Jaber WA, Prior DL, Marso SP, Houghtaling PL, Menon V, ...
Continuously improving the practice of cardiology (2004)
Simoons, M.L., Boer MJ De, Boersma E, Crijns HJGM, Deckers JW, Funke K?pper J, ...
Long-term outcome and quality of life in adult patients after the Fontan operation (2004)
Roos-Hesselink J, Domburg R Van, Bogers AJJC, Simoons, M.L., Meijboom FJ
Hartfalen in de dagelijkse praktijk: patientenkenmerken, diagnostiek en behandeling (2004)
Lenzen MJ, Ottervanger JP, Lucas CMHB, Simoons, M.L., Boersma E
Dirksen, M.T., Laarman, G.J., Giualiumi, G., Tonino, W.A.L., Tavazzi, L., ...
AIM: ITF-1697 is a C-reactive protein-derived tetrapeptide that, based on pre-clinical studies, is thought to reduce reperfusion injury. We performed a dose-finding study to assess safety,...
Haim M, Battler A, Behar S, Fioretti PM, Boyko V, Simoons, M.L., ...
Bartnik M, Ryden L, Ferrari R, Malmberg K, Simoons, M.L., ...
AIM: The objective behind the Euro Heart Survey on diabetes and the heart was to study the prevalence of abnormal glucose regulation in adult patients with coronary artery disease (CAD). METHODS AND...
Bountioukos, M., Elhendy, A., Domburg, R.T. Van, Schinkel, A.F., Bax, J.J., Krenning, B.J., ...
OBJECTIVE: To assess the prognostic value of dobutamine stress echocardiography (DSE) in patients with previous myocardial revascularisation. DESIGN: Prospective study. SETTING: Tertiary referral...
Roos-Hesselink, J.W, Meijboom, F.J, Spitaels, S.E.C, Van Domburg, R, ...
Background Long-term survival and clinical outcome after surgical closure of a VSD is poorly documented. Such data are important for the future perspectives, medical care, employability, and...
Roe, M.T., Mahaffey, K.W., Kilaru, R., Alexander, J.H., Akkerhuis, K.M., Simoons, M.L., ...
Aim To study the relationship between outcomes and peak creatine kinase (CK)-MB levels after percutaneous coronary intervention (PCI) in patients with non-ST-segment elevation acute coronary...
Roos-Hesselink, J.W, Meijboom, F.J, Spitaels, S.E.C, Van Domburg, R, ...
Background Great concern exists about the ability of the anatomic right ventricle to sustain the systemic circulation in patients with transposition of the great arteries who have undergone a Mustard...
Ottervanger, J.P., Armstrong, P., Barnathan, E.S., Boersma, E., Cooper, J.S., Ohman, E.M., ...
Background Immediate, as well as early, revascularisation is of benefit in patients with acute coronary syndromes (ACS) presenting with ST elevation. However, trials comparing invasive versus medical...
Acute myocardial infardion (2003)
Boersma E, Mercado N, Poldermans D, Gardien M, Vos J, Simoons, M.L.
Acute myocardial infarction is a common disease with serious consequences in mortality, morbidity, and cost to the society. Coronary atherosclerosis plays a pivotal part as the underlying substrate...
Logistics and quality control for DNA sampling in large multicenter studies (2003)
Nederhand, R.J., Droog, S., Kluft, C., Simoons, M.L., Maat, M.P. De
Bhatt, D.L., Chew, D.P., Lincoff, A.M., Simoons, M.L., Harrington, R.A., Ommen, S.R., ...
Inflammation is increasingly recognized as having an important role in patients with acute coronary syndromes. We sought to determine whether an elevated white blood cell (WBC) count would predict...
James SK, Lindahl B, Siegbahn A, Stridsberg M, Venge P, Armstrong P, ...
BACKGROUND: Biochemical markers are useful for prediction of cardiac events in patients with non-ST-segment-elevation acute coronary syndrome (ACS). The associations between N-terminal pro-brain...
Heeschen C, Dimmeler S, Hamm CW, Fichtlscherer S, Boersma E, Simoons, M.L., ...
BACKGROUND: Convincing evidence suggests that atherosclerosis is an inflammatory disease. The inflammatory response is an important determinant of atherosclerotic plaque instability. Therefore, we...
James, S.K., Armstrong, P., Barnathan, E., Califf, R., Lindahl, B., Siegbahn, A., ...
OBJECTIVES: We sought to evaluate C-reactive protein (CRP) and troponin T (TnT) as predictors of risk of the individual end points of mortality and myocardial infarction (MI) in a large cohort of...
Soluble CD40 ligand in acute coronary syndromes (2003)
Heeschen, C., Dimmeler, S., Hamm, C.W., Boersma, E., Zeiher, A.M., ...
BACKGROUND: CD40 ligand is expressed on platelets and released from them on activation. We investigated the predictive value of soluble CD40 ligand as a marker for clinical outcome and the...
Prognostic significance growth factor serum levels in patients with acute coronary syndromes (2003)
Heeschen, C., Dimmeler, S., Hamm, C.W., Boersma, E., Zeiher, A.M., Simoons, M.L.
BACKGROUND: In patients with acute coronary syndromes, compensatory processes are initiated, including angiogenesis and endothelial regeneration of ruptured or eroded plaques. Angiogenic growth...
Hasdai D, Topol EJ, Kilaru R, Battler A, Harrington RA, Vahanian A, ...
BACKGROUND: There is a paucity of data on the incidence of mild-to-moderate heart failure (HF) complicating ST-segment elevation acute myocardial infarction (MI) and its impact on short-term...
James S, Armstrong P, Califf R, Simoons, M.L., Venge P, Wallentin L, ...
BACKGROUND: A third-generation troponin T assay with improved precision and a lower detection limit has been developed. However, the appropriate cutoff for identifying patients with the acute...
Bassand JP, Martin J, Ryden L, Simoons, M.L.
The medical profession, in particular cardiologists, acknowledge the fact that during the last 30 years, much of the progress made in the field of medicine has resulted from fruitful and close...
Alexander JH, Harrington RA, Bhapkar M, Mahaffey KW, Lincoff AM, Ohman EM, ...
PURPOSE: To investigate the prognostic importance of new small Q waves following an acute coronary syndrome. METHODS: We assessed 6-month mortality in 10501 patients with non-ST-elevation acute...
Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes (2003)
Baldus S, Heeschen C, Meinertz T, Zeiher AM, Eiserich JP, Munzel T, ...
BACKGROUND: Polymorphonuclear neutrophils (PMNs) have gained attention as critical mediators of acute coronary syndromes (ACS). Myeloperoxidase (MPO), a hemoprotein abundantly expressed by PMNs and...
Prehospital thrombolysis with reteplase: the Nijmegen/Rotterdam study (2003)
Lamfers EJ, Schut A, Hooghoudt TE, Hertzberger DP, Boersma E, Simoons, M.L., ...
Aortic valve and aortic arch pathology after coarctation repair (2003)
Roos-Hesselink, J.W., Scholzel, B.E., Heijdra, R.J., Spitaels, S.E., Meijboom, F.J., Boersma, E., ...
Aortic valve and aortic arch pathology after coarctation repair (2003)
Roos-Hesselink, J.W., Scholzel, B.E., Heijdra, R.J., Spitaels, S.E., Meijboom, F.J., Boersma, E., ...
OBJECTIVE: To investigate the incidence of clinical problems related to a bicuspid valve (aortic stenosis and regurgitation) and the incidence of ascending aorta and aortic arch pathology in...
Soluble CD40 ligand in acute coronary syndromes (2003)
Heeschen, C., Dimmeler, S., Hamm, C.W., Boersma, E., Zeiher, A.M., ...
BACKGROUND: CD40 ligand is expressed on platelets and released from them on activation. We investigated the predictive value of soluble CD40 ligand as a marker for clinical outcome and the...
Ottervanger, J.P., Armstrong, P., Barnathan, E.S., Boersma, E., Cooper, J.S., Ohman, E.M., ...
BACKGROUND: This study was designed to investigate long-term effects of the glycoprotein IIb/IIIa inhibitor abciximab in patients with acute coronary syndrome without ST elevation who were not...
Lenderink, T., Boersma, E., Heeschen, C., Vahanian, A., Boer, M.J. De, Umans, V., ...
AIMS: Treatment with the glycoprotein IIb/IIIa receptor antagonist abciximab before and during coronary intervention in refractory unstable angina improves early outcome. We collected 4-year...
Heeschen, C., Dimmeler, S., Hamm, C.W., Boersma, E., Zeiher, A.M., Simoons, M.L.
BACKGROUND: In patients with acute coronary syndromes, compensatory processes are initiated, including angiogenesis and endothelial regeneration of ruptured or eroded plaques. Angiogenic growth...
Roos-Hesselink, J.W., Meijboom, F.J., Spitaels, S.E., Domburg, R. Van, Rijen, E.H. Van, Utens, E.M., ...
AIMS: Although studies have suggested good long-term results, arrhythmias, pulmonary hypertension and left ventricular dysfunction are mentioned as sequelae long-term after surgical atrial septal...
Roos-Hesselink, J.W, Meijboom, F.J, Spitaels, S.E.C, Van Domburg, R, ...
Aims Although studies have suggested good long-term results, arrhythmias, pulmonary hypertension and left ventricular dysfunction are mentioned as sequelae long-term after surgical atrial septal...
Lenderink, T, Boersma, E, Heeschen, C, Vahanian, A, Umans, V, ...
Aims Treatment with the glycoprotein IIb/IIIa receptor antagonist abciximab before and during coronary intervention in refractory unstable angina improves early outcome. We collected 4-year follow-up...
Brown, R.E., Henderson, R.A., Koster, D., Hutton, J., Simoons, M.L.
AIMS To assess the direct medical costs and cost effectiveness of routine eptifibatide use amongst patients with unstable angina and myocardial infarction without persistent ST-segment elevation in...
Ronner E, Van Domburg RT, De Feyter PJ, Foley DP, ...
Boersma E, Harrington RA, Moliterno DJ, White H, Theroux P, ...
Brown RE, Henderson RA, Koster D, Hutton J, Simoons, M.L.
AIMS: To assess the direct medical costs and cost effectiveness of routine eptifibatide use amongst patients with unstable angina and myocardial infarction without persistent ST-segment elevation in...
Akkerhuis KM, Alexander JH, Tardiff BE, Boersma E, Harrington RA, Lincoff AM, ...
BACKGROUND: The relevance of the adverse prognostic implications of CK-MB elevation after percutaneous coronary intervention (PCI) remains controversial. Therefore, we compared the relationship...
Troponin T levels in patients with acute coronary syndromes with or wityout renal dysfunction (2002)
Aviles, R.J., Askari, A.T., Lindahl, B., Wallentin, L., Jia, G., Ohman, E.M., ...
BACKGROUND: Among patients with suspected acute coronary syndromes, cardiac troponin T levels have prognostic value. However, there is concern that renal dysfunction may impair the prognostic value,...
Chang, W.C., Harrington, R.A., Simoons, M.L., Califf, R.M., Lincoff, A.M., Armstrong, P.W.
AIMS: To evaluate the differential effects of eptifibatide therapy on unstable angina vs non-ST elevation myocardial infarction at enrollment, since the separate impact on these two major diagnostic...
Hasdai D, Behar S, Wallentin L, Danchin N, Gitt AK, Boersma E, ...
AIMS: To better delineate the characteristics, treatments, and outcomes of patients with acute coronary syndromes (ACS) in representative countries across Europe and the Mediterranean basin, and to...
James S, Armstrong P, Califf R, Husted S, Kontney F, Niemminen M, ...
AIMS: The safety and efficacy of abciximab in addition to low-molecular-weight-heparin as the primary medical treatment of acute coronary syndromes has not previously been investigated. METHODS AND...
Bertrand ME, Simoons, M.L., Fox KAA, Wallentin LC, Hamm CW, McFadden E, ...
Al-Khatib SM, Granger CB, Huang Y, Lee KL, Califf RM, Simoons, M.L., ...
BACKGROUND: The prognosis of ventricular arrhythmias among patients with non-ST-elevation acute coronary syndromes is unknown. We studied the incidence, predictors, and outcomes of sustained...
Breeman, A., Mercado, N., Lenzen, M., Harrington, R.A., Califf, R.M., ...
BACKGROUND: The 6-month clinical outcome of patients with multivessel disease enrolled in PURSUIT (Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy) is...
Aviles, R.J., Newby, L.K., Califf, R.M., Lauer, M.S., Simoons, M.L., Berger, P., ...
BACKGROUND: Among patients with suspected acute coronary syndromes, cardiac troponin T levels have prognostic value. However, there is concern that renal dysfunction may impair the prognostic value,...
Labinaz, M., Kilaru, R., Pieper, K., Marso, S.P., Kitt, M.M., Simoons, M.L., ...
BACKGROUND: Patients with prior CABG with a subsequent non-ST-segment elevation acute coronary syndrome (ACS) pose an increasingly important clinical problem. Although GP IIb/IIIa inhibitors have...
Akkerhuis, K.M., Alexander, J.H., Tardiff, B.E., Boersma, E., Harrington, R.A., Lincoff, A.M., ...
BACKGROUND: The relevance of the adverse prognostic implications of CK-MB elevation after percutaneous coronary intervention (PCI) remains controversial. Therefore, we compared the relationship...
Al-Khatib, S.M., Werf, F. Van De, White, H.D., Harrington, R.A., Simes, R.J., Topol, E.J., ...
BACKGROUND: The prognosis of ventricular arrhythmias among patients with non-ST-elevation acute coronary syndromes is unknown. We studied the incidence, predictors, and outcomes of sustained...
Hasdai, D., Behar, S., Wallentin, L., Danchin, N., Gitt, A.K., Boersma, E., ...
AIMS: To better delineate the characteristics, treatments, and outcomes of patients with acute coronary syndromes (ACS) in representative countries across Europe and the Mediterranean basin, and to...
Ronner, E., Domburg, R.T. Van, Feyter, P.J. De, Foley, D.P., ...
In order to study the safety of 'rescue' strategies in the treatment of patients with failed thrombolysis, all 548 patients admitted with evolving myocardial infarction to the Thoraxcenter,...
James, S., Armstrong, P., Califf, R., Husted, S., Kontny, F., Niemminen, M., ...
AIMS: The safety and efficacy of abciximab in addition to low-molecular-weight-heparin as the primary medical treatment of acute coronary syndromes has not previously been investigated. METHODS AND...
Variability in abciximab (ReoPro) prescribing : evidence based or budget driven (2002)
Leufkens, H.G.M., Simoons, M.L., Broekmans, A.W.
Purpose: Abciximab improves outcomes in patients undergoing percutaneous transluminal coronary intervention (PTCA). Clinicians, however, have expressed concerns that they do not have enough budget to...
Simoons, M.L., Krzemiñska-Pakula, M., Alonso, A., Goodman, S.G., Kali, A., Loos, U., ...
Aims To establish whether the addition of enoxaparin (a low-molecular-weight heparin) to streptokinase therapy improves early and sustained coronary patency and clinical outcome in patients with...
Ronner, E., Van Domburg, R.T., De Feyter, P.J., Foley, D.P., Van Der Giessen, W.J., ...
In order to study the safety of ‘rescue’ strategies in the treatment of patients with failed thrombolysis, all 548 patients admitted with evolving myocardial infarction to the Thoraxcenter,...
James, S., Armstrong, P., Califf, R., Husted, S., Kontny, F., Niemminen, M., ...
Aims The safety and efficacy of abciximab in addition to low-molecular-weight-heparin as the primary medical treatment of acute coronary syndromes has not previously been investigated. Methods and...
Harrington, R.A., Simoons, M.L., Califf, R.M., Lincoff, A.M., Armstrong, P.W.
Aims To evaluate the differential effects of eptifibatide therapy on unstable angina vs non-ST elevation myocardial infarction at enrollment, since the separate impact on these two major diagnostic...
Brown, R.E., Henderson, R.A., Koster, D., Hutton, J., Simoons, M.L.
Aims To assess the direct medical costs and cost effectiveness of routine eptifibatide use amongst patients with unstable angina and myocardial infarction without persistent ST-segment elevation in...
Ronner, E., Boersma, E., Akkerhuis, K.M., Harrington, R.A., Lincoff, A.M., Deckers, J.W., ...
Background Many patients with acute coronary syndromes are offered percutaneous coronary intervention. However, the appropriate indications for, and optimal timing of, such procedures are uncertain....
Hasdai, D., Behar, S., Wallentin, L., Danchin, N., Gitt, A.K., Boersma, E., ...
Aims To better delineate the characteristics, treatments, and outcomes of patients with acute coronary syndromes (ACS) in representative countries across Europe and the Mediterranean basin, and to...
Managing ST elevation myocardial infarction (2002)
Van De Werf, F.J., Antman, E.M., Simoons, M.L.
Fibrinolytic therapy has long been an important component of the treatment of patients with ST-elevation myocardial infarction (STEMI). Several new treatment strategies are currently being developed...
Ross, A M, McCarthy, W F, Reiner, J S, Boyle, D, Fink, C, ...
BACKGROUND: Despite the significant survival benefit associated with successful reperfusion therapy for acute myocardial infarction, global indices of outcome left ventricular function, such as...
Groot MJM De, Muijtjens AMM, Simoons, M.L., Hermens WT, Gltz JFC
OBJECTIVE: To examine whether successful coronary reperfusion after thrombolytic treatment in patients with confirmed acute myocardial infarction can be diagnosed from the plasma marker fatty acid...
Hoogerbrugge N, Domburg R Van, Kemenade M Van, Bootsma A, Simoons, M.L.
BACKGROUND: In individuals at high cardiovascular risk, such as patients with hyperlipidaemia, low dietary fat intake is used to reduce this risk. The aim of the present study was to identify...
Akkerhuis KM, Peels HOJ, Suryapranata H, ...
OBJECTIVE: Lefradafiban is the orally active prodrug of fradafiban, a glycoprotein IIb/IIIa receptor antagonist. The present phase II study aimed to determine the dose of lefradafiban that provides...
Al-Khatib SM, Pieper KS, Lee K, Mahaffey KW, Hochman JS, Pepine CJ, ...
Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris (2001)
Kahler J, Gerth S, Schafer P,Boersma E, Koster R, Terres W, Simoons, M.L., ...
Greenbaum, A.B., Harrington, R.A., Hudson, M.P., MacAulay, C.M., Wilcox, R.G., Simoons, M.L., ...
OBJECTIVES: We aimed to evaluate the benefits of the glycoprotein (GP) IIb/IIIa antagonist, eptifibatide, after patients with acute coronary syndromes (ACS) were admitted to hospitals that approach...
Akkerhuis KM, Deckers JW, Lincoff AM, Tcheng JE, Boersma E, Anderson K, ...
CONTEXT: Abciximab, a potent inhibitor of the platelet glycoprotein IIb/IIIa receptor, reduces thrombotic complications in patients undergoing percutaneous coronary intervention (PCI). Because of its...
Boersma, E., Maas, A.C.P., Hartman, J.A.M., Ilmer, B., Vos, J., Simoons, M.L.
OBJECTIVE: To describe the results of thrombolysis prior to hospitalisation in patients with evolving myocardial infarction. DESIGN: Prospective cohort study. METHOD: The 'Reperfusion for acute...
Lundergan CF, Ross AM, McCarthy WF, Reiner JS, Boyle D, Fink C, ...
Lauer MA, Houghtaling PL, Granger CB, Bhatt DL, Sapp SK, ...
Groot, M.J., Muijtjens, A.M., Simoons, M.L., Hermens, W.T., Glatz, J.F.
OBJECTIVE: To examine whether successful coronary reperfusion after thrombolytic treatment in patients with confirmed acute myocardial infarction can be diagnosed from the plasma marker fatty acid...
Akkerhuis, K.M., Simoons, M.L., Zwaan, C. Van Der, Peels, H.O., Suryapranata, H., ...
OBJECTIVE: Lefradafiban is the orally active prodrug of fradafiban, a glycoprotein IIb/IIIa receptor antagonist. The present phase II study aimed to determine the dose of lefradafiban that provides...
Akkerhuis, K.M., Deckers, J.W., Lincoff, A.M., Tcheng, J.E., Boersma, E., Anderson, K., ...
CONTEXT: Abciximab, a potent inhibitor of the platelet glycoprotein IIb/IIIa receptor, reduces thrombotic complications in patients undergoing percutaneous coronary intervention (PCI). Because of its...
Lauer, M.A., Houghtaling, P.L., Peterson, J.G., Granger, C.B., Bhatt, D.L., Sapp, S.K., ...
Background- A reactivation of ischemia after the discontinuation of intravenous heparin in acute coronary syndromes has been described. The effect of glycoprotein IIb/IIIa blockade on heparin rebound...
Cost-effectiveness of HMG coenzyme reductase inhibitors. Whom to treat? (2001)
Aims Treatment guidelines have been developed for both ‘primary’ and ‘secondary’ prevention of coronary heart disease. These should consider both the efficacy as well as the costs of such...
Akkerhuis, K.M., Klootwijk, P.A.J., Lindeboom, W., Meij, S., ...
Aims Recurrent ischaemia, detected by continuous ECG monitoring, in patients with unstable angina increases the risk of unfavourable outcome. Studies that evaluated this relationship have been...
Argatroban and alteplase in patients with acute myocardial infarction: the ARGAMI Study (2000)
Vahanian, A, Fels, P W, Besse, P, Müller, E, ...
ARGAMI was designed to assess safety and efficacy of argatroban compared with heparin as adjunctive treatment to alteplase in the treatment of patients with acute myocardial infarction. ARGAMI...
Alexander, J.H., Sparapani, R.A., Mahaffey, K.W., Deckers, J.W., Newby, L.K., Ohman, E.M., ...
CONTEXT: Controversy surrounds the diagnostic and prognostic importance of slightly elevated cardiac markers in patients with acute coronary syndromes without ST-segment elevation. OBJECTIVES: To...
Prospective study of early discharge after acute myocardial infarction (SHORT) (2000)
Boersma H, Leenders CM, Pop GAM, Veerhoek MJ, Simoons, M.L., ...
Boersma, E., Pieper, K.S., Steyerberg, E.W., Wilcox, R.G., Chang, W.C., Lee, K.L., ...
BACKGROUND: Appropriate treatment policies should include an accurate estimate of a patient's baseline risk. Risk modeling to date has been underutilized in patients with acute coronary syndromes...
Akkerhuis, K.M., Deckers, J.W., Boersma, E., Harrington, R.A., Stepinska, J., Mahaffey, K.W., ...
AIMS: Variations in outcome of patients from different geographic regions have been observed in many large international trials. We analysed the factors that might contribute to the geographic...
Hasdai D, Harrington RA, Hochman JS, Califf RM, Battler A, Box JW, ...
OBJECTIVES: The study examined whether antiplatelet treatment with eptifibatide affected the frequency and outcome of shock among patients in the Platelet Glycoprotein IIb/IIIa in Unstable Angina:...
A European view on the north american fifth consensus on antithrombotic therapy (2000)
Verstraete, M., Prentice, C.R.M., Samama, M., Verhaeghe, R., Simoons, M.L.
Heeschen, C., Hamm, C.W., Bruemmer, J., Simoons, M.L.
OBJECTIVES: We evaluated C-reactive protein (CRP) and troponin T (TnT) for predicting six-month cardiac risk in patients with unstable angina. BACKGROUND: Troponin T is predictive of cardiac risk in...
Bertrand ME, Simoons, M.L., Fox KAA, Wallentin LC, Hamm CW, McFadden E, ...
Ronner E, Kesteren HAM Van, Zijnen P, Altmann E, Molhoek PG, ...
Huisartsvertraging bij een acuut myocardinfarct (2000)
Bleeker JK, Broer J, Bouma J, Erdman RAM, Walma EP, Simoons, M.L.
Argatroban and alteplase in patients with acute myocardial infarction: the ARGAMI study (2000)
Vermeer, F., Vahanioan, A., Fels, P.W., Besse, P., Muller, E., Werf, F. Van De, ...
The benefit of abciximab in percutaneous coronary revascularization is not device-specific (2000)
Bhatt, D.L., Lincoff, M., Califf, R.M., Simoons, M.L., Tcheng, J.E., Brener, S.J., ...
Abciximab has been shown to decrease adverse outcomes after percutaneous coronary interventions, but it is unclear whether this beneficial effect is more or less pronounced with specific devices....
Occurrence and clinical significance of pseudothrombocytopenia during abciximab therapy (2000)
Sane DC, Damaraju LV, Topol EJ, Cabot CF, Mascelli MA, Harrington RA, ...
Hasdal, D., Holmes, D.R. Jr, Criger, D.A., Topol, E.J., Califf, R.M., Wilcox, R.G., ...
BACKGROUND: Studies have shown that cigarette smokers constitute a substantial proportion of patients with acute coronary syndromes (ACS) and have platelet-rich coronary thrombi. We characterized the...
Geleijnse ML, Elhendy A, Kasprzak JD, Rambaldi R, Domburg RT Van, Cornel JH, ...
AIMS: To risk stratify and shorten hospital stay in patients with spontaneous (resting) chest pain and a non-diagnostic electrocardiogram (ECG). METHODS AND RESULTS: The study comprised 102 patients...
Akkerhuis, K.M., Neuhaus, K-L., Wilcox, R.G., Vahanian, A., Boland, J-L., Hoffmann, J., ...
AIMS: Oral glycoprotein IIb/IIIa inhibitors might enhance the early benefit of an intravenous agent and prevent subsequent cardiac events in patients with acute coronary syndromes. We assessed the...
Alexander, J.H., Chierchia, S.L., Boland, J.B., Harrington, R.A., Simoons, M.L., Topol, E.J., ...
CONTEXT: Controversy surrounds the diagnostic and prognostic importance of slightly elevated cardiac markers in patients with acute coronary syndromes without ST-segment elevation. OBJECTIVES: To...
Kleiman, N.S., Cokkinos, D.V., Simoons, M.L., Harrington, R.A., Boersma, E., Califf, R.M., ...
BACKGROUND: Platelet glycoprotein (GP) IIb/IIIa antagonists prevent the composite end point of death or myocardial infarction (MI) in patients with acute coronary syndromes. There is uncertainty...
Boersma, E., Chang, W.C., Lee, K.L., Akkerhuis, K.M., Simoons, M.L., Harrington, R.A., ...
BACKGROUND: Appropriate treatment policies should include an accurate estimate of a patient's baseline risk. Risk modeling to date has been underutilized in patients with acute coronary syndromes...
Prospective study of early discharge after acute myocardial infarction (SHORT) (2000)
Boersma, H., Leenders, C.M., Pop, G.A., Veerhoek, M.J., Simoons, M.L., ...
AIMS: To identify, without additional investigation, a large group of myocardial infarction patients at low risk who would qualify for early discharge. METHODS: The decision rule was developed in 647...
Lincoff, A.M., Guerci, A.D., Ohman, E.M., Pepine, C.J., Topol, E.J., Kopecky, S.L., ...
BACKGROUND: A multinational, randomized, placebo-controlled trial (Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy, PURSUIT) demonstrated that the...
Roe, M.T., Vahanian, A., Harrington, R.A., Prosper, D.M., Pieper, K.S., Topol, E.J., ...
BACKGROUND: A proportion of patients who present with suspected acute coronary syndrome (ACS) are found to have insignificant coronary artery disease (CAD) during coronary angiography, but these...
Akkerhuis, K.M, Deckers, J.W, Boersma, E, Harrington, R.A, Stepinska, J, Mahaffey, K.W, ...
Aims Variations in outcome of patients from different geographic regions have been observed in many large international trials. We analysed the factors that might contribute to the geographic...
Geleijnse, M.L, Elhendy, A, Kasprzak, J.D, Rambaldi, R, Van Domburg, R.T, Cornel, J.H, ...
Aims To risk stratify and shorten hospital stay in patients with spontaneous (resting) chest pain and a non-diagnostic electrocardiogram (ECG). Methods and Results The study comprised 102 patients...
Ronner, E, Zijnen, P, Altmann, E, Molhoek, P.G, Van Der Wieken, L.R, ...
Aims Thrombolytic therapy restores coronary patency in patients with acute myocardial infarction, although normal perfusion (TIMI 3 flow) is not achieved in all patients. In an attempt to improve...
Prospective study of early discharge after acute myocardial infarction (SHORT) (2000)
Van Der Vlugt, J.M, Boersma, H, Leenders, C.M, Pop, G.A.M, Veerhoek, M.J, Simoons, M.L, ...
Aims To identify, without additional investigation, a large group of myocardial infarction patients at low risk who would qualify for early discharge. Methods The decision rule was developed in 647...
Akkerhuis, K. M., Wilcox, R. G., Vahanian, A., Hoffmann, J., ...
Aims Oral glycoprotein IIb/IIIa inhibitors might enhance the early benefit of an intravenous agent and prevent subsequent cardiac events in patients with acute coronary syndromes. We assessed the...
Identificatie van postinfarctpatienten met een laag risico op mortaliteit (1999)
Domburg RT Van, Deckers JW, Bergen PFMM Van, Azar AJ, Donker JJC, Simoons, M.L.
Alexander JH, Harrington RA, Tuttle RH, Berdan LG, Lincoff AM, Deckers JW, ...
Aspirin is beneficial in the prevention and treatment of cardiovascular events, but patients who have events while taking aspirin may have worse outcomes than those not on aspirin. We investigated...
Stroke in patients with acute coronary syndromes (1999)
Mahaffey, K.W., Harrington, R.A., Simoons, M.L., Granger, C.B., Graffagnino, C.
Hamm, C.W., Heeschen, C., Goldmann, B., Vahanian, A., Adgey, J., Macaya, M., ...
BACKGROUND: In patients with refractory unstable angina, the platelet glycoprotein IIb/IIIa-receptor antibody abciximab reduces the incidence of cardiac events before and during coronary angioplasty....
Minimal myocardial damage during coronary intervention is associated with impaired outcome (1999)
Simoons, M.L., Lincoff M, Harrington R, Vahanian A, ...
Klootwijk P, Lenderink T, Meij S, Boersma H, Melkert R, Umans VAW, ...
In the beginning of this century a possible relation was observed between cholesterol-rich foods, blood cholesterol levels and atherosclerosis by "pioneers" in this field as Anitschkow and De Langen....
Effects of stroke on medical resource use and costs in acute myocardial i nfarction (1999)
Tung, C.Y., Granger, C.B., Sloan, M.A., Topol, E.J., Knight, J.D., Weaver, W.D., ...
Early experience with implantable dual chamber defibrillators (1999)
Jordaens L, Kimman GJ, Theuns D, Simoons, M.L., Roelandt JRTC
Cardiovascular diseases in Europe (1999)
Boersma H, Doornbos G, Bloemberg BPM, Wood DA, Kromhout D, Simoons, M.L.
Groot MJM De, Wodzig KWH, Simoons, M.L., Glatz JFC, Hermens WT
OBJECTIVE: In patients with acute myocardial infarction (AMI), estimation of infarct size from the early markers, fatty acid-binding protein (FABP) and myoglobin (MYO), usually assumes average...
Laarman GJ, Steg PG, De Scheerder I, Heyndricckx G, Beatt K, ...
Impact of smoking cessation and smoking interventions in patients with coronary heart disease (1999)
Berkel TFM Van, Boersma H, Roos-Hesselink JW, Erdman RAM, Simoons, M.L.
Boersma, E., Akkerhuis, K.M., Theroux, P., Califf, R.M., Topol, E.J., Simoons, M.L.
BACKGROUND: Glycoprotein (GP) IIb/IIIa receptor blockers prevent life-threatening cardiac complications in patients with acute coronary syndromes without ST-segment elevation and protect against...
Heeschen, C., Hamm, C.W., Simoons, M.L.
BACKGROUND: The CAPTURE (C7E3 fab AntiPlatelet Therapy in Unstable REfactory angina) trial enrolled patients with refractory unstable angina and documented a therapeutic benefit for abciximab, a...
Maas ACP, Domburg RT Van, Deckers JW, Vermeer F, Remme WJ, Kamp O, ...
Zijlstra F, Olsson H, Grip L, Veen G, Baer FWHM, ...
Mahaffey KW, Granger CB, Sloan MA, Green CL, Gore JM, Weaver WD,, ...
Hamm, C.W., Heeschen, C., Goldmann, B., Vahanian, A., Adgey, J., Miguel, C.M., ...
BACKGROUND: In patients with refractory unstable angina, the platelet glycoprotein IIb/IIIa-receptor antibody abciximab reduces the incidence of cardiac events before and during coronary angioplasty....
Tung, C.Y., White, H., Clapp-Channing, N., Mark, D.B., Simoons, M.L., Califf, R.M., ...
BACKGROUND: Stroke occurs concurrently with myocardial infarction (MI) in approximately 30 000 US patients each year. This number is expected to rise with the increasing use of thrombolytic therapy...
Poldermans, D., Fioretti, P.M., Boersma, E., Bax, J.J., Thomson, I.R., Roelandt, J.R., ...
BACKGROUND--The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected...
Mahaffey, K.W., MacAulay, C.M., Harrington, R.A., Simoons, M.L., Granger, C.B., Califf, R.M., ...
BACKGROUND: The incidence of stroke in patients with acute coronary syndromes has not been clearly defined because few trials in this patient population have been large enough to provide stable...
Maas, A.C., Domburg, R.T. Van, Deckers, J.W., Vermeer, F., Remme, W.J., Kamp, O., ...
AIMS: To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10-14 year outcome of 533 patients who were randomized to treatment with...
Heeschen, C., Hamm, C.W., Simoons, M.L.
BACKGROUND: The CAPTURE (C7E3 fab AntiPlatelet Therapy in Unstable REfactory angina) trial enrolled patients with refractory unstable angina and documented a therapeutic benefit for abciximab, a...
Boersma, E., Akkerhuis, K.M., Theroux, P., Califf, R.M., Topol, E.J., Simoons, M.L.
BACKGROUND: Glycoprotein (GP) IIb/IIIa receptor blockers prevent life-threatening cardiac complications in patients with acute coronary syndromes without ST-segment elevation and protect against...
Klootwijk, P., Lenderink, T., Meij, S., Boersma, H., Melkert, R., Umans, V.A.W., ...
Aims Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to...
Minimal myocardial damage during coronary intervention is associated with impaired outcome (1999)
Simoons, M.L., Lincoff, M., Harrington, R., Vahanian, A., ...
Aims Studies on the glycoprotein IIb-IIIa receptor blocker abciximab in patients undergoing percutaneous coronary intervention consistently show a reduction in procedure-related myocardial...
Impact of smoking cessation and smoking interventions in patients with coronary heart disease (1999)
Boersma, H., Roos-Hesselink, J.W., Erdman, R.A.M., Simoons, M.L.
Maas, A.C.P., Van Domburg, R.T., Deckers, J.W., Vermeer, F., Remme, W.J., Kamp, O., ...
Aims To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10–14 year outcome of 533 patients who were randomized to treatment with...
Maseri, A, Armstrong, P W, Califf, R M, Gibler, W B, Hamm, C W, ...
Platelet glycoprotein (GP) IIb/IIIa blockade has the potential to advance treatment of acute coronary syndromes, both as a primary pharmacologic approach and an adjunct to interventional treatment...
Coyne, K S, Moreyra, E, Reiner, J S, Greenhouse, S W, Walker, P L, ...
BACKGROUND: Reperfusion therapy for myocardial infarction, understood to reduce mortality by preserving left ventricular function, was initially expected to provide increasing benefits over time....
Maseri, A, Armstrong, P W, Califf, R M, Gibler, W B, Hamm, C W, ...
Platelet glycoprotein (GP) IIb/IIIa blockade has the potential to advance treatment of acute coronary syndromes, both as a primary pharmacologic approach and an adjunct to interventional treatment...
Peterson, E.D., Hathaway, W.R., Zabel, K.M., Pieper, K.S., Granger, C.B., Wagner, G.S., ...
OBJECTIVES: We examined the prognostic significance of precordial ST segment depression among patients with an acute inferior myocardial infarction. BACKGROUND: Although precordial ST segment...
Braunwald E, Maseri A, Armstrong PWE, Califf RM, Gibler WB, Hamm C, ...
Platelet glycoprotein (GP) IIb/IIIa blockade has the potential to advance treatment of acute coronary syndromes, both as a primary pharmacologic approach and an adjunct to interventional treatment...
Hout BA Van, Bowman L, Zelinger DJ, Simoons, M.L.
Cost-effectiveness analyses are routinely performed to determine whether the additional cost of a novel therapy is balanced by additional effectiveness. The definitions of costs and effects involve a...
Extended mortality benefit of early postinfarction reperfusion (1998)
Ross, A.M., Coyne, K.S., Moreyra, E., Reiner, J.S., Greenhouse, S.W., Walker, P.L., ...
Goodman, S.G., Langer, A., Ross, A.M., Wildermann, N.M., Barbagelata, A., Sgarbossa, E.B., ...
BACKGROUND: Although the stratification of patients with myocardial infarction into ECG subsets based on the presence or absence of new Q waves has important clinical and prognostic utility,...
Reperfusion therapy for acute myocardial infarction. Which strategy for which patient? (1998)
Boersma E, Steyerberg EW, Simoons, M.L.
Several modes of reperfusion therapy for evolving myocardial infarction (MI) have been developed, which differ in terms of effectiveness, complexity and costs. Reperfusion resources are often...
Fatty acid-binding protein and the early detection of acute myocardial infarction (1998)
Glatz JFC, Simoons, M.L., Kragten JA, Et Al
Fatty acid-binding protein (FABP) is a newly introduced plasma marker of acute myocardial infarction (AMI). The plasma kinetics of FABP (15 kD) closely resemble those of myoglobin (18 kD) in that...
Unstable angina: good long-term outcome after a complicated early course (1998)
Domburg RT Van, Miltenburg AJ Van, Veerhoek RJ, Simoons, M.L.
Identification of a low-risk population after myocardial infarction (1998)
Domburg RT Van, Deckers JW, Bergen PFMM Van, Azar AJ, Jonker JJC, Simoons, M.L.
EUROPA substudies, confirmation of pathophysiological concepts (1998)
Simoons, M.L., Vos J, Feyter PJ De, Bots ML, Remme WJ, Grobbee DE, ...
In patients with coronary disease, ACE inhibitors may improve endothelial function in the coronary arteries as well as peripheral arteries, and may have anti-proliferative effects which might result...
Fox KM, Henderson JR, Bertrand ME, Ferrari R, Remme WJ, Simoons, M.L.
BACKGROUND: Angiotensin-converting enzyme (ACE) inhibitors have an accepted place in the treatment of hypertension and heart failure. However, at present they have no specific role in the prevention...
Casparie AF, Hout BA Van, Simoons, M.L.
There is a growing interest in developing clinical guidelines which support the efficiency of medical care by weighting the potential benefits against the costs of interventions. In the recently...
Bhatt DL, Lincoff AM, Kereiakes DJ, Tcheng JE, Simoons, M.L., ...
Data from the 5 large randomized, double-blind, placebo-controlled trials that used glycoprotein IIb/IIIa inhibitors during percutaneous transluminal coronary angioplasty were pooled for a total of...
Vermeer F, Verheugt FWA, Krauss XH, ...
Goodman, S.G., Topol, E.J., Armstrong, P.W., Simoons, M.L., Langer, A., Ross, A.M., ...
BACKGROUND: Although the stratification of patients with myocardial infarction into ECG subsets based on the presence or absence of new Q waves has important clinical and prognostic utility,...
Mahaffey, K.W., Califf, R.M., Granger, C.B., Sloan, M.A., Thompson, T.D., Gore, J.M., ...
BACKGROUND: Nonhemorrhagic stroke occurs in 0.1% to 1.3% of patients with acute myocardial infarction who are treated with thrombolysis, with substantial associated mortality and morbidity. Little is...
Klootwijk, P., Meij, S., Melkert, R., Lenderink, T., Simoons, M.L.
BACKGROUND: In the CAPTURE (c7E3 Fab Anti Platelet Therapy in Unstable REfractory angina) trial, 1265 patients with refractory unstable angina were treated with abciximab or placebo, in addition to...
Sloan, M.A., Gore, J.M., Simoons, M.L., Califf, R.M., Weaver, W.D., Topol, E.J., ...
BACKGROUND: Limited information exists on risk factors for mortality after thrombolysis-related intracranial hemorrhage. We wished to determine the characteristics associated with 30-day mortality...
Wijbenga, J.A.M., Meij, S.H., Simoons, M.L., Malik, M.
Aim To evaluate the clinical and prognostic value of the heart rate variability index in patients with congestive heart failure. Methods Sixty-four patients with chronic congestive heart failure and...
Van Domburg, R.T, Klootwijk, P, Deckers, J.W, Jonker, J.J.C, Simoons, M.L
Aims The Cardiac Infarction Injury Score (CIIS) is an electrocardiographic classification system that was developed as a diagnostic tool to assess the extent of cardiac injury in acute myocardial...
Califf, R M, Berger, P B, Bates, E R, Simoons, M L, ...
BACKGROUND: Use of aggressive and invasive interventions is more common in the USA than in other countries. We have compared use of resources for patients with cardiogenic shock after myocardial...
Hermens, W T, Kint, P P, Klootwijk, P J, Simoons, M L
OBJECTIVE: Reperfusion of the infarct-related artery in patients with acute myocardial infarction limits infarct size, but also causes accelerated release into plasma of cardiac tissue proteins. The...
Balk, A.H., Zondervan, P.E., Van Gelder, T., Mochtar, B., Simoons, M.L., ...
BACKGROUND: Treatment policy of acute rejection after heart transplantation has been changed after adopting the ISHLT endomyocardial biopsy grading system in 1991. OBJECTIVE: To determine the effect...
Pietila, K., Hermens, W.T., Harmoinen, A., Baardman, T., Pasternack, A., Topol, E.J., ...
Peak serum C-reactive protein concentrations were measured in 146 patients randomized to receive streptokinase, alteplase, or a combination of streptokinase and alteplase in the GUSTO-I trial. Those...
Holmes, D.R., Califf, R.M., Werf, F. Van De, Berger, P.B., Bates, E.R., Simoons, M.L., ...
BACKGROUND: Use of aggressive and invasive interventions is more common in the USA than in other countries. We have compared use of resources for patients with cardiogenic shock after myocardial...
Cobbaert C, Hermens WT, Kint PP, Klootwijk APJ, Simoons, M.L.
OBJECTIVE: Reperfusion of the infarct-related artery in patients with acute myocardial infarction limits infarct size, but also causes accelerated release into plasma of cardiac tissue proteins. The...
Perspectives on Large-Scale Cardiovascular Clinical Trials for the New Millenium (1997)
Topol, E.J., Califf, R.M., Werf, F. Van Der, Simoons, M.L., Hampton, J., Lee, K.L., ...
Klootwijk P, Meij S, Es GA Van, M?ller EJ, Umans VAWM, Lenderink T, ...
AIMS: The selection of ECG leads used for ST monitoring may influence detection and quantitation of ischaemia. METHODS: We compared on-line continuous 48-h 12-lead against 3-lead ST monitoring in 130...
Bossuyt PMM, Nette RW, Simoons, M.L., Taylor TR
Previous studies of management of unstable angina have revealed substantial differences in management between different hospitals, especially with respect to the use of coronary angiography....
Califf, R.M., Woodlief, L.H., Harrell, F.E., Lee, K., White, H.D., Guerci, A., ...
We developed a logistic regression model with data from the GUSTO-I trial to predict mortality rate differences in individual patients who received accelerated tissue plasminogen activator (TPA)...
Berkowitz, S.C., Granger, C.B., Pieper, K.S., Lee, K.L., Gore, J.M., Simoons, M.L., ...
BACKGROUND: Although the benefit of thrombolytic therapy in reducing mortality in acute myocardial infarction is well established, the types of bleeding and risk factors for bleeding are less well...
BACKGROUND: Thrombolytic therapy should only be used when expected benefits outweigh the risks. In order to obtain a precise estimation of prognosis, with and without thrombolytic therapy, we...
Selection of reperfusion therapy for individual patients with evolving myocardial infarction (1997)
Collins, R., White, H., Love, T., Weaver, D.W., Ohman, M.E., Lee, K.L., ...
Verheugt, F.W.A., Simoons, M.L., Bär, F., Veen, G., ...
Klootwijk, P., Meij, S., Es, G. A. V., Müller, E. J., Lenderink, T., ...
Aims The selection of ECG leads used for ST monitoring may influence detection and quantitation of ischaemia. Methods We compared on-line continuous 48-h 12-lead against 3-lead ST monitoring in 130...
Arnold, A. E. R., Simoons, M. L.
Background Thrombolytic therapy should only be used when expected benefits outweigh the risks. In order to obtain a precise estimation of prognosis, with and without thrombolytic therapy, we...
White, H D, Sadowski, Z, Armstrong, P W, Vahanian, A, ...
BACKGROUND: In the randomized Global Utilization of t-PA and Streptokinase for Occluded Coronary Arteries (GUSTO-I) trial, 41021 patients received one of four thrombolytic regimens. Patients treated...
Rutsch, W R, Califf, R M, Simoons, M L, Aylward, P E, Armstrong, P W, ...
OBJECTIVES: This study sought to examine the relations among patient characteristics, time to thrombolysis and outcomes in the international GUSTO-I trial. BACKGROUND: Studies have shown better left...
Boersma H, Arnold AER, Deckers JW, Simoons, M.L.
Currently several modes of reperfusion therapy for acute myocardial infarction are available. Streptokinase, accelerated alteplase and direct angioplasty are the most frequently used. These options...
Grijseels EWM, Deckers JW, Hoes AW, Boersma E, Hartman JAM, ...
OBJECTIVE: To improve pre-hospital triage of patients with suspected acute cardiac disease. DESIGN: Prospective study. SUBJECTS. Patients with symptoms suggestive of acute cardiac pathology, who were...
Baardman T, Hermens WTh, Lenderink T, Molhoek GP, Grollier G, Pfisterer M, ...
BACKGROUND: The recent international GUSTO trial of 41,021 patients with acute myocardial infarction demonstrated improved 90-min infarct related artery patency as well as reduced mortality in...
Zijlstra F, Boer MJ De, Beukema WP, Liem AL, Reiffers S, Huysmans D, ...
The comparative efficacy of thrombolytic drugs and primary angioplasty for acute myocardial infarction have recently been studied, but long-term follow-up data have not yet been reported. We...
Klootwijk, P., Langer, A., Meij, S., Green, C., Veldkamp, F., Ross, A.M., ...
In the GUSTO-I ECG ischaemia monitoring substudy, 1067 patients underwent continuous ST segment monitoring, using vector-derived 12-lead (406 patients), 12-lead (373 patients) and 3-lead Holter (288...
Time From Symptom Onset to Treatment and Outcomes after Thrombolytic Therapy (1996)
Newby, L.K., Rutsch, W.R., Califf, R.M., Simoons, M.L., Aylward, P.E., Armstrong, P.W., ...
OBJECTIVES: This study sought to examine the relations among patient characteristics, time to thrombolysis and outcomes in the international GUSTO-I trial. BACKGROUND: Studies have shown better left...
Aufderheide TP, Kereiakes DJ, Weaver WD, Gibler WB, Simoons, M.L.
Prehospital 12-lead electrocardiographic (ECG) diagnostic strategies have been proven feasible and effective, provided they are designed and implemented properly. The authors of this communication...
Califf, R.M., White, H.D., Werf, F. Van De, Sadowski, Z., Armstrong, P.W., Vahanian, A., ...
BACKGROUND: In the randomized Global Utilization of t-PA and Streptokinase for Occluded Coronary Arteries (GUSTO-I) trial, 41021 patients received one of four thrombolytic regimens. Patients treated...
Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour (1996)
Boersma E, Maas ACP, Deckers JW, Simoons, M.L.
BACKGROUND: There is conclusive evidence from clinical trials that reduction of mortality by fibrinolytic therapy in acute myocardial infarction is related to the time elapsing between onset of...
Pre-hospital triage and thrombolytic therapy (1996)
Maas ACP, Grijseels EWM, Hartman JAM, Prins A, Deckers JW, Simoons, M.L.
Simoons, M.L., Bossuyts PMM, Taylor TR, Veerhoek MJ
OBJECTIVES: Examination of the difference in management strategies with respect to coronary angiography in patients with unstable angina pectoris, and the consequences of this difference on...
Woodfield SL, Lundergan CF, Reiner JS, Greenhouse SW, Thompson MA, Rohrbeck SC, ...
OBJECTIVES: This study sought to determine whether diabetes mellitus, in the setting of thrombolysis for acute myocardial infarction, affects 1) early infarct-related artery patency and reocclusion...
Zijlstra, F., De Boer, M. J., Beukema, W. P., Liem, A. L., Reiffers, S., Huysmans, D., ...
The comparative efficacy of thrombolytic drugs and primary angioplasty for acute myocardial infarction have recently been studied, but long-term follow-up data have not yet been reported. We...
Simoons, M. L., Bossuyt, P. M. M., Taylor, T. R., Veerhoek, M. J.
Objectives Examination of the difference in management strategies with respect to coronary angiography in patients with unstable angina pectoris, and the consequences of this difference on prognosis....
Baardman, T., Hermens, W. Th., Lenderink, T., Molhoek, G. P., Grollier, G., Pfisterer, M., ...
Background The recent international GUSTO trial of 41 021 patients with acute myocardial infarction demonstrated improved 90-mm infarct related artery patency as well as reduced mortality in patients...
Klootwijk, P., Langer, A., Meij, S., Green, C., Veldkamp, R. F., Ross, A. M., ...
In the GUSTO-I ECG ischaemia monitoring substudy, 1067 patients underwent continuous ST segment monitoring, using vector-derived 12-lead (406 patients), 12-lead (373 patients) and 3-lead Holter (288...
Boersma, H., Van Der Vlugt, M. J., Arnold, A. E. R., Deckers, J. W., Simoons, M. L.
Currently several modes of reperfusion therapy for acute myocardial infarction are available. Streptokinase, accelerated alteplase and direct angioplasty are the most frequently used. These options...
Grijseels, E. W. M., Deckers, J. W., Hoes, A. W., Boersma, E., Hartman, J. A. M., ...
Objective To improve pre-hospital triage of patients with suspected acute cardiac disease Design Prospective study Subjects Patients with symptoms suggestive of acute cardiac pathology, who were seen...
Granger, C B, Simoons, M L, Sloan, M A, Weaver, W D, White, H D, ...
BACKGROUND: Stroke is the most feared complication of thrombolysis for acute myocardial infarction because of the resulting mortality and disability. We analyzed the incidence, timing, and outcomes...
Simoons, M L, Van Es, G A, Arnold, A E
BACKGROUND: Long-term follow-up in patients treated with thrombolysis for acute myocardial infarction thus far has been reported in a few studies only, and no long-term follow-up is available for...
Incidence and follow-up of Braunwald Subgroups in unstable angina pectoris (1995)
Miltenburg AJM Van, Simoons, M.L., Veerhoek R, Bossuyt PMM
OBJECTIVES. This study was performed to establish the prognosis of patients with unstable angina within the subgroups of the Braunwald classification. BACKGROUND. Among many classifications of...
Grijseels EWM, Deckers JW, Hoes AW, Hartman JAM, Does E Vd, Loenen E Van, ...
OBJECTIVE: To evaluate previously developed algorithms for the improvement of pre-hospital triage of patients with suspected acute cardiac disease. DESIGN: Prospective study. SUBJECTS: Patients with...
Bleeker JK, Simoons, M.L., Erdman RAM, Leenders CM, Kruyssen HACM, Lamers LM, ...
BACKGROUND--Early thrombolytic therapy for patients having a myocardial infarct size and improves survival. AIM--A study was undertaken to examine the components of pre-hospital delay in patients...
Mark DB, Hlatky MA, Califf RM, Naylor CD, Lee KL, Armstrong PW, ...
BACKGROUND. Patients with acute myocardial infarction who were treated with accelerated tissue plasminogen activator (t-PA) (given over a period of 1 1/2 hours rather than the conventional 3 hours,...
Dellborg M, Steg PG, Simoons, M.L., Dietz R, Lotze U, ...
Reperfusion therapy has lowered mortality in patients suffering from acute myocardial infarction. Failure to reperfuse is associated with an increased short- and long-term mortality. In a prospective...
Bleeker JK, Lamers LM, Leenders IM, Kruyssen DC, Simoons, M.L., Trijsburg TW, ...
Survival of an acute myocardial infarction (AMI) and subsequent prognosis are highly dependent on the time between onset of symptoms and medical intervention. The purpose of this study is to...
Optimal use of coronary care units: a review (1995)
Grijseels EWM, Deckers JW, Hoes AW, Hartman JAM, Simoons, M.L.
Patients at a low probability of acute cardiac pathology constitute a considerable proportion in many coronary care units (CCUs), such that physicians should consider more effective alternatives than...
Lee, K.L., Woodlief, L.H., Topol, E.J., Weaver, W.G., Betriu, A., Col, J., ...
BACKGROUND: Despite remarkable advances in the treatment of acute myocardial infarction, substantial early patient mortality remains. Appropriate choices among alternative therapies and the use of...
Simes, R.J., Topol, E.J., Holmes, D.R., White, H.D., Rutsch, W.R., Vahanian, A., ...
BACKGROUND: The Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries (GUSTO-I) trial was designed to test whether thrombolytic strategies achieving more complete, early,...
Risk-benefit of thrombolysis (1995)
In larger trials the relative reduction in mortality rates brought about by thrombolytic therapy is similar among various subgroups. Accordingly, the absolute mortality reduction by thrombolytic...
Langer, A., Krucoff, M.W., Klootwijk, P., Veldkamp, R., Simoons, M.L., Granger, C., ...
OBJECTIVES. The ST segment monitoring substudy of the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-I) trial compared the speed and...
Ridogrel as an adjunct to thrombolysis in acute myocardial infarction (1995)
Simoons, M.L., Laarman GJK, Nijssen KM, Dellborg M, ...
An open pilot study was performed to assess the safety and preliminary efficacy of ridogrel, a selective thromboxane-A2 synthetase inhibitor and thromboxane-A2/prostaglandin endoperoxide receptor...
Lenderink, T., Simoons, M.L., Es, G.A. Van, Werf, F. Van De, Verstraete, M., Arnold, A.E.R.
BACKGROUND: Long-term follow-up in patients treated with thrombolysis for acute myocardial infarction thus far has been reported in a few studies only, and no long-term follow-up is available for...
Pre-hospitale trombolytische behandeling met alteplase of streptokinase (1995)
Grijseels EWM, Hartman JAM, Lenderink T, Deckers JW, Hoes AW, Simoons, M.L.
Stroke after thrombolysis: mortality and functional outcomes in the GUSTO-I trial (1995)
Gore, J.M., Granger, C.B., Simoons, M.L., Sloan, M.A., Weaver, W.D., White, H.D., ...
BACKGROUND: Stroke is the most feared complication of thrombolysis for acute myocardial infarction because of the resulting mortality and disability. We analyzed the incidence, timing, and outcomes...
A cost effectiveness study is presented on the use of c7E3 in high risk patients undergoing percutaneous coronary angioplasty (PTCA). The results from the EPIC study have been combined with cost data...
Antiplatelet therapy in therapy-resistant unstable angina. A pilot study with REO PRO (c7E3) (1995)
Simoons, M.L., Boer, M.J. De, Miltenburg, A. Van, Feyter, P.J. De
Patients with unstable angina, refractory to intensive medical therapy, are at high risk of developing thrombotic complications, such as myocardial infarction and coronary occlusion during coronary...
Thrombolytic therapy is a major step forward in the treatment of acute myocardial infarction and results in substantial reduction of mortality. However, in individual patients the benefits and...
Grijseels EWM, Bouten MJM, Lenderink T, Deckers JW, Hoes AW, Hartman JAM, ...
OBJECTIVE: To assess the practical application, safety and long-term outcome of pre-hospital thrombolytic intervention with either alteplase or streptokinase in patients with extensive myocardial...
GRIJSEELS, E. W. M., BOUTEN, M. J. M., LENDERINK, T., DECKERS, J. W., HOES, A. W., HARTMAN, J. A. M., ...
Objective To assess the practical application, safety and long-term outcome of pre-hospital thrombolytic intervention with either alteplase or streptokinase in patients with extensive myocardial...
ARNOLD, A. E. R., SIMOONS, M. L.
Thrombolytic therapy is a major step forward in the treatment of acute myocardial infarction and results in substantial reduction of mortality. However, in individual patients the benefits and...
GRUSEELS, E. W. M., DECKERS, J. W., HOES, A. W., HARTMAN, J. A. M., VAN DOES, E. DER, LOENEN, E. VAN, ...
Objective:To evaluate previously developed algorithms for the improvement of pre-hospital triage of patients with suspected acute cardiac disease. Design:Prospective study. Subjects:Patients with...
GRIJSEELS, E. W. M., BOUTEN, M. J. M., LENDERINK, T., DECKERS, J. W., HOES, A. W., HARTMAN, J. A. M., ...
Objective To assess the practical application, safety and long-term outcome of pre-hospital thrombolytic intervention with either alteplase or streptokinase in patients with extensive myocardial...
Van Den Brand, M.J., Van Miltenburg, A., De Boer, M.J., Van Der Wieken, L.R., De Feyter, P.J., Simoons, M.L.
Patients with unstable angina, refractory to intensive medical therapy, are at high risk for developing thrombotic complications, such as recurrent ischemia, myocardial infarction and coronary...
Long-term survival after successful out-of-hospital resuscitation (1994)
Kimman, G.P., Ivens, E.M., Hartman, J.A., Hart, H.N., Simoons, M.L.
Between 1983 and 1989, 962 patients in Rotterdam were resuscitated outside hospital, of whom 240 (25%) could be discharged alive. A follow-up study was performed to determine prognosis in these...
Randomized trial of a GPIIb/IIIa platelet receptor blocker in refractory unstable angina (1994)
Simoons, M.L., Boer MJ De, Miltenburg AJM Van, Hoorntje JCA, Heyndrickx GR, ...
BACKGROUND: Patients with unstable angina despite intensive medical therapy, ie, refractory angina, are at high risk for developing thrombotic complications: myocardial infarction or coronary...
Krucoff MW, Green CL, Langer A, Klootwijk P, Trollinger KM, Sawchak ST, ...
Prehospitale trombolyse: uitvoerbaarheid, veiligheid en effectiviteit (1994)
Grijseels EWM, Bouten MJM, Deckers JW, Hartman JAM, Simoons, M.L.
Reperfusion in acute myocardial infarction (1994)
Schlant RC, O'Rourke RA, Collen D, Kennedy JW, Kuschnir E, Meyer J, ...
Harmoinen, A, Hermens, W, Simoons, M L
Serum C-reactive protein rises in acute myocardial infarction, correlating positively with infarct size if thrombolytic treatment is not given. This correlation disappears if thrombolytic treatment...
Simoons, M L, Detry, J M, Von Essen, R, Deckers, J W, ...
The role of coronary angiography before hospital discharge after myocardial infarction was assessed in 1043 hospital survivors of the alteplase/placebo and the alteplase/PTCA trial of the European...
Retreatment with Alteplase for early Signs of Reocclusion after Thrombolysis (1993)
Simoons, M.L., Arnout, J., Brand, M. Van Den, Verstraete, M.
Recurrent chest pain with new ST-segment elevation was observed in 26 of 652 patients (4%) with myocardial infarction in a clinical trial of alteplase (recombinant tissue-type plasminogen activator;...
Verbetering opname-beleid op de hartbewakingseenheden (1993)
Grijseels EWM, Deckers JW, Hartman JAM, Maugenest A, Simoons, M.L.
Intracranial hemorrhage after thrombolytic therapy, a perspective (1993)
Simoons, M.L., Jaegere P. De, Domburg R. Van, Boersma E
The most feared complication of thrombolytic therapy is intracranial hemorrhage. Nevertheless, the benefits of thrombolysis far outweight the potential hazards of a cerebral bleed. In individual...
Arnold AER, Simoons, M.L., Detry JMR, Essen R Von, Deckers JW, ...
The role of coronary angiography before hospital discharge after myocardial infarction was assessed in 1043 hospital survivors of the alteplase/placebo and the alteplase/PTCA trial of the European...
Het Prehospitaal Electrocardiografie Project (PEP) (1993)
Maugenest A, Hartman JAM, Deckers JW, Grijseels E, Simoons, M.L.
Indications for thrombolytic therapy 1993 - 1994 (1993)
Simoons, M.L., Jaegere P De, Domburg R Van, Boersma E, Arnold AER
Uitstel bij het inroepen van hulp door hartinfarctpatienten (1993)
Bleeker JK, Lamers LM, Simoons, M.L., Leenders CM, Kruyssen HACM, Trijsburg RW, ...
Pietil? K, Harmoinen A, Hermens W, Simoons, M.L., Verstraete M.
Serum C-reactive protein rises in acute myocardial infarction, correlating positively with infarct size if thrombolytic treatment is not given. This correlation disappears if thrombolytic treatment...
Mannaerts HF, Simoons, M.L., Balk AH, Tijssen J, Zondervan PE, ...
The value of pulsed-wave transmitral Doppler for the diagnosis of moderate acute rejection was examined in a total of 347 Doppler recordings obtained in 32 consecutive cardiac allograft recipients....
Balk AHMM, Weimar W, Rothbarth PhH, Meeter K, Metselaar HJ, ...
We analyzed the results of passive immunization against CMV in 146 heart transplant recipients. The 65 seronegative recipients were prophylactically treated with anti-CMV immunoglobulins during and...
Retardation and arrest of progression or regression of cronary artery disease : a review (1993)
Vos J, Feyter PJ De, Simoons, M.L., Tijssen JGP, Deckers JW.
Tailored thrombolytic therapy. A perspective (1993)
BACKGROUND. In contrast with current standard regimens, it seems more appropriate to tailor thrombolytic therapy to individual patient characteristics. A proposed model for such tailored therapy is...
The Rotterdam Heart Transplant Program 1984-1993. 200 cardiac allograft recipients (1993)
Balk AHMM, Meeter K, Weimar W, Zietse R, Mochtar B, Bos E, ...
Individual risk assessment for intracranial haemorrhage during thrombolytic therapy (1993)
Simoons, M.L., Maggioni, A.P., Knatterud, G., Leimberger, J.D., Jaegere, P. De, Domburg, R. Van, ...
Thrombolytic therapy improves outcome in patients with myocardial infarction but is associated with an increased risk of intracranial haemorrhage. For some patients, this risk may outweigh the...
Vertraging bij de opname van hartinfarctpatienten (1993)
Bleeker JK, Erdman RAM, Lamers LM, Simoons, M.L.
Timely treatment of patients with an evolving myocardial infarction improves the short and long term prognoses. Because of a wrong judgement of the situation by the patient, a significant other or by...
Klootwijk P, Cobbaert C, Fioretti P, Kint PP, Simoons, M.L.
The clinical significance of ST-segment changes and of the time course of appearance in serum of different cardiac proteins has been reviewed for the diagnosis of coronary reperfusion and reocclusion...
Dellborg, M., Steg, P.G., Simoons, M.L., Dietz, R., Sen, S., ...
PIETILÄ, K., HARMOINEN, A., HERMENS, W., SIMOONS, M. L., VERSTRAETE, M.
Serum C-reactive protein rises in acute myocardial infarction, correlating positively with infarct size if thrombolytic treatment is not given. This correlation disappears if thrombolytic treatment...
ARNOLD, A. E. R., SIMOONS, M. L., DETRY, J.-M. R., VON ESSEN, R., DECKERS, J. W., ...
The role of coronary angiography before hospital discharge after myocardial infarction was assessed in 1043 hospital survivors of the alteplase/placebo and the alteplase/PTCA trial of the European...
Simoons, M L, De Bono, D P, Lubsen, J, Tijssen, J G, ...
BACKGROUND. The European Cooperative Study Group conducted two randomized trials in patients with suspected myocardial infarction to assess the effect of 100 mg single-chain recombinant tissue-type...
Simoons, M L, Tijssen, J, Arnold, A E, Betriu, A, Burgersdijk, C, ...
OBJECTIVE--To determine whether concomitant treatment with intravenous heparin affects coronary patency and outcome in patients treated with alteplase thrombolysis for acute myocardial infarction....
Well shaped ST segment and risk of cardiovasculair mortality. (1992)
Schouten, E.G., Dekker, J.M., Pool, J., Kok, F.J., Simoons, M.L.
Too early for cardiac transplantation-the right decision? (1992)
Balk AHMM, Meeter K, Simoons, M.L., Mochtar B, Weimar W, Bal E, ...
In 109 out of 479 patients who were referred for cardiac transplantation it was considered to be too early to put them on the waiting list for a donor heart. The clinical course of these 109 patients...
Topol, E.J., Armstrong, P., Werf, F. Van Der, Kleiman, N., Lee, K., Morris, D., ...
The Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) trial is a large scale international trial of new myocardial reperfusion strategies....
De Bono DP, Simoons, M.L., Tijssen J, Arnold AER, Betriu A, Et Al
OBJECTIVE--To determine whether concomitant treatment with intravenous heparin affects coronary patency and outcome in patients treated with alteplase thrombolysis for acute myocardial infarction....
Arnout J, Simoons, M.L., Rapold HJ, Collen D, Verstraete M.
BACKGROUND AND OBJECTIVES. The conjunctive use of intravenous heparin may influence the efficacy of alteplase for coronary thrombolysis in patients with acute myocardial infarction. In this study we...
P De, Arnold AA, Balk AH, Simoons, M.L.
In a period of 18 months, 2,469 patients with acute myocardial infarction treated with a thrombolytic agent were prospectively registered in 61 hospitals. Most patients (73%) were treated with...
Well shaped ST segment and risk of cardiovascular mortality (1992)
Schouten EG, Dekker JM, Pool J, Simoons, M.L.
OBJECTIVE--To investigate the prognostic value of frequently occurring slight variations in the ST segment for cardiovascular mortality in healthy subjects. DESIGN--Follow up study of mortality in...
Prehospital thrombolysis with alteplase (rt-PA) in acute myocardial infarction. (1992)
Bouten MJM, Simoons, M.L., Hartman JAM, Miltenburg AJM Van, Pool J
The improvement in survival in patients undergoing thrombolytic therapy in myocardial infarction is determined by the delay between coronary occlusion and reperfusion. The REPerfusion in Acute...
Arnold AER, Simoons, M.L., Bono D De, Lubsen J, Tijssen JGP, ...
BACKGROUND. The European Cooperative Study Group conducted two randomized trials in patients with suspected myocardial infarction to assess the effect of 100 mg single-chain recombinant tissue-type...
Randomized trial of deferred angioplasty after thrombolysis for acute myocardial infarction (1992)
Betriu A, Bescos LL, Nijssen K, Pfisterer ME, Renkin J, ...
Mannaerts HFJ, Balk AHMM, Simoons, M.L., Tijssen J, Zondervan P, ...
OBJECTIVE--Assessment of changes in left ventricular diastolic function and wall thickness after heart transplantation to verify whether these changes predicted acute rejection assessed by...
Bax WA, Bos E, Simoons, M.L., Saxena PR
The receptors mediating the contractile effect of 5-hydroxytryptamine (5-HT) on the human isolated saphenous vein, obtained from 42 patients undergoing coronary bypass surgery, have been further...
Prehospital thrombolysis with alteplase (rt-PA) in acute myocardial infarction (1992)
BOUTEN, M. J. M., SIMOONS, M. L., HARTMAN, J. A. M., VAN DOES, E. DER, POOL, J.
The improvement in survival in patients undergoing thrombolytic therapy in myocardial infarction is determined by the delay between coronary occlusion and reperfusion. The REPerfusion in Acute...
Too early for cardiac transplantation--the right decision? (1992)
BALK, A. H. M., SIMOONS, M. L., MEETER, K., MOCHTAR, B., BAL, E., VERWEY, H.F., ...
In 109 out of 479 patients who were referred for cardiac transplantation it was considered to be too early to put them on the waiting list for a donor heart. The clinical course of these 109 patients...
Een esthetisch fraai ST-segment 'beschermt' tegen sterfte aan hart-en vaatziekten . (1991)
Schouten, E.G., Dekker, J.M., Pool, J., Kok, F.J., Simoons, M.L.
Well-shaped ST-segment 'protects' against cardiovascular mortality. (1991)
Schouten, E.G., Dekker, J.M., Pool, J., Kok, F.J., Simoons, M.L.
Arnold, A.E.R., Rutsch, W., Simoons, M.L., De Bono, D.P., Tijssen, J.G.P., ...
Regional ventricular wall motion analysis utilizing three different methods was performed on predischarge left ventriculograms from 291 of 367 patients enrolled in a randomized trial of single chain...
Brand, M. Van Den, Zijl, A. Van, Geuskens, R., Feyter, P.J. De, Simoons, M.L.
To evaluate the effect of recombinant tissue plasminogen activator (alteplase) on the clinical course, angiographic changes and the outcome of subsequent coronary angioplasty, 36 patients with angina...
Strategies for pre-hospital thrombolysis: an overview (1991)
Improvement in survival as a result of thrombolytic therapy in patients with myocardial infarction is determined by the delay between coronary occlusion and reperfusion. Treatment at home can reduce...
Cost-utility analysis of thrombolytic therapy (1991)
Simoons, M.L., Vos J, Martens LL
An analysis of the cost-effectiveness of thrombolytic therapy was performed, based on 3- to 5-year follow-up data, from 533 patients randomized to receive conventional therapy or intracoronary...
Lange-termijnoverleving na succesvolle resuscitatie buiten het ziekenhuis (1991)
Kimman GP, Ivens EMA, Hartman JAM, Hart HN, Simoons, M.L.
Between 1983 and 1989, 962 patients in Rotterdam were resuscitated outside hospital, of whom 240 (25%) could be discharged alive. A follow-up study was performed to determine prognosis in these...
Balk AHMM, Simoons, M.L., Jutte NHPM, Brouwer ML, Meeter KJ, Mochtar B, ...
VAN ZIJL, A., GEUSKENS, R., DE FEYTER, P. J., SERRUYS, P. W., SIMOONS, M. L.
To evaluate the effect of recombinant tissue plasminogen activator (alteplase) on the clinical course, angiographic changes and the outcome of subsequent coronary angioplasty, 36 patients with angina...
VAN ZIJL, A., GEUSKENS, R., DE FEYTER, P. J., SERRUYS, P. W., SIMOONS, M. L.
To evaluate the effect of recombinant tissue plasminogen activator (alteplase) on the clinical course, angiographic changes and the outcome of subsequent coronary angioplasty, 36 patients with angina...
Een onverwachte complicatie van inspanningsonderzoek. (1990)
A male patient 40 years of age died after diagnostic exercise testing for stable exercise induced angina, which had existed for two months. The ECG prior to the stress was normal and there had been...
Vroege trombolyse verbetert de prognose op lange termijn voor patienten met een hartinfarct (1990)
Vos J, Tijssen JGP, Vermeer F, Verheugt FWA, Krauss XH, Simoons, M.L.
In a previously reported clinical study treatment of myocardial infarction with intracoronary streptokinase (269 patients) was compared with conventional therapy (264 patients). To determine the...
Weimar W, Vaessen LMB, Hesse CJ, Balk AHMM, Simoons, M.L., Mochtar B, ...
Cytoimmunological monitoring of heart transplant recipients (1990)
Jutte NHPM, Hop WCJ, Essed CE, Weimar W, Simoons, M.L., ...
Bouten MJM, Simoons, M.L., Hartman JAM, Van Miltenburg AJM, Pool J.
The gain in survival by thrombolytic therapy in patients with myocardial infarction is determined by the delay between coronary occlusion and reperfusion. The REPAIR study was designed to examine the...
Changes in the electrocardiographic response to exercise in healthy women (1990)
Deckers JW, Vinke RVH, Vos JR, Simoons, M.L.
Changes in the P wave, QRS complex, ST segment, and T wave during and after maximal exercise were quantitatively analysed in 116 healthy women with a mean age of 39. The corrected orthogonal Frank...
An algorithm for prehospital thrombolysis in acute MI (1990)
Bouten MJM, Simoons, M.L., Hartman JAM, Zeelenberg C, Pool J
Arnold, A.E.R., Brower, R.W., Collen, D., Es, G.A. Van, Lubsen, J., ...
The association of increasing serum levels of fibrinogen degradation products after recombinant tissue-type plasminogen activator (rt-PA) therapy with bleeding and early coronary patency was assessed...
The influence of ABO blood groups on the incidence of cardiac allograft rejection in males (1989)
Hendriks, G.F., Wenting, G.J., Mochtar, B., Bos, E., Simoons, M.L., Balk, A.H., ...
Acute consequences of ischemic myocardial damage (1989)
Hugenholtz, P.G., Simoons, M.L., Vermeer, F.
The current revolution in the treatment of acute myocardial infarction by means of thrombolytic therapy has as its underlying strategy three aims: early restoration of the blood flow in order to...
Abstossungsprophylaxe mit Orthoclone OKT3 nach Nieren- und Herztransplantation (1989)
Weimar W, Baumgartner D, Hendriks GFJ, Hesse CJ, Balk AHMM, Simoons, M.L., ...
Sluiters JF, Balk AHMM, Essed CE, Mochtar B, Weimar W, Simoons, M.L., ...
Toxoplasma gondii infections in heart transplant recipients were monitored by indirect enzyme-linked immunosorbent assay for immunoglobulin G (ELISA-IgG), indirect ELISA-IgM in serum IgM fractions,...
Cytoimmunological monitoring to detect rejection after heart transplantation (1989)
Jutte NHPM, Daane R, Hop WCJ, Essed CE, Simoons, M.L., ...
Thrombolytic therapy in acute myocardial infarction (1989)
Early thrombolytic therapy has been shown to reduce hospital mortality after myocardial infarction by 20-50%. This is achieved through reperfusion of the ischemic myocardium, which leads to...
Diagnostic merits of exercise testing in females (1989)
Deckers JW, Rensing BJ, Simoons, M.L., Roelandt JRTC
The diagnostic accuracy of conventional exercise electrocardiography was compared with exercise algorithms specifically aimed at application in females, with R wave and heart rate adjusted ST-segment...
Disturbed liver function in heart transplantation candidates : two case reports (1989)
Huisman AM, Schalm SW, Simoons, M.L., Laird-Meeter K, Weimar W
Heart transplantation candidates frequently have a disturbed liver function. Two cases with jaundice are described in whom the cause and prognosis of the associated liver disease were analysed. In...
Occlusion, reocclusion, and/or restenosis after interventions can be due to four mechanisms which require different approaches: 1) mechanical problems should be prevented by careful surgery and PTCA;...
Long term benefit of early thrombolytic therapy in patients with acute myocardial infarction (1989)
Simoons, M.L., Vos J, Tijssen JGP, Vermeer F, Verheugt FWA, Krauss XH, ...
Patients (n = 533) who participated in the Interuniversity Cardiology Institute of the Netherlands Trial were followed up for 3 to 7 years. The 5 year survival rate after thrombolytic therapy with...
A comparison of methods of analysing exercise tests for diagnosis of coronary artery disease (1989)
Deckers JW, Rensing BJ, Tijssen JGP, Vinke RVH, Azar AJ, Simoons, M.L.
The diagnostic accuracy of the following methods of analysing exercise tests were evaluated: (a) the cumulative area of ST segment depression during exercise normalised for workload and heart rate...
OKT3 delays rejection crises after heart transplantation (1989)
Weimar W, Essed CE, Balk AHMM, Simoons, M.L., Hendriks GFJ, Wenting GJ, ...
Laarse, A. Van Der, Kerkhof, P.L.M., Vermeer, F., Hermens, W.T., Verheugt, F.W.A., ...
Reperfusion of ischemic myocardium has been reported to increase the cumulative creatine kinase activity in plasma per gram of infarcted myocardium as assessed with the method of Shell et al. In an...
Vermeer, F., Simoons, M.L., Bär, F.W., Suryapranata, H., Fioretti, P., ...
Immediate PTCA following thrombolysis with streptokinase was performed in 46 out of 533 patients enrolled in a multicentre randomized trial of early reperfusion in patients with acute myocardial...
Van Der Wall, E.E., Van Den Pol, R.C., Vermeer, F., Verheugt, F.W., Krauss, X.H., ...
In a randomized study on early intracoronary thrombolytic therapy in patients with acute myocardial infarction (AMI), serial plasma enzyme activities were measured to analyze the rate of enzyme...
At the time of hospital admission the distinction between reversible ischaemia (angina) and myocardial damage (infarction) is often difficult. Thus it would be advantageous when a similar therapeutic...
Simoons, M.L., Arnold, A.E.R., Betriu, A., Bokslag, M., Bono, D.P. De, Brower, R.W., ...
A randomised trial of 367 patients with acute myocardial infarction was performed to determine whether an invasive strategy combining thrombolysis with recombinant tissue-type plasminogen activator...
Enzyme tests in the evaluation of thrombolysis in acute myocardial infarction (1988)
Zwaan C De, Willems GM, Vermeer F, Res J, Verheugt FWA, ...
The activity of alpha-hydroxybutyrate dehydrogenase, creatine kinase, creatine kinase MB and aspartate aminotransferase was measured on serial plasma samples from patients with acute myocardial...
Vermeer F, Simoons, M.L., Zwaan Chr De, Es GA Van, Verheugt FWA, Laarse A Vd, ...
The costs and benefits of early thrombolytic treatment with intracoronary streptokinase in acute myocardial infarction were compared in a randomised trial. All hospital admissions were recorded and...
Res JCJ, Vermeer F, Braat S, ...
The effects of recanalization by early intracoronary streptokinase in acute myocardial infarction on myocardial perfusion were studied in a subset of 236 out of 533 patients enrolled in a prospective...
Simoons, M.L., Demey HE, Bossaert LL, Colardijn F, Essed CE
We describe a new stainless steel, teflon-coated 2.4 F pacemaker wire with a flexible tip that can be introduced through an extra lumen of a specially designed 7.5 F Swan-Ganz catheter. The extra...
Hendriks GFJ, Steenberge EPM Van, Schruder GMTh, Wenting GJ, Mochtar B, Bos E, Simoons, M.L., ...
In a consecutive series of 146 kidney transplant recipients treated with cyclosporin A a strong correlation between matching for the HLA-A, HLA-B, and HLA-DR loci specificities and outcome of the...
Towards quantification of myocardial infarct size using In-111 labeled antimyosin (1988)
Anema PC, Fioretti P, Reiber JHC, Simoons, M.L., Bucx JJJ, Bakker WH, ...
Can Thrombolysis prevent ischemic heart failure? (1988)
In the present era of thrombolysis, congestive heart failure secondary to (sub)acute coronary artery obstruction can be reduced to a considerable extent or even avoided altogether. Evidence from...
The prophylactic use of Orthoclone OKT3 in kidney and heart transplantation (1988)
Weimar, W., Baumgartner, D., Hendriks, G.F., Hesse, C.J., Balk, A.H., Simoons, M.L., ...
VAN DER WALL, E. E., RES, J.C.J., VERMEER, F., BRAAT, S., ...
The effects of recanalization by early intracoronary streptokinase in acute myocardial infarction on myocardial perfusion were studied in a subset of 236 out of 533 patients enrolled in a prospective...
VERMEER, F., SIMOONS, M. L., DE FEYTER, P. I., BÄR, F. W., SURYAPRANATA, H., FIORETTI, P., ...
Immediate PTCA following thrombolysis with streptokinase was performed in 46 out of 533 patients enrolled in a multicentre randomized trial of early reperfusion in patients with acute myocardial...
Thrombolytic therapy for acute coronary thrombosis (1987)
Simoons, M.L., Lubsen, J., Hugenholtz, P.G.
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Suryapranata, H., Vermeer, F., Feyter, P.J. De, Brand, M. Van Den, Simoons, M.L., ...
A total of 533 patients with acute myocardial infarction of less than 4-h duration were enrolled in the multicenter randomized trial of intracoronary thrombolysis compared to conventional treatment....
Circadian variation of heart rate but not of blood pressure after heart transplantation (1987)
Wenting, G.J., Vd Meiracker, A.H., Simoons, M.L., Bos, E., Ritsema V Eck, H.J., ...
Thrombolysetherapie beim frischen Myokardinfarkt (1987)
Hugenholtz, P.G., Simoons, M.L., Suryapranata, H., Vermeer, F., Lubsen, J.
In this overview the characteristics have been defined of those patients with acute myocardial infarction to whom early thrombolytic therapy would offer a major benefit. However, this concerns only...
Deckers JW, Fioretti P, Brower RW, Baardman T, Beelen A, Simoons, M.L.
After myocardial infarction (MI), the additive prognostic value of exercise variables to clinical variables has been questioned. The merits of a symptom-limited predischarge exercise test were...
Bär FW, Vermeer F, Zwaan C De, Ramentol M, Braat S, Simoons, M.L., Hermens WT, ...
To determine the value of the admission 12-lead electrocardiogram to predict infarct size limitation by thrombolytic therapy, data were analyzed in 488 of 533 patients with acute myocardial...
Fioretti P, Deckers J, Baardman T, Beelen A, Katen HJ Ten, Brower RW, Simoons, M.L.
The clinical significance of repetitive ventricular complexes (RVCs) during pre-discharge bicycle ergometry after acute myocardial infarction has been assessed in 408 consecutive patients. RVCs...
Effect of beta-blockers on the relation between QT interval and heart rate in exercise ECG. (1987)
Algra A, Roelandt JRTC, Tijssen JGP, Simoons, M.L., Pool J
QT-interval prolongation is a recognized risk indicator for ventricular arrhythmias and sudden cardiac death. The effect of beta-blockers on the change of the QT-interval relative to the change in...
Holland Interuniversity Nifedipine/Metoprolol Trial (HINT). Unstable angina pectoris (1987)
Tijssen JGP, Simoons, M.L., Feijter PJ De, Hugenholtz PG, Lubsen J
Fioretti P, Simoons, M.L., Zwiers G, Baardman T, Brower RW, Kazemir M, ...
The aim of this study was to assess whether data related to predischarge clinical examinations, resting radionuclide ventriculography and symptom-limited bicycle ergometry can predict the achievement...
Letter to the editor : double failure of influenza vaccination in a heart transplant patient (1987)
Beyer, W.E.P., Diepersloot RJA, Masurel N, Simoons, M.L., Weimar W
Unstable angina pectoris (1987)
Tijssen, J. G. P., Simoons, M. L., De Feijter, P. J., Hugenholtz, P. G., Lubsen, J.
Thrombolytic therapy for acute coronary thrombosis (1987)
Simoons, M. L., Lubsen, J., Serruys, P. W., Hugenholtz, P. G.
Fioretti, P., Deckers, J., Baardman, T., Beelen, A., Katen, H. J. Ten, Brower, R. W., ...
The clinical significance of repetitive ventricular complexes (RVCs) during pre-discharge bicycle ergometry after acute myocardial infarction has been assessed in 408 consecutive patients. RVCs...
Effect of beta-blockers on the relation between QT-interval and heart rate in exercise ECG (1987)
Algra, A., Tussen, J. G. P., Simoons, M. L., Pool, J.
QT-interval prolongation is a recognized risk indicator for ventricular arrhythmias and sudden cardiac death. The effect of beta-blockers on the change of the QT-interval relative to the change in...
At the time of hospital admission the distinction between reversible ischaemia (angina) and myocardial damage (infarction) is often difficult. Thus it would be advantageous when a similar therapeutic...
Verbeterde prognose als gevolg van vroeg thrombolyse bij patienten met een acuut hartinfarct (1986)
Simoons, M.L., Brand, M. Van Den, Bär, F.W., Zwaan, C. De, Res, J., ...
Simoons, M.L., Suryapranata, H., Vermeer, F., Wijns, W., Brand, M. Van Den, ...
The effect of early myocardial reperfusion (within 4 hours after onset of symptoms) on regional left ventricular function in patients with acute myocardial infarction has been quantitated by analysis...
Simoons, M.L., Brand, M. Van Den, Res, J., Verheugt, F.W.A., Krauss, X.H., ...
The effect of thrombolysis in acute myocardial infarction on infarct size, left ventricular function, clinical course and patient survival was studied in a randomized trial comparing thrombolysis...
Thrombolytic therapy for acute coronary obstruction: status in 1986 (1986)
Hugenholtz, P.G., Simoons, M.L., Lubsen, J.
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Randomized trial with intracoronary streptokinase versus placebo (The Netherlands) (1986)
Simoons, M.L., Brand, M. Van Den, Bar, F., Zwaan, C. De, Res, J., ...
Feyter, P.J. De, Arnold, A., Simoons, M.L., Wijns, W., Geuskens, R., ...
This study is a retrospective analysis of the efficacy of percutaneous transluminal coronary angioplasty of the ischaemia-related vessel in patients with unstable angina. Forty-three patients had...
Hugenholtz, P.G., Fioretti, P.M., Simoons, M.L.
Right after the first signs and symptoms of acute myocardial infarctions the prognosis is determined by the interventions which are carried out at that time. Preservation of as much myocardial tissue...
Hugenholtz, P.G., Fioretti, P., Simoons, M.L., Lubsen, J.
Immediately after the first signs and symptoms of acute myocardial infarction are detected, its prognosis is determined by the size of the area at risk, the availability of collaterals and the time...
Which patients benefit most from early thrombolytic therapy with intracoronary streptokinase? (1986)
Vermeer, F., Simoons, M.L., Bär, F.W., Tijssen, J.G.P., Domburg, R.T. Van, ...
The effect of thrombolysis in acute myocardial infarction on enzymatic infarct size, left ventricular function, and early mortality was studied in subsets of patients in a randomized trial. Early...
Laarse, A. Van Der, Vermeer, F., Hermens, W.T., Willems, G.M., Neef, K. De, Simoons, M.L., ...
The effects of early intracoronary streptokinase (SK) on enzymatic infarct size and rate of enzyme release were studied in a randomized multicenter trial. A total of 533 patients with acute...
Thrombolytic therapy for acute coronary obstruction: status in 1986 (1986)
Hugenholtz, P.G., Simoons, M.L., Lubsen, J.
The effect of thrombolysis in acute myocardial infarction on enzymatic infarct size, left ventricular function, and early mortality was studied in subsets of patients in a randomized trial at The...
Res, J.C.J., Simoons, M.L., Eenige, M.J. Van, Vermeer, F., Verheugt, F.W.A., ...
The effect of reperfusion achieved by early intracoronary streptokinase in acute myocardial infarction on left ventricular function was studied in 533 patients enrolled in a prospective randomised...
Thallium scintigrafie bij onstabiele angina pectoris (1986)
Wall EE Vd, Simoons, M.L., Kerkkamp HJJ, Eenige MJ Van, Rijk PP Van, Reiber JHC, ...
Technetium 99m-angiografie bij patienten met onstabiele angina pectoris (1986)
Wall EE Vd, Simoons, M.L., Kerkkamp HJJ, Eenige MJ Van, Rijk PP Van, Reiber JHC, ...
Fioretti P, Brower RW, Simoons, M.L., Katen H Ten, Beelen A, Baardman T, ...
The relative value of predischarge clinical variables, bicycle ergometry, radionuclide ventriculography and 24 hour ambulatory electrocardiographic monitoring for predicting survival during the first...
Wall EE Vd, Res JCJ, Eenige MJ Van, Verheugt FWA, Wijns W, Braat S, ...
Wall, EE Vd, Kerkkamp J, Simoons, M.L., Rijk PP Van, Reiber JHC, Bom N, Lubsen JC, ...
In 1981, a large, double-blind, randomized trial was started in The Netherlands to evaluate the therapeutic effects of nifedipine and/or metoprolol in patients with unstable angina. This study has...
Kerkkamp, H.J.J., Simoons, M.L., Rijk, P.P. Van, Reiber, J.H.C., Bom, N., ...
In 1981, a large, double-blind, randomized, multicenter trial was started in The Netherlands to evaluate the therapeutic effects of nifedipine or metoprolol in patients with unstable angina. This...
Results of heart transplantation at Rotterdam, the Netherlands : 1985 to March 1986. (1986)
Bos, E., Essed, N., Balakumaran, K., Laird-Meeter, K., Simoons, M.L., Weimar, W., ...
Thallium 201 tomography : developments towards quantitative analysis (1986)
Reijs AEM, Reiber JHC, Fioretti PM, Gerbrands JJ, Simoons, M.L., Kooij PPM
DE FEYTER, P. J., SERRUYS, P. W., ARNOLD, A., SIMOONS, M. L., WIJNS, W., GEUSKENS, R., ...
This study is a retrospective analysis of the efficacy of percutaneous transluminal coronary angioplasty of the ischaemia-related vessel in patients with unstable angina. Forty-three patients had...
Wijns, W., Reiber, J.H.C., Brand, M. Van Den, Simoons, M.L., Kooijman, C.J., ...
To evaluate, during cardiac catheterization, what constitutes a physiologically significant obstruction to blood flow in the human coronary system, computer-based quantitative analysis of coronary...
Wijns, W., Simoons, M.L., Brand, M. Van Den, Feyter, P.J. De, Reiber, J.H.C., ...
Restenosis of the dilated vessel after percutaneous transluminal coronary angioplasty can be detected by non-invasive procedures but their ability to predict later restenosis soon after a successful...
Wijns, W., Reiber, J.H.C., Feyter, P.J. De, Brand, M. Van Den, Simoons, M.L., ...
The value of exercise testing and thallium scintigraphy in predicting recurrence of angina pectoris and restenosis after a primary successful transluminal coronary angioplasty (PTCA) was...
Intracoronary streptokinase in acute myocardial infarction. A review (1985)
Hugenholtz, P.G., Simoons, M.L., Brand, M. Van Den
The attempt to salvage myocardium threatened by ischemia during temporary or permanent occlusion of one or more of the nutrient arteries, is based on the observation that the major determinant of...