Sensitization to the Lysosomal Cell Death Pathway upon Immortalization and Transformation (2004)
Fehrenbacher, Nicole, Gyrd-Hansen, Mads, Poulsen, Birgit, Felbor, Ute, Kallunki, Tuula, Boes, Marianne, ...
Tumorigenesis is associated with several changes that alter the cellular susceptibility to programmed cell death. Here, we show that immortalization and transformation sensitize cells in particular...
Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...
Lademann, Ulrik, Cain, Kelvin, Gyrd-Hansen, Mads, Brown, David, Peters, Dan, Jäättelä, Marja
The release of mitochondrial proapoptotic proteins into the cytosol is the key event in apoptosis signaling, leading to the activation of caspases. Once in the cytosol, cytochrome c triggers the...
Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9▿ †
Gyrd-Hansen, Mads, Farkas, Thomas, Fehrenbacher, Nicole, Bastholm, Lone, Høyer-Hansen, Maria, Elling, Folmer, ...
The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically...
Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization
Nylandsted, Jesper, Gyrd-Hansen, Mads, Danielewicz, Agnieszka, Fehrenbacher, Nicole, Lademann, Ulrik, Høyer-Hansen, Maria, ...
Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by...