Pevear, Daniel C, Davies, Marc H, Collett, Marc S, Bailey, Tom, Rippen, Susan, ...
ST-246 is a low-molecular-weight compound (molecular weight = 376), that is potent (concentration that inhibited virus replication by 50% = 0.010 microM), selective (concentration of compound that...
Flavivirus RNA Replication: Essential Viral Functions as Targets for Antiviral Therapeutics (2005)
Collett, Marc S., Suzich, JoAnn A.
The objective of this contract research is to gain a detailed understanding of the molecular events involved in flavivirus RNA replication, with the ultimate aim being the identification of...
The mission of this contract was to elucidate the molecular and biologic properties of the middle (M) genomic segment of Rift Valley fever virus (RVFV), and the apply the new-found basic research...
The molecular and biologic properties of the M segment RNA of Rift Valley fever virus (RVFV) were studied, with focus on elucidation of the expression strategy of this molecule. The results indicate...
Flavivirus RNA Replication: Essential Viral Functions as Targets for Antiviral Therapeutics (2003)
Collett, Marc S., Suzich, JoAnn A.
The objective of this contract research was to gain a detailed understanding of the molecular events involved in flavivirus RNA replication, with the ultimate aim being the identification of...
The coding capacity and expression strategy of the Rift Valley Fever Virus M segment were investigated in detail employing cell-free transcription-translation and recombinant vaccinia virus systems....
Synthetic Vaccines: Test of Concepts and Application to Rift Valley Fever Virus. Phase 1. (1996)
Use of synthetic peptides, comprising both B and T cell determinants, is being considered a viable approach to vaccine development. We explored several aspects this strategy employing Rift Valley...
Palmenberg, Ann C., Kirby, Ellen M., Janda, Michael R., Drake, Neil L., Duke, Gregory M., Potratz, Kimberly F., ...
The nucleotide sequence of 7200 bases of encephalomyocarditis (EMC) viral RNA, including the complete polyprotein-coding region, was determined. The polyprotein is encoded within a unique...
Lau, Alan F., Ruddon, Raymond W., Collett, Marc S., Faras, Anthony J.
Stimulation of the T3C12 clone of Friend erythroleukemia cells with 1.2% dimethyl sulfoxide (DMSO) results in progressive increase in the concentration of globin mRNA sequences in the total cellular...
Collett, Marc S., Kieras, Rita M., Faras, Anthony J.
Infection of stationary chick embryo fibroblasts by reticuloendotheliosis virus (REV) is sensitive to cytosine arabinoside, an inhibitor of DNA synthesis. Furthermore, the majority of the nucleic...
Morphological changes accompanying actinomycin production in Streptomyces antibioticus (1974)
Collett, Marc S., Jones, George H.
The fine structure of the actinomycin producing bacterium Streptomyces antibioticus has been studied. The typical appearance of freshly inoculated cells is one of a generally electron dense...
Mechanism of action of a pestivirus antiviral compound
Baginski, Scott G., Pevear, Daniel C., Seipel, Marty, Sun, Siu Chi Chang, Benetatos, Christopher A., Chunduru, Srinivas K., ...
We report here the discovery of a small molecule inhibitor of pestivirus replication. The compound, designated VP32947, inhibits the replication of bovine viral diarrhea virus (BVDV) in cell culture...
Mendez, Ernesto, Ruggli, Nicolas, Collett, Marc S., Rice, Charles M.
Bovine viral diarrhea virus (BVDV), strain NADL, was originally isolated from an animal with fatal mucosal disease. This isolate is cytopathic in cell culture and produces two forms of NS3-containing...
Brugge, Joan S., Collett, Marc S., Siddiqui, Aleem, Marczynska, Barbara, Deinhardt, F., Erikson, R. L.
Genetic analyses have defined a single gene (src) as that portion of the avian sarcoma virus (ASV) genome which encodes the protein directly responsible for ASV-induced neoplastic transformation. We...
Collett, Marc S., Perdue, Michael L., Faras, Anthony J.
We have investigated the use of oligodeoxycytidylic acid [oligo(dC)] as a primer for the initiation of DNA synthesis by the avian retrovirus reverse transcriptase in vitro, employing the viral RNA...
Ledford, Rebecca M., Patel, Nitesh R., Demenczuk, Tina M., Watanyar, Adiba, Herbertz, Torsten, Collett, Marc S., ...
Rhinoviruses are the most common infectious agents of humans. They are the principal etiologic agents of afebrile viral upper-respiratory-tract infections (the common cold). Human rhinoviruses (HRVs)...
Yang, Guang, Pevear, Daniel C., Collett, Marc S., Chunduru, Srinivas, Young, Dorothy C., Benetatos, Christopher, ...
Biochemical characterization of hepatitis C virus (HCV) replication using purified, membrane-associated replication complexes is hampered by the presence of endogenous nuclease activity that...
Collett, Marc S., Faras, Anthony J.
The influence of Rous sarcoma virus (RSV)-associated RNase H on the in vitro synthesis of DNA by the RSV RNA-directed DNA polymerase was determined under conditions whereby RNase H activity was...
Yang, Guang, Pevear, Daniel C., Davies, Marc H., Collett, Marc S., Bailey, Tom, Rippen, Susan, ...
ST-246 is a low-molecular-weight compound (molecular weight = 376), that is potent (concentration that inhibited virus replication by 50% = 0.010 μM), selective (concentration of compound that...
Pevear, Daniel C., Hayden, Frederick G., Demenczuk, Tina M., Barone, Linda R., McKinlay, Mark A., Collett, Marc S.
Pleconaril, a specific inhibitor of human picornaviruses, showed therapeutic efficacy against community-acquired colds caused by rhinoviruses in two placebo-controlled trials. Virological assessments...
Mechanism of action of a pestivirus antiviral compound
Baginski, Scott G., Pevear, Daniel C., Seipel, Marty, Sun, Siu Chi Chang, Benetatos, Christopher A., Chunduru, Srinivas K., ...
We report here the discovery of a small molecule inhibitor of pestivirus replication. The compound, designated VP32947, inhibits the replication of bovine viral diarrhea virus (BVDV) in cell culture...
Mendez, Ernesto, Ruggli, Nicolas, Collett, Marc S., Rice, Charles M.
Bovine viral diarrhea virus (BVDV), strain NADL, was originally isolated from an animal with fatal mucosal disease. This isolate is cytopathic in cell culture and produces two forms of NS3-containing...
Brugge, Joan S., Collett, Marc S., Siddiqui, Aleem, Marczynska, Barbara, Deinhardt, F., Erikson, R. L.
Genetic analyses have defined a single gene (src) as that portion of the avian sarcoma virus (ASV) genome which encodes the protein directly responsible for ASV-induced neoplastic transformation. We...
Collett, Marc S., Perdue, Michael L., Faras, Anthony J.
We have investigated the use of oligodeoxycytidylic acid [oligo(dC)] as a primer for the initiation of DNA synthesis by the avian retrovirus reverse transcriptase in vitro, employing the viral RNA...
Ledford, Rebecca M., Patel, Nitesh R., Demenczuk, Tina M., Watanyar, Adiba, Herbertz, Torsten, Collett, Marc S., ...
Rhinoviruses are the most common infectious agents of humans. They are the principal etiologic agents of afebrile viral upper-respiratory-tract infections (the common cold). Human rhinoviruses (HRVs)...
Yang, Guang, Pevear, Daniel C., Collett, Marc S., Chunduru, Srinivas, Young, Dorothy C., Benetatos, Christopher, ...
Biochemical characterization of hepatitis C virus (HCV) replication using purified, membrane-associated replication complexes is hampered by the presence of endogenous nuclease activity that...
Collett, Marc S., Faras, Anthony J.
The influence of Rous sarcoma virus (RSV)-associated RNase H on the in vitro synthesis of DNA by the RSV RNA-directed DNA polymerase was determined under conditions whereby RNase H activity was...
Yang, Guang, Pevear, Daniel C., Davies, Marc H., Collett, Marc S., Bailey, Tom, Rippen, Susan, ...
ST-246 is a low-molecular-weight compound (molecular weight = 376), that is potent (concentration that inhibited virus replication by 50% = 0.010 μM), selective (concentration of compound that...
Pevear, Daniel C., Hayden, Frederick G., Demenczuk, Tina M., Barone, Linda R., McKinlay, Mark A., Collett, Marc S.
Pleconaril, a specific inhibitor of human picornaviruses, showed therapeutic efficacy against community-acquired colds caused by rhinoviruses in two placebo-controlled trials. Virological assessments...