Marco Salemi

Fogel G: Prediction of R5, X4, and R5X4 HIV-1 coreceptor usage with evolved neural networks (2009)

Susanna L. Lamers, Marco Salemi, Michael S. Mcgrath, Gary B. Fogel

Abstract—The HIV-1 genome is highly heterogeneous. This variation affords the virus a wide range of molecular properties, including the ability to infect cell types, such as macrophages and...

Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4 (2009)

Switzer, William M, Salemi, Marco, Qari, Shoukat H, Jia, Hongwei, Gray, Rebecca R, Katzourakis, Aris, ...

Abstract Background Human T-lymphotropic virus type 4 (HTLV-4) is a new deltaretrovirus recently identified in a primate hunter in Cameroon. Limited sequence analysis previously showed that HTLV-4...

Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design? (2004)

Salemi, Marco, Gordon, Michelle, Van Rensburg, Estrelita Janse, Engelbrecht, Susan, ...

A safe and effective HIV-1 vaccine is urgently needed to control the worldwide AIDS epidemic. Traditional methods of vaccine development have been frustratingly slow, and it is becoming increasingly...

HIVbase: a PC/Windows-based software offering storage and querying power for locally held HIV-1 genetic, experimental, and clinical data (2004)

Lamers, Susanna, Beason, Scott, Dunlap, Luke, Compton, Robert, Salemi, Marco

Background: Human Immunodeficiency Virus (HIV) research involves ongoing, repetitious sequencing of the HIV genome and the massive accumulation of associated investigational data. As a result, the...

HIVbase: a PC/Windows-based software offering storage and querying power for locally held HIV-1 genetic, experimental and clinical data (2004)

Lamers, Susanna, Beason, Scott, Dunlap, Luke, Compton, Robert, Salemi, Marco

Background: Human immunodeficiency virus (HIV) research involves ongoing, repetitious sequencing of the HIV genome and the massive accumulation of associated investigational data. As a result, the...

HIVbase: a PC/Windows-based software offering storage and querying power for locally held HIV-1 genetic, experimental, and clinical data (2004)

Lamers, Susanna, Beason, Scott, Dunlap, Luke, Compton, Robert, Salemi, Marco

Background: Human Immunodeficiency Virus (HIV) research involves ongoing, repetitious sequencing of the HIV genome and the massive accumulation of associated investigational data. As a result, the...

Site stripping based on likelihood ratio reduction is a useful tool to evaluate the impact of non-clock-like behavior on viral phylogenetic reconstructions (2003)

Salemi, Marco, Wang, Bin, Duffy, Margaret, Hall, William H, Saksena, Nitin K, ...

The site stripping for clock detection procedure was implemented in the recently developed maximum likelihood framework for estimating evolutionary rates and divergence times in measurably evolving...

U.S. Human immunodeficiency virus type 1 epidemic: date of origin, population history, and characterization of early strains (2003)

Pybus, Oliver G, Jaffe, Harold W, Youngpairoj, Ae S, Brown, Teresa M, ...

Human immunodeficiency virus (HIV) type 1 subtype B sequences (whole envelope and the p17 region of gag) were obtained from peripheral blood mononuclear cell samples collected in 1981 from seven...

Brazilian HTLV type 2a strains from intravenous drug users (IDUs) appear to have originated from two sources: Brazilian Amerindians and European/North American IDUs (2003)

Shindo, Nice, Salemi, Marco, Costa, Maria C R, Kashima, Simone, ...

In Brazil, HTLV-2 has been detected in blood donors, in intravenous drug users (IDUs) from urban areas, and in Amerindians living in the Amazon basin. Of the three main HTLV-2 subtypes (2a, 2b, and...

Tracing the origin and history of the HIV-2 epidemic (2003)

Pybus, Oliver G, Wang, Bin, Saksena, Nitin K, Salemi, Marco

In this study we date the introduction of HIV-2 into the human population and estimate the epidemic history of HIV-2 subtype A in Guinea-Bissau, the putative geographic origin of HIV-2. The...

Mosaic Genomes of the Six Major Primate Lentivirus Lineages Revealed by Phylogenetic Analyses (2002)

Marco Salemi, Tulio De Oliveira, Valerie Courgnaud, Vincent Moulton, Barbara Holl, Sharon Cassol, ...

To clarify the origin and evolution of the primate lentiviruses (PLVs), which include human immunodeficiency virus types 1 and 2 as well as their simian relatives, simian immunodeficiency viruses...

Dating the common ancestor of SIVcpz and HIV-1 group M and the origin of HIV-1 subtypes using a new method to uncover clock-like molecular evolution (2001)

Salemi, Marco; U0008167, Strimmer, K, Hall, W W, Duffy, Maria; U0035072, Delaporte, E, Mboup, S, ...

Attempts to estimate the time of origin of human immunodeficiency virus (HIV)-1 by using phylogenetic analysis are seriously flawed because of the unequal evolutionary rates among different viral...

Different population dynamics of human T cell lymphotropic virus type II in intravenous drug users compared with endemically infected tribes

Salemi, Marco, Lewis, Martha, Egan, John Fergal, Hall, William W., Desmyter, Jan, Vandamme, Anne-Mieke

The phylogeny of human T cell lymphotropic virus type II (HTLV-II) was investigated by using strains isolated from Amerindian and Pygmy tribes, in which the virus is maintained primarily through...

African Origin of Human T-Lymphotropic Virus Type 2 (HTLV-2) Supported by a Potential New HTLV-2d Subtype in Congolese Bambuti Efe Pygmies

Vandamme, Anne-Mieke, Salemi, Marco, Van Brussel, Marianne, Liu, Hsin-Fu, Van Laethem, Kristel, Van Ranst, Marc, ...

We identified a potential new subtype within human T-cell lymphotropic virus type 2 (HTLV-2), HTLV-2d, present in members of an isolated Efe Bambuti Pygmy tribe. Two of 23 Efe Pygmies were HTLV-2...

Evolutionary Rate and Genetic Drift of Hepatitis C Virus Are Not Correlated with the Host Immune Response: Studies of Infected Donor-Recipient Clusters

Allain, Jean-Pierre, Dong, Yan, Vandamme, Anne-Mieke, Moulton, Vincent, Salemi, Marco

Six donor-recipient clusters of hepatitis C virus (HCV)-infected individuals were studied. For five clusters the period of infection of the donor could be estimated, and for all six clusters the time...

Tracing the origin and history of the HIV-2 epidemic

Lemey, Philippe, Pybus, Oliver G., Wang, Bin, Saksena, Nitin K., Salemi, Marco, Vandamme, Anne-Mieke

In this study we date the introduction of HIV-2 into the human population and estimate the epidemic history of HIV-2 subtype A in Guinea-Bissau, the putative geographic origin of HIV-2. The...

Mosaic Genomes of the Six Major Primate Lentivirus Lineages Revealed by Phylogenetic Analyses

Salemi, Marco, De Oliveira, Tulio, Courgnaud, Valerie, Moulton, Vincent, Holland, Barbara, Cassol, Sharon, ...

To clarify the origin and evolution of the primate lentiviruses (PLVs), which include human immunodeficiency virus types 1 and 2 as well as their simian relatives, simian immunodeficiency viruses...

Phylodynamic Analysis of Human Immunodeficiency Virus Type 1 in Distinct Brain Compartments Provides a Model for the Neuropathogenesis of AIDS

Salemi, Marco, Lamers, Susanna L., Yu, Stephanie, De Oliveira, T., Fitch, Walter M., McGrath, Michael S.

“Phylodynamic” analysis combines various statistical procedures that can be used to correlate the epidemiological and evolutionary behavior of viral pathogens with the immune system of the host....

U.S. Human Immunodeficiency Virus Type 1 Epidemic: Date of Origin, Population History, and Characterization of Early Strains

Robbins, Kenneth E., Lemey, Philippe, Pybus, Oliver G., Jaffe, Harold W., Youngpairoj, Ae S., Brown, Teresa M., ...

Human immunodeficiency virus (HIV) type 1 subtype B sequences (whole envelope and the p17 region of gag) were obtained from peripheral blood mononuclear cell samples collected in 1981 from seven...

Characterization of a Novel Simian Immunodeficiency Virus with a vpu Gene from Greater Spot-Nosed Monkeys (Cercopithecus nictitans) Provides New Insights into Simian/Human Immunodeficiency Virus Phylogeny

Courgnaud, Valérie, Salemi, Marco, Pourrut, Xavier, Mpoudi-Ngole, Eitel, Abela, Bernadette, Auzel, Philippe, ...

In the present study, we describe a new simian immunodeficiency virus (SIV), designated SIVgsn, naturally infecting greater spot-nosed monkeys (Cercopithecus nictitans) in Cameroon. Together with...

Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design?

De Oliveira, Tulio, Salemi, Marco, Gordon, Michelle, Vandamme, Anne-Mieke, Van Rensburg, Estrelita Janse, Engelbrecht, Susan, ...

A safe and effective HIV-1 vaccine is urgently needed to control the worldwide AIDS epidemic. Traditional methods of vaccine development have been frustratingly slow, and it is becoming increasingly...

Different population dynamics of human T cell lymphotropic virus type II in intravenous drug users compared with endemically infected tribes

Salemi, Marco, Lewis, Martha, Egan, John Fergal, Hall, William W., Desmyter, Jan, Vandamme, Anne-Mieke

The phylogeny of human T cell lymphotropic virus type II (HTLV-II) was investigated by using strains isolated from Amerindian and Pygmy tribes, in which the virus is maintained primarily through...

African Origin of Human T-Lymphotropic Virus Type 2 (HTLV-2) Supported by a Potential New HTLV-2d Subtype in Congolese Bambuti Efe Pygmies

Vandamme, Anne-Mieke, Salemi, Marco, Van Brussel, Marianne, Liu, Hsin-Fu, Van Laethem, Kristel, Van Ranst, Marc, ...

We identified a potential new subtype within human T-cell lymphotropic virus type 2 (HTLV-2), HTLV-2d, present in members of an isolated Efe Bambuti Pygmy tribe. Two of 23 Efe Pygmies were HTLV-2...

Evolutionary Rate and Genetic Drift of Hepatitis C Virus Are Not Correlated with the Host Immune Response: Studies of Infected Donor-Recipient Clusters

Allain, Jean-Pierre, Dong, Yan, Vandamme, Anne-Mieke, Moulton, Vincent, Salemi, Marco

Six donor-recipient clusters of hepatitis C virus (HCV)-infected individuals were studied. For five clusters the period of infection of the donor could be estimated, and for all six clusters the time...

U.S. Human Immunodeficiency Virus Type 1 Epidemic: Date of Origin, Population History, and Characterization of Early Strains

Robbins, Kenneth E., Lemey, Philippe, Pybus, Oliver G., Jaffe, Harold W., Youngpairoj, Ae S., Brown, Teresa M., ...

Human immunodeficiency virus (HIV) type 1 subtype B sequences (whole envelope and the p17 region of gag) were obtained from peripheral blood mononuclear cell samples collected in 1981 from seven...

Characterization of a Novel Simian Immunodeficiency Virus with a vpu Gene from Greater Spot-Nosed Monkeys (Cercopithecus nictitans) Provides New Insights into Simian/Human Immunodeficiency Virus Phylogeny

Courgnaud, Valérie, Salemi, Marco, Pourrut, Xavier, Mpoudi-Ngole, Eitel, Abela, Bernadette, Auzel, Philippe, ...

In the present study, we describe a new simian immunodeficiency virus (SIV), designated SIVgsn, naturally infecting greater spot-nosed monkeys (Cercopithecus nictitans) in Cameroon. Together with...

Tracing the origin and history of the HIV-2 epidemic

Lemey, Philippe, Pybus, Oliver G., Wang, Bin, Saksena, Nitin K., Salemi, Marco, Vandamme, Anne-Mieke

In this study we date the introduction of HIV-2 into the human population and estimate the epidemic history of HIV-2 subtype A in Guinea-Bissau, the putative geographic origin of HIV-2. The...

Mosaic Genomes of the Six Major Primate Lentivirus Lineages Revealed by Phylogenetic Analyses

Salemi, Marco, De Oliveira, Tulio, Courgnaud, Valerie, Moulton, Vincent, Holland, Barbara, Cassol, Sharon, ...

To clarify the origin and evolution of the primate lentiviruses (PLVs), which include human immunodeficiency virus types 1 and 2 as well as their simian relatives, simian immunodeficiency viruses...

Phylodynamic Analysis of Human Immunodeficiency Virus Type 1 in Distinct Brain Compartments Provides a Model for the Neuropathogenesis of AIDS

Salemi, Marco, Lamers, Susanna L., Yu, Stephanie, De Oliveira, T., Fitch, Walter M., McGrath, Michael S.

“Phylodynamic” analysis combines various statistical procedures that can be used to correlate the epidemiological and evolutionary behavior of viral pathogens with the immune system of the host....

Mapping sites of positive selection and amino acid diversification in the HIV genome: an alternative approach to vaccine design?

De Oliveira, Tulio, Salemi, Marco, Gordon, Michelle, Vandamme, Anne-Mieke, Van Rensburg, Estrelita Janse, Engelbrecht, Susan, ...

A safe and effective HIV-1 vaccine is urgently needed to control the worldwide AIDS epidemic. Traditional methods of vaccine development have been frustratingly slow, and it is becoming increasingly...

Extensive HIV-1 Intra-Host Recombination Is Common in Tissues with Abnormal Histopathology

Lamers, Susanna L., Salemi, Marco, Galligan, Derek C., De Oliveira, Tulio, Fogel, Gary B., Granier, Sara C., ...

There is evidence that immune-activated macrophages infected with the Human Immunodeficiency Virus (HIV) are associated with tissue damage and serve as a long-lived viral reservoir during therapy. In...