Marie-France Cesbron-Delauw

Transmembrane Insertion of the Toxoplasma gondii GRA5 Protein Occurs after Soluble Secretion into the Host Cell

Lecordier, Laurence, Mercier, Corinne, Sibley, L. David, Cesbron-Delauw, Marie-France

The intracellular parasite Toxoplasma gondii resides within a specialized compartment, the parasitophorous vacuole (PV), that resists fusion with host cell endocytic and lysosomal compartments. The...

Enzyme-Linked Immunosorbent Assays Using the Recombinant Dense Granule Antigens GRA6 and GRA1 of Toxoplasma gondii for Detection of Immunoglobulin G Antibodies

Lecordier, Laurence, Fourmaux, Marie-Pierre, Mercier, Corinne, Dehecq, Eric, Masy, E., Cesbron-Delauw, Marie-France

The potential of the dense granule antigens GRA1 and GRA6 of Toxoplasma gondii to be used as diagnosis reagents in a recombinant form was evaluated. Both proteins were expressed in Escherichia coli...

Biogenesis of Nanotubular Network in Toxoplasma Parasitophorous Vacuole Induced by Parasite Proteins

Mercier, Corinne, Dubremetz, Jean-François, Rauscher, Béatrice, Lecordier, Laurence, Sibley, L. David, Cesbron-Delauw, Marie-France

The intracellular parasite Toxoplasma gondii develops within a nonfusogenic vacuole containing a network of elongated nanotubules that form connections with the vacuolar membrane. Parasite secretory...

Toxoplasma gondii-Infected Human Myeloid Dendritic Cells Induce T-Lymphocyte Dysfunction and Contact-Dependent Apoptosis

Wei, Shuang, Marches, Florentina, Borvak, Jozef, Zou, Weiping, Channon, Jacqueline, White, Michael, ...

Dendritic cells ignite adaptive immunity by priming naïve T lymphocytes. Human monocyte-derived dendritic cells (MDDCs) infected with Toxoplasma gondii induce T-lymphocyte gamma interferon...

Innate Refractoriness of the Lewis Rat to Toxoplasmosis Is a Dominant Trait That Is Intrinsic to Bone Marrow-Derived Cells

Sergent, Véronique, Cautain, Bastien, Khalife, Jamal, Deslée, Didier, Bastien, Patrick, Dao, Anne, ...

Toxoplasmosis is a ubiquitous parasitic infection causing a wide spectrum of diseases. It is usually asymptomatic but can lead to severe ocular and neurological disorders. Among the small-animal...

Histone-Modifying Complexes Regulate Gene Expression Pertinent to the Differentiation of the Protozoan Parasite Toxoplasma gondii†

Saksouk, Nehmé, Bhatti, Micah M., Kieffer, Sylvie, Smith, Aaron T., Musset, Karine, Garin, Jérôme, ...

Pathogenic apicomplexan parasites like Toxoplasma and Plasmodium (malaria) have complex life cycles consisting of multiple stages. The ability to differentiate from one stage to another requires...

The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms

Cavaillès, Pierre, Sergent, Véronique, Bisanz, Cordelia, Papapietro, Olivier, Colacios, Céline, Mas, Magali, ...

Toxoplasmosis is a healthcare problem in pregnant women and immunocompromised patients. Like humans, rats usually develop a subclinical chronic infection. LEW rats exhibit total resistance to...

Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors

Bisanz, Cordelia, Bastien, Olivier, Grando, Delphine, Jouhet, Juliette, Maréchal, Eric, Cesbron-Delauw, Marie-France

Toxoplasma gondii is an obligate intracellular parasite that contains a relic plastid, called the apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic labelling...

Transmembrane Insertion of the Toxoplasma gondii GRA5 Protein Occurs after Soluble Secretion into the Host Cell

Lecordier, Laurence, Mercier, Corinne, Sibley, L. David, Cesbron-Delauw, Marie-France

The intracellular parasite Toxoplasma gondii resides within a specialized compartment, the parasitophorous vacuole (PV), that resists fusion with host cell endocytic and lysosomal compartments. The...

Enzyme-Linked Immunosorbent Assays Using the Recombinant Dense Granule Antigens GRA6 and GRA1 of Toxoplasma gondii for Detection of Immunoglobulin G Antibodies

Lecordier, Laurence, Fourmaux, Marie-Pierre, Mercier, Corinne, Dehecq, Eric, Masy, E., Cesbron-Delauw, Marie-France

The potential of the dense granule antigens GRA1 and GRA6 of Toxoplasma gondii to be used as diagnosis reagents in a recombinant form was evaluated. Both proteins were expressed in Escherichia coli...

Biogenesis of Nanotubular Network in Toxoplasma Parasitophorous Vacuole Induced by Parasite Proteins

Mercier, Corinne, Dubremetz, Jean-François, Rauscher, Béatrice, Lecordier, Laurence, Sibley, L. David, Cesbron-Delauw, Marie-France

The intracellular parasite Toxoplasma gondii develops within a nonfusogenic vacuole containing a network of elongated nanotubules that form connections with the vacuolar membrane. Parasite secretory...

Toxoplasma gondii-Infected Human Myeloid Dendritic Cells Induce T-Lymphocyte Dysfunction and Contact-Dependent Apoptosis

Wei, Shuang, Marches, Florentina, Borvak, Jozef, Zou, Weiping, Channon, Jacqueline, White, Michael, ...

Dendritic cells ignite adaptive immunity by priming naïve T lymphocytes. Human monocyte-derived dendritic cells (MDDCs) infected with Toxoplasma gondii induce T-lymphocyte gamma interferon...

Innate Refractoriness of the Lewis Rat to Toxoplasmosis Is a Dominant Trait That Is Intrinsic to Bone Marrow-Derived Cells

Sergent, Véronique, Cautain, Bastien, Khalife, Jamal, Deslée, Didier, Bastien, Patrick, Dao, Anne, ...

Toxoplasmosis is a ubiquitous parasitic infection causing a wide spectrum of diseases. It is usually asymptomatic but can lead to severe ocular and neurological disorders. Among the small-animal...

Histone-Modifying Complexes Regulate Gene Expression Pertinent to the Differentiation of the Protozoan Parasite Toxoplasma gondii†

Saksouk, Nehmé, Bhatti, Micah M., Kieffer, Sylvie, Smith, Aaron T., Musset, Karine, Garin, Jérôme, ...

Pathogenic apicomplexan parasites like Toxoplasma and Plasmodium (malaria) have complex life cycles consisting of multiple stages. The ability to differentiate from one stage to another requires...

The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms

Cavaillès, Pierre, Sergent, Véronique, Bisanz, Cordelia, Papapietro, Olivier, Colacios, Céline, Mas, Magali, ...

Toxoplasmosis is a healthcare problem in pregnant women and immunocompromised patients. Like humans, rats usually develop a subclinical chronic infection. LEW rats exhibit total resistance to...

Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors

Bisanz, Cordelia, Bastien, Olivier, Grando, Delphine, Jouhet, Juliette, Maréchal, Eric, Cesbron-Delauw, Marie-France

Toxoplasma gondii is an obligate intracellular parasite that contains a relic plastid, called the apicoplast, deriving from a secondary endosymbiosis with an ancestral alga. Metabolic labelling...