Mark A. Ditzler

Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme (2009)

Ditzler, Mark A., Sponer, Jirí, Walter, Nils G.

Despite numerous structural and biochemical investigations, the catalytic mechanism of hairpin ribozyme self-cleavage remains elusive. To gain insight into the coupling of active site dynamics with...

Focus on function: Single molecule RNA enzymology

Ditzler, Mark A., AlemÁn, Elvin A., Rueda, David, Walter, Nils G.

The ability of RNA to catalyze chemical reactions was first demonstrated 25 years ago with the discovery that group I introns and RNase P function as RNA enzymes (ribozymes). Several additional...

Folding and Conformational Dynamics of the Hairpin Ribozyme and the Spliceosome: Combining Computational and Experimental Analyses.

Ditzler, Mark A.

The vital role of RNA structure and dynamics in determining biological function is increasingly appreciated throughout the life sciences. RNA-coding genes are now recognized to be far more abundant...

Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme

Ditzler, Mark A., Šponer, Jiří, Walter, Nils G.

Despite numerous structural and biochemical investigations, the catalytic mechanism of hairpin ribozyme self-cleavage remains elusive. To gain insight into the coupling of active site dynamics with...