Patzer, Jan A., Walsh, Timothy R., Weeks, Janis, Dzierzanowska, Danuta, Toleman, Mark A.
Objectives The aim was to perform a genetically detailed study of the emergence of metallo-β-lactamase (MBL) genes in Pseudomonas spp. in the Children's Memorial Health Institute over a 9 year...
Mark A. Toleman, Jessica M. Toleman
an integrated graphical computing environment that allowed students to access electronic mail, USENET newsgroups and the Internet. The system was based on the Netscape suite of products and replaced...
Can Design Choices for Language-Based Editors be Analysed with Keystroke-Level Models? (2007)
Mark A. Toleman, Mark A. Toleman, Jim Welsh, Jim Welsh
We have been concerned for some time with the lack of rigorous experimental evaluation of design options chosen for tools used by software engineers. In a series of studies using various evaluation...
Toleman, Mark A., Bennett, Peter M., Walsh, Timothy R.
The ability of bacteria to procure, sometimes rearrange, and evince acquired DNA continues to impress us—even more so if this genetic plasticity involves the sequestering of antibiotic resistance...
Toleman, Mark A., Bennett, Peter M., Walsh, Timothy R.
The ability of bacteria to procure, sometimes rearrange, and evince acquired DNA continues to impress us--even more so if this genetic plasticity involves the sequestering of antibiotic resistance...
Toleman, Mark A., Biedenbach, Doug, Bennett, David M. C., Jones, Ronald N., Walsh, Timothy R.
Objectives: As part of the SENTRY Antimicrobial Surveillance Programme, 383 non-replicative randomly collected Pseudomonas aeruginosa isolates were collected during 1999–2002. These strains...
Patzer, Jan, Toleman, Mark A., Deshpande, Lalitagauri M., Kamiska, Wanda, Dzieranowska, Danuta, Bennett, Peter M., ...
Objectives: During 1997-2001, 151 isolates of imipenem-resistant Pseudomonas aeruginosa were obtained from clinical specimens taken from children hospitalized in Warsaw, Poland. These strains were...
Toleman, Mark A., Biedenbach, Doug, Bennett, David M. C., Jones, Ronald N., Walsh, Timothy R.
Objectives: As part of the SENTRY Antimicrobial Surveillance Programme, 383 non-replicative randomly collected Pseudomonas aeruginosa isolates were collected during 1999-2002. These strains...
Patzer, Jan, Toleman, Mark A., Deshpande, Lalitagauri M., Kaminska, Wanda, Dzierzanowska, Danuta, Bennett, Peter M., ...
Objectives: During 1997–2001, 151 isolates of imipenem-resistant Pseudomonas aeruginosa were obtained from clinical specimens taken from children hospitalized in Warsaw, Poland. These strains were...
Walsh, Timothy R., Toleman, Mark A., Hryniewicz, Waleria, Bennett, Peter M., Jones, Ronald N.
As part of the SENTRY Antimicrobial Surveillance Program, an imipenem-resistant Pseudomonas aeruginosa strain (81-11963A) was isolated from the blood culture of a female neonate institutionalized at...
Walsh, Timothy R., Toleman, Mark A., Hryniewicz, Waleria, Bennett, Peter M., Jones, Ronald N.
As part of the SENTRY Antimicrobial Surveillance Program, an imipenem-resistant Pseudomonas aeruginosa strain (81-11963A) was isolated from the blood culture of a female neonate institutionalized at...
Toleman, Mark A., Biedenbach, Doug, Bennett, David, Jones, Ronald N., Walsh, Timothy R.
Objective: In 2001, as part of the SENTRY worldwide antimicrobial surveillance programme, Pseudomonas aeruginosa 86-14571A was isolated at a hospital in Rome from a cancer patient with a bloodstream...
Toleman, Mark A., Biedenbach, Doug, Bennett, David, Jones, Ronald N., Walsh, Timothy R.
Objective: In 2001, as part of the SENTRY worldwide antimicrobial surveillance programme, Pseudomonas aeruginosa 86–14571A was isolated at a hospital in Rome from a cancer patient with a...
Walsh, Timothy R., Toleman, Mark A., Hryniewicz, Waleria, Bennett, Peter M., Jones, Ronald N.
As part of the SENTRY Antimicrobial Surveillance Program, an imipenem-resistant Pseudomonas aeruginosa strain (81-11963A) was isolated from the blood culture of a female neonate institutionalized at...
Toleman, Mark A., Biedenbach, Doug, Bennett, David, Jones, Ronald N., Walsh, Timothy R.
Objective: In 2001, as part of the SENTRY worldwide antimicrobial surveillance programme, Pseudomonas aeruginosa 86-14571A was isolated at a hospital in Rome from a cancer patient with a bloodstream...
Toleman, Mark A., Simm, Alan M., Murphy, Tanya A., Gales, Ana C., Biedenbach, Doug J., Jones, Ronald N., ...
The gene encoding the metallo-ß-lactamase SPM-1 was cloned from a genomic library of Pseudomonas aeruginosa strain 48-1997A. The insert carrying spm-1 possessed a GC content of 47%, indicating that...
Toleman, Mark A., Simm, Alan M., Murphy, Tanya A., Gales, Ana C., Biedenbach, Doug J., Jones, Ronald N., ...
The gene encoding the metallo-&bgr;-lactamase SPM-1 was cloned from a genomic library of Pseudomonas aeruginosa strain 48-1997A. The insert carrying spm-1 possessed a GC content of 47%,...
Toleman, Mark A., Simm, Alan M., Murphy, Tanya A., Gales, Ana C., Biedenbach, Doug J., Jones, Ronald N., ...
The gene encoding the metallo-ß-lactamase SPM-1 was cloned from a genomic library of Pseudomonas aeruginosa strain 48-1997A. The insert carrying spm-1 possessed a GC content of 47%, indicating that...
Systematic Evaluation of Design Choices for Software Development Tools (1998)
Mark A. Toleman, Mark A. Toleman, Jim Welsh, Jim Welsh
Most design and evaluation of software tools is based on the intuition and experience of the designers. Software tool designers consider themselves typical users of the tools that they build and tend...
The Design of the User Interface for Software Development Tools (1996)
Mark Anthony Toleman, To Margaret, Mark A. Toleman
This thesis is concerned with design options for user interfaces for language-based editors and in particular the evaluation of these options where competing choices are available. Most design and...
Can Design Choices for Language-Based Editors be Analysed with Keystroke-Level Models? (1996)
We have been concerned for some time with the lack of rigorous experimental evaluation of design options chosen for tools used by software engineers. In a series of studies using various evaluation...
An Empirical Investigation Of Language-Based Editing Paradigms (1995)
Mark A. Toleman, Mark A. Toleman, Jim Welsh, Jim Welsh
We have been concerned for some time with the lack of rigorous experimental evaluation of design options chosen for tools used by software engineers. In a series of studies of various evaluation...
An Empirical Investigation Of Language-Based Editing Paradigms (1995)
We have been concerned for some time with the lack of rigorous experimental evaluation of design options chosen for tools used by software engineers. In a series of studies of various evaluation...
Biochemical Characterization of the Acquired Metallo-β-Lactamase SPM-1 from Pseudomonas aeruginosa
Murphy, Tanya A., Simm, Alan M., Toleman, Mark A., Jones, Ronald N., Walsh, Timothy R.
SPM-1 is a new metallo-β-lactamase recently identified in Pseudomonas aeruginosa strain 48-1997A, isolated in Sao Paulo, Brazil. Kinetic analysis demonstrated that SPM-1 has a broad hydrolytic...
Toleman, Mark A., Rolston, Kenneth, Jones, Ronald N., Walsh, Timothy R.
As part of the CANCER Antimicrobial Surveillance Program in North America, a clinical strain of Pseudomonas aeruginosa, strain 07-406, isolated in Texas was found to be resistant to all...
Toleman, Mark A., Rolston, Kenneth, Jones, Ronald N., Walsh, Timothy R.
As part of the CANCER Antimicrobial Surveillance Program in North America, a Pseudomonas aeruginosa isolate, strain 07-406, was shown to possess a metallo-β-lactamase, designated VIM-7. blaVIM-7 is...
Mendes, Rodrigo E., Castanheira, Mariana, Garcia, Patricia, Guzman, Manuel, Toleman, Mark A., Walsh, Timothy R., ...
Castanheira, Mariana, Toleman, Mark A., Jones, Ronald N., Schmidt, Franz J., Walsh, Timothy R.
As part of the SENTRY Antimicrobial Surveillance Program in 2002, five multidrug-resistant Pseudomonas aeruginosa clinical isolates were detected with metallo-β-lactamase (MβL) activity. The...
Mendes, Rodrigo E., Toleman, Mark A., Ribeiro, Julival, Sader, Helio S., Jones, Ronald N., Walsh, Timothy R.
Since January 2002 Pseudomonas sp. strains resistant to carbapenems and ceftazidime have been routinely screened as part of the SENTRY Antimicrobial Surveillance Program for metallo-β-lactamase...
Metallo-β-Lactamases: the Quiet before the Storm?
Walsh, Timothy R., Toleman, Mark A., Poirel, Laurent, Nordmann, Patrice
The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant Pseudomonas...
Biochemical Characterization of the Acquired Metallo-β-Lactamase SPM-1 from Pseudomonas aeruginosa
Murphy, Tanya A., Simm, Alan M., Toleman, Mark A., Jones, Ronald N., Walsh, Timothy R.
SPM-1 is a new metallo-β-lactamase recently identified in Pseudomonas aeruginosa strain 48-1997A, isolated in Sao Paulo, Brazil. Kinetic analysis demonstrated that SPM-1 has a broad hydrolytic...
Toleman, Mark A., Rolston, Kenneth, Jones, Ronald N., Walsh, Timothy R.
As part of the CANCER Antimicrobial Surveillance Program in North America, a clinical strain of Pseudomonas aeruginosa, strain 07-406, isolated in Texas was found to be resistant to all...
Toleman, Mark A., Rolston, Kenneth, Jones, Ronald N., Walsh, Timothy R.
As part of the CANCER Antimicrobial Surveillance Program in North America, a Pseudomonas aeruginosa isolate, strain 07-406, was shown to possess a metallo-β-lactamase, designated VIM-7. blaVIM-7 is...
Mendes, Rodrigo E., Castanheira, Mariana, Garcia, Patricia, Guzman, Manuel, Toleman, Mark A., Walsh, Timothy R., ...
Castanheira, Mariana, Toleman, Mark A., Jones, Ronald N., Schmidt, Franz J., Walsh, Timothy R.
As part of the SENTRY Antimicrobial Surveillance Program in 2002, five multidrug-resistant Pseudomonas aeruginosa clinical isolates were detected with metallo-β-lactamase (MβL) activity. The...
Mendes, Rodrigo E., Toleman, Mark A., Ribeiro, Julival, Sader, Helio S., Jones, Ronald N., Walsh, Timothy R.
Since January 2002 Pseudomonas sp. strains resistant to carbapenems and ceftazidime have been routinely screened as part of the SENTRY Antimicrobial Surveillance Program for metallo-β-lactamase...
Metallo-β-Lactamases: the Quiet before the Storm?
Walsh, Timothy R., Toleman, Mark A., Poirel, Laurent, Nordmann, Patrice
The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant Pseudomonas...
ISCR Elements: Novel Gene-Capturing Systems of the 21st Century?
Toleman, Mark A., Bennett, Peter M., Walsh, Timothy R.
“Common regions” (CRs), such as Orf513, are being increasingly linked to mega-antibiotic-resistant regions. While their overall nucleotide sequences show little identity to other mobile elements,...
Mendes, Rodrigo E., Castanheira, Mariana, Toleman, Mark A., Sader, Helio S., Jones, Ronald N., Walsh, Timothy R.
Seven blaIMP-1-harboring Acinetobacter sp. isolates and one Pseudomonas putida clinical isolate were recovered from hospitalized patients. All isolates possessed a class 1 integron, named In86,...
Toleman, Mark A., Vinodh, Hemalatha, Sekar, Uma, Kamat, Vijaylakshmi, Walsh, Timothy R.
The metallo-β-lactamase gene blaVIM-2 was identified in a strain of Pseudomonas aeruginosa isolated in India. The integron encoding blaVIM-2 was virtually identical to those recently found in the...
Li, Hongyang, Toleman, Mark A., Bennett, Peter M., Jones, Ronald N., Walsh, Timothy R.
An outbreak involving a Pseudomonas aeruginosa strain that was resistant to all tested antimicrobials except polymyxin B occurred in a hospital in Houston, TX. Previous studies on this strain showed...
Evolution of the ISCR3 Group of ISCR Elements▿
Toleman, Mark A., Walsh, Timothy R.
The ISCR elements ISCR3, ISCR4, ISCR5, ISCR14, and ISCR16 all share a percent G+C of 68 to 69%. They also share between 75% and 97% identity in their transposase open reading frames. Furthermore,...
Samuelsen, Ørjan, Buarø, Liselotte, Toleman, Mark A., Giske, Christian G., Hermansen, Nils O., Walsh, Timothy R., ...
Li, Hongyang, Walsh, Timothy R., Toleman, Mark A.
The blaOXA-45 gene of Pseudomonas aeruginosa 07-406 is driven by a promoter found within a truncated ISPme1 insertion sequence. The gene is located between nonidentical repeats of a new ISCR element,...
Toleman, Mark A., Bennett, Peter M., Bennett, David M.C., Jones, Ronald N., Walsh, Timothy R.
The first sul2 genes have been found in S. maltophilia from several different countries.