A proposal for a new clinical classification of chronic pancreatitis (2009)
Büchler, Markus W, Martignoni, Marc E, Friess, Helmut, Malfertheiner, Peter
Abstract Background The clinical course of chronic pancreatitis is still unpredictable, which relates to the lack of the availability of a clinical classification. Therefore, patient populations...
Märten, Angela, Wente, Moritz N, Ose, Jennifer, Büchler, Markus W, Rötzer, Ingeborg, Decker-Baumann, Christiane, ...
Abstract Background Pancreatic cancer is an extremely aggressive malignancy. Subjects are afflicted with a variety of disconcerting symptoms, including profound cachexia. Recent data indicate that...
Rahbari, Nuh N, Zimmermann, Johannes B, Koch, Moritz, Bruckner, Thomas, Schmidt, Thomas, Elbers, Heike, ...
Abstract Background Intraoperative haemorrhage is a known predictor for perioperative outcome of patients undergoing hepatic resection. While anaesthesiological lowering of central venous pressure...
Bachmann, Jeannine, Ketterer, Knut, Marsch, Christiane, Fechtner, Kerstin, Krakowski-Roosen, Holger, Büchler, Markus W, ...
Abstract Background Dramatic weight loss is an often underestimated symptom in pancreatic cancer patients. Cachexia- defined as an unintended loss of stable weight exceeding 10% – is present in up...
Bruns, Helge, Rahbari, Nuh N, Löffler, Thorsten, Diener, Markus K, Seiler, Christoph M, Glanemann, Matthias, ...
Abstract Background Concomitant treatment in addition to intervention may influence the primary outcome, especially in complex interventions such as surgical trials. Evidence-based standards for...
Güralp Onur Ceyhan, Ihsan Ekin Demir, Ulrich Rauch, Frank Bergmann, Michael W Müller, Markus W Büchler, ...
Märten, Angela, Schmidt, Jan, Ose, Jennifer, Harig, Sabine, Abel, Ulrich, Münter, Marc W, ...
Abstract Background The 5-year survival of patients with resected pancreatic adenocarcinoma is still unsatisfying. The ESPAC-1 and the CONKO 001 trial proofed that adjuvant chemotherapy improves...
Neurotensin Receptor-1 mRNA Analysis in Normal Pancreas and Pancreatic Disease (2008)
Li Wang, Helmut Friess, Zhaowen Zhu, Hans Graber, Arthur Zimmermann, Murray Korc, ...
By autoradiography, neurotensin (NT) binding is specifically detectable in pancreatic cancer, but not in the normal pancreas, chronic pancreatitis (CP), or other pancreatic disorders. In the present...
Fritz, Stefan, Hartwig, Werner, Lehmann, Ronny, Will-Schweiger, Katja, Kommerell, Mechthild, Hackert, Thilo, ...
Abstract Introduction High morbidity and mortality rates in patients with severe acute pancreatitis are mainly caused by bacterial superinfection of pancreatic necrosis and subsequent sepsis. The...
Knebel, Philip, Fischer, Lars, Cremonese, Eva, Lopez-Benitez, Ruben, Stampfl, Ulrike, Radeleff, Boris, ...
Abstract Background Totally Implantable Access Ports (TIAP) are being extensively used world-wide and can be expected to gain further importance with the introduction of new neoadjuvant and adjuvant...
Ampullary adenocarcinoma – differentiation matters (2008)
Schirmacher, Peter, Büchler, Markus W
Abstract The periampullary region gives rise to two main subtypes of adenocarcinoma that show either pancreatobiliary or intestinal differentiation. New data demonstrates that the histological...
Fischer, Lars, Schoebinger, Max, Neumann, Jan-Oliver, Müller, Sascha, Meinzer, Hans-Peter, Büchler, Markus W, ...
Abstract Background Three-dimensional (3D) visualization is thought to improve the anatomical understanding of clinicians, thus improving patient safety. Case presentation A 58-year-old male was...
A concept for trial institutions focussing on randomised controlled trials in surgery (2008)
Rahbari, Nuh N, Diener, Markus K, Fischer, Lars, Wente, Moritz N, Kienle, Peter, Büchler, Markus W, ...
Abstract Background Although considered the reference standard for generating valid scientific evidence of a treatment's benefits and harms, the number of Randomised Controlled Trials (RCT) comparing...
Schemmer, Peter, Nickkholgh, Arash, Schneider, Heinz, Sobirey, Michael, Weigand, Markus, Koch, Moritz, ...
Abstract Background Major surgical procedures facilitate systemic endotoxinemia and formation of free radicals with subsequent inflammatory changes that can influence the postoperative course....
BMC Cancer BioMed Central Commentary (2008)
Peter Schirmacher, Markus W Büchler, Peter Schirmacher, Markus W Büchler
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The periampullary region gives rise to two main subtypes of adenocarcinoma...
Weigand, Kilian, Köninger, Jörg, Encke, Jens, Büchler, Markus W, Stremmel, Wolfgang, Gutt, Carsten N
Abstract Background Acute cholecystitis occurs frequently in the elderly and in patients with gall stones. Most cases of severe or recurrent cholecystitis eventually require surgery, usually...
Nickkholgh, Arash, Weitz, Jürgen, Encke, Jens, Sauer, Peter, Mehrabi, Arianeb, Büchler, Markus W., ...
Organ shortage has driven many transplant programs to extend their criteria to accept donors. The goal of the present work is to further characterize the most important extended donor criteria (EDC)...
Nickkholgh, Arash, Schneider, Heinz, Encke, Jens, Büchler, Markus W, Schmidt, Jan, Schemmer, Peter
Abstract Background Patients with end stage liver disease are characteristically malnourished which is associated with poor outcome. Formulas enriched with arginine, ω-3 fatty acids, and...
Antolovic, Dalibor, Kienle, Peter, Knaebel, Hanns-Peter, Schmidt, Jan, Gutt, Carsten N, Weitz, Jürgen, ...
Abstract Background Restorative proctocolectomy is increasingly being performed minimal invasively but a totally laparoscopic technique has not yet been compared to the standard open technique in a...
Splenic and portal vein thrombosis in pancreatic metastasis from Renal cell carcinoma (2006)
Shrikhande, Shailesh V, Büchler, Peter, Esposito, Irene, Loos, Martin, Büchler, Markus W, Friess, Helmut
Abstract Background Pancreatic metastases from previously treated renal cell carcinoma are uncommon. Surgical resection of pancreatic metastasis remains the only worthwhile modality of treatment....
Köninger, Jörg, Seiler, Christoph M, Wente, Moritz N, Reidel, Margot A, Gazyakan, Emre, Mansmann, Ulrich, ...
Abstract Background Chronic pancreatitis is an inflammatory disease which is characterized by an irreversible conversion of pancreatic parenchyma to fibrous tissue. Beside obstructive jaundice and...
Zhang, Chengwen, Kolb, Armin, Büchler, Peter, Cato, Andrew CB, Mattern, Jürgen, Rittgen, Werner, ...
Abstract Background Chemotherapy for pancreatic carcinoma often has severe side effects that limit its efficacy. The glucocorticoid (GC) dexamethasone (DEX) is frequently used as co-treatment to...
Bachmann, Jeannine, Kleeff, Jorg, Bergmann, Frank, Shrikhande, Shailesh V, Hartschuh, Wolfgang, Büchler, Markus W, ...
Abstract Background Merkel cell carcinomas are rare neoplasm of neuroendocrine origin, usually observed in elderly people in areas with abundant sunlight, and predominantly located on the head and...
Luntz, Steffen P, Unnebrink, Kristina, Seibert-Grafe, Monika, Bunzendahl, Hartwig, Kraus, Thomas W, Büchler, Markus W, ...
Abstract Background Kupffer cell-dependent ischemia / reperfusion (I/R) injury after liver transplantation is still of high clinical relevance, as it is strongly associated with primary dysfunction...
Li, Junsheng, Kleeff, Jörg, Abiatari, Ivane, Kayed, Hany, Giese, Nathalia A, Felix, Klaus, ...
Abstract Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with...
Knaebel, Hanns-Peter, Koch, Moritz, Sauerland, Stefan, Diener, Markus K, Büchler, Markus W, Seiler, Christoph M, ...
Abstract Background The closure of the abdomen after median laparotomy is still a matter of debate among surgeons. Further well designed and performed randomised controlled trials determining the...
Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells (2005)
El Fitori, Jamael, Kleeff, Jörg, Giese, Nathalia A, Guweidhi, Ahmed, Bosserhoff, Anja K, Büchler, Markus W, ...
Abstract Background Melanoma inhibitory activity (MIA) is a small secreted protein that interacts with extracellular matrix proteins. Its over-expression promotes the metastatic behavior of malignant...
Pancreatic metastasis from gastric carcinoma: a case report (2004)
Wente, Moritz N, Bergmann, Frank, Fröhlich, Boris E, Schirmacher, Peter, Büchler, Markus W, Friess, Helmut
Abstract Background The pancreas is a rare but occasionally favored target for metastasis. Metastatic lesions in the pancreas have been described for various primary cancers, such as carcinomas of...
Cell wounding in early experimental acute pancreatitis (2004)
Dale E Bockman, Junchao Guo, Michael W Müller, Helmut Friess, Markus W Büchler
Mehrabi, Arianeb, Golling, Markus, Körting, Michael, Hashemi, Bahram, Ahmadi, Rezvan, Kashfi, Arash, ...
Background. Despite the growing use of kidneys from living donors, organs harvested from brain dead donors are the dominant graft types used in renal transplantation. It is accepted that brain death...
Moxifloxacin penetration into human gastrointestinal tissues (2004)
Wirtz, Martin, Kleeff, Jörg, Swoboda, Stefanie, Halaceli, Irfan, Geiss, Heiko K., Hoppe-Tichy, Torsten, ...
Objective: Moxifloxacin is a recently developed fourth-generation methoxyquinolone with a broad spectrum of activity against both Gram-positive and Gram-negative aerobic bacteria and anaerobes. The...
Mehrabi, Arianeb, Schemmer, Peter, Schmidt, Jan, Sauer, Peter, Friess, Helmut, Kraus, Thomas, ...
Background. Since indications for liver transplantation (LTx) have increased and the shortage of brain dead transplant organs continues, an increase in deaths related to extended waiting periods can...
New aspects on reperfusion injury to liver--impact of organ harvest (2004)
Schemmer, Peter, Mehrabi, Arianeb, Kraus, Thomas, Sauer, Peter, Gutt, Carsten, Uhl, Waldemar, ...
The aetiology of primary graft non-function and dysfunction is unknown but most likely involves Kupffer cell-dependent reperfusion injury; however, reasons for transplant failure are complex and...
Mehrabi, Arianeb, Wiesel, Manfred, Zeier, Martin, Kashfi, Arash, Schemmer, Peter, Kraus, Thomas, ...
Background. Although a majority of patients undergoing renal transplantation currently receive a cadaver kidney, living donors continue to be an important source of transplanted kidneys. Recipients...
Mehrabi, Arianeb, Kashfi, Arash, Tönshoff, Burkhard, Feneberg, Reinhard, Mehls, Otto, Schemmer, Peter, ...
Background. Kidney transplantation remains the most effective treatment for children with end-stage renal disease. We analysed data from the University of Heidelberg transplant programme to present...
Guweidhi, Ahmed, Kleeff, Jörg, Giese, Nathalia, El Fitori, Jamael, Ketterer, Knut, Giese, Thomas, ...
Background: 14-3-3sigma belongs to the 14-3-3 family of proteins, which are involved in the modulation of diverse signal transduction pathways. Loss of 14-3-3sigma expression has been observed in a...
Moxifloxacin penetration into human gastrointestinal tissues (2004)
Wirtz, Martin, Kleeff, Jörg, Swoboda, Stefanie, Halaceli, Irfan, Geiss, Heiko K., Hoppe-Tichy, Torsten, ...
Objective: Moxifloxacin is a recently developed fourth-generation methoxyquinolone with a broad spectrum of activity against both Gram-positive and Gram-negative aerobic bacteria and anaerobes. The...
Guweidhi, Ahmed, Kleeff, Jörg, Giese, Nathalia, Fitori, Jamael El, Ketterer, Knut, Giese, Thomas, ...
14-3-3sigma belongs to the 14-3-3 family of proteins, which are involved in the modulation of diverse signal transduction pathways. Loss of 14-3-3sigma expression has been observed in a number of...
Mehrabi, Arianeb, Golling, Markus, Körting, Michael, Hashemi, Bahram, Ahmadi, Rezvan, Kashfi, Arash, ...
Background. Despite the growing use of kidneys from living donors, organs harvested from brain dead donors are the dominant graft types used in renal transplantation. It is accepted that brain death...
Guweidhi, Ahmed, Kleeff, Jörg, Giese, Nathalia, El Fitori, Jamael, Ketterer, Knut, Giese, Thomas, ...
Background: 14-3-3sigma belongs to the 14-3-3 family of proteins, which are involved in the modulation of diverse signal transduction pathways. Loss of 14-3-3sigma expression has been observed in a...
Moxifloxacin penetration into human gastrointestinal tissues (2004)
Wirtz, Martin, Kleeff, Jörg, Swoboda, Stefanie, Halaceli, Irfan, Geiss, Heiko K., Hoppe-Tichy, Torsten, ...
Objective: Moxifloxacin is a recently developed fourth-generation methoxyquinolone with a broad spectrum of activity against both Gram-positive and Gram-negative aerobic bacteria and anaerobes. The...
Reidel, Margot A, Knaebel, Hanns-Peter, Seiler, Christoph M, Knauer, Christine, Motsch, Johann, Victor, Norbert, ...
Abstract Background There are two ways to open the abdominal cavity in elective general surgery: vertically or transversely. Various clinical studies and a meta-analysis have postulated that the...
Effects of STI571 (gleevec) on pancreatic cancer cell growth (2003)
Li, Junsheng, Kleeff, Jörg, Guo, Junchao, Fischer, Lars, Giese, Nathalia, Büchler, Markus W, ...
Abstract Background Pancreatic cancer is an aggressive malignancy characterized by low responsiveness to chemotherapy and radiotherapy. This resistance is partly due to the overexpression of several...
New molecular aspects in pathogenesis and progression of pancreatic cancer (2003)
Büchler, Peter, Büchler, Markus W, Friess, Helmut
No abstract available.
Invasion and metastasis in pancreatic cancer (2003)
Keleg, Shereen, Büchler, Peter, Ludwig, Roman, Büchler, Markus W, Friess, Helmut
Abstract Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate below 1%. The process of cancer initiation, progression and metastasis is still not understood...
Borgström, Anders, Appelros, Stefan, Müller, Christophe A, Uhl, Waldemar, Büchler, Markus W
Abstract is not available
Galectin-1 and Galectin-3 in Chronic Pancreatitis (2000)
Li Wang, Helmut Friess, Zhaowen Zhu, Luciano Frigeri, Arthur Zimmermann, Murray Korc, ...
Altered expression of transforming growth factor-βs in chronic renal rejection (1996)
Laszlo Zs Horvath, Friess Helmut, Martin Schilling, Bettina Borisch, Judith Deflorin, Leslie I Gold, ...
Fluconazole Penetration into the Pancreas
Shrikhande, Shailesh, Friess, Helmut, Issenegger, Claudia, Martignoni, Marcus E., Yong, Huang, Gloor, Beat, ...
Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of...
Invasion and metastasis in pancreatic cancer
Keleg, Shereen, Büchler, Peter, Ludwig, Roman, Büchler, Markus W, Friess, Helmut
Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate below 1%. The process of cancer initiation, progression and metastasis is still not understood well....
Effects of STI571 (gleevec) on pancreatic cancer cell growth
Li, Junsheng, Kleeff, Jörg, Guo, Junchao, Fischer, Lars, Giese, Nathalia, Büchler, Markus W, ...
Reidel, Margot A, Knaebel, Hanns-Peter, Seiler, Christoph M, Knauer, Christine, Motsch, Johann, Victor, Norbert, ...
Pancreatic metastasis from gastric carcinoma: a case report
Wente, Moritz N, Bergmann, Frank, Fröhlich, Boris E, Schirmacher, Peter, Büchler, Markus W, Friess, Helmut
Knaebel, Hanns-Peter, Koch, Moritz, Sauerland, Stefan, Diener, Markus K, Büchler, Markus W, Seiler, Christoph M
Li, Junsheng, Kleeff, Jörg, Abiatari, Ivane, Kayed, Hany, Giese, Nathalia A, Felix, Klaus, ...
Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding...
Luntz, Steffen P, Unnebrink, Kristina, Seibert-Grafe, Monika, Bunzendahl, Hartwig, Kraus, Thomas W, Büchler, Markus W, ...
Bachmann, Jeannine, Kleeff, Jorg, Bergmann, Frank, Shrikhande, Shailesh V, Hartschuh, Wolfgang, Büchler, Markus W, ...
Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells
El Fitori, Jamael, Kleeff, Jörg, Giese, Nathalia A, Guweidhi, Ahmed, Bosserhoff, Anja K, Büchler, Markus W, ...
Phosphatidylserine Receptor in Chronic Pancreatitis: Evidence for a Macrophage Independent Role
Köninger, Jörg, Balaz, Peter, Wagner, Markus, Shi, Xin, Cima, Igor, Zimmermann, Arthur, ...
The phosphatidylserine receptor (PSR) is the crucial factor in the engulfment of apoptotic cells by macrophages. In the present study, we found PSR for the first time on degenerating acinar cells and...
Schwarzbach, Matthias H. M., Hinz, Ulf, Dimitrakopoulou-Strauss, Antonia, Willeke, Frank, Cardona, Servando, Mechtersheimer, Gunhild, ...
The prognostic significance of preoperative [18-F] fluorodeoxyglucose (FDG) positron emission tomography (PET) using standardized uptake values (SUV) was evaluated in patients with localized soft...
Osteonectin Influences Growth and Invasion of Pancreatic Cancer Cells
Guweidhi, Ahmed, Kleeff, Jörg, Adwan, Hassan, Giese, Nathalia A., Wente, Moritz N., Giese, Thomas, ...
The glycoprotein osteonectin plays a critical role in malignant tumors and correlates with disease progression and poor prognosis. In the present study we revealed an influence on pancreatic cancer...
Connective Tissue Growth Factor Is a Regulator for Fibrosis in Human Chronic Pancreatitis
Di Mola, Fabio F., Friess, Helmut, Martignoni, Marcus E., Di Sebastiano, Pierluigi, Zimmermann, Arthur, Innocenti, Paolo, ...
Nerve Growth Factor and Its High-Affinity Receptor in Chronic Pancreatitis
Friess, Helmut, Zhu, Zhao-Wen, Di Mola, Fabio F., Kulli, Christoph, Graber, Hans U., Andren-Sandberg, Åke, ...
Growth Factor Receptors Are Differentially Expressed in Cancers of the Papilla of Vater and Pancreas
Friess, Helmut, Wang, Li, Zhu, Zhaowen, Gerber, Rolf, Schröder, Michael, Fukuda, Akira, ...
Phospholipase A2 Isoforms in Acute Pancreatitis
Friess, Helmut, Shrikhande, Shailesh, Riesle, Erick, Kashiwagi, Mikiya, Baczako, Karl, Zimmermann, Arthur, ...
Acute Necrotizing Pancreatitis: Treatment Strategy According to the Status of Infection
Büchler, Markus W., Gloor, Beat, Müller, Christophe A., Friess, Helmut, Seiler, Christian A., Uhl, Waldemar
Neoptolemos, John P., Stocken, Deborah D., Dunn, Janet A., Almond, Jennifer, Beger, Hans G., Pederzoli, Paolo, ...
Identification of Disease-specific Genes in Chronic Pancreatitis Using DNA Array Technology
Friess, Helmut, Ding, Jiayi, Kleeff, Jörg, Liao, Quan, Berberat, Pascal O., Hammer, Jürgen, ...
Z’graggen, Kaspar, Maurer, Christoph A., Birrer, Stefan, Giachino, Daniel, Kern, Beatrice, Büchler, Markus W.
Di Mola, Fabio F., Friess, Helmut, Riesle, Erick, Koliopanos, Alexander, Büchler, Peter, Zhu, Zhaowen, ...
Redaelli, Claudio A., Dufour, Jean-François, Wagner, Markus, Schilling, Martin, Hüsler, Jürg, Krähenbühl, Lukas, ...
Human Macrophage Metalloelastase Worsens the Prognosis of Pancreatic Cancer
Balaz, Peter, Friess, Helmut, Kondo, Yasuo, Zhu, Zhaowen, Zimmermann, Arthur, Büchler, Markus W.
VEGF-RII Influences the Prognosis of Pancreatic Cancer
Büchler, Peter, Reber, Howard A., Büchler, Markus W., Friess, Helmut, Hines, Oscar J.
Zhang, Chengwen, Kolb, Armin, Büchler, Peter, Cato, Andrew CB, Mattern, Jürgen, Rittgen, Werner, ...
The Notch Signaling Pathway Is Related to Neurovascular Progression of Pancreatic Cancer
Büchler, Peter, Gazdhar, Amiq, Schubert, Mario, Giese, Nathalia, Reber, Howard A., Hines, Oscar J., ...
The Notch signaling pathway is well known as a neuronal pathway. This study shows that the Notch pathway plays a pivotal role in angiogenesis in pancreatic cancer. Jagged-1, a Notch ligand, and...
Köninger, Jörg, Seiler, Christoph M, Wente, Moritz N, Reidel, Margot A, Gazayakan, Emre, Mansmann, Ulrich, ...
Splenic and portal vein thrombosis in pancreatic metastasis from Renal cell carcinoma
Shrikhande, Shailesh V, Büchler, Peter, Esposito, Irene, Loos, Martin, Büchler, Markus W, Friess, Helmut
Antolovic, Dalibor, Kienle, Peter, Knaebel, Hanns-Peter, Schmidt, Jan, Gutt, Carsten N, Weitz, Jürgen, ...
Fluconazole Penetration into the Pancreas
Shrikhande, Shailesh, Friess, Helmut, Issenegger, Claudia, Martignoni, Marcus E., Yong, Huang, Gloor, Beat, ...
Because of antibiotic prophylaxis for necrotizing pancreatitis, the frequency of fungal superinfection in patients with pancreatic necrosis is increasing. In this study we analyzed the penetration of...
Invasion and metastasis in pancreatic cancer
Keleg, Shereen, Büchler, Peter, Ludwig, Roman, Büchler, Markus W, Friess, Helmut
Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate below 1%. The process of cancer initiation, progression and metastasis is still not understood well....
Effects of STI571 (gleevec) on pancreatic cancer cell growth
Li, Junsheng, Kleeff, Jörg, Guo, Junchao, Fischer, Lars, Giese, Nathalia, Büchler, Markus W, ...
Reidel, Margot A, Knaebel, Hanns-Peter, Seiler, Christoph M, Knauer, Christine, Motsch, Johann, Victor, Norbert, ...
Pancreatic metastasis from gastric carcinoma: a case report
Wente, Moritz N, Bergmann, Frank, Fröhlich, Boris E, Schirmacher, Peter, Büchler, Markus W, Friess, Helmut
Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells
El Fitori, Jamael, Kleeff, Jörg, Giese, Nathalia A, Guweidhi, Ahmed, Bosserhoff, Anja K, Büchler, Markus W, ...
Knaebel, Hanns-Peter, Koch, Moritz, Sauerland, Stefan, Diener, Markus K, Büchler, Markus W, Seiler, Christoph M
Li, Junsheng, Kleeff, Jörg, Abiatari, Ivane, Kayed, Hany, Giese, Nathalia A, Felix, Klaus, ...
Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding...
Luntz, Steffen P, Unnebrink, Kristina, Seibert-Grafe, Monika, Bunzendahl, Hartwig, Kraus, Thomas W, Büchler, Markus W, ...
Bachmann, Jeannine, Kleeff, Jorg, Bergmann, Frank, Shrikhande, Shailesh V, Hartschuh, Wolfgang, Büchler, Markus W, ...
Phosphatidylserine Receptor in Chronic Pancreatitis: Evidence for a Macrophage Independent Role
Köninger, Jörg, Balaz, Peter, Wagner, Markus, Shi, Xin, Cima, Igor, Zimmermann, Arthur, ...
The phosphatidylserine receptor (PSR) is the crucial factor in the engulfment of apoptotic cells by macrophages. In the present study, we found PSR for the first time on degenerating acinar cells and...
Schwarzbach, Matthias H. M., Hinz, Ulf, Dimitrakopoulou-Strauss, Antonia, Willeke, Frank, Cardona, Servando, Mechtersheimer, Gunhild, ...
The prognostic significance of preoperative [18-F] fluorodeoxyglucose (FDG) positron emission tomography (PET) using standardized uptake values (SUV) was evaluated in patients with localized soft...
Osteonectin Influences Growth and Invasion of Pancreatic Cancer Cells
Guweidhi, Ahmed, Kleeff, Jörg, Adwan, Hassan, Giese, Nathalia A., Wente, Moritz N., Giese, Thomas, ...
The glycoprotein osteonectin plays a critical role in malignant tumors and correlates with disease progression and poor prognosis. In the present study we revealed an influence on pancreatic cancer...
The Notch Signaling Pathway Is Related to Neurovascular Progression of Pancreatic Cancer
Büchler, Peter, Gazdhar, Amiq, Schubert, Mario, Giese, Nathalia, Reber, Howard A., Hines, Oscar J., ...
The Notch signaling pathway is well known as a neuronal pathway. This study shows that the Notch pathway plays a pivotal role in angiogenesis in pancreatic cancer. Jagged-1, a Notch ligand, and...
Connective Tissue Growth Factor Is a Regulator for Fibrosis in Human Chronic Pancreatitis
Di Mola, Fabio F., Friess, Helmut, Martignoni, Marcus E., Di Sebastiano, Pierluigi, Zimmermann, Arthur, Innocenti, Paolo, ...
Nerve Growth Factor and Its High-Affinity Receptor in Chronic Pancreatitis
Friess, Helmut, Zhu, Zhao-Wen, Di Mola, Fabio F., Kulli, Christoph, Graber, Hans U., Andren-Sandberg, Åke, ...
Growth Factor Receptors Are Differentially Expressed in Cancers of the Papilla of Vater and Pancreas
Friess, Helmut, Wang, Li, Zhu, Zhaowen, Gerber, Rolf, Schröder, Michael, Fukuda, Akira, ...
Phospholipase A2 Isoforms in Acute Pancreatitis
Friess, Helmut, Shrikhande, Shailesh, Riesle, Erick, Kashiwagi, Mikiya, Baczako, Karl, Zimmermann, Arthur, ...
Acute Necrotizing Pancreatitis: Treatment Strategy According to the Status of Infection
Büchler, Markus W., Gloor, Beat, Müller, Christophe A., Friess, Helmut, Seiler, Christian A., Uhl, Waldemar
Neoptolemos, John P., Stocken, Deborah D., Dunn, Janet A., Almond, Jennifer, Beger, Hans G., Pederzoli, Paolo, ...
Identification of Disease-specific Genes in Chronic Pancreatitis Using DNA Array Technology
Friess, Helmut, Ding, Jiayi, Kleeff, Jörg, Liao, Quan, Berberat, Pascal O., Hammer, Jürgen, ...
Z’graggen, Kaspar, Maurer, Christoph A., Birrer, Stefan, Giachino, Daniel, Kern, Beatrice, Büchler, Markus W.
Di Mola, Fabio F., Friess, Helmut, Riesle, Erick, Koliopanos, Alexander, Büchler, Peter, Zhu, Zhaowen, ...
Redaelli, Claudio A., Dufour, Jean-François, Wagner, Markus, Schilling, Martin, Hüsler, Jürg, Krähenbühl, Lukas, ...
Human Macrophage Metalloelastase Worsens the Prognosis of Pancreatic Cancer
Balaz, Peter, Friess, Helmut, Kondo, Yasuo, Zhu, Zhaowen, Zimmermann, Arthur, Büchler, Markus W.
VEGF-RII Influences the Prognosis of Pancreatic Cancer
Büchler, Peter, Reber, Howard A., Büchler, Markus W., Friess, Helmut, Hines, Oscar J.
Zhang, Chengwen, Kolb, Armin, Büchler, Peter, Cato, Andrew CB, Mattern, Jürgen, Rittgen, Werner, ...
Köninger, Jörg, Seiler, Christoph M, Wente, Moritz N, Reidel, Margot A, Gazayakan, Emre, Mansmann, Ulrich, ...
Splenic and portal vein thrombosis in pancreatic metastasis from Renal cell carcinoma
Shrikhande, Shailesh V, Büchler, Peter, Esposito, Irene, Loos, Martin, Büchler, Markus W, Friess, Helmut
Antolovic, Dalibor, Kienle, Peter, Knaebel, Hanns-Peter, Schmidt, Jan, Gutt, Carsten N, Weitz, Jürgen, ...
The Neurotrophic Factor Artemin Promotes Pancreatic Cancer Invasion
Ceyhan, Güralp O., Giese, Nathalia A., Erkan, Mert, Kerscher, Annika G., Wente, Moritz N., Giese, Thomas, ...
In this study, we analyzed the expression of Artemin and its receptors GFRα3/RET in pancreatic ductal adenocarcinoma and evaluated its possible influences on pain and pancreatic cancer cell...
Ritzel, Robert A., Isermann, Berend, Schilling, Tobias, Knaebel, Hanns-Peter, Büchler, Markus W., Nawroth, Peter P.
A 40-year-old woman with recurrent episodes of hypoglycemia was referred because of suspected insulinoma. Prolonged fasting was discontinued after 24 h due to symptomatic hypoglycemia (29 mg/dl,...
Platelet Function in Acute Experimental Pancreatitis
Hackert, Thilo, Pfeil, Dagmar, Hartwig, Werner, Fritz, Stefan, Schneider, Lutz, Gebhard, Martha-Maria, ...
Acute pancreatitis (AP) is characterized by disturbances of pancreatic microcirculation. It remains unclear whether platelets contribute to these perfusion disturbances. The aim of our study was to...
Characterization of Keratinocyte Growth Factor and Receptor Expression in Human Pancreatic Cancer
Ishiwata, Toshiyuki, Friess, Helmut, Büchler, Markus W., Lopez, Martha E., Korc, Murray
Keratinocyte growth factor (KGF) is an angiogenic and mitogenic polypeptide that has been implicated in cancer growth and tissue development and repair. Its actions are dependent on its binding to a...
Middle Segmental Pancreatic Resection: An Option to Treat Benign Pancreatic Body Lesions
Müller, Michael W., Friess, Helmut, Kleeff, Jörg, Hinz, Ulf, Wente, Moritz N., Paramythiotis, Daniel, ...
In the past, lesions of the pancreatic body were treated by pancreaticoduodenectomy or distal pancreatectomy. To preserve normal pancreatic tissue, middle segmental pancreatic resection has been...
Koch, Moritz, Beckhove, Philipp, Op Den Winkel, Jan, Autenrieth, Daniel, Wagner, Philipp, Nummer, Daniel, ...
This study examines the activation status of cytotoxic tumor infiltrating T lymphocytes (TIL) in colorectal cancer patients and demonstrates for the first time tumor-selective activation and...
Maruyama, Haruhisa, Kleeff, Jörg, Wildi, Stefan, Friess, Helmut, Büchler, Markus W., Israel, Mark A., ...
Id proteins antagonize basic helix-loop-helix proteins, inhibit differentiation, and enhance cell proliferation. In this study we compared the expression of Id-1, Id-2, and Id-3 in the normal...
Hennig, René, Ding, Xian-Zhong, Tong, Wei-Gang, Schneider, Matthias B., Standop, Jens, Friess, Helmut, ...
The 5-lipoxygenase (5-LOX) pathway is critical for pancreatic cancer cell growth and escape from apoptosis. Inhibition of 5-LOX blocks proliferation and induces apoptosis in human pancreatic cancer...
Diener, Markus K., Knaebel, Hanns-Peter, Heukaufer, Christina, Antes, Gerd, Büchler, Markus W., Seiler, Christoph M.
A systematic review and meta-analysis comparing pylorus-preserving pancreaticoduodenectomy versus classic Whipple procedure showed no difference in overall morbidity, mortality, and survival....
Distal Pancreatectomy: Risk Factors for Surgical Failure in 302 Consecutive Cases
Kleeff, Jörg, Diener, Markus K., Z'graggen, Kaspar, Hinz, Ulf, Wagner, Markus, Bachmann, Jeannine, ...
Pancreatic fistula after distal pancreatectomy remains a common and important problem. Closure of the pancreatic remnant using a stapling device and an operating time ≥8 hours are associated with a...
Surgery for Recurrent Pancreatic Ductal Adenocarcinoma
Kleeff, Jörg, Reiser, Carolin, Hinz, Ulf, Bachmann, Jeannine, Debus, Jürgen, Jaeger, Dirk, ...
Resection for recurrent pancreatic cancer does not seem to change the natural progression of the disease in most patients. Better diagnostic modalities and further studies will help to identify the...
Rau, Bettina M., Kemppainen, Esko A., Gumbs, Andrew A., Büchler, Markus W., Wegscheider, Karl, Bassi, Claudio, ...
Early and reliable assessment of pancreatic infections is of major importance for timely goal-directed treatment in acute pancreatitis. The results of our prospective international multicenter study...
Hennig, René, Kehl, Timo, Noor, Seema, Ding, Xian-Zhong, Rao, Sambasiva M, Bergmann, Frank, ...
Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PanINs), the precursor lesions, are a potential...
Weigand, Kilian, Köninger, Jörg, Encke, Jens, Büchler, Markus W, Stremmel, Wolfgang, Gutt, Carsten N
Pancreatic resection for pancreatic cancer
Bachmann, Jeannine, Michalski, Christoph W., Martignoni, Marc E., Büchler, Markus W., Friess, Helmut
Complications of pancreatic surgery
Ho, Choon-Kiat, Kleeff, Jörg, Friess, Helmut, Büchler, Markus W.
Pancreatic resection is the only treatment option that can lead to a meaningful prolonged survival in pancreatic cancer and, in some instances, perhaps a potential chance for cure. With the advent of...
Second-Look Operation for Unresectable Pancreatic Ductal Adenocarcinoma at a High-Volume Center
Michalski, Christoph W., Kleeff, Jörg, Bachmann, Jeannine, AlKhatib, Jaber, Erkan, Mert, Esposito, Irene, ...
Schemmer, Peter, Nickkholgh, Arash, Schneider, Heinz, Sobirey, Michael, Weigand, Markus, Koch, Moritz, ...
A concept for trial institutions focussing on randomised controlled trials in surgery
Rahbari, Nuh N, Diener, Markus K, Fischer, Lars, Wente, Moritz N, Kienle, Peter, Büchler, Markus W, ...
Esposito, Irene, Born, Diana, Bergmann, Frank, Longerich, Thomas, Welsch, Thilo, Giese, Nathalia A., ...
The need for venovenous bypass in liver transplantation
Fonouni*, Hamidreza, Mehrabi*, Arianeb, Soleimani, Mehrdad, Müller, Sascha A., Büchler, Markus W., Schmidt, Jan
Since introduction of the conventional liver transplantation (CLTx) by Starzl, which was based on the resection of recipient inferior vena cava (IVC) along the liver, the procedure has undergone...
Liver transection using vascular stapler: a review
Schemmer, Peter, Bruns, Helge, Weitz, Jürgen, Schmidt, Jan, Büchler, Markus W.
The clinical experience using a novel technique of liver resection with vascular staplers for dissection of hepatic parenchyma, was documented most recently in a prospective manner. These data have...
Fischer, Lars, Schoebinger, Max, Neumann, Jan-Oliver, Müller, Sascha, Meinzer, Hans-Peter, Büchler, Markus W, ...
Ampullary adenocarcinoma – differentiation matters
Schirmacher, Peter, Büchler, Markus W
The periampullary region gives rise to two main subtypes of adenocarcinoma that show either pancreatobiliary or intestinal differentiation. New data demonstrates that the histological subtype –...
Knebel, Philip, Fischer, Lars, Cremonese, Eva, Lopez-Benitez, Ruben, Stampfl, Ulrike, Radeleff, Boris, ...
Fritz, Stefan, Hartwig, Werner, Lehmann, Ronny, Will-Schweiger, Katja, Kommerell, Mechthild, Hackert, Thilo, ...
Bruns, Helge, Rahbari, Nuh N, Löffler, Thorsten, Diener, Markus K, Seiler, Christoph M, Glanemann, Matthias, ...
Bruns, Helge, Rahbari, Nuh N, Löffler, Thorsten, Diener, Markus K, Seiler, Christoph M, Glanemann, Matthias, ...
Bachmann, Jeannine, Ketterer, Knut, Marsch, Christiane, Fechtner, Kerstin, Krakowski-Roosen, Holger, Büchler, Markus W, ...
Total pancreatectomy for pancreatic cancer: indications and operative technique
Kulu, Yakup, Schmied, Bruno M, Werner, Jens, Muselli, Pietro, Büchler, Markus W, Schmidt, Jan
Total pancreatectomy (TP) was abandoned by many surgeons because of its lack of benefits and other major drawbacks. The potential benefits of TP, including its oncological as well as its technical...
Rahbari, Nuh N, Zimmermann, Johannes B, Koch, Moritz, Bruckner, Thomas, Schmidt, Thomas, Elbers, Heike, ...
Märten, Angela, Wente, Moritz N, Ose, Jennifer, Büchler, Markus W, Rötzer, Ingeborg, Decker-Baumann, Christiane, ...
Surgical treatment of patients with acute cholecystitis: Tokyo Guidelines
Yamashita, Yuichi, Takada, Tadahiro, Kawarada, Yoshifumi, Nimura, Yuji, Hirota, Masahiko, Miura, Fumihiko, ...
Cholecystectomy has been widely performed in the treatment of acute cholecystitis, and laparoscopic cholecystectomy has been increasingly adopted as the method of surgery over the past 15 years....
Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines
Tsuyuguchi, Toshio, Takada, Tadahiro, Kawarada, Yoshifumi, Nimura, Yuji, Wada, Keita, Nagino, Masato, ...
Biliary decompression and drainage done in a timely manner is the cornerstone of acute cholangitis treatment. The mortality rate of acute cholangitis was extremely high when no interventional...
Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines
Wada, Keita, Takada, Tadahiro, Kawarada, Yoshifumi, Nimura, Yuji, Miura, Fumihiko, Yoshida, Masahiro, ...
Because acute cholangitis sometimes rapidly progresses to a severe form accompanied by organ dysfunction, caused by the systemic inflammatory response syndrome (SIRS) and/or sepsis, prompt diagnosis...
Diagnostic criteria and severity assessment of acute cholecystitis: Tokyo Guidelines
Hirota, Masahiko, Takada, Tadahiro, Kawarada, Yoshifumi, Nimura, Yuji, Miura, Fumihiko, Hirata, Koichi, ...
The aim of this article is to propose new criteria for the diagnosis and severity assessment of acute cholecystitis, based on a systematic review of the literature and a consensus of experts. A...