Bmc Bioinformatics, Tao Han, Jianyong Wang, Weida Tong, Martha M Moore, James C Fuscoe, ...
Proceedings Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells
The Mouse Lymphoma Assay Detects Recombination, Deletion, and Aneuploidy (2009)
Wang, Jianyong, Sawyer, Jeffrey R., Chen, Ling, Chen, Tao, Honma, Masamitsu, Mei, Nan, ...
The mouse lymphoma assay (MLA) uses the thymidine kinase (Tk) gene of the L5178Y/Tk+/−-3.7.2C mouse lymphoma cell line as a reporter gene to evaluate the mutagenicity of chemical and physical...
Hotchkiss, Charlotte E., Bishop, Michelle E., Dertinger, Stephen D., Slikker, William, Moore, Martha M., MacGregor, James T.
We report evaluation in rhesus monkeys of a flow cytometric procedure (MicroFlow) that has previously been shown to allow assessment of micronucleated reticulocytes (MN-RETs) in the peripheral blood...
Han, Tao, Wang, Jianyong, Tong, Weida, Moore, Martha M, Fuscoe, James C, Chen, Tao
Abstract Background The Thymidine kinase ( Tk ) mutants generated from the widely used L5178Y mouse lymphoma assay fall into two categories, small colony and large colony. Cells from the large...
MacGregor, James T., Bishop, Michelle E., McNamee, James P., Hayashi, Makoto, Asano, Norhide, Wakata, Akihiro, ...
We have evaluated a flow cytometric method that allows assessment of micronucleated reticulocytes (MN-RETs) in microliter quantities of peripheral blood and compared results using this assay with...
Photomutagenicity of Retinyl Palmitate by Ultraviolet A Irradiation in Mouse Lymphoma Cells (2005)
Mei, Nan, Xia, Qingsu, Chen, Ling, Moore, Martha M., Fu, Peter P., Chen, Tao
Retinyl palmitate (RP), a storage form of vitamin A, is frequently used as a cosmetic ingredient, with more than 700 RP-containing cosmetic products on the U.S. market in 2004. There are concerns for...
Photomutagenicity of Retinyl Palmitate by Ultraviolet A Irradiation in Mouse Lymphoma Cells (2005)
Mei, Nan, Xia, Qingsu, Chen, Ling, Moore, Martha M., Fu, Peter P., Chen, Tao
Retinyl palmitate (RP), a storage form of vitamin A, is frequently used as a cosmetic ingredient, with more than 700 RP-containing cosmetic products on the U.S. market in 2004. There are concerns for...
Clark, L.Scott, Harrington-Brock, Karen, Wang, Jianyong, Sargent, Linda, Lowry, David, Reynolds, Steve H., ...
The mouse lymphoma L5178Y Tk+/– 3.7.2C assay is a well‐characterized in vitro system used for the study of somatic cell mutation. It was determined that this cell line has a heterozygous...
Chen, Tao, Harrington-Brock, Karen, Moore, Martha M.
N-ethyl-N-nitrosourea (ENU) is a potent monofunctional ethylating agent that has been found to be mutagenic in a wide variety of organisms from viruses to mammalian germ cells. To elucidate the...
Moore, Martha M., Claxton, Larry, Houk, Virginia, Nelson, Gail M., Harrington-Brock, Karen
Dyes are used by the military in M18 marker signaling grenades. A number of organic dyes are presently being evaluated for potential use in these grenades. In addition to engineering studies for...
Moore, Martha M., Claxton, Larry, Houk, Virginia, Nelson, Gail M., Harrington-Brock, Karen
Three dyes (Solvent Red 1, Disperse Blue 3, and Disperse Red 11) were tested for mutagenicity in the Salmonella reversion assay and the L5178Y/TK + or - mouse lymphoma assay. These in vitro assays...
Clark, L.Scott, Hart, Daniel W., Vojta, Patrick J., Harrington-Brock, Karen, Barrett, J.Carl, Moore, Martha M., ...
The thymidine kinase locus (Tk1) in Tk +\−-3.7.2C mouse lymphoma cells is widely used to identify mutagenic agents. Because Trp53 (the mouse homolog of human TP53) is located with Tk1 on...
Fuscoe, James C., Setzer, R.Woodrow, Collard, Deborah D., Moore, Martha M.
A t(14; 18) chromosomal translocation is found in ∼85% of follicular lymphomas by both cytogenetic and molecular analyses. This rearrangement deregulates expression of the bcl-2 proto-oncogene by...
Fuscoe, James C., Zimmerman, Lisa J., Harrington-Brock, Karen, Moore, Martha M.
The DNA sequence of 11 in vivo-arising intragenic deletion junctions occurring in the hypoxanthine-guanine phospho-ribosyltransferase (hprt) gene of human T-lymphocytes was determined. These...
Analysis of the genotoxicity of anthraquinone dyes in the mouse lymphoma assay (1991)
Harrington-Brock, Karen, Parker, Lisa, Doerr, Carolyn, Cimino, Michael C., Moore, Martha M.
Despite their widespread use and potential for significant human exposure, genotoxicity data on anthraquinones and other dyes are limited. In this study, 16 anthraquinones and one azo dye (Solvent...
Moore, Martha M., Parker, Lisa, Huston, Jamie, Harrington-Brock, Karen, Dearfield, Kerry L.
The Chinese hamster ovary (CHO) assay, which measures newly induced mutations at the hypoxanthine-guanine phosphoribosyltransferase (hgprt) locus, has been widely used for mutagenesis testing. The...
Genotoxicity in mouse lymphoma cells of chemicals capable of Michael addition (1991)
Dearfield, Kerry L., Harrington-Brock, Karen, Doerr, Carolyn L., Rabinowitz, James R., Moore, Martha M.
Over the past several years, we have been evaluating the mutagenicity and clastogenicity of compounds capable of Michael-type reactions. These compounds, including acryla-mide, several acrylate and...
Backer, Lorraine C., Allen, James W., Harrington-Brock, Karen, Campbell, James A., DeMarini, David M., Doerr, Carolyn L., ...
The present study was designed to determine and compare the clastogenicity of m-AMSA and camptothecin (CAMP) in vivo in mouse bone marrow and peripheral blood lympho–cytes (PBLs), and in vitro in...
Moore, Martha M., Doerr, Carolyn L.
The L5178Y/TK+/−-3.7.2C mouse lymphoma assay is used to quantitate the induction of thymidine kinase (TK)deficient mutants. The mutants detected in the assay form colonies that can be...
Dearfield, Kerry L., Millis, C.Sherry, Harrington-Brock, Karen, Doerr, Carolyn L., Moore, Martha M.
Nine acrylate/methacrylate esters were tested for the induction of mutations, aberrations and micronuclei in cultured L5178Y mouse lymphoma cells without exogenous activation. With the exception...
Differential mutant quantitation at the mouse lymphoma tk and CHO hgprt loci (1989)
Moore, Martha M., Harrington-Brock, Karen, Doerr, Carolyn L., Dearfield, Kerry L.
Recent reports by several laboratories indicate that not all non-essential target loci are equally capable of detecting chromosomal mutations. The present study was undertaken to determine if both...
DeMarini, David M., Doerr, Carolyn L., Meyer, Mary K., Brock, Karen H., Hozier, John, Moore, Martha M.
We evaluated the ability of the antitumor agent 4-(9-acridinyl-amino)-methanesulfon-m-anisidide (amsacrine or m-AMSA) and its congener, o-AMSA, to induce specific-locus mutations at the heterozygous...
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 1980.
Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 1980.