Steinhoff, Christine, Paulsen, Martina, Kielbasa, Szymon, Walter, Jörn, Vingron, Martin
Abstract Background In mammals, imprinted genes are regulated by an epigenetic mechanism that results in parental origin-specific expression. Though allele-specific regulation of imprinted genes has...
Kircher, Martin, Bock, Christoph, Paulsen, Martina
Abstract Background MicroRNAs play an important functional role in post-transcriptional gene regulation. One of the largest known microRNA clusters is located within the imprinted Dlk1/Gtl2 region on...
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
Genomic DNA methylation profiles exhibit substantial variation within the human population, with important functional implications for gene regulation. So far little is known about the...
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
Genomic DNA methylation profiles exhibit substantial variation within the human population, with important functional implications for gene regulation. So far little is known about the...
CpG Island Mapping by Epigenome Prediction (2007)
Christoph Bock, Jörn Walter, Martina Paulsen, Thomas Lengauer
CpG islands were originally identified by epigenetic and functional properties, namely, absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by...
CpG island mapping by epigenome prediction (2007)
Christoph Bock, Jorn E Walter, Martina Paulsen, Thomas Lengauer
CpG islands were originally identified by epigenetic and functional properties, namely absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by...
CpG Island Mapping by Epigenome Prediction (2007)
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
Christoph Bock, Martina Paulsen, Sascha Tierling, Thomas Mikeska, Thomas Lengauer, Jörn Walter
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
Christoph Bock, Martina Paulsen, Sascha Tierling, Thomas Mikeska, Thomas Lengauer, Jorn E Walter
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
Bock, Christoph, Paulsen, Martina, Tierling, Sascha, Mikeska, Thomas, Lengauer, Thomas, Walter, Jörn
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
Christoph Bock, Sabine Reither, Thomas Mikeska, Martina Paulsen, Jörn Walter, Thomas Lengauer
Summary: Manual processing of DNA methylation data from bisulfite sequencing is a tedious and error-prone task. Here we present an interactivesoftwaretool that providesstart-to-endsupportfor...
Bock, Christoph, Lengauer, Thomas, Reither, Sabine, Mikeska, Thomas, Paulsen, Martina, Walter, Jörn
SUMMARY: Manual processing of DNA methylation data from bisulfite sequencing is a tedious and error-prone task. Here we present an interactive software tool that provides start-to-end support for...
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates (2005)
Paulsen, Martina, Khare, Tarang, Burgard, Christopher, Tierling, Sascha, Walter, Jörn
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes...
Bock, Christoph, Reither, Sabine, Mikeska, Thomas, Paulsen, Martina, Walter, Jörn, Lengauer, Thomas
Summary: Manual processing of DNA methylation data from bisulphite sequencing is a tedious and error-prone task. Here we present an interactive software tool that provides start-to-end support for...
Bock, Christoph, Reither, Sabine, Mikeska, Thomas, Paulsen, Martina, Walter, Jörn, Lengauer, Thomas
Summary: Manual processing of DNA methylation data from bisulfite sequencing is a tedious and error-prone task. Here we present an interactive software tool that provides start-to-end support for...
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates (2004)
Paulsen, Martina, Khare, Tarang, Burgard, Christopher, Tierling, Sascha, Walter, Jörn
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes...
The potential role of gene duplications in the evolution of imprinting mechanisms (2003)
Walter, Jörn, Paulsen, Martina
Using the completed genomic sequences of mouse and human we performed a comparative analyses of imprinted genes and gene clusters. For many imprinted genes we could detect imprinted as well as non...
The potential role of gene duplications in the evolution of imprinting mechanisms (2003)
Walter, Jörn, Paulsen, Martina
Using the completed genomic sequences of mouse and human we performed a comparative analyses of imprinted genes and gene clusters. For many imprinted genes we could detect imprinted as well as...
The potential role of gene duplications in the evolution of imprinting mechanisms (2003)
Walter, Jörn, Paulsen, Martina
Using the completed genomic sequences of mouse and human we performed a comparative analyses of imprinted genes and gene clusters. For many imprinted genes we could detect imprinted as well as non...
Cavaillé, Jérôme, Seitz, Hervé, Paulsen, Martina, Ferguson-Smith, Anne C., Bachellerie, Jean-Pierre
A human imprinted domain at 14q32 contains two co-expressed and reciprocally imprinted genes, DLK1 and GTL2, which are expressed from the paternally and maternally inherited alleles, respectively. We...
Takada, Shuji, Paulsen, Martina, Tevendale, Maxine, Tsai, Chen-En, Kelsey, Gavin, Cattanach, Bruce M., ...
Dlk1 and Gtl2 are reciprocally imprinted genes located 80 kb apart on mouse chromosome 12. Similarities between this domain and that of the well characterized Igf2–H19 locus have been previously...
Paulsen, Martina, Takada, Shuji, Youngson, Neil A., Benchaib, Mehdi, Charlier, Carole, Segers, Karin, ...
Engemann, Sabine, Strödicke, Martin, Paulsen, Martina, Franck, Olivia, Reinhardt, Richard, Lane, Natasha, ...
The clustered organization of most imprinted genes in mammals suggests coordinated genetic and epigenetic control mechanisms. Comparisons between human and mouse will help in elucidating these...
Paulsen, Martina, El-Maarri, Osman, Engemann, Sabine, Strödicke, Martin, Franck, Olivia, Davies, Karen, ...
In human and mouse most imprinted genes are arranged in chromosomal clusters. This linked organization suggests coordinated mechanisms controlling imprinted expression. We have sequenced 250 kb in...
Berlin, Techn. Universiẗat, Diss., 1995.
Paulsen, Martina, Takada, Shuji, Youngson, Neil A., Benchaib, Mehdi, Charlier, Carole, Segers, Karin, ...
The Dlk1–Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control. We have...
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates
Paulsen, Martina, Khare, Tarang, Burgard, Christopher, Tierling, Sascha, Walter, Jörn
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes...
Bock, Christoph, Paulsen, Martina, Tierling, Sascha, Mikeska, Thomas, Lengauer, Thomas, Walter, Jörn
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
Paulsen, Martina, Takada, Shuji, Youngson, Neil A., Benchaib, Mehdi, Charlier, Carole, Segers, Karin, ...
The Dlk1–Gtl2 domain on mouse chromosome 12 contains reciprocally imprinted genes with the potential to contribute to our understanding of common features involved in imprinting control. We have...
Evolution of the Beckwith-Wiedemann syndrome region in vertebrates
Paulsen, Martina, Khare, Tarang, Burgard, Christopher, Tierling, Sascha, Walter, Jörn
In the animal kingdom, genomic imprinting appears to be restricted to mammals. It remains an open question how structural features for imprinting evolved in mammalian genomes. The clustering of genes...
Bock, Christoph, Paulsen, Martina, Tierling, Sascha, Mikeska, Thomas, Lengauer, Thomas, Walter, Jörn
CpG island methylation plays an important role in epigenetic gene control during mammalian development and is frequently altered in disease situations such as cancer. The majority of CpG islands is...
CpG Island Mapping by Epigenome Prediction
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
CpG islands were originally identified by epigenetic and functional properties, namely, absence of DNA methylation and frequent promoter association. However, this concept was quickly replaced by...
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Bock, Christoph, Walter, Jörn, Paulsen, Martina, Lengauer, Thomas
Genomic DNA methylation profiles exhibit substantial variation within the human population, with important functional implications for gene regulation. So far little is known about the...