Kaschani, Farnusch, Verhelst, Steven H. L., Van Swieten, Paul F., Verdoes, Martijn, Wong, Chung-Sing, Wang, Zheming, ...
Kaschani, Farnusch, Verhelst, Steven H. L., Van Swieten, Paul F., Verdoes, Martijn, Wong, Chung-Sing, Wang, Zheming, ...
Kailash C. Pandey, Naresh Singh, Shirin Arastu-Kapur, Matthew Bogyo, Philip J. Rosenthal
Erythrocytic malaria parasites utilize proteases for a number of cellular processes, including hydrolysis of hemoglobin, rupture of erythrocytes by mature schizonts, and subsequent invasion of...
Bogyo, Matthew, McMaster, John S., Gaczynska, Maria, Tortorella, Domenico, Goldberg, Alfred L., Ploegh, Hidde
The proteasome is a multicatalytic protease complex that plays a key role in diverse cellular functions. The peptide vinyl sulfone, carboxybenzyl-leucyl-leucyl-leucine vinyl sulfone (Z-L3VS)...
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
Wang, Evelyn W., Kessler, Benedikt M., Borodovsky, Anna, Cravatt, Benjamin F., Bogyo, Matthew, Ploegh, Hidde L., ...
Cytosolic proteolysis is carried out predominantly by the proteasome. We show that a large oligopeptidase, tripeptidylpeptidase II (TPPII), can compensate for compromised proteasome activity....
The proteasome is a large protease complex consisting of multiple catalytic subunits that function simultaneously to digest protein substrates. This complexity has made deciphering the role each...
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
Selzer, Paul M., Pingel, Sabine, Hsieh, Ivy, Ugele, Bernhard, Chan, Victor J., Engel, Juan C., ...
Papain family cysteine proteases are key factors in the pathogenesis of cancer invasion, arthritis, osteoporosis, and microbial infections. Targeting this enzyme family is therefore one strategy in...
Li, Jun, Gao, Xiaolin, Ortega, Joaquin, Nazif, Tamim, Joss, Lisa, Bogyo, Matthew, ...
11S REGs (PA28s) are multimeric rings that bind proteasomes and stimulate peptide hydrolysis. Whereas REGα activates proteasomal hydrolysis of peptides with hydrophobic, acidic or basic residues in...
Yasothornsrikul, Sukkid, Greenbaum, Doron, Medzihradszky, Katalin F., Toneff, Thomas, Bundey, Richard, Miller, Ruthellen, ...
Multistep proteolytic mechanisms are essential for converting proprotein precursors into active peptide neurotransmitters and hormones. Cysteine proteases have been implicated in the processing of...
Activity Profiling of Papain-Like Cysteine Proteases in Plants1
Leeuwenburgh, Michiel A., Bogyo, Matthew, Peck, Scott C.
Transcriptomic and proteomic technologies are generating a wealth of data that are frequently used by scientists to predict the function of proteins based on their expression or presence. However,...
Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion
Pandey, Kailash C, Singh, Naresh, Arastu-Kapur, Shirin, Bogyo, Matthew, Rosenthal, Philip J
Erythrocytic malaria parasites utilize proteases for a number of cellular processes, including hydrolysis of hemoglobin, rupture of erythrocytes by mature schizonts, and subsequent invasion of...
Bogyo, Matthew, McMaster, John S., Gaczynska, Maria, Tortorella, Domenico, Goldberg, Alfred L., Ploegh, Hidde
The proteasome is a multicatalytic protease complex that plays a key role in diverse cellular functions. The peptide vinyl sulfone, carboxybenzyl-leucyl-leucyl-leucine vinyl sulfone (Z-L3VS)...
Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity
Wang, Evelyn W., Kessler, Benedikt M., Borodovsky, Anna, Cravatt, Benjamin F., Bogyo, Matthew, Ploegh, Hidde L., ...
Cytosolic proteolysis is carried out predominantly by the proteasome. We show that a large oligopeptidase, tripeptidylpeptidase II (TPPII), can compensate for compromised proteasome activity....
The proteasome is a large protease complex consisting of multiple catalytic subunits that function simultaneously to digest protein substrates. This complexity has made deciphering the role each...
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
Selzer, Paul M., Pingel, Sabine, Hsieh, Ivy, Ugele, Bernhard, Chan, Victor J., Engel, Juan C., ...
Papain family cysteine proteases are key factors in the pathogenesis of cancer invasion, arthritis, osteoporosis, and microbial infections. Targeting this enzyme family is therefore one strategy in...
Li, Jun, Gao, Xiaolin, Ortega, Joaquin, Nazif, Tamim, Joss, Lisa, Bogyo, Matthew, ...
11S REGs (PA28s) are multimeric rings that bind proteasomes and stimulate peptide hydrolysis. Whereas REGα activates proteasomal hydrolysis of peptides with hydrophobic, acidic or basic residues in...
Yasothornsrikul, Sukkid, Greenbaum, Doron, Medzihradszky, Katalin F., Toneff, Thomas, Bundey, Richard, Miller, Ruthellen, ...
Multistep proteolytic mechanisms are essential for converting proprotein precursors into active peptide neurotransmitters and hormones. Cysteine proteases have been implicated in the processing of...
Activity Profiling of Papain-Like Cysteine Proteases in Plants1
Leeuwenburgh, Michiel A., Bogyo, Matthew, Peck, Scott C.
Transcriptomic and proteomic technologies are generating a wealth of data that are frequently used by scientists to predict the function of proteins based on their expression or presence. However,...
Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion
Pandey, Kailash C, Singh, Naresh, Arastu-Kapur, Shirin, Bogyo, Matthew, Rosenthal, Philip J
Erythrocytic malaria parasites utilize proteases for a number of cellular processes, including hydrolysis of hemoglobin, rupture of erythrocytes by mature schizonts, and subsequent invasion of...
Cysteine Protease Inhibitors Block Toxoplasma gondii Microneme Secretion and Cell Invasion▿
Teo, Chin Fen, Zhou, Xing Wang, Bogyo, Matthew, Carruthers, Vern B.
Toxoplasma gondii enters host cells via an active, self-driven process to fulfill its need for intracellular replication and survival. Successful host cell invasion is governed by sequential release...
Rose, Patrick P., Bogyo, Matthew, Moses, Ashlee V., Früh, Klaus
Kaposi's sarcoma-associated herpesvirus (KSHV) is the pathological agent of Kaposi's sarcoma (KS), a tumor characterized by aberrant proliferation of endothelial-cell-derived spindle cells. Since in...
Finding the needles in the haystack: mapping constitutive proteolytic events in vivo
Our quest to understand the complex inner workings of the cell depends on the development of new technologies that allow the study of global regulatory events as they happen within their native...
Blum, Galia, Weimer, Robby M., Edgington, Laura E., Adams, Walter, Bogyo, Matthew
Recent advances in the field of non-invasive optical imaging have included the development of contrast agents that report on the activity of enzymatic targets associated with disease pathology. In...