Xie, Wei, Jiang, Peng, Miao, Lin, Zhao, Ying, Zhimin, Zhai, Qing, Li, ...
Deregulated expression of E2F1 not only promotes S-phase entry but also induces apoptosis. Although it has been well documented that E2F1 is able to induce p53-dependent apoptosis via raising ARF...
Höti, Naseruddin, Ma, Jun, Tabassum, Sartaj, Wang, Yi, Wu, Mian
Here we report the effect of TPT-benzimidazolethiol, a novel anti-tumor agent developed by our group, on the apoptotic pathway of human cervical carcinoma cells. Treatment of HeLa cells with...
A Single Amino Acid Change (Asp 53→ Ala53) Converts Survivin from Anti-apoptotic to Pro-apoptotic
Song, Zhiyin, Liu, Shixin, He, He, Hoti, Naser, Wang, Yi, Feng, Shanshan, ...
Survivin is a member of the inhibitor of apoptosis protein (IAP) family that has been implicated in both apoptosis inhibition and cell cycle control. Recently, Survivin has attracted growing...
Zhao, Ying, Lu, Shaoli, Wu, Lipeng, Chai, Guolin, Wang, Haiying, Chen, Yingqi, ...
Generally, histone deacetylase (HDAC) inhibitor-induced p21Waf1/Cip1 expression is thought to be p53 independent. Here we found that an inhibitor of HDAC, depsipeptide (FR901228), but not...
Xie, Wei, Jiang, Peng, Miao, Lin, Zhao, Ying, Zhimin, Zhai, Qing, Li, ...
Deregulated expression of E2F1 not only promotes S-phase entry but also induces apoptosis. Although it has been well documented that E2F1 is able to induce p53-dependent apoptosis via raising ARF...
A Single Amino Acid Change (Asp 53→ Ala53) Converts Survivin from Anti-apoptotic to Pro-apoptotic
Song, Zhiyin, Liu, Shixin, He, He, Hoti, Naser, Wang, Yi, Feng, Shanshan, ...
Survivin is a member of the inhibitor of apoptosis protein (IAP) family that has been implicated in both apoptosis inhibition and cell cycle control. Recently, Survivin has attracted growing...
Zhao, Ying, Lu, Shaoli, Wu, Lipeng, Chai, Guolin, Wang, Haiying, Chen, Yingqi, ...
Generally, histone deacetylase (HDAC) inhibitor-induced p21Waf1/Cip1 expression is thought to be p53 independent. Here we found that an inhibitor of HDAC, depsipeptide (FR901228), but not...
Xie, Wei, Jiang, Peng, Miao, Lin, Zhao, Ying, Zhimin, Zhai, Qing, Li, ...
Deregulated expression of E2F1 not only promotes S-phase entry but also induces apoptosis. Although it has been well documented that E2F1 is able to induce p53-dependent apoptosis via raising ARF...
Jiang, Peng, Du, Wenjing, Heese, Klaus, Wu, Mian
Although the regulation of several Bcl-2 family molecules, including Puma, Noxa, Bax, and Bid, by p53 has been studied intensively, the interplay between Bad (Bcl-2 antagonist of cell death) and p53...
Noxa/Mcl-1 Balance Regulates Susceptibility of Cells to Camptothecin-Induced Apoptosis1
Mei, Yide, Xie, Chongwei, Xie, Wei, Tian, Xu, Li, Mei, Wu, Mian
Although camptothecin (CPT) has been reported to induce apoptosis in various cancer cells, the molecular details of this regulation remain largely unknown. In this study, we demonstrate that BH3-only...
Yao, Zhan, Duan, Shanshan, Hou, Dezhi, Heese, Klaus, Wu, Mian
Activation of the apical caspase-8 is crucial to the extrinsic apoptotic pathway. Although the death effector domain (DED) of caspase-8 has been reported to be involved in death-inducing signaling...
Phosphorylation of Pirh2 by Calmodulin-dependent kinase II impairs its ability to ubiquitinate p53
Duan, Shanshan, Yao, Zhan, Hou, Dezhi, Wu, Zhengsheng, Zhu, Wei-guo, Wu, Mian
Although the recently identified Pirh2 protein is known as a p53-induced ubiquitin-protein E3 ligase, which negatively regulates p53, the detailed mechanism underlying the regulation of Pirh2 remains...