Michael H. Shaw

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

Shaw, Michael H., Boyartchuk, Victor, Wong, Sandy, Karaghiosoff, Marina, Ragimbeau, Josiane, Pellegrini, Sandra, ...

The B10.Q/J strain of mice was serendipitously discovered to be highly susceptible to infection by the intracellular protozoan parasite, Toxoplasma gondii but markedly resistant to induction of...

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

Shaw, Michael H., Boyartchuk, Victor, Wong, Sandy, Karaghiosoff, Marina, Ragimbeau, Josiane, Pellegrini, Sandra, ...

The B10.Q/J strain of mice was serendipitously discovered to be highly susceptible to infection by the intracellular protozoan parasite, Toxoplasma gondii but markedly resistant to induction of...

Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

Ling, Yun M., Shaw, Michael H., Ayala, Carol, Coppens, Isabelle, Taylor, Gregory A., Ferguson, David J.P., ...

Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV). Here we present evidence for...