Michael J. Kirisits

Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection (2008)

Hermes, Gretchen, Ajioka, James W, Kelly, Krystyna A, Mui, Ernest, Roberts, Fiona, Kasza, Kristen, ...

Abstract Background Worldwide, approximately two billion people are chronically infected with Toxoplasma gondii with largely unknown consequences. Methods To better understand long-term effects and...

Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection (2008)

Hermes, Gretchen, Ajloka, James W., Kelly, Krystyna, Mui, Ernest, Roberts, Fiona, Kasza, Kirsten, ...

Worldwide, approximately two billion people are chronically infected with Toxoplasma gondii with largely unknown consequences. To better understand long-term effects and pathogenesis of this common,...

Maternal Inheritance and Stage-Specific Variation of the Apicoplast in Toxoplasma gondii during Development in the Intermediate and Definitive Host

Ferguson, David J. P., Henriquez, Fiona L., Kirisits, Michael J., Muench, Stephen P., Prigge, Sean T., Rice, David W., ...

The structure and location of Toxoplasma gondii apicoplasts were examined in intermediate and definitive hosts and shown to vary in a stage-specific manner. Immunocytochemistry and electron...

Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo

Mui, Ernest J., Jacobus, David, Milhous, Wilbur K., Schiehser, Guy, Hsu, Honghue, Roberts, Craig W., ...

The triazine WR99210 [4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichlorophenoxypropyloxy)-1,3,5 triazine] inhibits Toxoplasma gondii in vitro at nanomolar levels (P < 0.05). The 50% inhibitory...

Maternal Inheritance and Stage-Specific Variation of the Apicoplast in Toxoplasma gondii during Development in the Intermediate and Definitive Host

Ferguson, David J. P., Henriquez, Fiona L., Kirisits, Michael J., Muench, Stephen P., Prigge, Sean T., Rice, David W., ...

The structure and location of Toxoplasma gondii apicoplasts were examined in intermediate and definitive hosts and shown to vary in a stage-specific manner. Immunocytochemistry and electron...

Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo

Mui, Ernest J., Jacobus, David, Milhous, Wilbur K., Schiehser, Guy, Hsu, Honghue, Roberts, Craig W., ...

The triazine WR99210 [4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichlorophenoxypropyloxy)-1,3,5 triazine] inhibits Toxoplasma gondii in vitro at nanomolar levels (P < 0.05). The 50% inhibitory...

Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase

Muench, Stephen P., Prigge, Sean T., Zhu, Liqun, Kirisits, Michael J., Roberts, Craig W., Wernimont, Sarah, ...

Crystals of T. gondii ENR in complex with NAD+ and triclosan were grown using the hanging-drop vapour-diffusion method with PEG 8000 as precipitant.

Genetic and Epigenetic Factors at COL2A1 and ABCA4 Influence Clinical Outcome in Congenital Toxoplasmosis

Jamieson, Sarra E., De Roubaix, Lee-Anne, Cortina-Borja, Mario, Tan, Hooi Kuan, Mui, Ernest J., Cordell, Heather J., ...

Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

Muench, Stephen P., Prigge, Sean T., McLeod, Rima, Rafferty, John B., Kirisits, Michael J., Roberts, Craig W., ...

The crystal structures of T. gondii and P. falciparum ENR in complex with NAD+ and triclosan and of T. gondii ENR in an apo form have been solved to 2.6, 2.2 and 2.8 Å, respectively.

Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

Hermes, Gretchen, Ajioka, James W, Kelly, Krystyna A, Mui, Ernest, Roberts, Fiona, Kasza, Kristen, ...

Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo

Mui, Ernest J., Schiehser, Guy A., Milhous, Wilbur K., Hsu, Honghue, Roberts, C.W., Kirisits, Michael J., ...

Toxoplasma gondii causes substantial morbidity, mortality, and costs for healthcare in the developed and developing world. Current medicines are not well tolerated and cause hypersensitivity...