Xu, Jian, Baase, Walter A., Quillin, Michael L., Baldwin, Enoch P., Matthews, Brian W.
To investigate the structural and thermodynamic basis of the binding of solvent at internal sites within proteins a number of mutations were constructed in T4 lysozyme. Some of these were designed to...
Structural determinants of functional behavior in distal pocket mutants of myoglobin (1995)
Quillin, Michael L., Quillin, Michael L.
The physiological role of myoglobin depends on the modulation of heme activity by the protein. The hypothesis that functional properties are governed by conserved residues in the distal pocket has...
Collins, Marcus D., Hummer, Gerhard, Quillin, Michael L., Matthews, Brian W., Gruner, Sol M.
Formation of a water-expelling nonpolar core is the paradigm of protein folding and stability. Although experiment largely confirms this picture, water buried in “hydrophobic” cavities is...
Collins, Marcus D., Hummer, Gerhard, Quillin, Michael L., Matthews, Brian W., Gruner, Sol M.
Formation of a water-expelling nonpolar core is the paradigm of protein folding and stability. Although experiment largely confirms this picture, water buried in “hydrophobic” cavities is...
Determination of solvent content in cavities in IL-1β using experimentally phased electron density
Quillin, Michael L., Wingfield, Paul T., Matthews, Brian W.
The extent to which water is present within apolar cavities in proteins remains unclear. In the case of interleukin-1β (IL-1β), four independent structures solved by x-ray crystallography indicate...
Structural and thermodynamic analysis of the binding of solvent at internal sites in T4 lysozyme
Xu, Jian, Baase, Walter A., Quillin, Michael L., Baldwin, Enoch P., Matthews, Brian W.
To investigate the structural and thermodynamic basis of the binding of solvent at internal sites within proteins a number of mutations were constructed in T4 lysozyme. Some of these were designed to...
Liu, Lijun, Quillin, Michael L., Matthews, Brian W.
There is conflicting evidence as to whether cavities in proteins that are nonpolar and large enough to accommodate solvent are empty or are occupied by disordered water molecules. Here, we use...