Thiaville, Michelle M., Dudenhausen, Elizabeth E., Awad, Keytam S., Gjymishka, Altin, Zhong, Can, Kilberg, Michael S.
It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress. In mammals, amino acid...
The regulation of neutral amino acid transport in mammalian cells (1983)
Shotwell, Mark A., Kilberg, Michael S., Oxender, Dale L.
Peer Reviewed
Ohsawa, Motoyasu, Kilberg, Michael S., Kimmel, Gene, Christensen, Halvor N.
We redirect attention to contributions to the energization of the active transport of amino acids in the Ehrlich cell, beyond the known energization by down-gradient comigration of Na+, beyond...
Cysteine as a system-specific substrate for transport system in rat hepatocytes (1979)
Kilberg, Michael S., Christensen, Halvor N., Handlogten, Mary E.
The rapid transport of -cysteine into isolated rat hepatocytes escapes detectable inhibition by 2-(methylamino)-isobutyric acid at levels up to 50 mM. The system transporting cysteine instead is...
Chang, Se-Ho, Garcia, Jairo, Melendez, J Andres, Kilberg, Michael S, Agarwal, Anupam
Glucose depletion results in cellular stress and reactive oxygen species (ROS) production, which evokes adaptive and protective responses. One such protective response is the induction of haem...
Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.
Zhong, Can, Chen, Chin, Kilberg, Michael S
Transcription from the human asparagine synthetase (A.S.) gene is increased in response to either amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) deprivation....
Leung-Pineda, Van, Pan, YuanXiang, Chen, Hong, Kilberg, Michael S
mRNA abundance for a number of genes is increased by amino acid limitation. From an array screening study in HepG2 human hepatoma cells, it was established that one set of genes affected by amino...
Chang, Se-Ho, Garcia, Jairo, Melendez, J Andres, Kilberg, Michael S, Agarwal, Anupam
Glucose depletion results in cellular stress and reactive oxygen species (ROS) production, which evokes adaptive and protective responses. One such protective response is the induction of haem...
Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter.
Zhong, Can, Chen, Chin, Kilberg, Michael S
Transcription from the human asparagine synthetase (A.S.) gene is increased in response to either amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) deprivation....
Leung-Pineda, Van, Pan, YuanXiang, Chen, Hong, Kilberg, Michael S
mRNA abundance for a number of genes is increased by amino acid limitation. From an array screening study in HepG2 human hepatoma cells, it was established that one set of genes affected by amino...
Thiaville, Michelle M., Dudenhausen, Elizabeth E., Awad, Keytam S., Gjymishka, Altin, Zhong, Can, Kilberg, Michael S.
It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress. In mammals, amino acid...
Aiken, Kimberly J., Bickford, Justin S., Kilberg, Michael S., Nick, Harry S.
Organisms respond to available nutrient levels by rapidly adjusting metabolic flux, in part through changes in gene expression. A consequence of adaptations in metabolic rate is the production of...
Thiaville, Michelle M., Pan, Yuan-Xiang, Gjymishka, Altin, Zhong, Can, Kaufman, Randal J., Kilberg, Michael S.
The mammalian amino acid response (AAR) pathway is up-regulated by protein or amino acid depletion. This pathway involves detection of uncharged tRNA by the GCN2 kinase, phosphorylation of the...
Gjymishka, Altin, Palii, Stela S., Shan, Jixiu, Kilberg, Michael S.
The activated amino acid response (AAR) and unfolded protein response (UPR) stress signaling pathways converge at the phosphorylation of translation initiation factor eIF2α. This eIF2α modification...