Regulation of insulin granule turnover in pancreatic ß-cells by cleaved ICA512 (2008)
Trajkovski, Mirko, Mziaut, Hassan, Schubert, Sandra, Kalaidzidis, Yannis, Altkrüger, Anke, Solimena, Michele
Insulin maintains homeostasis of glucose by promoting its uptake into cells from the blood. Hyperglycemia triggers secretion of insulin from pancreatic beta-cells. This process is mediated by...
Mziaut, Hassan, Kersting, Stephan, Knoch, Klaus-Peter, Fan, Wan-Hung, Trajkovski, Mirko, Erdmann, Katja, ...
Changes in metabolic demands dynamically regulate the total mass of adult pancreatic beta-cells to adjust insulin secretion and preserve glucose homeostasis. Glucose itself is a major regulator of...
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5 (2006)
Mziaut, Hassan, Trajkovski, Mirko, Kersting, Stephan, Ehninger, Armin, Altkruger, Anke, Lemaitre, Regis P, ...
Nutrients and growth hormones promote insulin production and the proliferation of pancreatic beta-cells. An imbalance between ever-increasing metabolic demands and insulin output causes diabetes....
Regulated secretion and gene expression in ss-cells [beta-cells]: link through : ICA512 / (2005)
Dresden, Techn. Univ., Diss., 2005.
Hauptsacht. entsprechend Buchausg.
Trajkovski, Mirko, Mziaut, Hassan, Altkrüger, Anke, Ouwendijk, Joke, Knoch, Klaus-Peter, Müller, Stefan, ...
Islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated with the insulin secretory granules (SGs) of pancreatic β-cells. Here, we show that exocytosis of...
ICA512 signaling enhances pancreatic β-cell proliferation by regulating cyclins D through STATs
Mziaut, Hassan, Kersting, Stephan, Knoch, Klaus-Peter, Fan, Wan-Hung, Trajkovski, Mirko, Erdmann, Katja, ...
Changes in metabolic demands dynamically regulate the total mass of adult pancreatic β-cells to adjust insulin secretion and preserve glucose homeostasis. Glucose itself is a major regulator of...
miR-375 maintains normal pancreatic α- and β-cell mass
Poy, Matthew N., Hausser, Jean, Trajkovski, Mirko, Braun, Matthias, Collins, Stephan, Rorsman, Patrik, ...
Altered growth and development of the endocrine pancreas is a frequent cause of the hyperglycemia associated with diabetes. Here we show that microRNA-375 (miR-375), which is highly expressed in...