Na Li

Details der Publikationsliste

Zeitraum

1996 - 2009

Anzahl

108

Co-Autoren

Genome-wide association study identifies single-nucleotide polymorphism in KCNB1associated with left ventricular mass in humans: The HyperGEN Study (2009)

Arnett, Donna K, Li, Na, Tang, Weihong, Rao, Dabeeru C, Devereux, Richard B, Claas, Steven A, ...

Abstract Background We conducted a genome-wide association study (GWAS) and validation study for left ventricular (LV) mass in the Family Blood Pressure Program – HyperGEN population. LV mass is a...

Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study (2009)

Tang, Weihong, Devereux, Richard B, Li, Na, Oberman, Albert, Kitzman, Dalane W, Rao, Dabeeru C, ...

Abstract Background Left ventricular (LV) mass and wall thickness are closely associated with measures of body size and blood pressure and also correlated with systolic and diastolic function,...

A Common Polymorphism of Upstream Transcription Factor 1 Gene is associated with Lipid Profile: A Study in Chinese Type 2 Diabetes Families (2009)

Yan Song, Na Li, Yonghua Hu, Liu He, Xun Tang, Dafang Chen

Upstream transcription factor 1 (USF1) is capable of controlling various members in glucose and lipid metabolism pathways. Much evidence suggests that the rs3737787 polymorphism in the USF1 gene may...

Development of China Disease Knowledge Total Database (2009)

Zhang, Wenju, Zhan, Youxiang, Li, Yan, Li, Na, Zhang, Yu

Aims: This paper is to present China Disease Knowledge Total Database (CDD) developed by Medical Library of Chinese PLA and establish a Chinese version of clinical content database. The objective is...

MIQR: A MULTILEVEL INCOMPLETE QR PRECONDITIONER FOR LARGE SPARSE LEAST-SQUARES PROBLEMS ∗ (2008)

Na Li, Yousef Saad

Abstract. This paper describes a Multilevel Incomplete QR (MIQR) factorization for solving large sparse least-squares problems. The algorithm builds the factorization by exploiting structural...

General Terms (2008)

Indrakshi Ray, Na Li, Dae-kyoo Kim

Organizations use Role-Based Access Control (RBAC) to protect information resources from unauthorized access. We propose an approach, based on the Unified Modeling Language (UML), that shows how RBAC...

Li and Zhang Assessing Perceived Affective Quality of IT ABSTRACT A Research Agenda toward Assessing Perceived Affective Quality of IT (2008)

Na Li, Ping Zhang

Most IT evaluation and usage studies emphasize cognition or high-order affective reactions that come from more deliberate cognitive processing. A primitive concept, perceived affective quality (PAQ)...

the Association for Computing Machinery (CACM), Forthcoming (2008)

Ping Zhang, Na Li

Affect (mood, emotion, feelings) is a fundamental aspect of human beings and is found to influence reflex, perception, cognition, and behavior [6,7]. Studies in organizational behavior, marketing,...

What Makes Customers Shop Online? (2008)

Na Li, Ping Zhang

Electronic commerce Customer Relationship Management (e-CRM) has emerged to be a fundamental research area as business-to-customer (B2C) e-commerce is growing at a phenomenal rate. Among the many...

General Terms (2008)

Indrakshi Ray, Na Li, Dae-kyoo Kim

Organizations use Role-Based Access Control (RBAC) to protect information resources from unauthorized access. We propose an approach, based on the Unified Modeling Language (UML), that shows how RBAC...

Analysis of Influence of Environmental Conditions on Ganoderic Acid Content: in Ganoderma lucidum Using Orthogonal Design (2008)

Li, Na, Liu, Xiao Hua, Zhou, Jie, Li, Yu Xiang, Zhao, Ming Wen

The influence of environmental conditions on the ganoderic acid (GA) content in the fungus Ganoderma lucidum was investigated using a one-factor-at-a-time design and orthogonal design. Among the...

C-banding Karyotypes of Two Species of Chorthippus (Orthoptera: Arcypteridae) from China (2008)

Na Li, Wenjuan Wei, Bingzhong Ren

Chromosomes and C-banding karyotypes of Chorthippus brunneus huabeiensis Xia et Jin and Chorthippus minutus Zhang were studied for the first time, which respectively collected in Songhua Lake, Jilin...

2-(1,3-Dithian-2-ylidene)-1-phenylbutane-1,3-dione (2008)

Lan-Cui Zhang, Na Li, Xiao-Hui Li, Cui-Ying Huang, Guang-Hua Zhou

The title compound, C13H12O2S2, belonging to the group of dioxoketene cyclic S,S-acetals, was prepared from the corresponding dione in high yield. In the structure, the C=O and C=C bonds are not...

A protein domain-based interactome network for C. elegans early embryogenesis (2008)

Boxem, Mike, Maliga, Zoltan, Klitgord, Niels, Li, Na, Lemmens, Irma, Mana, Miyeko, ...

Many protein-protein interactions are mediated through independently folding modular domains. Proteome-wide efforts to model protein-protein interaction or "interactome" networks have largely ignored...

Tapetum Degeneration Retardation is Critical for Aliphatic Metabolism and Gene Regulation during Rice Pollen Development (2008)

Zhang, Da-Sheng, Liang, Wan-Qi, Yuan, Zheng, Li, Na, Shi, Jing, Wang, Jue, ...

As a complex wall system in flowering plants, the pollen outer wall mainly contains aliphatic sporopollenin; however, the mechanism for synthesizing these lipidic precursors during pollen development...

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase (2008)

Li, Na, Wang, Yuxuan, Pothukuchy, Arti, Syrett, Angel, Husain, Naeem, Gopalakrisha, Siddharth, ...

Drug-resistant variants of HIV-1 reverse transcriptase (RT) are also known to be resistant to anti-RT RNA aptamers. In order to be able to develop diagnostics and therapies that can focus on...

Mapping translocation breakpoints by next-generation sequencing (2008)

Chen, Wei, Kalscheuer, Vera, Tzschach, Andreas, Menzel, Corinna, Ullmann, Reinhard, Schulz, Marcel Holger, ...

Balanced chromosome rearrangements (BCRs) can cause genetic diseases by disrupting or inactivating specific genes, and the characterization of breakpoints in disease-associated BCRs has been...

Genetic Analysis Workshop 15: simulation of a complex genetic model for rheumatoid arthritis in nuclear families including a dense SNP map with linkage disequilibrium between marker loci and trait loci (2007)

Miller, Michael B, Lind, Gregg R, Li, Na, Jang, Soon-Young

Abstract Data for Problem 3 of the Genetic Analysis Workshop 15 were generated by computer simulation in an attempt to mimic some of the genetic and epidemiological features of rheumatoid arthritis...

Functional group-based linkage analysis of gene expression trait loci (2007)

Li, Na, Wu, Baolin, Wei, Peng, Xie, Benhuai, Xie, Yang, Xiao, Guanghua, ...

Abstract We explored approaches to using multiple related traits (gene expression levels) in linkage analysis. We first grouped mRNA transcripts according to their functions annotated in biological...

A NOVEL FRAMEWORK FOR SEMI-AUTOMATIC VIDEO OBJECT SEGMENTATION (2007)

Na Li, Shipeng Li, Wen-yin Liu, Chun Chen

A novel framework for semi-automatic video object segmentation is proposed to facilitate user interaction and improve the performance of the system. The proposed framework scans the video sequence...

Crout versions of ILU for general sparse matrices (2007)

Na Li Yousef, Na Li, Yousef Saad, Edmond Chow

This paper presents an e#cient implementation of incomplete LU (ILU) factorizations that are derived from the Crout version of Gaussian elimination (GE). At step k of the elimination, the k-th row of...

Design and Preparation of Highly Active Pt-Pd/C Catalyst for the Oxygen Reduction Reaction (2007)

Li, Huanqiao, Sun, Gongquan, Li, Na, Sun, Shiguo, Su, Dang Sheng, Xin, Qin

ORR (Oxygen Reduction Reaction) has been studied on Pt-Pd/C catalyst both experimentally and theoretically to gain insight into the promotion effect of PtPd nanoclusters to ORR and to provide...

HUMS: An Autonomous Moving Strategy for Mobile Sinks in Data-Gathering Sensor Networks (2007)

Yanzhong Bi, Limin Sun, Jian Ma, Na Li, Imran Ali Khan, Canfeng Chen

Sink mobility has attracted much research interest in recent years because it can improve network performance such as energy efficiency and throughput. An energy-unconscious moving strategy is...

HUMS: An Autonomous Moving Strategy for Mobile Sinks in Data-Gathering Sensor Networks (2007)

Yanzhong Bi, Limin Sun, Jian Ma, Na Li, Imran Ali Khan, Canfeng Chen

Sink mobility has attracted much research interest in recent years because it can improve network performance such as energy efficiency and throughput. An energy-unconscious moving strategy is...

Construction and Count of Boolean Functions of an Odd Number of Variables with Maximum Algebraic Immunity (2006)

Li, Na, Qi, Wen-Feng

Algebraic immunity has been proposed as an important property of Boolean functions. To resist algebraic attack, a Boolean function should possess high algebraic immunity. It is well known now that...

As(III) oxidation by different oxidizers / (2006)

Li, Na.

Arsenic (III) is much more toxic and difficult in removal than Arsenic (V) by conventional arsenic removal technologies. However, As(III) may be more prevalent in groundwater than As(V). Furthermore,...

Defending against instant messaging worms (2006)

Zhijun Liu, Guoqiang Shu, Na Li, David Lee

Abstract — Due to the real time nature and buddy list presence information of Instant Messaging (IM) systems worms can spread over IM networks rapidly, causing severe damages, however, it is a...

Symmetric Boolean function depending on odd number of variables with maximum algebraic immunity (2006)

Na Li, Wen-feng Qi

Abstract—To resist algebraic attacks, Boolean functions should possess high algebraic immunity. In 2003, Courtois and Meier showed that the algebraic immunity of an-variable Boolean function is...

Improving the Experience of Controlling Avatars in Camera-Based Games Using Physical Input (2006)

Na Li, Neema Moraveji, Hiroaki Kimura, Eyal Ofek

This paper investigates two methods of improving the user experience of camera-based interaction. First, problems that arise when avatars are designed to mimic a user’s physical actions are...

A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide (2006)

Li, Na, Guo, Ruifang, Li, Wenmei, Shao, Jianmin, Li, Shuting, Zhao, Kang, ...

Garlic is generally used as a therapeutic reagent against various diseases worldwide. Although a great effort is made to understand the pharmaceutical mechanisms of garlic and its derivatives, there...

Symmetric Boolean Function with Maximum Algebraic Immunity on Odd Number of Variables (2005)

Li, Na, Qi, Wen-feng

To resist algebraic attack, a Boolean function should possess good algebraic immunity (AI). Several papers constructed symmetric functions with the maximum algebraic immunity $\lceil...

The Genomes of Oryza sativa: A History of Duplications (2005)

Jun Yu, Jun Wang, Wei Lin, Songgang Li, Heng Li, Jun Zhou, ...

Comparative genome sequencing of indica and japonica rice reveals that duplication of genes and genomic regions has played a major part in the evolution of grass genomes.

The Genomes of Oryza sativa: A History of Duplications (2005)

Jun Yu, Jun Wang, Wei Lin, Songgang Li, Heng Li, Jun Zhou, ...

We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested...

The Importance of Affective Quality (2005)

Ping Zhang, Na Li

Users aren’t always rational logical beings— emotion plays an often overlooked role in user acceptance of technology. Affect, a term that encompasses mood, emotions, and feelings, is a...

Novel cyanine-AMP conjugates for efficient 5' RNA fluorescent labeling by one-step transcription and replacement of [{gamma}-32P]ATP in RNA structural investigation (2005)

Li, Na, Yu, Changjun, Huang, Faqing

Two novel fluorescent cyanine-AMP conjugates, F550/570 and F650/670, have been synthesized to serve as transcription initiators under the T7 &phgr;2.5 promoter. Efficient fluorophore labeling of 5′...

A Novel Retinoic Acid Receptor Isoform and Retinoid Resistance in Lung Carcinogenesis (2005)

Petty, W. Jeffrey, Li, Na, Biddle, Adrian, Bounds, Rebecca, Nitkin, Christopher, Ma, Yan, ...

Background: We previously reported that all-trans-retinoic acid (RA) treatment can prevent in vitro transformation of immortalized human bronchial epithelial (HBE) cells. Methods: To determine...

A proteomic investigation into a human gastric cancer cell line BGC823 treated with diallyl trisulfide (2005)

Li, Na, Guo, Ruifang, Li, Wenmei, Shao, Jianmin, Li, Shuting, Zhao, Kang, ...

Garlic is generally used as a therapeutic reagent against various diseases worldwide. Although a great effort is made to understand the pharmaceutical mechanisms of garlic and its derivatives, there...

An aspect-based approach to modeling access control concerns (2004)

Indrakshi Ray, Robert France, Na Li, Geri Georg

Specifying, enforcing and evolving access control policies is essential to prevent security breaches and unavailability of resources. These access control design concerns impose requirements that...

Love at first sight or sustained effect? The role of perceived affective quality on users’ cognitive reactions to IT (2004)

Ping Zhang, Na Li

This research examines the impact of primitive affective reactions to information technology on subsequent cognitive reactions and behavioral intention on IT use, and the potential change of such...

Modeling role-based access control using parameterized UML models (2004)

Dae-kyoo Kim, Indrakshi Ray, Robert France, Na Li

Abstract. Organizations use Role-Based Access Control (RBAC) to protect computer-based resources from unauthorized access. There has been considerable work on formally specifying RBAC policies but...

An aspect-based approach to modeling access control concerns (2004)

Robert France, Na Li, Geri Georg, Contact Address, Indrakshi Ray, Indrakshi Ray

Organizations define and enforce access control policies to protect sensitive information resources. Access control policies impose additional requirements which ensure that only authorized users...

An Assessment Of Human-Computer Interaction Research In Management Information Systems: Topics And Methods (2004)

Ping Zhang, Na Li, Ping Zhang* Nali

As an emerging subfield of Management Information Systems (MIS), Human--Computer Interaction (HCI) or Human Factors studies in MISare concernedwith th wayshysS# interactwith information, techmation,S...

Crout versions of ILU factorization with pivoting for sparse symmetric matrices (2004)

Na Li, Yousef Saad

Abstract. The Crout variant of ILU preconditioner (ILUC) developed recently has been shown to have a number of advantages over ILUT, the conventional row-based ILU preconditioner [14]. This paper...

Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus (2004)

Li, Na, Nakamura, Kazuhiro, Jiang, Yi, Tsurui, Hiromichi, Matsuoka, Shuji, Abe, Masaaki, ...

Systemic lupus erythematosus (SLE), a complex multigenic disease, is a typical antibody-mediated autoimmune disease characterized by production of autoantibodies against a variety of autoantigens and...

Approaches to mapping genetically correlated complex traits (2003)

George, Andrew W, Basu, Saonli, Li, Na, Rothstein, Joseph H, Sieberts, Solveig K, Stewart, William, ...

Abstract Our Markov chain Monte Carlo (MCMC) methods were used in linkage analyses of the Framingham Heart Study data using all available pedigrees. Our goal was to detect and map loci associated...

Simple Parallel Statistical Computing in R (2003)

Rossini, Anthony, Tierney, Luke, Li, Na

Theoretically, many modern statistical procedures are trivial to parallelize. However, practical deployment of a parallelized implementation which is robust and reliably runs on different...

Simple Parallel Statistical Computing in R (2003)

Rossini, Anthony, Tierney, Luke, Li, Na

Theoretically, many modern statistical procedures are trivial to parallelize. However, practical deployment of a parallelized implementation which is robust and reliably runs on different...

Simple Parallel Statistical Computing in R (2003)

Rossini, Anthony, Tierney, Luke, Li, Na

Theoretically, many modern statistical procedures are trivial to parallelize. However, practical deployment of a parallelized implementation which is robust and reliably runs on different...

Simple Parallel Statistical Computing in R (2003)

Rossini, Anthony, Tierney, Luke, Li, Na

Theoretically, many modern statistical procedures are trivial to parallelize. However, practical deployment of a parallelized implementation which is robust and reliably runs on different...

Using Parameterized UML to Specify and Compose Access Control Models (2003)

Indrakshi Ray, Na Li, Dae-kyoo Kim, Robert France

Abstract: Situations can arise in which organizations have to merge policies that are based on different access control frameworks, such as Role Based Access Control (RBAC) and Mandatory Access...

Consumer Online Shopping Attitudes and Behavior: An Assessment of Research (2002)

Na Li, Ping Zhang

The current status of studies of online shopping attitudes and behavior is investigated through an analysis of 35 empirical articles found in nine primary Information Systems (IS) journals and three...

Crout versions of ILU for general sparse matrices (2002)

Na Li, Yousef Saad, Edmond Chow

This paper presents an e#cient implementation of incomplete LU #ILU# factorizations that are derived from the Crout version of Gaussian elimination #GE#. At step k of the elimination, the k-th rowofU...

Crout versions of ILU for general sparse matrices (2002)

Na Li, Yousef Saad, Edmond Chow

This paper presents an efficient implementation of incomplete LU (ILU) factorizations that are derived from the Crout version of Gaussian elimination (GE). At step k of the elimination, the k-th row...

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing (2001)

Grishok, Alla, Pasquinelli, Amy E., Conte, Darryl, Li, Na, Parrish, Susan, Ha, Ilho, ...

RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In Caenorhabditis elegans, lin-4 and...

Genetically determined aberrant down-regulation of Fc{gamma}RIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus (1999)

Jiang, Yi, Hirose, Sachiko, Sanokawa-Akakura, Reiko, Abe, Masaaki, Mi, Xiaoyi, Li, Na, ...

Systemic lupus erythematosus (SLE) is a multigenic disease associated with IgG hypergammaglobulinemia, IgG anti-nuclear antibodies and immune complex (IC)-type glomerulonephritis. In both human and...

The analysis and design of high-temperature superconducting leaky-wave antennas /--by Na Li. (1997)

Li, Na.

Degree granted by Dept. of Electrical and Computer Engineering, Cullen College of Engineering.

Wood treatability / (1996)

Li, Na.

Report (M.S.)--Michigan Technological University, 1996.

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

Zhang, Yu, Li, Na, Caron, Cécile, Matthias, Gabriele, Hess, Daniel, Khochbin, Saadi, ...

Microtubules are cylindrical cytoskeletal structures found in almost all eukaryotic cell types which are involved in a great variety of cellular processes. Reversible acetylation on the ε-amino...

The Genomes of Oryza sativa: A History of Duplications

Yu, Jun, Wang, Jun, Lin, Wei, Li, Songgang, Li, Heng, Zhou, Jun, ...

We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested...

Novel cyanine-AMP conjugates for efficient 5′ RNA fluorescent labeling by one-step transcription and replacement of [γ-32P]ATP in RNA structural investigation

Li, Na, Yu, Changjun, Huang, Faqing

Two novel fluorescent cyanine-AMP conjugates, F550/570 and F650/670, have been synthesized to serve as transcription initiators under the T7 φ2.5 promoter. Efficient fluorophore labeling of 5′ RNA...

Oct-1 Counteracts Autoinhibition of Runx2 DNA Binding To Form a Novel Runx2/Oct-1 Complex on the Promoter of the Mammary Gland-Specific Gene β-casein

Inman, Claire K., Li, Na, Shore, Paul

The transcription factor Runx2 is essential for the expression of a number of bone-specific genes and is primarily considered a master regulator of bone development. Runx2 is also expressed in...

β1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli

Li, Na, Zhang, Yu, Naylor, Matthew J, Schatzmann, Franziska, Maurer, Francisca, Wintermantel, Tim, ...

Integrin–extracellular matrix interactions play important roles in the coordinated integration of external and internal cues that are essential for proper development. To study the role of β1...

Direct energy delivery improves tissue perfusion after resuscitated shock

Zakaria, El Rasheid, Ehringer, William D., Tsakadze, Nina, Li, Na, Garrison, R. Neal

Background. Conventional resuscitation (CR) from hemorrhagic shock (HS) does not restore intestinal blood flow. Indicators of anaerobic metabolism suggest that cellular energy production also is...

Synthesis of adenosine derivatives as transcription initiators and preparation of 5′ fluorescein- and biotin-labeled RNA through one-step in vitro transcription

HUANG, FAQING, WANG, GUOCAN, COLEMAN, TRICIA, LI, NA

Expanding our previous finding of an adenosine-initiated transcription system, we now demonstrate that either the 5′ site or the N6 site of adenosine nucleotides can be modified extensively without...

Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data.

Li, Na, Stephens, Matthew

We introduce a new statistical model for patterns of linkage disequilibrium (LD) among multiple SNPs in a population sample. The model overcomes limitations of existing approaches to understanding,...

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

Zhang, Yu, Li, Na, Caron, Cécile, Matthias, Gabriele, Hess, Daniel, Khochbin, Saadi, ...

Microtubules are cylindrical cytoskeletal structures found in almost all eukaryotic cell types which are involved in a great variety of cellular processes. Reversible acetylation on the ε-amino...

The Genomes of Oryza sativa: A History of Duplications

Yu, Jun, Wang, Jun, Lin, Wei, Li, Songgang, Li, Heng, Zhou, Jun, ...

We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested...

Novel cyanine-AMP conjugates for efficient 5′ RNA fluorescent labeling by one-step transcription and replacement of [γ-32P]ATP in RNA structural investigation

Li, Na, Yu, Changjun, Huang, Faqing

Two novel fluorescent cyanine-AMP conjugates, F550/570 and F650/670, have been synthesized to serve as transcription initiators under the T7 φ2.5 promoter. Efficient fluorophore labeling of 5′ RNA...

Oct-1 Counteracts Autoinhibition of Runx2 DNA Binding To Form a Novel Runx2/Oct-1 Complex on the Promoter of the Mammary Gland-Specific Gene β-casein

Inman, Claire K., Li, Na, Shore, Paul

The transcription factor Runx2 is essential for the expression of a number of bone-specific genes and is primarily considered a master regulator of bone development. Runx2 is also expressed in...

β1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli

Li, Na, Zhang, Yu, Naylor, Matthew J, Schatzmann, Franziska, Maurer, Francisca, Wintermantel, Tim, ...

Integrin–extracellular matrix interactions play important roles in the coordinated integration of external and internal cues that are essential for proper development. To study the role of β1...

Synthesis of adenosine derivatives as transcription initiators and preparation of 5′ fluorescein- and biotin-labeled RNA through one-step in vitro transcription

HUANG, FAQING, WANG, GUOCAN, COLEMAN, TRICIA, LI, NA

Expanding our previous finding of an adenosine-initiated transcription system, we now demonstrate that either the 5′ site or the N6 site of adenosine nucleotides can be modified extensively without...

Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data.

Li, Na, Stephens, Matthew

We introduce a new statistical model for patterns of linkage disequilibrium (LD) among multiple SNPs in a population sample. The model overcomes limitations of existing approaches to understanding,...

Approaches to mapping genetically correlated complex traits

George, Andrew W, Basu, Saonli, Li, Na, Rothstein, Joseph H, Sieberts, Solveig K, Stewart, William, ...

Our Markov chain Monte Carlo (MCMC) methods were used in linkage analyses of the Framingham Heart Study data using all available pedigrees. Our goal was to detect and map loci associated with...

A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice

Chen, Desu, Liao, Jiayu, Li, Na, Zhou, Caihong, Liu, Qing, Wang, Guangxing, ...

Peptidic mimics of the gut hormone glucagon-like peptide (GLP) 1, exemplified by the recently approved drug exenatide, show promise as therapies for type 2 diabetes. Such “incretin mimetics”...

The Rice Tapetum Degeneration Retardation Gene Is Required for Tapetum Degradation and Anther Development[W]

Li, Na, Zhang, Da-Sheng, Liu, Hai-Sheng, Yin, Chang-Song, Li, Xiao-xing, Liang, Wan-qi, ...

In flowering plants, tapetum degeneration is proposed to be triggered by a programmed cell death (PCD) process during late stages of pollen development; the PCD is thought to provide cellular...

B Cell Response Is Required for Granuloma Formation in the Early Infection of Schistosoma japonicum

Ji, Fang, Liu, Zhanjie, Cao, Jianping, Li, Na, Liu, Zhijian, Zuo, Jinxin, ...

Schistosoma egg-induced liver granuloma is a dynamic inflammatory reaction that results from complex immune responses to the infection. However, the role of B cells in inflammatory granuloma...

Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation

Naylor, Matthew J., Li, Na, Cheung, Julia, Lowe, Emma T., Lambert, Elise, Marlow, Rebecca, ...

Integrin-mediated adhesion regulates the development and function of a range of tissues; however, little is known about its role in glandular epithelium. To assess the contribution of β1 integrin,...

Heterodimerization, trafficking and membrane topology of the two proteins, Ostα and Ostβ, that constitute the organic solute and steroid transporter

Li, Na, Cui, Zhifeng, Fang, Fang, Lee, Jin Young, Ballatori, Nazzareno

Co-immunoprecipitation studies using mouse ileal proteins and transfected HEK-293 (human embryonic kidney-293) cells revealed that the two proteins, Ostα and Ostβ, which generate the organic-solute...

Genetic Analysis Workshop 15: simulation of a complex genetic model for rheumatoid arthritis in nuclear families including a dense SNP map with linkage disequilibrium between marker loci and trait loci

Miller, Michael B, Lind, Gregg R, Li, Na, Jang, Soon-Young

Data for Problem 3 of the Genetic Analysis Workshop 15 were generated by computer simulation in an attempt to mimic some of the genetic and epidemiological features of rheumatoid arthritis (RA) such...

Functional group-based linkage analysis of gene expression trait loci

Li, Na, Wu, Baolin, Wei, Peng, Xie, Benhuai, Xie, Yang, Xiao, Guanghua, ...

We explored approaches to using multiple related traits (gene expression levels) in linkage analysis. We first grouped mRNA transcripts according to their functions annotated in biological process of...

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally▿ †

Zhang, Yu, Kwon, SoHee, Yamaguchi, Teppei, Cubizolles, Fabien, Rousseaux, Sophie, Kneissel, Michaela, ...

Posttranslational modifications play important roles in regulating protein structure and function. Histone deacetylase 6 (HDAC6) is a mostly cytoplasmic class II HDAC, which has a unique structure...

Interleukin-1 Receptor Type I Signaling Critically Regulates Infarct Healing and Cardiac Remodeling

Bujak, Marcin, Dobaczewski, Marcin, Chatila, Khaled, Mendoza, Leonardo H., Li, Na, Reddy, Anilkumar, ...

The proinflammatory cytokine interleukin (IL)-1 signals exclusively through the type I IL-1 receptor (IL-1RI). IL-1 expression is markedly induced in the infarcted heart; however, its role in cardiac...

Mapping translocation breakpoints by next-generation sequencing

Chen, Wei, Kalscheuer, Vera, Tzschach, Andreas, Menzel, Corinna, Ullmann, Reinhard, Schulz, Marcel Holger, ...

Balanced chromosome rearrangements (BCRs) can cause genetic diseases by disrupting or inactivating specific genes, and the characterization of breakpoints in disease-associated BCRs has been...

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase

Li, Na, Wang, Yuxuan, Pothukuchy, Arti, Syrett, Angel, Husain, Naeem, Gopalakrisha, Siddharth, ...

Drug-resistant variants of HIV-1 reverse transcriptase (RT) are also known to be resistant to anti-RT RNA aptamers. In order to be able to develop diagnostics and therapies that can focus on...

Novel Insights into Lung Transplant Rejection by Microarray Analysis

Lande, Jeffrey D., Patil, Jagadish, Li, Na, Berryman, Todd R., King, Richard A., Hertz, Marshall I.

Gene expression microarrays can estimate the prevalence of mRNA for thousands of genes in a small sample of cells or tissue. Organ transplant researchers are increasingly using microarrays to...

Characterization of the complete mitochondrial genome of the giant silkworm moth, Eriogyna pyretorum (Lepidoptera: Saturniidae)

Jiang, Shao-Tong, Hong, Gui-Yun, Yu, Miao, Li, Na, Yang, Ying, Liu, Yan-Qun, ...

The complete mitochondrial genome (mitogenome) of Eriogyna pyretorum (Lepidoptera: Saturniidae) was determined as being composed of 15,327 base pairs (bp), including 13 protein-coding genes (PCGs), 2...

Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites

Mortusewicz, Oliver, Roth, Wera, Li, Na, Cardoso, M. Cristina, Meisterernst, Michael, Leonhardt, Heinrich

The multifunctional nuclear protein positive cofactor 4 (PC4) is involved in various cellular processes including transcription, replication, and chromatin organization. Recently, PC4 has been...

Evaluation of a Recombinant Hc of Clostridium botulinum Neurotoxin Serotype F as an Effective Subunit Vaccine▿

Yu, Yun-Zhou, Li, Na, Wang, Rui-Lin, Zhu, Heng-Qi, Wang, Shuang, Yu, Wei-Yuan, ...

A new gene encoding the Hc domain of Clostridium botulinum neurotoxin serotype F (FHc) was designed and completely synthesized with oligonucleotides. A soluble recombinant Hc of C. botulinum...

Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver

Ballatori, Nazzareno, Fang, Fang, Christian, Whitney V., Li, Na, Hammond, Christine L.

Mice deficient in the organic solute transporter (Ost)-α subunit of the heteromeric organic solute and steroid transporter, Ostα-Ostβ, were generated and were found to be viable and fertile but...

Cryptosporidium Genotype and Subtype Distribution in Raw Wastewater in Shanghai, China: Evidence for Possible Unique Cryptosporidium hominis Transmission▿

Feng, Yaoyu, Li, Na, Duan, Liping, Xiao, Lihua

To identify the genotype and subtype distributions of Cryptosporidium oocysts in domestic wastewater in Shanghai, China, and to facilitate the characterization of the endemic transmission of...

Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice

Chelu, Mihail G., Sarma, Satyam, Sood, Subeena, Wang, Sufen, Van Oort, Ralph J., Skapura, Darlene G., ...

Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic reticulum via “leaky”...

Disruption of the BMEI0066 gene attenuates the virulence of Brucella melitensis and decreases its stress tolerance

Zhang, Xinglin, Ren, Jie, Li, Na, Liu, Wenjuan, Wu, Qingmin

Brucella melitensis is a facultative intracellular pathogen. An operon composed of BMEI0066, which encodes a two-component response regulator CenR, and BMEI0067, which encodes a cAMP-dependent...