Park, Narae, Yamanaka, Kinrin, Tran, Dat, Chandrangsu, Pete, Akers, Johnny C., De Leon, Jessica C., ...
Objectives In the course of studies to identify novel treatment strategies against the pathogenic bacterium, Chlamydia, we tested the carrier peptide, Pep-1, for activity against an intracellular...
Dinitroanilines Bind �-Tubulin to Disrupt (2003)
Naomi S. Morrissette, Arpita Mitra, David Sept, L. David Sibley
Protozoan parasites are remarkably sensitive to dinitroanilines such as oryzalin, which disrupt plant but not animal microtubules. To explore the basis of dinitroaniline action, we isolated 49...
Cytoskeleton of Apicomplexan Parasites
Morrissette, Naomi S., Sibley, L. David
The Apicomplexa are a phylum of diverse obligate intracellular parasites including Plasmodium spp., the cause of malaria; Toxoplasma gondii and Cryptosporidium parvum, opportunistic pathogens of...
ε-Tubulin Is an Essential Component of the Centriole
Dutcher, Susan K., Morrissette, Naomi S., Preble, Andrea M., Rackley, Craig, Stanga, John
Centrioles and basal bodies are cylinders composed of nine triplet microtubule blades that play essential roles in the centrosome and in flagellar assembly. Chlamydomonas cells with the bld2-1...
Dinitroanilines Bind α-Tubulin to Disrupt Microtubules
Morrissette, Naomi S., Mitra, Arpita, Sept, David, Sibley, L. David
Protozoan parasites are remarkably sensitive to dinitroanilines such as oryzalin, which disrupt plant but not animal microtubules. To explore the basis of dinitroaniline action, we isolated 49...
Cytoskeleton of Apicomplexan Parasites
Morrissette, Naomi S., Sibley, L. David
The Apicomplexa are a phylum of diverse obligate intracellular parasites including Plasmodium spp., the cause of malaria; Toxoplasma gondii and Cryptosporidium parvum, opportunistic pathogens of...
ε-Tubulin Is an Essential Component of the Centriole
Dutcher, Susan K., Morrissette, Naomi S., Preble, Andrea M., Rackley, Craig, Stanga, John
Centrioles and basal bodies are cylinders composed of nine triplet microtubule blades that play essential roles in the centrosome and in flagellar assembly. Chlamydomonas cells with the bld2-1...
Dinitroanilines Bind α-Tubulin to Disrupt Microtubules
Morrissette, Naomi S., Mitra, Arpita, Sept, David, Sibley, L. David
Protozoan parasites are remarkably sensitive to dinitroanilines such as oryzalin, which disrupt plant but not animal microtubules. To explore the basis of dinitroaniline action, we isolated 49...
Mutations in α-Tubulin Confer Dinitroaniline Resistance at a Cost to Microtubule Function
Ma, Christopher, Li, Catherine, Ganesan, Lakshmi, Oak, Jean, Tsai, Susan, Sept, David, ...
Protozoan microtubules are sensitive to disruption by dinitroanilines, compounds that kill intracellular Toxoplasma gondii parasites without affecting microtubules in vertebrate host cells. We...
Dynamin 2 Is Required for Phagocytosis in Macrophages
Gold, Elizabeth S., Underhill, David M., Morrissette, Naomi S., Guo, Jian, McNiven, Mark A., Aderem, Alan
Cells internalize soluble ligands through endocytosis and large particles through actin-based phagocytosis. The dynamin family of GTPases mediates the scission of endocytic vesicles from the plasma...
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells
Bell, Bryan D., Leverrier, Sabrina, Weist, Brian M., Newton, Ryan H., Arechiga, Adrian F., Luhrs, Keith A., ...
Fas-associated death domain protein (FADD) and caspase-8 (casp8) are vital intermediaries in apoptotic signaling induced by tumor necrosis factor family ligands. Paradoxically, lymphocytes lacking...