Homhuan, Atthachai, Kogure, Kentaro, Nakamura, Takashi, Shastri, Nilabh, Harashima, Hideyoshi
To improve uptake and cross-presentation of exogenous antigens (Ag) by dendritic cells (DCs), octaarginine-modified liposomes (R8-Lip) were used as a novel strategy for protein-Ag transduction....
Hammer, Gianna Elena, Gonzalez, Federico, James, Edward, Nolla, Hector, Shastri, Nilabh
Immunosurveillance by cytotoxic T cells requires that cells generate a diverse spectrum of peptides for presentation by major histocompatibility complex (MHC) class I molecules. Those peptides are...
Kwon, Young Jik, James, Edward, Shastri, Nilabh, Fréchet, Jean M.J.
Activating the immune system to trigger a specific response is a major challenge in vaccine development. In particular, activating sufficient cytotoxic T lymphocyte-mediated cellular immunity, which...
Unanticipated Antigens: Translation Initiation at CUG with Leucine (2004)
Susan R. Schwab, Jessica A. Shugart, Tiffany Horng, Subramaniam Malarkannan, Nilabh Shastri
Proteins have been identified for which a unique translational machinery makes use of unconventional start codons.
Unanticipated Antigens: Translation Initiation at CUG with Leucine (2004)
Susan R. Schwab, Jessica A. Shugart, Tiffany Horng, Subramaniam Malarkannan, Nilabh Shastri
Major histocompatibility class I molecules display tens of thousands of peptides on the cell surface for immune surveillance by T cells. The peptide repertoire represents virtually all cellular...
LacZ inducible, antigen/MHC-specific T cell hybrids (1994)
Sanderson, Sarah, Shastri, Nilabh
The nuclear factor of activated T cells (NFAT) enhancer element of the IL-2 gene can regulate expression of the Escherichia coli lacZ reporter gene in activated T cells. Based upon this observation,...
Malissen, Bernard, Shastri, Nilabh, Pierres, Michel, Hood, Leroy
Ia molecules play a key role in antigen recognition by T lymphocytes. To analyze the structural features of the individual α and β chains relevant to the assembly of intact Ia molecules, mouse...
Shastri, Nilabh, Malissen, Bernard, Hood, Leroy
We studied the antigen-presenting capacity of mouse L fibroblasts transfected with genes encoding Ia polypeptides of the major histocompatibility complex (MHC). These cells function as efficient...
Malarkannan, Subramaniam, Serwold, Thomas, Nguyen, Vu, Sherman, Linda A., Shastri, Nilabh
CD8+ cytotoxic T cells recognize their targets by the presence of unique peptide bound to a major histocompatibility complex (MHC) class I molecules on the cell surface. The MHC molecules normally...
Murthy, Niren, Xu, Mingcheng, Schuck, Stephany, Kunisawa, Jun, Shastri, Nilabh, Fréchet, Jean M. J.
The development of protein-based vaccines remains a major challenge in the fields of immunology and drug delivery. Although numerous protein antigens have been identified that can generate immunity...
Unanticipated Antigens: Translation Initiation at CUG with Leucine
Schwab, Susan R, Shugart, Jessica A, Horng, Tiffany, Malarkannan, Subramaniam, Shastri, Nilabh
Major histocompatibility class I molecules display tens of thousands of peptides on the cell surface for immune surveillance by T cells. The peptide repertoire represents virtually all cellular...
Gubbels, Marc-Jan, Striepen, Boris, Shastri, Nilabh, Turkoz, Mustafa, Robey, Ellen A.
The intracellular parasite Toxoplasma gondii, the causative agent of toxoplasmosis, induces a protective CD8 T-cell response in its host; however, the mechanisms by which T. gondii proteins are...
Kwon, Young Jik, James, Edward, Shastri, Nilabh, Fréchet, Jean M. J.
Activating the immune system to trigger a specific response is a major challenge in vaccine development. In particular, activating sufficient cytotoxic T lymphocyte-mediated cellular immunity, which...
Malarkannan, Subramaniam, Serwold, Thomas, Nguyen, Vu, Sherman, Linda A., Shastri, Nilabh
CD8+ cytotoxic T cells recognize their targets by the presence of unique peptide bound to a major histocompatibility complex (MHC) class I molecules on the cell surface. The MHC molecules normally...
Murthy, Niren, Xu, Mingcheng, Schuck, Stephany, Kunisawa, Jun, Shastri, Nilabh, Fréchet, Jean M. J.
The development of protein-based vaccines remains a major challenge in the fields of immunology and drug delivery. Although numerous protein antigens have been identified that can generate immunity...
Unanticipated Antigens: Translation Initiation at CUG with Leucine
Schwab, Susan R, Shugart, Jessica A, Horng, Tiffany, Malarkannan, Subramaniam, Shastri, Nilabh
Major histocompatibility class I molecules display tens of thousands of peptides on the cell surface for immune surveillance by T cells. The peptide repertoire represents virtually all cellular...
Gubbels, Marc-Jan, Striepen, Boris, Shastri, Nilabh, Turkoz, Mustafa, Robey, Ellen A.
The intracellular parasite Toxoplasma gondii, the causative agent of toxoplasmosis, induces a protective CD8 T-cell response in its host; however, the mechanisms by which T. gondii proteins are...
Kwon, Young Jik, James, Edward, Shastri, Nilabh, Fréchet, Jean M. J.
Activating the immune system to trigger a specific response is a major challenge in vaccine development. In particular, activating sufficient cytotoxic T lymphocyte-mediated cellular immunity, which...
Sahara, Hiroeki, Shastri, Nilabh
CD4 T cells regulate immune responses that cause chronic graft rejection and graft versus host disease but their target antigens remain virtually unknown. We developed a new method to identify CD4 T...
Fassò, Marcella, Waitz, Rebecca, Hou, Yafei, Rim, Tae, Greenberg, Norman M., Shastri, Nilabh, ...
Discovery of immunologically relevant antigens in prostate cancer forms the basis for developing more potent active immunotherapy. We report here a strategy using the transgenic adenocarcinoma of...
A Distinct Translation Initiation Mechanism Generates Cryptic Peptides for Immune Surveillance
Starck, Shelley R., Ow, Yongkai, Jiang, Vivian, Tokuyama, Maria, Rivera, Mark, Qi, Xin, ...
MHC class I molecules present a comprehensive mixture of peptides on the cell surface for immune surveillance. The peptides represent the intracellular protein milieu produced by translation of...
Labelle, Philippe, Hahn, Nina E, Fraser, Jenelle K, Kendall, Lonnie V, Ziman, Melanie, James, Edward, ...
An outbreak of mousepox in a research institution was caused by Ectromelia-contaminated mouse serum that had been used for bone marrow cell culture and the cells subsequently injected into the...