Hara, Toshiaki, Yamakura, Fumiyuki, Takikawa, Osamu, Hiramatsu, Rie, Kawabe, Tsutomu, Isobe, Ken-ichi, ...
Indoleamine 2,3-dioxygenase (IDO)-initiated tryptophan metabolism along the kynurenine (Kyn) pathway regulates T-cell responses in some dendritic cells (DC) such as plasmacytoid DC. A Kyn assay using...
Hara, Toshiaki, Ogasawara, Nanako, Akimoto, Hidetoshi, Takikawa, Osamu, Hiramatsu, Rie, Kawabe, Tsutomu, ...
Indoleamine 2,3-dioxygenase (IDO)-initiated tryptophan metabolism along the kynurenine (Kyn) pathway in some dendritic cells (DC) such as plasmacytoid DC regulates T-cell responses. It is unclear...
Maekawa, Satoshi, Mori, Daisuke, Nishiya, Tadashi, Takikawa, Osamu, Horinouchi, Takahiro, Nishimoto, Arata, ...
A novel organic cation transporter OCTN2 is indispensable for carnitine transport across plasma membrane and subsequent fatty acid metabolism in the mitochondria. Here, we report a novel splice...
Maekawa, Satoshi, Mori, Daisuke, Nishiya, Tadashi, Takikawa, Osamu, Horinouchi, Takahiro, Nishimoto, Arata, ...
A novel organic cation transporter OCTN2 is indispensable for carnitine transport across plasma membrane and subsequent fatty acid metabolism in the mitochondria. Here, we report a novel splice...
Nagai, Kazuhiko, Takikawa, Osamu, Kawakami, Naoko, Fukao, Mitsuhiro, Soma, Takamitsu, Oda, Atsushi, ...
Acetylcarnitine exerts therapeutic effects on some neurological disorders including Alzheimer’s disease. OCTN2 is known as a transporter for acetylcarnitine, but its expression in the brain is very...
Nagai, Kazuhiko, Takikawa, Osamu, Kawakami, Naoko, Fukao, Mitsuhiro, Soma, Takamitsu, Oda, Atsushi, ...
Acetylcarnitine exerts therapeutic effects on some neurological disorders including Alzheimer's disease. OCTN2 is known as a transporter for acetylcarnitine, but its expression in the brain is very...
Nagai, Kazuhiko, Takikawa, Osamu, Kawakami, Naoko, Fukao, Mitsuhiro, Soma, Takamitsu, Oda, Atsushi, ...
Acetylcarnitine exerts therapeutic effects on some neurological disorders including Alzheimer's disease. OCTN2 is known as a transporter for acetylcarnitine, but its expression in the brain is very...
Inhibition of indoleamine 2,3 dioxygenase activity by H₂O₂ (2006)
Poljak, Anne, Grant, Ross, Smythe, George A, Austin, Chris J.D, Jamie, Joanne F, Willows, Robert D, ...
Indoleamine 2,3-dioxygenase is the first and rate limiting enzyme of the kynurenine pathway of tryptophan metabolism, has potent effects on cell proliferation and mediates antimicrobial,...
Inhibition of indoleamine 2,3 dioxygenase activity by H₂O₂ (2006)
Poljak, Anne, Grant, Ross, Smythe, George A, Austin, Chris J.D, Jamie, Joanne F, Willows, Robert D, ...
Indoleamine 2,3-dioxygenase is the first and rate limiting enzyme of the kynurenine pathway of tryptophan metabolism, has potent effects on cell proliferation and mediates antimicrobial,...
Miwa, Naoko, Hayakawa, Satoshi, Miyazaki, Satomi, Myojo, Subaru, Sasaki, Yasushi, Sakai, Masatoshi, ...
Recent data demonstrated that CD4+CD25+ regulatory T (Treg) cells and an enzyme called indoleamine 2,3-dioxygenase (IDO) mediate maternal tolerance to the fetus. Interestingly, Treg cells express the...
Miwa, Naoko, Hayakawa, Satoshi, Miyazaki, Satomi, Myojo, Subaru, Sasaki, Yasushi, Sakai, Masatoshi, ...
Recent data demonstrated that CD4+CD25+ regulatory T (Treg) cells and an enzyme called indoleamine 2,3-dioxygenase (IDO) mediate maternal tolerance to the fetus. Interestingly, Treg cells express the...
Kudo, Yoshiki, Hara, Tetsuaki, Katsuki, Takafumi, Toyofuku, Aya, Katsura, Yuki, Takikawa, Osamu, ...
BACKGROUND: Expression of the tryptophan catabolizing enzyme, indoleamine 2,3‐dioxygenase, in the mouse placenta has been shown to be critical in preventing immunological rejection of the fetal...
Kudo, Yoshiki, Hara, Tetsuaki, Katsuki, Takafumi, Toyofuku, Aya, Katsura, Yuki, Takikawa, Osamu, ...
BACKGROUND: Expression of the tryptophan catabolizing enzyme, indoleamine 2,3-dioxygenase, in the mouse placenta has been shown to be critical in preventing immunological rejection of the fetal...
Tone, Shigenobu, Takikawa, Osamu, Habara-Ohkubo, Akemi, Kadoya, Akihiko, Yoshida, Ryotaro, Kido, Ryo
Grant, Ross S., Naif, Hassan, Thuruthyil, Sophie J., Nasr, Najla, Littlejohn, Tamantha, Takikawa, Osamu, ...
Increased kynurenine pathway metabolism has been implicated in the etiology of AIDS dementia complex (ADC). The rate-limiting enzyme for this pathway is indolamine 2,3-dioxygenase (IDO). We tested...
Hucke, Christian, MacKenzie, Colin R., Adjogble, Koku D. Z., Takikawa, Osamu, Däubener, Walter
Tryptophan depletion resulting from indoleamine 2,3-dioxygenase (IDO) activity within the kynurenine pathway is one of the most prominent gamma interferon (IFN-γ)-inducible antimicrobial effector...
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase
Hayashi, Tomoko, Beck, Lucinda, Rossetto, Cyprian, Gong, Xing, Takikawa, Osamu, Takabayashi, Kenji, ...
Epidemiological evidence points to the inverse relationship between microbial exposure and the prevalence of allergic asthma and autoimmune diseases in Westernized countries. The molecular basis for...
Grant, Ross S., Naif, Hassan, Thuruthyil, Sophie J., Nasr, Najla, Littlejohn, Tamantha, Takikawa, Osamu, ...
Increased kynurenine pathway metabolism has been implicated in the etiology of AIDS dementia complex (ADC). The rate-limiting enzyme for this pathway is indolamine 2,3-dioxygenase (IDO). We tested...
Hucke, Christian, MacKenzie, Colin R., Adjogble, Koku D. Z., Takikawa, Osamu, Däubener, Walter
Tryptophan depletion resulting from indoleamine 2,3-dioxygenase (IDO) activity within the kynurenine pathway is one of the most prominent gamma interferon (IFN-γ)-inducible antimicrobial effector...
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase
Hayashi, Tomoko, Beck, Lucinda, Rossetto, Cyprian, Gong, Xing, Takikawa, Osamu, Takabayashi, Kenji, ...
Epidemiological evidence points to the inverse relationship between microbial exposure and the prevalence of allergic asthma and autoimmune diseases in Westernized countries. The molecular basis for...
Hainz, Ursula, Obexer, Petra, Winkler, Christiana, Sedlmayr, Peter, Takikawa, Osamu, Greinix, Hildegard, ...
T-cell dysfunction after human hematopoietic stem-cell transplantation (HSCT) is generally attributed to intrinsic T-cell defects. Here we show that the characteristic impaired proliferative...
Potula, Raghava, Poluektova, Larisa, Knipe, Bryan, Chrastil, Jesse, Heilman, David, Dou, Huanyu, ...
Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism. IDO activity is linked with immunosuppression by its ability to inhibit lymphocyte...
Nawate, Satoshi, Fukao, Mitsuhiro, Sakuma, Ichiro, Soma, Takamitsu, Nagai, Kazuhiko, Takikawa, Osamu, ...
To explore the effects of estrogen on arterial functions, we examined endothelium-derived hyperpolarizing factor (EDHF)- and NO-mediated responses in isolated mesenteric arteries of female rats, 4...
Suh, Hyeon-Sook, Zhao, Meng-Liang, Rivieccio, Mark, Choi, Shinyeop, Connolly, Erin, Zhao, Yongmei, ...
Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of tryptophan catabolism and has been implicated in neurotoxicity and suppression of the antiviral...
Indoleamine 2,3-Dioxygenase (IDO) : The Antagonist of Type I Interferon-Driven Skin Inflammation?
Scheler, Marina, Wenzel, Joerg, Tüting, Thomas, Takikawa, Osamu, Bieber, Thomas, Von Bubnoff, Dagmar
Recent studies have provided evidence that a type I interferon (IFN)-driven immune response might play an important role in the pathogenesis of lichen planus (LP), an inflammatory disorder of the...