Eprodisate for the treatment of renal disease in AA amyloidosis (2007)
Dember, L.M., Hawkins, P.N., Hazenberg, B.P.C., Gorevic, P.D., Merlini, G., Butrimiene, I., ...
Background: Amyloid A (AA) amyloidosis is a complication of chronic inflammatory conditions that develops when proteolytic fragments of serum amyloid A protein (SAA) are deposited in tissues as...
The 93-kilodalton protein of Borrelia burgdorferi: an immunodominant protoplasmic cylinder antigen.
Luft, B J, Mudri, S, Jiang, W, Dattwyler, R J, Gorevic, P D, Fischer, T, ...
Using immunoblots, we identified proteins of Borrelia burgdorferi recognized by sera from 62 patients with either acute or chronic Lyme disease. In all groups studied, the 41-kDa flagellar protein...
Biochemical and immunological characterization of the surface proteins of Borrelia burgdorferi.
Luft, B J, Jiang, W, Munoz, P, Dattwyler, R J, Gorevic, P D
The immunodominant proteins and glycoproteins of Borrelia burgdorferi were analyzed by one-dimensional (1D) and 2D gel electrophoresis. More than 100 polypeptide species could be detected on...
Mapping the major antigenic domains of the native flagellar antigen of Borrelia burgdorferi.
Jiang, W, Luft, B J, Schubach, W, Dattwyler, R J, Gorevic, P D
Purified flagellar protein (p41) of Borrelia burgdorferi (strain B31) was subjected to chemical cleavage with hydroxylamine or proteolysis with V8 protease, endoproteinase Asp-N, or...
Gorevic, P D, Prelli, F C, Wright, J, Pras, M, Frangione, B
Isolated amyloid fibrils from three cases of systemic senile amyloidosis (SSA) contained subunit proteins with molecular masses of 14 (10-20%), 10-12 (60-80%), and 5-6 kD (5-10%) when fractionated...
Transthyretin Ile 122 and cardiac amyloidosis in African-Americans. 2 case reports.
Jacobson, D R, Ittmann, M, Buxbaum, J N, Wieczorek, R, Gorevic, P D
Two cases of cardiac amyloidosis resulting from deposition of the Ile 122 variant of transthyretin in African-Americans are presented. These cases illustrate several typical features of this...
Jiang, W, Gorevic, P D, Dattwyler, R J, Dunn, J J, Luft, B J
The major outer surface protein, OspA, of Borrelia burgdorferi is a lipoprotein which is a particular interest because of its potential as a vaccine candidate. However, serotypic and genetic analysis...
Gorevic, P D, Munoz, P C, Casey, T T, DiRaimondo, C R, Stone, W J, Prelli, F C, ...
Systemic amyloidosis with a predilection for bone and synovium may complicate the course of patients on long-term hemodialysis. This form of amyloidosis can be typed as distinct from other amyloid...
Beta-2 microglobulin is an amyloidogenic protein in man.
Gorevic, P D, Casey, T T, Stone, W J, DiRaimondo, C R, Prelli, F C, Frangione, B
Curvilinear fibrils with the tinctorial properties of amyloid were isolated from a patient with bone and joint involvement complicating chronic dialysis for renal disease. Subunit fractions of 24,000...
Ghiso, J, Rostagno, A, Gardella, J E, Liem, L, Gorevic, P D, Frangione, B
Amyloid beta (A beta), the major constituent of the fibrils composing senile plaques and vascular amyloid deposits in Alzheimer's disease (AD) and related disorders, is a 39-42-residue...
Gardella, J E, Gorgone, G A, Candela, L, Ghiso, J, Castaño, E M, Frangione, B, ...
We amplified DNA encoding the 3' 109 codons of Alzheimer's-disease amyloid precursor protein (APP) inclusive of the beta protein (A beta) and cytoplasmic domains from cDNA using oligonucleotide...
Jacobson, D R, Gorevic, P D, Buxbaum, J N
Senile systemic amyloidosis (SSA) is a late-onset disease characterized by deposition of amyloid fibrils containing transthyretin (TTR). Amino acid sequencing of protein isolated from the amyloid...
The 93-kilodalton protein of Borrelia burgdorferi: an immunodominant protoplasmic cylinder antigen.
Luft, B J, Mudri, S, Jiang, W, Dattwyler, R J, Gorevic, P D, Fischer, T, ...
Using immunoblots, we identified proteins of Borrelia burgdorferi recognized by sera from 62 patients with either acute or chronic Lyme disease. In all groups studied, the 41-kDa flagellar protein...
Biochemical and immunological characterization of the surface proteins of Borrelia burgdorferi.
Luft, B J, Jiang, W, Munoz, P, Dattwyler, R J, Gorevic, P D
The immunodominant proteins and glycoproteins of Borrelia burgdorferi were analyzed by one-dimensional (1D) and 2D gel electrophoresis. More than 100 polypeptide species could be detected on...
Mapping the major antigenic domains of the native flagellar antigen of Borrelia burgdorferi.
Jiang, W, Luft, B J, Schubach, W, Dattwyler, R J, Gorevic, P D
Purified flagellar protein (p41) of Borrelia burgdorferi (strain B31) was subjected to chemical cleavage with hydroxylamine or proteolysis with V8 protease, endoproteinase Asp-N, or...
Gorevic, P D, Prelli, F C, Wright, J, Pras, M, Frangione, B
Isolated amyloid fibrils from three cases of systemic senile amyloidosis (SSA) contained subunit proteins with molecular masses of 14 (10-20%), 10-12 (60-80%), and 5-6 kD (5-10%) when fractionated...
Transthyretin Ile 122 and cardiac amyloidosis in African-Americans. 2 case reports.
Jacobson, D R, Ittmann, M, Buxbaum, J N, Wieczorek, R, Gorevic, P D
Two cases of cardiac amyloidosis resulting from deposition of the Ile 122 variant of transthyretin in African-Americans are presented. These cases illustrate several typical features of this...
Jiang, W, Gorevic, P D, Dattwyler, R J, Dunn, J J, Luft, B J
The major outer surface protein, OspA, of Borrelia burgdorferi is a lipoprotein which is a particular interest because of its potential as a vaccine candidate. However, serotypic and genetic analysis...
Gorevic, P D, Munoz, P C, Casey, T T, DiRaimondo, C R, Stone, W J, Prelli, F C, ...
Systemic amyloidosis with a predilection for bone and synovium may complicate the course of patients on long-term hemodialysis. This form of amyloidosis can be typed as distinct from other amyloid...
Beta-2 microglobulin is an amyloidogenic protein in man.
Gorevic, P D, Casey, T T, Stone, W J, DiRaimondo, C R, Prelli, F C, Frangione, B
Curvilinear fibrils with the tinctorial properties of amyloid were isolated from a patient with bone and joint involvement complicating chronic dialysis for renal disease. Subunit fractions of 24,000...
Ghiso, J, Rostagno, A, Gardella, J E, Liem, L, Gorevic, P D, Frangione, B
Amyloid beta (A beta), the major constituent of the fibrils composing senile plaques and vascular amyloid deposits in Alzheimer's disease (AD) and related disorders, is a 39-42-residue...
Gardella, J E, Gorgone, G A, Candela, L, Ghiso, J, Castaño, E M, Frangione, B, ...
We amplified DNA encoding the 3' 109 codons of Alzheimer's-disease amyloid precursor protein (APP) inclusive of the beta protein (A beta) and cytoplasmic domains from cDNA using oligonucleotide...
Jacobson, D R, Gorevic, P D, Buxbaum, J N
Senile systemic amyloidosis (SSA) is a late-onset disease characterized by deposition of amyloid fibrils containing transthyretin (TTR). Amino acid sequencing of protein isolated from the amyloid...
Williams, J M, Gorevic, P D, Looney, R J, Abraham, G N
Previous studies have demonstrated that the IgM monoclonal anti-IgG autoantibodies (AGAs) characteristic of essential mixed cryoglobulinaemia (EMC) display preferential use of kappa light chains of...
Heinicke, M H, Zarrabi, M H, Gorevic, P D
A 60-year-old man presented with polyarthralgias, a psoriasiform rash, and severe elbow pain. Peripheral blood smear and bone marrow biopsy established a diagnosis of myelofibrosis with myeloid...
Gruber, B, Ballan, D, Gorevic, P D
IgE rheumatoid factor activity was found to be significantly elevated (P less than 0.01) using an ELISA assay when paired synovial fluid and sera from 13 patients with active RA were compared to ten...
Clonal B cell expansions in patients with essential mixed cryoglobulinaemia.
Perl, A, Gorevic, P D, Ryan, D H, Condemi, J J, Ruszkowski, R J, Abraham, G N
In essential mixed, type II, cryoglobulinaemia (EMC) monoclonal autoantibodies with rheumatoid factor activity are synthesized at an accelerated rate by non-malignant B lymphocytes. In order to...