McGraw, Adam P., Bevilacqua, Philip C., Babitzke, Paul
TRAP regulates expression of the Bacillus subtilis trpEDCFBA operon by a transcription attenuation mechanism in which tryptophan-activated TRAP binds to 11 (G/U)AG repeats in the nascent trp leader...
Suzuki, Kazushi, Babitzke, Paul, Kushner, Sidney R., Romeo, Tony
In Escherichia coli, the global regulatory protein CsrA (carbon store regulator A) binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by...
RNA sequence and secondary structure participate in high-affinity CsrA-RNA interaction (2005)
DUBEY, ASHOK K., BAKER, CAROL S., ROMEO, TONY, BABITZKE, PAUL
The global Csr regulatory system controls bacterial gene expression post-transcriptionally. CsrA of Escherichia coli is an RNA binding protein that plays a central role in repressing several...
RNA sequence and secondary structure participate in high-affinity CsrA-RNA interaction (2005)
DUBEY, ASHOK K., BAKER, CAROL S., ROMEO, TONY, BABITZKE, PAUL
The global Csr regulatory system controls bacterial gene expression post-transcriptionally. CsrA of Escherichia coli is an RNA binding protein that plays a central role in repressing several...
Sudershana, Subita, Du, Hansen, Mahalanabis, Madhumita, Babitzke, Paul
The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by transcription attenuation. Tryptophan-activated TRAP binds to the nascent trp leader...
Yakhnin, Helen, Babiarz, Joshua E., Yakhnin, Alexander V., Babitzke, Paul
The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by transcription attenuation and translational control mechanisms. Both mechanisms...
Gudapaty, Seshagirirao, Suzuki, Kazushi, Wang, Xin, Babitzke, Paul, Romeo, Tony
The global regulator CsrA (carbon storage regulator) of Escherichia coli is a small RNA binding protein that represses various metabolic pathways and processes that are induced in the stationary...
Du, Hansen, Yakhnin, Alexander V., Dharmaraj, Subramanian, Babitzke, Paul
The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by a novel transcription attenuation mechanism. Tryptophan-activated TRAP binds to the...
The Escherichia coli mrsC Gene Is Required for Cell Growth and mRNA Decay
Granger, Laurie L., O’Hara, Eileen B., Wang, Rong-Fu, Meffen, Frances V., Armstrong, Katherine, Yancey, Stephanie D., ...
We have identified a gene in Escherichia coli that is required for both the normal decay of mRNA and RNA synthesis. Originally designated mrsC (mRNA stability), the mrsC505 mutation described here...
Yakhnin, Alexander V., Babitzke, Paul
The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by transcription attenuation and translation control mechanisms. Both mechanisms require...
Regulatory Circuitry of the CsrA/CsrB and BarA/UvrY Systems of Escherichia coli
Suzuki, Kazushi, Wang, Xin, Weilbacher, Thomas, Pernestig, Anna-Karin, Melefors, Öjar, Georgellis, Dimitris, ...
The global regulator CsrA (carbon storage regulator) is an RNA binding protein that coordinates central carbon metabolism, activates flagellum biosynthesis and motility, and represses biofilm...
Dubey, Ashok K., Baker, Carol S., Suzuki, Kazushi, Jones, A. Daniel, Pandit, Pallavi, Romeo, Tony, ...
CsrA is a global regulator that binds to two sites in the glgCAP leader transcript, thereby blocking ribosome access to the glgC Shine-Dalgarno sequence. The upstream CsrA binding site (GCACACGGAU)...
Yakhnin, Helen, Zhang, Hong, Yakhnin, Alexander V., Babitzke, Paul
Expression of the Bacillus subtilis tryptophan biosynthetic genes (trpEDCFBA and pabA [trpG]) is regulated in response to tryptophan by TRAP, the trp RNA-binding attenuation protein. TRAP-mediated...
Recycling of a regulatory protein by degradation of the RNA to which it binds
Deikus, Gintaras, Babitzke, Paul, Bechhofer, David H.
When Bacillus subtilis is grown in the presence of excess tryptophan, transcription of the trp operon is regulated by binding of tryptophan-activated TRAP to trp leader RNA, which promotes...
SCHAAK, JANELL E., BABITZKE, PAUL, BEVILACQUA, PHILIP C.
Expression of the trpEDCFBA operon of Bacillus subtilis is regulated by transcription attenuation and translation control mechanisms. We recently determined that the B. subtilis trp leader...
RNA sequence and secondary structure participate in high-affinity CsrA–RNA interaction
DUBEY, ASHOK K., BAKER, CAROL S., ROMEO, TONY, BABITZKE, PAUL
The global Csr regulatory system controls bacterial gene expression post-transcriptionally. CsrA of Escherichia coli is an RNA binding protein that plays a central role in repressing several...
Sudershana, Subita, Du, Hansen, Mahalanabis, Madhumita, Babitzke, Paul
The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by transcription attenuation. Tryptophan-activated TRAP binds to the nascent trp leader...
Yakhnin, Helen, Babiarz, Joshua E., Yakhnin, Alexander V., Babitzke, Paul
The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by transcription attenuation and translational control mechanisms. Both mechanisms...
Gudapaty, Seshagirirao, Suzuki, Kazushi, Wang, Xin, Babitzke, Paul, Romeo, Tony
The global regulator CsrA (carbon storage regulator) of Escherichia coli is a small RNA binding protein that represses various metabolic pathways and processes that are induced in the stationary...
Du, Hansen, Yakhnin, Alexander V., Dharmaraj, Subramanian, Babitzke, Paul
The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by a novel transcription attenuation mechanism. Tryptophan-activated TRAP binds to the...
The Escherichia coli mrsC Gene Is Required for Cell Growth and mRNA Decay
Granger, Laurie L., O’Hara, Eileen B., Wang, Rong-Fu, Meffen, Frances V., Armstrong, Katherine, Yancey, Stephanie D., ...
We have identified a gene in Escherichia coli that is required for both the normal decay of mRNA and RNA synthesis. Originally designated mrsC (mRNA stability), the mrsC505 mutation described here...
Yakhnin, Alexander V., Babitzke, Paul
The trp RNA-binding attenuation protein (TRAP) regulates expression of the Bacillus subtilis trpEDCFBA operon by transcription attenuation and translation control mechanisms. Both mechanisms require...
Regulatory Circuitry of the CsrA/CsrB and BarA/UvrY Systems of Escherichia coli
Suzuki, Kazushi, Wang, Xin, Weilbacher, Thomas, Pernestig, Anna-Karin, Melefors, Öjar, Georgellis, Dimitris, ...
The global regulator CsrA (carbon storage regulator) is an RNA binding protein that coordinates central carbon metabolism, activates flagellum biosynthesis and motility, and represses biofilm...
Dubey, Ashok K., Baker, Carol S., Suzuki, Kazushi, Jones, A. Daniel, Pandit, Pallavi, Romeo, Tony, ...
CsrA is a global regulator that binds to two sites in the glgCAP leader transcript, thereby blocking ribosome access to the glgC Shine-Dalgarno sequence. The upstream CsrA binding site (GCACACGGAU)...
Yakhnin, Helen, Zhang, Hong, Yakhnin, Alexander V., Babitzke, Paul
Expression of the Bacillus subtilis tryptophan biosynthetic genes (trpEDCFBA and pabA [trpG]) is regulated in response to tryptophan by TRAP, the trp RNA-binding attenuation protein. TRAP-mediated...
Recycling of a regulatory protein by degradation of the RNA to which it binds
Deikus, Gintaras, Babitzke, Paul, Bechhofer, David H.
When Bacillus subtilis is grown in the presence of excess tryptophan, transcription of the trp operon is regulated by binding of tryptophan-activated TRAP to trp leader RNA, which promotes...
SCHAAK, JANELL E., BABITZKE, PAUL, BEVILACQUA, PHILIP C.
Expression of the trpEDCFBA operon of Bacillus subtilis is regulated by transcription attenuation and translation control mechanisms. We recently determined that the B. subtilis trp leader...
RNA sequence and secondary structure participate in high-affinity CsrA–RNA interaction
DUBEY, ASHOK K., BAKER, CAROL S., ROMEO, TONY, BABITZKE, PAUL
The global Csr regulatory system controls bacterial gene expression post-transcriptionally. CsrA of Escherichia coli is an RNA binding protein that plays a central role in repressing several...
Suzuki, Kazushi, Babitzke, Paul, Kushner, Sidney R., Romeo, Tony
In Escherichia coli, the global regulatory protein CsrA (carbon store regulator A) binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by...
Yakhnin, Helen, Yakhnin, Alexander V., Babitzke, Paul
Bacillus subtilis trpG encodes a glutamine amidotransferase subunit that participates in the biosynthesis of both tryptophan and folic acid. TRAP inhibits translation of trpG in response to...
Baker, Carol S., Eöry, Lél A., Yakhnin, Helen, Mercante, Jeffrey, Romeo, Tony, Babitzke, Paul
Csr (carbon storage regulation) of Escherichia coli is a global regulatory system that consists of CsrA, a homodimeric RNA binding protein, two noncoding small RNAs (sRNAs; CsrB and CsrC) that...
McGraw, Adam P., Bevilacqua, Philip C., Babitzke, Paul
TRAP regulates expression of the Bacillus subtilis trpEDCFBA operon by a transcription attenuation mechanism in which tryptophan-activated TRAP binds to 11 (G/U)AG repeats in the nascent trp leader...
Yakhnin, Alexander V., Yakhnin, Helen, Babitzke, Paul
NusA and NusG are transcription elongation factors that bind to RNA polymerase (RNAP) after σ subunit release. Escherichia coli NusA (NusAEc) stimulates intrinsic termination and RNAPEc pausing,...
McGraw, Adam P., Mokdad, Ali, Major, François, Bevilacqua, Philip C., Babitzke, Paul
Expression of the Bacillus subtilis trpEDCFBA operon is regulated by the interaction of tryptophan-activated TRAP with 11 (G/U)AG trinucleotide repeats that lie in the leader region of the nascent...
A Genome-Wide Analysis of Small Regulatory RNAs in the Human Pathogen Group A Streptococcus
Perez, Nataly, Treviño, Jeanette, Liu, Zhuyun, Ho, Siu Chun Michael, Babitzke, Paul, Sumby, Paul
The coordinated regulation of gene expression is essential for pathogens to infect and cause disease. A recently appreciated mechanism of regulation is that afforded by small regulatory RNA (sRNA)...