Scientific Commons: Paul Rutgeerts

TI - Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. (2007)

Libioulle, Cécile, Louis, Edouard, Hansoul, Sarah, Sandor, Cynthia, Farnir, Frédéric, Franchimont, Denis, ...

To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three...

Validation of 16S rDNA sequencing in microdissected bowel biopsies from Crohn's disease patients to assess bacterial flora diversity (2006)

Aerssens, J, De Hoogt, R, Peeters, P, Verhasselt, P, Van Eyken, P, ...

The bowel flora is implicated in Crohn's disease (CD) pathogenesis but its precise role is still unclear. Several non-mutually exclusive hypotheses have been proposed: an unidentified persistent...

Dose-response effect of arabinoxylanoligosacharides on the colonic NH3- metabolism using lactose-(N-15, N-15')-ureide in healthy volunteers (2006)

Cloetens, Lieselotte; U0047008, Rutgeerts, Paul; U0007636, Swennen, Katrien; U0041940

The angiogenic chemokine granulocyte chemoattractant protein-2 (GCP-2) is selectively expressed by endothelial cells in ulcer beds in chronic inflammatory bowel diseases (IBD) (2006)

Gijsbers, Klara; U0038132, Rutgeerts, Paul; U0007636, Geboes, Karel; U0003611

Laser capture microdissection is compatible with 16s Rdna-based genomic technologies in bowel biopsies from Crohn's disease patients (2005)

Aerssens, J, De Hoogt, R, Peeters, P, Verhasselt, P, Van Eyken, P, ...

Anti-murine TNF-A reverses Tnbs colitis in mice but not oxazolone colitis: Potential role of apoptosis induction (2005)

Shen, Chong; U0037090, Maerten, Philippe; U0006925, Van Assche, Ge, Geboes, K, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358

Myenteric ganglionitis in unaffected ileal section margins predicts severe and early postoperative Crohn's disease recurrence (2005)

Hlavaty, T, D'Haens, G, Rutgeerts, Paul; U0007636, ...

Induction of tolerance by blockade of CD40L and B7-1: studies in the T cell transfer model of colitis (2005)

Maerten, Philippe; U0006925, Shen, Chong; U0037090, Geboes, K, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358

Agonistic Anti-4-1bb (cd 137) monoclonal antibody (mab) aggravates experimental colitis, but do not abrogate tolerance in the T cell transfer model of colitis (2005)

Maerten, PJ, Shen, Chong; U0037090, Cadot, Pascal; U0012786, ...

Effects of interleukin 4 on CD25(+)CD4(+) regulatory T cell function (2005)

Maerten, Philippe; U0006925, Shen, Chong; U0037090, Bullens, DM, Van Gool, Stefaan; U0011326, Geboes, K, ...

Immunomodulatory role of IL-4 on regulatory T cells in vitro and in experimentel colitis (2004)

Maerten, Philippe; U0006925, Shen, Chong; U0037090, Geboes, K, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358

NOD2/CARD15 and TLR4 gene polymorphisms and histopathological features of surgical specimens in Crohn's disease (2004)

Pierik, Marie; U0038547, Joossens, Sofie; U0015650, Claessens, G, Van Eyken, P, ...

Granulomas, pattern recognition receptors (PRR) and phenotypes of Crohn's disease (CD) (2004)

Joossens, Sofie; U0015650, Van Eyken, P, Claessens, G, ...

Effects of natalizumab on gut healing in a phase 3 study of active Crohn's disease therapy (ENACT-1) (2004)

Rutgeerts, Paul; U0007636, Allison, MC, Cortot, A, D'Haens, G, Dahlerup, JF, Hebuterne, X, ...

A fully human anti-TNF mAb adalimumab (D2E7) induces caspase-dependent apoptosis of human peripheral blood monocyte and T cells (2004)

Shen, Chong; U0037090, Maerten, Philippe; U0006925, Geboes, K, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358

Infliximab induces death of human monocytes in vitro and in the Thp-1-Scid mice model (2003)

Shen, Chong; U0037090, Colpaert, S, Maerten, Philippe; U0006925, Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, ...

Anti-murine TNF-alpha induces apoptosis of peritoneal macrophages from SCID mice (2003)

Shen, Chong; U0037090, Maerten, Philippe; U0006925, Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358

Role of CD137 (4-1BB) in the SCID T cell transfer colitis model (2003)

Maerten, Philippe; U0006925, Shen, Chong; U0037090, Cadot, Pascal; U0012786, Geboes, Karel; U0003611, Kwon, B, ...

Panel of serologic antibodies in patients with indeterminate colitis (2003)

Colombel, JF, Landers, CJ, Sendid, B, Poulain, D, ...

Pre-operative treatment with infliximab does not reduce the length of resected bowel in Crohn's disease (2003)

Marchal, Ludwig; U0041145, D'Haens, G, D'Hoore, A, Geboes, Karel; U0003611, ...

IL-12 modulates regulatory T cells in vitro and in a model of colitis (2003)

Maerten, Philippe; U0006925, Shen, Chong; U0037090, Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Ceuppens, Jan; U0014358

CD4+ T cells mediate epithelial colonic barrier and secretory function in SCID mice (2003)

Suenaert, PPA, Maerten, Philippe; U0006925, Bulteel, V, Geboes, Karel; U0003611, Ceuppens, JL, ...

Basic fibroblast growth factor (BFGF) as a response parameter to infliximab (Remicade)in fistulizing Crohn's disease (2003)

Gao, Q, Verspaget, HW, Lamers, CB, Rutgeerts, Paul; U0007636, Geboes, Karel; U0003611, Van Deventer, SJ, ...

Infliximab targets mucosal inflammatory cells, resulting in histological and endoscopic healing in patients with Crohn's disease (2003)

Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Tilg, H

Magnesium chloride slows gastric emptying, but does not affect digestive functions (2002)

Geboes, K P, Maes, B, Luypaerts, A, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088, ...

BACKGROUND: An inverse relationship has been established between serum magnesium and serum lipid levels. By means of breath tests, we tested the hypothesis that magnesium inhibits intraluminal lipid...

Clinical improvement precedes mucosal healing in ulcerative colitis treated with anti-IL-2-agents (2002)

Claessens, C, Dalle, I, D'Haens, G, Geboes, K, Rutgeerts, Paul; U0007636

4-1BB (CD137) is expressed in Crohn's disease patients and enhances proliferation of lamina propria T cells (2002)

Maerten, PP, Colpaert, S, Chen, C, Geboes, K, ...

Crohn's-like pattern in colonic mucosal biopsies in mycophenolate-mofetil treated patient: a link to side effects? (2002)

Dalle, IJ, Maes, BD, Geboes, KP, Geypens, Benny; U0001694, ...

Infliximab induces apoptosis of human monocytes in vitro and in THP-1-SCID-mice model (2002)

Shen, Chong; U0037090, Colpaert, S, Maerten, Philippe; U0006925, Geboes, K, Rutgeerts, Paul; U0007636, ...

The role of aminosalicylates in the treatment of ulcerative colitis. (2002)

Van Assche, Gert, Baert, Filip, De Reuck, Marc, Devos, Martine, De Wit, Olivier, Hoang, Pierre, ...

Aminosalicylates (5-ASA, sulfasalazine and mesalazine) play a central role in the treatment of ulcerative colitis (UC). For acute treatment of mild to moderate flares and in maintenance treatment,...

Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis (2001)

D'Haens, G, Lemmens, L, Geboes, K, Vandeputte, L, Van Acker, F, ...

BACKGROUND & AIMS: Cyclosporine has been effective in patients with steroid-refractory attacks of ulcerative colitis (UC). We investigated the effects of intravenous (IV) cyclosporine as single IV...

Tc-99m HMPAO white blood cell scintigraphy in the assessment of the extent and severity of an acute exacerbation of ulcerative colitis (2001)

Bennink, R, Peeters, M, D'Haens, G, Rutgeerts, Paul; U0007636

PURPOSE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with frequent exacerbations, including the risk for toxic megacolon and severe complications. In very active disease,...

Gastric unusual lymphoid infiltrates - as marginal zone cell lymphomas (MZCL) - may regress after Helicobacter pylory (Hp) eradication (2001)

Driessen, A, Peeters, M, Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, Geboes, K, ...

Long-term outcome of treatment with cyclosporine IV for patients with intractable ulcerative colitis (2001)

Arts, J, Zeegers, M, D'Haens, G, Geboes, K, ...

In vitro evaluation of IL-18 effects in Crohn's disease (2001)

Maerten, Philippe; U0006925, Colpaert, Stefaan; U0021314, Liu, Z, Geboes, K, Ceuppens, Jan; U0014358, Rutgeerts, Paul; U0007636, ...

The use of humanized, anti interleukin-2 receptor antibodies (ZenapaxR, Roche) in refractory ulcerative colitis (2001)

Dalle, Ignace; U0034587, Noman, M, Aerden, I, Swijsen, C, Maes, B, ...

Like low grade marginal zone B-cell lymphomas (MZCL), atypical lymphoid infiltrates in stomach may regress after Helicobacter Pylori eradication (2001)

Driessen, A, Peeters, M, Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, Geboes, K, ...

Prospective evaluation of endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) for pancreatic lesions (2001)

Claessens, C, Bourgeois, S, Schurmans, P, Delvaux, Veerle; U0034590, ...

Anticorps anti-saccharomyces cerevisiae (ASCA) et anticorps anti-cytoplasme des polynucleaires neutrophiles (pANCA): étude prospective dans les colites inclassées (2001)

Reinisch, W, Sendid, B, Poulain, D, Peeters, M, ...

Genome-wide scanning in a Belgian IBD population reveals novel linkages and validates previous linkages (2001)

Joossens, Sofie; U0015650, Esters, Nele; U0034784, Peeters, M, Rutgeerts, Paul; U0007636

CT-colonography : experiences at the Uni-Hospital of Leuven (2001)

Thomeer, M, Van Beckevoort, D, Bielen, Didier; U0007495, Rutgeerts, Paul; U0007636, ...

International workshop on 3D imaging and virtual endoscopy, February 1-3, 2001, Essen, Germany

Faecal tagging, a possible relief in patient preparation (2001)

Bielen, Didier; U0007495, Dymarkowski, Steven; U0016915, Thomeer, M, Van Beckevoort, D, Gevers, Ann; U0004702, Rutgeerts, Paul; U0007636, ...

XIIIth Belgian week of gastroenterology, March 2001, Knokke, Belgium

The effects of smoking and indomethacin on small intestinal permeability (2000)

Suenaert, Peter; U0019635, Bulteel, Veerle; U0012256, Hiele, Martin; U0011266, Peeters, M, Monsuur, F, ...

BACKGROUND: Smoking modulates inflammatory bowel disease, protecting from ulcerative colitis on the one hand and worsening the course of Crohn's disease on the other. This influence might occur...

Tumour necrosis factor (TNF) gene polymorphism in Crohn's disease (CD): influence on disease behaviour? (2000)

Louis, E, Peeters, M, Franchimont, D, Seidel, L, Fontaine, F, Demolin, G, ...

Crohn's disease (CD) is a multifactorial disease with genetic heterogeneity. TNF-alpha plays a key role in the development of the mucosal lesions. The aim of our work was to study a single base pair...

Phenotypical and functional characterization of the antigen presenting cell in Crohn's disease (2000)

Colpaert, SA, Vanstraelen, K, Liu, Z, Adé, M, Geboes, K, Ceuppens, Jan; U0014358, ...

Are anti-saccharomyces cerevisiae antibodies (ASCA) and perinuclear antineutrophil cytoplasmic antibodies (pANCA) useful in indeterminate colitis? A prospective follow-up study (2000)

Cassagnou, M, Peeters, M, Geboes, K, ...

Anti-interleukin 12 antibody prevents experimental colitis in SCID mice reconstituted with CD45RBHIGH CD4+ T cells (2000)

Liu, Z, Colpaert, Stefaan; U0021314, Overbergh, Lutgart; U0016266, Heremans, H, Ceuppens, Jan; U0014358, Geboes, Karel; U0003611, ...

Comparative study on the in vivo efficacy of metronidazole, aztreonam and amoxycillin/clavulanic acid in the indomethacin model/ evidence for immuno-modulatory properties of metronidazole (2000)

Colpaert, SA, Liu, Z, Ceuppens, Jan; U0014358, Geboes, K, Rutgeerts, Paul; U0007636

Surgery is associated with fluctuations in ASCA levels suggesting antigenic stimulation (2000)

Sendid, B, Cassagnou, M, Joossens, Sofie; U0015650, Collet, F, Quandalle, P, ...

Is ASCA (anti-Saccharomyces cerevisiae antibodies) related to the major histocompatibility complex (HLA)? (2000)

Vlietnick, R, Fajardy, I, Danze, PM, Peeters, M, Joossens, Sofie; U0015650, ...

Replication of linkage on 14q11-12 in inflammatory bowel disease (IBD) (2000)

Groenen, P, Peeters, M, Rutgeerts, Paul; U0007636

ASCA and pANCA do not predict response to anti-TNFA (Remicade (R)) treatment (2000)

Joossens, Sofie; U0015650, Peeters, M, Rutgeerts, Paul; U0007636

Positron emission tomography (PET) compared to EUS & spiral CT in staging of patients with potentially operable esophageal carcinoma (2000)

Flamen, P, Bourgeois, S, Peeters, M, Van Cutsem, Eric; U0003840, Lerut, Antoon; U0004205, ...

Response to anti-TNFAtreatment is associated with the TNFA-308*1 allele (2000)

Monsuur, F, Groenen, P, Peeters, M, Rutgeerts, Paul; U0007636

Diagnostic value of ASCA (anti-saccharomyces cerevisae antibodies) and pANCA (perinuclear antineutrophil cytoplasmic antibodies) in inflammatory bowel disease (2000)

Peeters, M, Joossens, Sofie; U0015650, Monsuur, F, Rutgeerts, Paul; U0007636

Validation of the lactose-[13C]ureide breath test for determination of orocecal transit time by scintigraphy (1999)

Geypens, Benny; U0001694, Bennink, R, Peeters, M, Maes, B, ...

The breath test using oral administration of a 13C-labeled substrate, lactose-ureide (LU), to measure orocecal transit time (OCTT) was validated against 99mTc-scintigraphy. Although LU is not...

Deconvolution of octanoic acid breath test results to produce gastric emptying curves, correlating well with scintigraphy (1999)

Geypens, Benny; U0001694, Luypaerts, A, Maes, B, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088

Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis (1999)

Baert, F J, D'Haens, G R, Peeters, M, Hiele, Martin; U0011266, Schaible, T F, Shealy, D, ...

BACKGROUND & AIMS: Anti-tumor necrosis factor alpha monoclonal antibody treatment (infliximab) reduces clinical signs and symptoms in patients with Crohn's disease. The effects of infliximab on...

cA2 can upregulate TCR/CD3 complex-mediated CD28-triggered IFN-gamma production in pathological ileal Crohn's disease (1999)

Colpaert, Stefaan; U0021314, Liu, Z, Adé, M, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...

Proinflammatory effects of IL-10 in pathological ileal Crohn's disease (1999)

Colpaert, Stefaan; U0021314, Liu, Z, Adé, M, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...

Are lympho-epithelial lesions the diagnostic hallmark of gastric marginal zone cell lymphomas (1999)

Driessen, A, Ectors, Nadine; U0016969, Peeters, M, Demeester, X, Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, ...

The diagnostic problem of gasric unusual lymphoid infiltrates is not solved by the scoring scale of Wotherspoon (1999)

Driessen, A, Ectors, Nadine; U0016969, Peeters, M, Demeester, X, Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, ...

CD40 ligand is overexpressed and induces cytokine production in inflammatory bowel disease (1999)

Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...

Interleukin-15 induces T cell activation in inflammatory bowel disease (1999)

Liu, Z, Colpaert, Stefaan; U0021314, Ade, M, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...

Blockade of CD40 signaling improves experimental colitis in scid mice (1999)

Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, G, Ceuppens, Jan; U0014358, Geboes, K, ...

CD40 can be a stronger costimulatory signal than CD80 in upregulating TNF production in pathological ileal Crohn's disease (1999)

Colpaert, SA, Liu, Z, Ade, M, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...

The scoring scale of Wotherspoon is not useful in diagnosis of gastric unusual lymphoid infiltrates (1999)

Driessen, A, Ectors, Nadine; U0016969, Peeters, M, Demeester, X, Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, ...

Hyperexpression of CD40 ligand and its role in pathogenic cytokine producton in inflammatory bowel disease (1999)

Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, GR, Ceuppens, JL, Rutgeerts, Paul; U0007636, Geboes, K

Effect of cA2 on pathological ileum of Crohn's disease: not merely TNF down regulation (1999)

Colpaert, Stefaan; U0021314, Liu, Z, Ade, M, D'Haens, G, Rutgeerts, Paul; U0007636, Geboes, K, ...

Inflammatory lesions of the myenteric plexus in Crohn's disease (1999)

Geboes, K, Rutgeerts, Paul; U0007636

Falk Symposium 106

Can Tc99m-HMPAO WBC scintigraphy predict early therapy response in severe attacks of ulcerative colitis? (1999)

Bennink, R, Peeters, M, D'Haens, G, Rutgeerts, Paul; U0007636

Evaluation of small-bowel transit for solid and liquid test meal in healthy men and women (1999)

Bennink, R, Peeters, M, Geypens, Benny; U0001694, Rutgeerts, Paul; U0007636, De Roo, Michel; U0010768, ...

Evaluation of severe functional gastrointestinal motility disorders requires an investigation of the entire gastrointestinal tract. This should be possible with a single radionuclide imaging study....

Fine mapping a susceptibility locus on the X chromosome in the Belgian population in inflammatory bowel disease (IBD) (1999)

Vermeire, SAAR, Satsangi, J, Peeters, M, Parkes, M, Jewell, D, ...

The value of anti-Saccharomyces cerevisiae antibodies (ASCA) as subclinical marker in Crohn's disease (CD) (1999)

Peeters, M, Joossens, Sofie; U0015650, Dantonio, R, Bossuyt, L, Sendid, B, ...

The relationship between the presence of ASCA antibodies and increased intestinal permeability in Crohn's disease (1999)

Peeters, M, Dantonio, R, Joossens, Sofie; U0015650, Sendid, B, Poulain, D, ...

ASCA and PANCA prevalence in mixed-IBD families (1999)

Peeters, M, Dantonio, R, Joossens, Sofie; U0015650, Bossuyt, L, Sendid, B, ...

Comparison of total and compartmental gastric emptying and antral motility between healthy men and women (1998)

Bennink, R, Peeters, M, Geypens, Benny; U0001694, Rutgeerts, Paul; U0007636, De Roo, Michel; U0010768, ...

There is increasing evidence of gender-related differences in gastric emptying. The purpose of this study was first, to confirm the difference in gastric emptying for both solid and liquid test meals...

Evidence for impaired assimilation and increased colonic fermentation of protein, related to gastric acid suppression therapy (1998)

Evenepoel, Pieter; U0034199, Claus, D, Geypens, Benny; U0001694, Maes, B, Hiele, Martin; U0011266, Rutgeerts, Paul; U0007636, ...

BACKGROUND: Although the role of gastric digestion (by acid-dependent pepsins) in overall protein assimilation has never thoroughly been studied, it is generally considered to be limited. Protein...

In vivo butyrate metabolism and colonic permeability in extensive ulcerative colitis (1998)

Hiele, Martin; U0011266, Peeters, M, Ghoos, Yvo; U0005088, Rutgeerts, Paul; U0007636

BACKGROUND & AIMS: Impaired short-chain fatty acid metabolism by the colonocyte has been suggested as a pathogenic factor in ulcerative colitis (UC). The aim of this study was to measure in vivo...

Bone turnover during short-term therapy with methylprednisolone or budesonide in Crohn's disease (1998)

D'Haens, G, Verstraete, Anneli; U0004977, Cheyns, K, Aerden, I, Bouillon, Roger; U0010150, Rutgeerts, Paul; U0007636

BACKGROUND: Glucocorticosteroids are used frequently for the treatment of relapses of Crohn's disease. AIM: To investigate the influence of the new topically active glucocorticosteroid budesonide in...

Simultaneous measurement of gastric emptying and orocecal transit in children using C-13 breath tests (1998)

Geypens, Benny; U0001694, Van Den Driessche, Mieke; U0006407, Maes, B, Veereman, Genevieve; U0017937, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088

The lactose-(C-13)-ureide breath test in combination with the (C-14)-octanoate breath test to assess pharmacological modulation by erythromycin and propantheline of proximal gastro-intestinal transit (1998)

Geypens, Benny; U0001694, Maes, B, Ghoos, Yvo; U0005088, Rutgeerts, Paul; U0007636

Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil (1998)

Macken, E, Gevers, Anna-Maria; U0004709, Hendrickx, A, Rutgeerts, Paul; U0007636

BACKGROUND: The efficacy and tolerance of midazolam (Dormicum R) versus diazepam in lipid emulsion (Diazemuls R, Dumex) was evaluated in a randomized, controlled, double-blind trial in 200 patients...

Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum (1998)

D'Haens, G R, Geboes, K, Peeters, M, Baert, Frank; U0004588, Penninckx, Freddy; U0018132, Rutgeerts, Paul; U0007636

BACKGROUND & AIMS: Postoperative recurrence of Crohn's disease may be triggered by agents in the fecal stream. The aim of this study was to examine intestinal mucosal inflammation induced by contact...

Expression of interleukin-15 in inflammatory bowel disease (1998)

Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, G, Ceuppens, Jan; U0014358, Geboes, K, ...

Expression of CD40 and CD40L in inflammatory bowel disease (1998)

Liu, Z, Colpaert, Stefaan; U0021314, D'Haens, G, Ceuppens, Jan; U0014358, Geboes, K, ...

The presence and severity of neural inflammation predict severe postoperative recurrence of Crohn's disease (1998)

D'Haens, G, Colpaert, Stefaan; U0021314, Peeters, M, Baert, Frank; U0004588, Penninckx, Freddy; U0018132, Rutgeerts, Paul; U0007636, ...

Intravenous cyclosporine (CyA) monotherapy versus intravenous methylprednisolone (MP) monotherapy in severe ulcerative colitis: a randomized, double blind controlled trial (1998)

Lemmens, L, Vandeputte, L, Peeters, M, ...

Efficacy of anti-TNF in comparison with metronidazole in the indomethacin-induced small bowel inflammation model (1998)

Colpaert, Stefaan; U0021314, Liu, Z, Degreef, B, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...

Diminshed sensitivity of ileal lamina propria mononuclear cells to the inhibitory effect of IL-10 in Crohn's disease (1998)

Colpaert, Stefaan; U0021314, Liu, Z, Ade, M, D'Haens, G, Geboes, K, Ceuppens, Jan; U0014358, ...

Comparison of endorectal ultrasound and CT-scan in the preoperative staging of colorectal cancer (1998)

Hiele, Martin; U0011266, Gevers, Anna-Maria; U0004709, Mertens, Luc; U0010600, Van Hoe, L, Van Cutsem, Eric; U0003840, Macken, L, ...

Are collagenous and lymphocytic colitis one disease? A histologic analysis of 178 cases (1998)

Wouters, K, Baert, Frank; U0004588, Sempoux, C, Tanghe, W, Marichal, M, Cuvelier, C, ...

Cytoplasmic accumulation of p53 occurs in intestinal metaplasia associated with gastric ulcers but not with duodenal ulcers (1998)

Driessen, A, Ectors, Nadine; U0016969, Chen, I, Peeters, M, Van Cutsem, Eric; U0003840, ...

Microscopic Barrett's esophagus: relationship to acid and bile reflux in man (1998)

Van Vaerenbergh, W, Tack, Jan; U0015849, Geboes, K, Gevers, Anna-Maria; U0004709, Rutgeerts, Paul; U0007636, Lerut, Antoon; U0004205, ...

No evidence for linkage on chromosome 16-12-7 and 3 in the Belgian population may reflect genetic heterogeneity of inflammatory bowel disease (1998)

Peeters, M, Parkes, M, Satsangi, J, Jewell, D, ...

Genetics of inflammatory bowel disease: Contribution of the X chromosome (1998)

Satsangi, J, Parkes, M, Peeters, M, Vyas, P, Rutgeerts, Paul; U0007636, ...

Tc99m-HMPAO white blood cell scintigraphy is useful in the assessment of the extent and severity of an acute exacerbation of ulcerative colitis (1998)

Peeters, M, Bennink, R, D'Haens, G, Baert, Frank; U0004588, Rutgeerts, Paul; U0007636

Confirmation of the importance of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease (1998)

Peeters, M, Dantonio, R, Baert, Frank; U0004588, D'Haens, G, ...

Direct demonstration of the effect of lactulose on colonic bacterial metabolism by application of lactose-(N-15)-ureide (1998)

Geypens, Benny; U0001694, Peeters, M, Luypaerts, A, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088

Microscopic Barrett's esophagus: Relationship to acid and bile reflux in man (1998)

Van Vaerenbergh, W, Tack, Jan; U0015849, Geboes, K, Gevers, Anna-Maria; U0004709, Rutgeerts, Paul; U0007636, Lerut, Antoon; U0004205, ...

Influence of dietary protein supplements on the formation of bacterial metabolites in the colon (1997)

Geypens, Benny; U0001694, Claus, D, Hiele, Martin; U0011266, Maes, B, Peeters, M, ...

BACKGROUND: To evaluate the influence of increased dietary protein intake on bacterial colonic metabolism in healthy volunteers. METHODS: Short chain fatty acids, ammonia, and volatile organic...

Helicobacter pylori infection and growth delay in older children (1997)

Perri, F, Pastore, M, Leandro, G, Clemente, R, Ghoos, Yvo; U0005088, Peeters, M, ...

It is thought that Helicobacter pylori infection may influence growth rate in children. The aim of this study was to evaluate the prevalence of H pylori infection in healthy Italian children, and to...

DNA polymorphism in the human motilin gene in inflammatory bowel disease (1997)

Declercq, Peggy, Peeters, M, Cheyns, K, Depoortere, Inge; U0009906, Gasparini, P, Rutgeerts, Paul; U0007636, ...

Endogenous and exogenous protein, escaping digestion and absorption in the small intestine after ingestion of a physiological load of egg protein (1997)

Geypens, Benny; U0001694, Maes, B, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088

The intraluminal digestion is a rate limiting step in the assimilation process of egg protein (1997)

Geypens, Benny; U0001694, Maes, B, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088

Endometriosis and Crohn's disease (1997)

Cokelaere, K, Ectors, Nadine; U0016969, Baert, Frank; U0004588, Rutgeerts, Paul; U0007636, Geboes, K

Orocaecal transit time: The lactose-C-13-ureid breath test shows a good correlation with scintigraphy (1997)

Geypens, Benny; U0001694, Bennink, R, Peeters, M, Vandenmaegdenbergh, V, ...

Lactulose causes an important and unpredictable acceleration of the orocaecal transit time (1997)

Geypens, Benny; U0001694, Peeters, M, Maes, B, Luypaerts, A, Rutgeerts, Paul; U0007636, ...

Comparison of total and regional gastric emptying and antral motility between normal men and women (1997)

Bennink, R, Peeters, M, VandenMaegdenbergh, V, Geypens, Benny; U0001694, Ghoos, Yvo; U0005088, Rutgeerts, Paul; U0007636, ...

No evidence for genetic anticipation in Crohn's disease (1997)

Grandbastien, B, Peeters, M, Franchimont, D, GowerRousseau, C, Rutgeerts, Paul; U0007636, Belaiche, J, ...

Presence of pANCA in Crohn's patients with ''UC-like'' clinical, phenotype is related to disease activity (1997)

Peeters, M, Rutgeerts, Paul; U0007636, Cheyns, K, Baert, Frank; U0004588, DHaens, G

Screening for colorectal cancer (1996)

Van Cutsem, Eric; U0003840, Tejpar, Sabine; U0016241, Rutgeerts, Paul; U0007636, Janssens, J

The authors review the place of faecal occult blood testing, sigmoidoscopy and total colonoscopy in the screening of colorectal cancer. Strategy in high risk patients is also discussed.

Gastric digestion plays a substantial role in normal protein assimilation (1996)

Hiele, Martin; U0011266, Geypens, Benny; U0001694, Maes, B, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088

Egg protein assimilation in pancreatic disease studied with a C-13 egg white breath test (1996)

Hiele, Martin; U0011266, Geypens, Benny; U0001694, Maes, B, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088

Volatile organic fermentation products in the mouth (1996)

Geypens, Benny; U0001694, Claus, D, Rutgeerts, Paul; U0007636, Hiele, Martin; U0011266, Maes, B, Ghoos, Yvo; U0005088

Colorectal cancer in colonic Crohn's disease-High frequency of DNA-aneuploidy (1996)

Löfberg, R, Befrits, R, Sjökvist, U, Karlen, P, Ost, A, Rubio, C, ...

Recurrence of Crohn's disease after ileal resection: is prophylaxis useful (1996)

Rutgeerts, Paul; U0007636, Geboes, K

Staging of rectal tumors by means of endoscopic ultrasound (1996)

Hiele, Martin; U0011266, Kockaerts, Y, Schurmans, P, Geboes, K, Rutgeerts, Paul; U0007636

The prevalence of lymphoid follicles and aggregates in the gastric mucosa from neonatal period to young adulthood (1996)

Ectors, Nadine; U0016969, Driessen, A, Veereman, Genevieve; U0017937, Rutgeerts, Paul; U0007636, Geboes, K

Osteoblast function is suppressed by oral methylprednisolone but not by budesonide CIR in active ileocolonic Crohn's disease (1996)

DHaens, G, Verstraete, Anneli; U0004977, Baert, Frank; U0004588, Peeters, M, Bouillon, Roger; U0010150, Rutgeerts, Paul; U0007636

Increasing TNF-alpha and decreasing IFN-gamma tissue concentrations in early recurrent Crohn's disease and correlation with endoscopic lesions (1996)

DHaens, G, Peeters, M, Baert, Frank; U0004588, Cheyns, K, Geboes, K, Ceuppens, Jan; U0014358, ...

High age adjusted risk for daughters of patients with Crohn's disease (1996)

Peeters, M, Nevens, H, Hiele, Martin; U0011266, Rutgeerts, Paul; U0007636

Concordance in clinical characteristics of Crohn's disease: A within generation phenomenon (1996)

Peeters, M, Nevens, H, Hiele, Martin; U0011266, De Meyer, Anna Maria; U0008702, Rutgeerts, Paul; U0007636

The influence of isolated doses of drugs, feeding and colonic bacterial ureolysis on urea breath test results (1995)

Perri, F, Maes, B, Geypens, Benny; U0001694, Ghoos, Yvo; U0005088, Hiele, Martin; U0011266, Rutgeerts, Paul; U0007636

BACKGROUND: Aim of this work was to improve standardization of the 13C-urea breath test (13C-UBT) by evaluating the effect of drug administration, feeding and colonic ureolysis on the UBT results....

Successful treatment of a squamous papilloma of the hypopharynx-esophagus by local injections of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (1995)

Van Cutsem, Eric; U0003840, Snoeck, Robert; U0012760, Van Ranst, Marc; U0015875, Fiten, Pierre; U0001568, Opdenakker, Ghislain; U0015938, Geboes, Karel; U0003611, ...

Human papillomaviruses (HPV) are associated with benign lesions and show specificity towards the location or tissues that they infect. HPVs are responsible for warts. Among more than 60 different HPV...

Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection (1995)

Rutgeerts, Paul; U0007636, Hiele, Martin; U0011266, Geboes, K, Peeters, M, Penninckx, Freddy; U0018132, Aerts, Raymond; U0002616, ...

BACKGROUND/AIMS: New lesions recur within weeks to months after ileal resection and ileocolonic anastomosis for Crohn's ileitis. A double-blind controlled trial was performed using metronidazole to...

A separation model for breath test analysis (1995)

Maes, B, Mys, G, Ghoos, Yvo; U0005088, Rutgeerts, Paul; U0007636

Gastric metaplasia in the distal duodenum - Crohn's disease rather than peptic ulcer disease (1995)

Ectors, Nadine; U0016969, Geboes, K, Rutgeerts, Paul; U0007636, Broeckaert, L, D'Haens, G, Janssens, J

No induction of cytokine release by hsp-65 in biopsy cultures from crohns-disease patients (1995)

Peeters, M, Dhaens, G, Peetermans, Willy; U0017444, Ceuppens, Jan; U0014358, Geboes, K, Rutgeerts, Paul; U0007636

Increased proinflammatory cytokine production in macroscopically normal ileum and colon in crohns-disease (1995)

Peeters, M, Daenis, G, Ceuppens, Jan; U0014358, Peetemans, W, Geboes, K, Rutgeerts, Paul; U0007636

Clinical and immunological effects of ornidazole in active crohns-disease - an 8-week open-label trial (1995)

Dhaens, G, Peeters, M, Ceuppens, Jan; U0014358, Rutgeerts, Paul; U0007636

Azathioprine induces mucosal healing in severe recurrent crohns ileitis after surgery (1995)

Dhaens, G, Peeters, M, Geboes, K, Rutgeerts, Paul; U0007636

Increased permeability of macroscopically normal small bowel in Crohn's disease (1994)

Peeters, M, Ghoos, Yvo; U0005088, Maes, B, Hiele, Martin; U0011266, Geboes, K, Vantrappen, Gaston; U0017164, ...

To investigate permeability alterations of the macroscopically normal jejunum in Crohn's disease, the permeation of two probes was measured during perfusion of an isolated jejunal segment. The data...

Screening method for the determination of volatiles in biomedical samples by means of an off-line closed-loop trapping system and high-resolution gas chromatography-ion trap detection (1994)

Ghoos, Yvo; U0005088, Claus, D, Geypens, Benny; U0001694, Hiele, Martin; U0011266, Maes, B, Rutgeerts, Paul; U0007636

A method is described for the analysis of volatile organic compounds in biological matrices (faeces and urine). The technique is based on off-line preconcentration by means of a closed-loop trapping...

Influence of octreotide on gastric-emptying rate of solids, as measured by the c-14 octanoic-acid breath test (1994)

Maes, B, Rutgeerts, Paul; U0007636, Ghoos, Yvo; U0005088, Perri, F, Hiele, Martin; U0011266

The combined 13c-glycine/14c-octanoic acid breath test to monitor gastric-emptying rate of liquids and solids simultaneously (1994)

Maes, B, Ghoos, Yvo; U0005088, Geypens, Benny; U0001694, Rutgeerts, Paul; U0007636, Hiele, Martin; U0011266

Depressed T cell reactivity to recall antigens in Crohn's disease before and after surgical resection (1994)

D'Haens, G, Hiele, Martin; U0011266, Rutgeerts, Paul; U0007636, Geboes, K

Earlier studies regarding possible primary immune disturbances participating in the pathogenesis of Crohn's disease yielded conflicting results. Peripheral blood lymphocyte subsets and lymphocyte...

Recurrence of Crohn's disease after ileocolonic resection : endoscopic assessment (1994)

Rutgeerts, Paul; U0007636, Geboes, K

Squamous papilloma of the oesophagus and human papilloma virus (1994)

Van Cutsem, Eric; U0003840, Geboes, K, Snoeck, Robert; U0012760, Janssens, J, Rutgeerts, Paul; U0007636, De Clercq, Erik; U0003934

Mucosal expression of human heat shock proteins in Crohn's disease (1994)

D'Haens, G, Geboes, K, Rutgeerts, Paul; U0007636

Increased HSP-65 antibodies but decreased lymphocyte proliferative response to HSP-65 in Crohn's disease (1994)

D'Haens, G, Cueppens, J, Geboes, K, Rutgeerts, Paul; U0007636

Push enteroscopy has a higher yield for the diagnosis of the source of occult bleeding than sonde-type enteroscopy (1994)

Dewyspelaere, J, Rutgeerts, Paul; U0007636, Broeckaert, L, Willemse, P, Gevers, Anna-Maria; U0004709, Van Cutsem, Eric; U0003840, ...

RFD7-RFD9 coexpression by macrophages points to T cells. Macrophage interaction deficiency in Whipple's disease (1994)

Ectors, Nadine; U0016969, Geboes, K, Rutgeerts, Paul; U0007636, Delabie, J, Desmet, Valeer; U0011957, Janssens, J

Ulcerative jejunitis in patients with established ulcerative colitis (1994)

Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, Geboes, K, Desmet, Valeer; U0011957

Infusion of ileal fluid through diverted neoterminal ileum causes acute mucosal lesions in patients operated for Cronh's ileocolitis (1994)

Geboes, K, Rutgeerts, Paul; U0007636, Ectors, Nadine; U0016969

Scurvy in Whipple's disease: a rare complication of a malabsorption syndrome (1994)

Frans, Eric; U0002693, Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, Bobbaers, J

Simultaneous measurement of gastric-emptying rate of solids and rate of intraduodenal lipolysis by means of a dual-labeled breath test (1993)

Maes, B, Ghoos, Yvo; U0005088, Rutgeerts, Paul; U0007636, Hiele, Martin; U0011266, Vantrappen, Gaston; U0017164

Influence of dietary-protein supplements on formation of fecal volatile metabolites (1993)

Hiele, Martin; U0011266, Ghoos, Yvo; U0005088, Maes, B, Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164

Gastric-emptying rate of solids in non-dyspeptic pregnant-women using the c-13-octanoic acid breath test (1993)

Maes, B, Ghoos, Yvo; U0005088, Hiele, Martin; U0011266, Spitz, Bernard; U0013436, Rutgeerts, Paul; U0007636, Vanassche, A, ...

Microscopic lesions of the duodenum in Crohn's disease (1993)

Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, D'Haens, G, Geboes, K, Vantrappen, Gaston; U0017164

Interstitial thermotherapy for liver tumours : studies of different fibres and radiation characteristics (1993)

Hiele, Martin; U0011266, Gevers, Anna-Maria; U0004709, Van Eyken, P, Geboes, K, ...

Endoskopie bei entzündlichen Darmerkrankungen (1993)

Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164, Geboes, K

Inflammatory Bowel Disease. Crohn's disease and pre-aphthoid lesions (1993)

Rutgeerts, Paul; U0007636, Geboes, K

Demonstration of nitric oxide positive neurons in Crohn's disease (1993)

Geboes, K, Mebis, Joseph; U0009630, Rutgeerts, Paul; U0007636, Ectors, Nadine; U0016969, Vantrappen, Gaston; U0017164

Microscopic spectrum of duodenitis in Crohn's disease (1993)

Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, D'Haens, G, Geboes, K, Vantrappen, Gaston; U0017164

The role of fecal stream in recurrence of Crohn's disease in the neoterminal ileum (1992)

Rutgeerts, Paul; U0007636, Geboes, Karel; U0003611

A placebo controlled trial of metronidazole for recurrence prevention of Crohn's disease after resection of the terminal ileum (1992)

Rutgeerts, Paul; U0007636, Peeters, M, Hiele, Martin; U0011266, Kerremans, Raymond; U0016624, Aerts, Raymond; U0002616, ...

Different NSAIDS have different direct effects on human intestinal epithelial cells (1992)

Ectors, Nadine; U0016969, Geboes, Karel; U0003611, Desmet, Valeer; U0011957, Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164

Increased expression of high endothelial venule characteristics by epithelial cells in Crohn's disease (1991)

Peeters, M, Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164, Desmet, Valeer; U0011957, Meuwissen, S, ...

Infectious enterocolitis: diagnostic aspects and relation to chronic idiopathic inflammatory bowel disease (1991)

Rutgeerts, Paul; U0007636, Geboes, Karel; U0003611, Peeters, M, Vantrappen, Gaston; U0017164

Permeability for water soluble macromolecules is increased in macroscopically normal jejunal mucosa of patients with Crohn's disease (1991)

Rutgeerts, Paul; U0007636, Peeters, M, Ghoos, Yvo; U0005088, Hiele, Martin; U0011266, Geboes, Karel; U0003611, Vantrappen, Gaston; U0017164

Comparative study of low power neodymium-Yag laser interstitial hyperthermia versus ethanol injection for controlled hepatic tissue destruction (1991)

Van Eyken, P, Fevery, Johan; U0018702, Geboes, Karel; U0003611, Vantrappen, Gaston; U0017164, ...

Light microscopic, immunohistochemical and ultrastructural immunocytochemical follow-up study of Whipple's disease (1990)

Ectors, Nadine; U0016969, De Vos, Rita; U0012983, Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Desmet, Valeer; U0011957, Vantrappen, Gaston; U0017164

Lymphocyte interactions with smooth muscle cells and nerves (1990)

Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Desmet, Valeer; U0011957

Ch 21

Are section margins useful for the prediction of recurrence of Crohn's disease after all? (1990)

Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Ectors, Nadine; U0016969, Mebis, Joseph; U0009630, Desmet, Valeer; U0011957, Vantrappen, Gaston; U0017164

Treatment of bleeding gastrointestinal telangiectasias with estragen-progesterone (1989)

Van Cutsem, Eric; U0003840, Rutgeerts, Paul; U0007636, Geboes, Karel; U0003611, Vantrappen, Gaston; U0017164

Preliminary evidence that development of early Crohn's recurrence in the neoterminal ileium is fecal stream dependent (1989)

Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164, Geboes, Karel; U0003611

Interstitial Yag laser hyperthermia is more suitable for intrahepatic tumor destruction than alcoholisation (1989)

Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164, Fevery, F, Van Eyken, P, ...

The destruction of the autonomic nervous system in Crohn's disease is due to immunologic effector cells (1989)

Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Desmet, Valeer; U0011957, Vantrappen, Gaston; U0017164

Monocytes/macrophages of the human ileum in Crohn's disease a disturbed recruitment ? (1989)

Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Ectors, Nadine; U0016969, Desmet, Valeer; U0011957, Vantrappen, Gaston; U0017164

Pseudomelanosis of the esophagus (1989)

Geboes, Karel; U0003611, Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, Janssens, J, Vantrappen, Gaston; U0017164

Drug induced recurrent chronic gastric and small bowel ulcers: an x-ray spectroscopy analysis of mucosal biopsies (1989)

Ectors, Nadine; U0016969, Geboes, Karel; U0003611, Van Isveldt, J, Rutgeerts, Paul; U0007636, Desmet, Valeer; U0011957, Vantrappen, Gaston; U0017164

Immunological effector cells associated with the destruction of the autonomic nervous system in Crohn's disease (1989)

Ectors, Nadine; U0016969, Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Mebis, Joseph; U0009630, Desmet, Valeer; U0011957, ...

Estrogen-progesterone treatment of Osler-Weber-Rendu disease (1988)

Rutgeerts, Paul; U0007636, Geboes, Karel; U0003611, Van Gompel, F, Vantrappen, Gaston; U0017164

A 56-year-old woman with Osler-Weber-Rendu disease had longstanding iron deficiency anemia from recurrent melena. Since neither laser photocoagulation nor surgery were successful in stopping the...

Symptomatic gastrointestinal metastases from malignant melanoma (1988)

Geboes, Karel; U0003611, De Jaeger, E, Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164

Prevention of duodenal ulcer recurrence by pirenzepine 50 mg twice daily (1987)

Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164, Brassine, A, Van Maercke, Y, Pen, J, Pelckmans, P, ...

Eighty-four patients with healed duodenal ulcers were treated for 1 year with pirenzepine, 50 mg twice daily, or placebo in this double-blind, randomized, multicenter trial. Clinical follow-up and...

Endoscopic contact Nd-Yag laser therapy for colorectal cancer : a randomized comparison with non-contact therapy (1987)

Rutgeerts, Paul; U0007636, Vantrappen, Gaston; U0017164, D'Heygere, F, Geboes, Karel; U0003611

Endoscopic findings in the neoterminal ileum within one year of surgery for Crohn's disease accurately predict further endoscopic and clinical outcome (1987)

Rutgeerts, Paul; U0007636, Geboes, Karel; U0003611, Vantrappen, Gaston; U0017164, Beyls, J, Kerremans, Raymond; U0016624

Left-sided colitis : how localized is it ? (1987)

Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Ectors, Nadine; U0016969, Vantrappen, Gaston; U0017164

Distal ulcerative colitis is mostly accompanied by inflammatory lesions of the cecum : results of a prospective endoscopic study (1987)

Geboes, Karel; U0003611, Rutgeerts, Paul; U0007636, Ectors, Nadine; U0016969, Vantrappen, Gaston; U0017164

Light microscopic and ultrastructural immunocytochemical study of Whipple's disease (1987)

Geboes, Karel; U0003611, De Vos, Rita; U0012983, Rutgeerts, Paul; U0007636, Desmet, Valeer; U0011957, Vantrappen, Gaston; U0017164

How localized is ulcerative proctitis ? (1987)

Ectors, Nadine; U0016969, Rutgeerts, Paul; U0007636, Geboes, Karel; U0003611, Desmet, Valeer; U0011957, Vantrappen, Gaston; U0017164