Toyoda, Hiroki, Zhao, Ming-Gao, Ulzhöfer, Bettina, Wu, Long-Jun, Xu, Hui, Seeburg, Peter H, ...
Abstract Cortical areas including the anterior cingulate cortex (ACC) are important for pain and pleasure. Recent studies using genetic and physiological approaches have demonstrated that the...
Sanderson, David J., Good, Mark A., Skelton, Kathryn, Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., ...
The GluA1 AMPA receptor subunit is a key mediator of hippocampal synaptic plasticity and is especially important for a rapidly-induced, short-lasting form of potentiation. GluA1 gene deletion impairs...
Of Spatiotemporal Discontiguity, Wolfram B. Schmitt, Roozbeh Arianpour, Peter H. Seeburg, Rolf Sprengel, ...
Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluR-A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild-type and sham-operated controls,...
Bannerman, David M., Niewoehner, Burkhard, Lyon, Louisa, Romberg, Carola, Schmitt, Wolfram B., Taylor, Amy, ...
NMDA receptors (NMDARs) containing NR2A ({varepsilon}1) subunits are key contributors to hippocampal long−term potentiation (LTP) induction in adult animals and have therefore been widely...
The role of the GluR−A (GluR1) AMPA receptor subunit in learning and memory (2008)
Sanderson, D. J., Good, M. A., Seeburg, Peter H., Sprengel, Rolf, Rawlins, J. N. P., Bannerman, D. M.
It is widely believed that synaptic plasticity may provide the neural mechanism that underlies certain kinds of learning and memory in the mammalian brain. The expression of long−term potentiation...
Luo, Ceng, Seeburg, Peter H., Sprengel, Rolf, Kuner, Rohini
The second messenger calcium is a key mediator of activity−dependent neural plasticity. How persistent nociceptive activity alters calcium influx and release in the spinal cord is not...
Role of GluR1 in activity−dependent motor system development (2008)
Zhang, Lujia, Schessl, Joachim, Werner, Markus, Bonnemann, Carsten, Xiong, Guoxiang, Mojsilovic−Petrovic, Jelena, ...
Activity−dependent specification of neuronal architecture during early postnatal life is essential for refining the precision of communication between neurons. In the spinal cord under normal...
Von Engelhardt, Jakob, Doganci, Beril, Jensen, Vidar, Hvalby, Øivind, Göngrich, Christina, Taylor, Amy, ...
Controversy revolves around the differential contribution of NR2A− and NR2B−containing NMDA receptors, which coexist in principal forebrain neurons, to synaptic plasticity and learning in the...
Silencing and un−silencing of tetracycline−controlled genes in neurons (2007)
Zhu, P. H., Aller, M. I., Baron, U., Cambridge, S., Bausen, Melanie, Herb, Jan, ...
Excitotoxicity in vitro by NR2A− and NR2B−containing NMDA receptors (2007)
Von Engelhardt, Jakob, Coserea, Irina, Pawlak, Verena, Fuchs, Elke, Köhr, Georg, Seeburg, Peter H., ...
Excitotoxicity, exacerbating acute brain damage from brain trauma or stroke, is mediated in part by excessive Ca2+−influx from prolonged NMDA receptor activation. However, the contribution to...
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy (2007)
Tan, Heneu, Reid, Christopher, Single, Frank Nicolai, Davies, Philip, Chiu, Cindy, Murphy, Susan, ...
Mutations in the GABAA receptor {gamma}2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed...
Select overexpression of Homer1a in dorsal hippocampus impairs spatial working memory (2007)
Celikel, Tansu, Marx, Verena, Freudenberg, Florian, Zivkovic, Aleksandar, Resnik, Evgeny, Hasan, Mazahir T., ...
Long Homer proteins forge assemblies of signaling components involved in glutamate receptor signaling in postsynaptic excitatory neurons, including those underlying synaptic transmission and...
Gene expression analysis of in vivo fluorescent cells (2007)
Khodosevich, Konstantin, Inta, Dragos, Seeburg, Peter H., Monyer, Hannah
Silencing and un−silencing of tetracycline−controlled genes in neurons (2007)
Zhu, P. H., Aller, M. I., Baron, U., Cambridge, S., Bausen, Melanie, Herb, Jan, ...
Excitotoxicity in vitro by NR2A− and NR2B−containing NMDA receptors (2007)
Von Engelhardt, Jakob, Coserea, Irina, Pawlak, Verena, Fuchs, Elke, Köhr, Georg, Seeburg, Peter H., ...
Excitotoxicity, exacerbating acute brain damage from brain trauma or stroke, is mediated in part by excessive Ca2+−influx from prolonged NMDA receptor activation. However, the contribution to...
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy (2007)
Tan, Heneu, Reid, Christopher, Single, Frank Nicolai, Davies, Philip, Chiu, Cindy, Murphy, Susan, ...
Mutations in the GABAA receptor {gamma}2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed...
Select overexpression of Homer1a in dorsal hippocampus impairs spatial working memory (2007)
Celikel, Tansu, Marx, Verena, Freudenberg, Florian, Zivkovic, Aleksandar, Resnik, Evgeny, Hasan, Mazahir T., ...
Long Homer proteins forge assemblies of signaling components involved in glutamate receptor signaling in postsynaptic excitatory neurons, including those underlying synaptic transmission and...
Bonn, Stefan, Seeburg, Peter H., Schwarz, Martin K.
Alpha− and gamma−protocadherins (Pcdhs) are type I transmembrane receptors expressed predominantly in the central nervous system and located in part in synapses. They are transcribed from complex...
Complex, multimodal behavioral profile of the Homer1 knockout mouse (2007)
Jaubert, P. J., Golub, M. S., Lo, Y. Y., Germann, S. L., Dehoff, M. H., Worley, P. F., ...
Proteins of the Homer1 immediate early gene family have been associated with synaptogenesis and synaptic plasticity suggesting broad behavioral consequences of loss of function. This study examined...
Niewoehner, B., Single, Frank Nicolai, Hvalby, Ø., Jensen, V., Seeburg, Peter H., ...
Novel spatially restricted genetic manipulations can be used to assess contributions made by synaptic plasticity to learning and memory, not just selectively within the hippocampus, but even within...
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy (2007)
Tan, Heneu O., Reid, Catherine, Single, Frank N., Davies, Philip J., Chiu, Chun-Jen, Murphy, Susan, ...
Copyright © 2007 by The National Academy of Sciences of the USA
Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy (2007)
Tan, Heneu O., Reid, Catherine, Single, Frank N., Davies, Philip J., Chiu, Chun-Jen, Murphy, Susan, ...
Copyright © 2007 by The National Academy of Sciences of the USA
Shimshek, Derya R., Jensen, Vidar, Celikel, Tansu, Geng, Yu, Schupp, Bettina, Bus, Thorsten, ...
We demonstrate the fundamental importance of glutamate receptor B (GluR−B) containing AMPA receptors in hippocampal function by analyzing mice with conditional GluR−B deficiency in postnatal...
Shimshek, Derya R., Jensen, Vidar, Celikel, Tansu, Geng, Yu, Schupp, Bettina, Bus, Thorsten, ...
We demonstrate the fundamental importance of glutamate receptor B (GluR−B) containing AMPA receptors in hippocampal function by analyzing mice with conditional GluR−B deficiency in postnatal...
Shimshek, Derya R., Bus, Thorsten, Grinevich, Valery, Single, Frank Nicolai, Mack, Volker, Sprengel, Rolf, ...
The roles of ionotropic glutamate receptors in mammalian reproduction are unknown. We therefore generated mice lacking a major subtype of...
Modulation of microRNA processing and expression through RNA editing by ADAR deaminases (2006)
Yang, Weidong, Chendrimada, Thimmaiah, Wang, Qingde, Higuchi, Miyoko, Seeburg, Peter H., Shiekhattar, Ramin, ...
Adenosine deaminases acting on RNA (ADARs) are involved in editing of adenosine residues to inosine in double−stranded RNA (dsRNA). Although this editing recodes and alters functions of several...
Derya R. Shimshek, Thorsten Bus, Jinhyun Kim, Andre Mihaljevic, Volker Mack, Peter H. Seeburg, ...
Genetic manipulation of AMPA receptors in mouse forebrain dissects specific contributions of AMPA receptor expression variation in piriform cortex and hippocampus to olfactory learning and memory,...
Derya R. Shimshek, Thorsten Bus, Jinhyun Kim, Andre Mihaljevic, Volker Mack, Peter H. Seeburg, ...
Genetic perturbations of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study,...
Kuner, Rohini, Groom, Anthony J., Müller, Gerald, Kornau, Hans−Christian, Stefovska, Vanya, Bresink, Iris, ...
To reveal whether increased Ca2+ permeability of glutamate AMPA channels triggered by the transgene for GluR−B(N) induces decline in motor functions and neurodegeneration in the spinal cord, we...
SVC: Structured visualization of evolutionary sequence conservation (2005)
Roepcke, S., Fiziev, P., Seeburg, Peter H., Vingron, M.
We have developed a web application for the detailed analysis and visualization of evolutionary sequence conservation in complex vertebrate genes. Given a pair of orthologous genes, the...
Lominac, KevKevin, Oleson, Erik, Pava, Matthew, Klugmann, Matthias, Schwarz, Martin K., Seeburg, Peter H., ...
Homer1 mutant mice exhibit behavioral and neurochemical abnormalities that are consistent with an animal model of schizophrenia. Because the Homer1 gene encodes both immediate early gene (IEG) and...
Shimshek, Derya R., Bus, Thorsten, Kim, Jinhyun, Mihaljevic, André, Mack, Volker, Seeburg, Peter H., ...
Genetic perturbations of á−amino−3−hydroxy−5−methyl−4−isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In...
Lack of NMDAR subtype selectivity for hippocampal LTP (2005)
Berberich, Sven, Punnakkal, Pradeep, Jensen, Vidar, Pawlak, Verena, Seeburg, Peter H., Hvalby, Øivind, ...
NMDA receptor (NMDAR) 2A (NR2A)− and NR2B−type NMDARs coexist in synapses of CA1 pyramidal cells. Recent studies using pharmacological blockade of NMDAR subtypes proposed that the NR2A type is...
Pawlak, Verena, Jensen, Vidar, Schupp, Bettina J., Kvello, Ane, Hvalby, Øivind, Seeburg, Peter H., ...
Changes in postsynaptic Ca2+ levels are essential for alterations in synaptic strength. At hippocampal CA3−to−CA1 synapses, the Ca2+ elevations required for LTP induction are typically mediated...
Late−onset motoneuron disease caused by a functionally modified AMPA receptor subunit (2005)
Kuner, Rohini, Groom, Anthony, Bresink, Iris, Kornau, Hans−Christian, Stefovska, Vanya, Müller, Gerald, ...
Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the central nervous system in middle and old age that leads to progressive loss of spinal motoneurons. Transgenic mice overexpressing...
Hambsch, Boris, Grinevich, Valery, Seeburg, Peter H., Schwarz, Martin K.
γ−Protocadherins (γ−pcdhs) are type I membrane−spanning glycoproteins, widely expressed in the mammal and required for survival. These cell adhesion molecules are expressed from a complex...
Restoration of spatial working memory by genetic rescue of GluR−A−deficient mice (2005)
Schmitt, W., Sprengel, Rolf, Mack, Volker, Draft, Ryan, Seeburg, Peter H., Deacon, Robert M. J., ...
Gene−targeted mice lacking the AMPA receptor subunit GluR−A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3−CA1 long−term potentiation (LTP) and have...
Pawlak, Verena, Schupp, Bettina, Single, Frank Nicolai, Seeburg, Peter H., Köhr, Georg
NMDA receptors (NMDARs) play a crucial role for the acquisition of functional AMPARs during Hebbian synaptic plasticity at cortical and hippocampal synapses over a short timescale of seconds to...
Shimshek, Derya R., Bus, Thorsten, Kim, Jinhyun, Mihaljevic, André, Mack, Volker, Seeburg, Peter H., ...
Genetic perturbations of á−amino−3−hydroxy−5−methyl−4−isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In...
Lack of NMDAR subtype selectivity for hippocampal LTP (2005)
Berberich, Sven, Punnakkal, Pradeep, Jensen, Vidar, Pawlak, Verena, Seeburg, Peter H., Hvalby, Øivind, ...
NMDA receptor (NMDAR) 2A (NR2A)− and NR2B−type NMDARs coexist in synapses of CA1 pyramidal cells. Recent studies using pharmacological blockade of NMDAR subtypes proposed that the NR2A type is...
Pawlak, Verena, Jensen, Vidar, Schupp, Bettina J., Kvello, Ane, Hvalby, Øivind, Seeburg, Peter H., ...
Changes in postsynaptic Ca2+ levels are essential for alterations in synaptic strength. At hippocampal CA3−to−CA1 synapses, the Ca2+ elevations required for LTP induction are typically mediated...
A genetic switch for epilepsy in adult mice (2004)
Krestel,Heinz Eric, Shimshek,Derya R., Jensen,Vidar, Nevian,Thomas, Kim,Jin−Hyun, Geng,Yu, ...
Premature death from seizures afflicts gene−targeted mice expressing the Q/R site−unedited glutamate receptor subunit GluR−B(Q) of AMPA receptors in central neurons. Early seizure−related...
A genetic switch for epilepsy in adult mice (2004)
Krestel,Heinz Eric, Shimshek,Derya R., Jensen,Vidar, Nevian,Thomas, Kim,Jin−Hyun, Geng,Yu, ...
Premature death from seizures afflicts gene−targeted mice expressing the Q/R site−unedited glutamate receptor subunit GluR−B(Q) of AMPA receptors in central neurons. Early seizure−related...
Hartmann,Bettina, Ahmadi,Seifollah, Heppenstall,Paul, Lewin,Gary, Schott,Claus, Borchardt,Thilo, ...
Ca2+−permeable AMPA receptors are densely expressed in the spinal dorsal horn, but their functional significance in pain processing is not understood. By disrupting the genes encoding GluR−A or...
Schulz,Torsten W., Nakagawa,Terunaga, Licznerski,Pawel, Pawlak,Verena, Kolleker,Alexander, Rozov,Andrei, ...
The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the...
Schulz,Torsten W., Nakagawa,Terunaga, Licznerski,Pawel, Pawlak,Verena, Kolleker,Alexander, Rozov,Andrei, ...
The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the...
Schulz,Torsten W., Nakagawa,Terunaga, Licznerski,Pawel, Pawlak,Verena, Kolleker,Alexander, Rozov,Andrei, ...
The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the...
Aronoff,Rachel, Mellem,Jerry E., Maricq,Andres Villu, Sprengel,Rolf, Seeburg,Peter H.
Ionotropic glutamate receptors (iGluRs) in Caenorhabditis elegans are predicted to have high permeability for Ca2+ because of glutamine (Q) residues in the pore loop. This contrasts to the low Ca2+...
Schmitt,Wolfram B., Arianpour,Roozbeh, Deacon,Robert M. J., Seeburg,Peter H., Sprengel,Rolf, Rawlins,J. Nicholas P., ...
Gene−targeted mice lacking the AMPA receptor subunit glutamate receptor−A (GluR−A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild−type and sham−operated...
Bannerman,David M., Deacon,Robert M. J., Brady,S., Bruce,A., Sprengel,Rolf, Seeburg,Peter H., ...
Previous studies have demonstrated a spatial working memory deficit in glutamate receptor (GluR)−A (GluR1) AMPA receptor subunit knockout mice. The present study evaluated male and female...
Kim,Jin−Hyun, Dittgen,Tanjew, Nimmerjahn,Axel, Waters,David Jack, Pawlak,Verena, Helmchen,Fritjof, ...
Sindbis virus−based vectors have been successfully used for transient heterologous protein expression in neurons. Their main limitation arises from infection−associated cytotoxicity, attributed...
Kim,Jin−Hyun, Dittgen,Tanjew, Nimmerjahn,Axel, Waters,David Jack, Pawlak,Verena, Helmchen,Fritjof, ...
Sindbis virus−based vectors have been successfully used for transient heterologous protein expression in neurons. Their main limitation arises from infection−associated cytotoxicity, attributed...
Liver disintegration in the mouse embryo by deficiency in RNA editing enzyme ADAR1 (2004)
Hartner,Jochen C., Schmittwolf,Carolin, Kispert,Andreas, Müller,Albrecht, Higuchi,Miyoko, Seeburg,Peter H.
Adenosine deaminase acting on RNA 1 (ADAR1) is widely expressed in the mammal, but its biological role is unknown. We show here by gene targeting that ADAR1 selectively edits in vivo two of five...
Schmitt,Wolfram B., Deacon,Robert M. J., Reisel,D., Sprengel,Rolf, Seeburg,Peter H., Rawlins,J. Nicholas P., ...
Genetically modified mice lacking the L−−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) receptor subunit, GluR−A (GluR1), and deficient in hippocampal CA3−CA1 long−term...
Schmitt,Wolfram B., Deacon,Robert M. J., Reisel,D., Sprengel,Rolf, Seeburg,Peter H., Rawlins,J. Nicholas P., ...
Genetically modified mice lacking the L−−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) receptor subunit, GluR−A (GluR1), and deficient in hippocampal CA3−CA1 long−term...
Schmitt, Wolfram B., Deacon, Robert M. J., Reisel, D., Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., ...
Genetically modified mice lacking the L−−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) receptor subunit, GluR−A (GluR1), and deficient in hippocampal CA3−CA1 long−term...
Schulz, Torsten W., Nakagawa, Terunaga, Licznerski, Pawel, Pawlak, Verena, Kolleker, Alexander, Rozov, Andrei, ...
The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the...
A genetic switch for epilepsy in adult mice (2004)
Krestel, Heinz Eric, Shimshek, Derya R., Jensen, Vidar, Nevian, Thomas, Kim, Jin−Hyun, Geng, Yu, ...
Premature death from seizures afflicts gene−targeted mice expressing the Q/R site−unedited glutamate receptor subunit GluR−B(Q) of AMPA receptors in central neurons. Early seizure−related...
Kim, Jin−Hyun, Dittgen, Tanjew, Nimmerjahn, Axel, Waters, David Jack, Pawlak, Verena, Helmchen, Fritjof, ...
Sindbis virus−based vectors have been successfully used for transient heterologous protein expression in neurons. Their main limitation arises from infection−associated cytotoxicity, attributed...
Schulz, Torsten W., Nakagawa, Terunaga, Licznerski, Pawel, Pawlak, Verena, Kolleker, Alexander, Rozov, Andrei, ...
The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the...
Kim, Jin−Hyun, Dittgen, Tanjew, Nimmerjahn, Axel, Waters, David Jack, Pawlak, Verena, Helmchen, Fritjof, ...
Sindbis virus−based vectors have been successfully used for transient heterologous protein expression in neurons. Their main limitation arises from infection−associated cytotoxicity, attributed...
A genetic switch for epilepsy in adult mice (2004)
Krestel, Heinz Eric, Shimshek, Derya R., Jensen, Vidar, Nevian, Thomas, Kim, Jin−Hyun, Geng, Yu, ...
Premature death from seizures afflicts gene−targeted mice expressing the Q/R site−unedited glutamate receptor subunit GluR−B(Q) of AMPA receptors in central neurons. Early seizure−related...
Schulz, Torsten W., Nakagawa, Terunaga, Licznerski, Pawel, Pawlak, Verena, Kolleker, Alexander, Rozov, Andrei, ...
The efficacy of excitatory transmission in the brain depends to a large extent on synaptic AMPA receptors, hence the importance of understanding the delivery and recycling of the receptors at the...
Bannerman, David M., Deacon, Robert M. J., Brady, S., Bruce, A., Sprengel, Rolf, Seeburg, Peter H., ...
Previous studies have demonstrated a spatial working memory deficit in glutamate receptor (GluR)−A (GluR1) AMPA receptor subunit knockout mice. The present study evaluated male and female...
Hartmann, Bettina, Ahmadi, Seifollah, Heppenstall, Paul, Lewin, Gary, Schott, Claus, Borchardt, Thilo, ...
Ca2+−permeable AMPA receptors are densely expressed in the spinal dorsal horn, but their functional significance in pain processing is not understood. By disrupting the genes encoding GluR−A or...
Aronoff, Rachel, Mellem, Jerry E., Maricq, Andres Villu, Sprengel, Rolf, Seeburg, Peter H.
Ionotropic glutamate receptors (iGluRs) in Caenorhabditis elegans are predicted to have high permeability for Ca2+ because of glutamine (Q) residues in the pore loop. This contrasts to the low Ca2+...
Schmitt, Wolfram B., Arianpour, Roozbeh, Deacon, Robert M. J., Seeburg, Peter H., Sprengel, Rolf, Rawlins, J. Nicholas P., ...
Gene−targeted mice lacking the AMPA receptor subunit glutamate receptor−A (GluR−A or GluR1) and mice with cytotoxic hippocampal lesions were compared with wild−type and sham−operated...
Liver disintegration in the mouse embryo by deficiency in RNA editing enzyme ADAR1 (2004)
Hartner, Jochen C., Schmittwolf, Carolin, Kispert, Andreas, Müller, Albrecht, Higuchi, Miyoko, Seeburg, Peter H.
Adenosine deaminase acting on RNA 1 (ADAR1) is widely expressed in the mammal, but its biological role is unknown. We show here by gene targeting that ADAR1 selectively edits in vivo two of five...
Schmitt, Wolfram B., Deacon, Robert M. J., Reisel, D., Sprengel, Rolf, Seeburg, Peter H., Rawlins, J. Nicholas P., ...
Genetically modified mice lacking the L−−amino−3−hydroxy−5−methylisoxazole−4−propionate (AMPA) receptor subunit, GluR−A (GluR1), and deficient in hippocampal CA3−CA1 long−term...
Glutamatergic Plasticity by Synaptic Delivery of GluR-Blong-Containing AMPA Receptors (2003)
Kolleker,Alexander, Zhu,J. Julius, Schupp,Bettina J., Qin,Yi, Mack,Volker, Borchardt,Thilo, ...
Activity-driven delivery of AMPA receptors is proposed to mediate glutamatergic synaptic plasticity, both during development and learning. In hippocampal CA1 principal neurons, such trafficking is...
Jensen,Vidar, Kaiser,Katharina M. M., Borchardt,Thilo, Adelmann,Giselind, Rozov,Andrei, Burnashev,Nail, ...
In adult mice, long-term potentiation (LTP) of synaptic transmission at CA3-to-CA1 synapses induced by tetanic stimulation requires L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)...
Köhr,Georg, Jensen,Vidar, Koester,Helmut J., Mihaljevic,Andre L. A., Utvik,Jo Kristian, Kvello,Ane, ...
NMDA receptors (NMDARs) are essential for modulating synaptic strength at central synapses. At hippocampal CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality...
Homer binds TRPC family channels and is required for gating of TRPC1 by IP 3 receptors (2003)
Yuan,Joseph P., Kiselyov,Kirill, Shin,Dong M., Chen,Jin, Shcheynikov,Nikolay, Kang,Shin H., ...
Receptor signaling at the plasma membrane often releases calcium from intracellular stores. For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C activates an...
Neurobiology: A thorny issue (2003)
The neurons in our brain communicate with one another through specialized structures called synapses. In certain types of neuron, synapses sit on spiny protrusions. These spines are more than just...
Bannerman,David M., Deacon,Robert M. J., Seeburg,Peter H., Rawlins,J. Nicholas P.
Acquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the AMPA receptor subunit GluR-A (GluR1),...
Regulation of ion channel/neurotransmitter receptor function by RNA editing (2003)
Seeburg,Peter H., Hartner,Jochen
RNA editing by select adenosine deamination (A-to-I editing) alters functional determinants in certain ion channels and neurotransmitter receptors in vertebrates and invertebrates. In most cases,...
Schmitt,Wolfram B., Deacon,Robert M. J., Seeburg,Peter H., Rawlins,J. Nicholas P., Bannerman,David M.
Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluRA) (GluR1) and wild-type controls were compared on a radial-maze task in which the same three of six arms were always...
A common architecture for K+ channels and ionotropic glutamate receptors? (2003)
Kuner,Thomas, Seeburg,Peter H., Guy,H. Robert
K+ channels and ionotropic glutamate receptors are thought to share a common architecture in their transmembrane pores. This oft-cited hypothesis has been derived from sequence comparisons, topology...
A common architecture for K+ channels and ionotropic glutamate receptors? (2003)
Kuner, Thomas, Seeburg, Peter H., Guy, H. Robert
K+ channels and ionotropic glutamate receptors are thought to share a common architecture in their transmembrane pores. This oft-cited hypothesis has been derived from sequence comparisons, topology...
Schmitt, Wolfram B., Deacon, Robert M. J., Seeburg, Peter H., Rawlins, J. Nicholas P., Bannerman, David M.
Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluRA) (GluR1) and wild-type controls were compared on a radial-maze task in which the same three of six arms were always...
Bannerman, David M., Deacon, Robert M. J., Seeburg, Peter H., Rawlins, J. Nicholas P.
Acquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the AMPA receptor subunit GluR-A (GluR1),...
Jensen, Vidar, Kaiser, Katharina M. M., Borchardt, Thilo, Adelmann, Giselind, Rozov, Andrei, Burnashev, Nail, ...
In adult mice, long-term potentiation (LTP) of synaptic transmission at CA3-to-CA1 synapses induced by tetanic stimulation requires L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)...
Glutamatergic Plasticity by Synaptic Delivery of GluR-Blong-Containing AMPA Receptors (2003)
Kolleker, Alexander, Zhu, J. Julius, Schupp, Bettina J., Qin, Yi, Mack, Volker, Borchardt, Thilo, ...
Activity-driven delivery of AMPA receptors is proposed to mediate glutamatergic synaptic plasticity, both during development and learning. In hippocampal CA1 principal neurons, such trafficking is...
Köhr, Georg, Jensen, Vidar, Koester, Helmut J., Mihaljevic, Andre L. A., Utvik, Jo Kristian, Kvello, Ane, ...
NMDA receptors (NMDARs) are essential for modulating synaptic strength at central synapses. At hippocampal CA3-to-CA1 synapses of adult mice, different NMDAR subtypes with distinct functionality...
Neurobiology: A thorny issue (2003)
Seeburg, Peter H., Osten, Pavel
The neurons in our brain communicate with one another through specialized structures called synapses. In certain types of neuron, synapses sit on spiny protrusions. These spines are more than just...
Regulation of ion channel/neurotransmitter receptor function by RNA editing (2003)
Seeburg, Peter H., Hartner, Jochen
RNA editing by select adenosine deamination (A-to-I editing) alters functional determinants in certain ion channels and neurotransmitter receptors in vertebrates and invertebrates. In most cases,...
Homer binds TRPC family channels and is required for gating of TRPC1 by IP 3 receptors (2003)
Yuan, Joseph P., Kiselyov, Kirill, Shin, Dong M., Chen, Jin, Shcheynikov, Nikolay, Kang, Shin H., ...
Receptor signaling at the plasma membrane often releases calcium from intracellular stores. For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C activates an...
Spatial memory dissociations in mice lacking GluR1 (2002)
Reisel,D., Bannerman,David M., Schmitt,W. B., Deacon,Robert M. J., Flint,J., Borchardt,Thilo, ...
Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3CA1 long-term potentiation. We now report that they showed normal spatial reference learning and...
Codon-improved Cre recombinase (iCre) expression in the mouse (2002)
Shimshek,Derya R., Kim,Jin-Hyun, Hübner,Michael R., Spergel,Daniel J., Buchholz,Frank, Casanova,James E., ...
By applying the mammalian codon usage to Cre recombinase, we improved Cre expression, as determined by immunoblot and functional analysis, in three different mammalian cell lines. The improved Cre...
Bottai,Daniele, Guzowski,John F., Schwarz,Martin K., Kang,Shin H., Xiao,Bo, Lanahan,Anthony, ...
Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR5 and their coupling to releasable intracellular Ca2+ pools and ion channels. Only the Homer 1 gene...
Bottai, Daniele, Guzowski, John F., Schwarz, Martin K., Kang, Shin H., Xiao, Bo, Lanahan, Anthony, ...
Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR5 and their coupling to releasable intracellular Ca2+ pools and ion channels. Only the Homer 1 gene...
Spatial memory dissociations in mice lacking GluR1 (2002)
Reisel, D., Bannerman, David M., Schmitt, W. B., Deacon, Robert M. J., Flint, J., Borchardt, Thilo, ...
Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3CA1 long-term potentiation. We now report that they showed normal spatial reference learning and...
A-to-I editing: new and old sites, functions and speculations (2002)
Nuclear pre-mRNA editing by selective adenosine deamination (A-to-I editing) occurs in all organisms from C. elegans to humans. This rare posttranscriptional mechanism can alter codons and hence the...
Codon-improved Cre recombinase (iCre) expression in the mouse (2002)
Shimshek, Derya R., Kim, Jin-Hyun, Hübner, Michael R., Spergel, Daniel J., Buchholz, Frank, Casanova, James E., ...
By applying the mammalian codon usage to Cre recombinase, we improved Cre expression, as determined by immunoblot and functional analysis, in three different mammalian cell lines. The improved Cre...
Jerecic,Jasna, Schulze, Christian H., Seeburg,Peter H., Jonas,Peter, Sprengel,Rolf, Bischofsberger,Josef
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to...
Jerecic,Jasna, Schulze, Christian H., Seeburg,Peter H., Jonas,Peter, Sprengel,Rolf, Bischofsberger,Josef
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to...
Seeburg,Peter H., Single,Frank N., Kuner,Thomas, Higuchi,Miyoko, Sprengel,Rolf
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...
Seeburg,Peter H., Single,Frank N., Kuner,Thomas, Higuchi,Miyoko, Sprengel,Rolf
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice (2001)
Mack,Volker, Burnashev,Nail, Kaiser,Katharina M. M., Rozov,Andrej, Jensen,Vidar, Hvalby,Øivind, ...
Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In...
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice (2001)
Mack,Volker, Burnashev,Nail, Kaiser,Katharina M. M., Rozov,Andrej, Jensen,Vidar, Hvalby,Øivind, ...
Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In...
Vekovischeva,Olga Y., Zamanillo,Daniel, Echenko,Oxana, Seppälä,Timo, Uusi-Oukari,Mikko, Honkanen,Aapo, ...
AMPA-type glutamate receptors have been suggested to be involved in the neurobiological mechanisms of drug addiction. We have made use of two mouse lines, which both have modulated AMPA receptor...
Kuner,Thomas, Beck,Christine, Sakmann,Bert, Seeburg,Peter H.
In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and...
Kuner,Thomas, Beck,Christine, Sakmann,Bert, Seeburg,Peter H.
In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and...
Spergel,Daniel J., Krüth,Ulrich, Shimshek,Derya R., Sprengel,Rolf, Seeburg,Peter H.
This review summarizes recent work on the use of reporter genes to label selected neuronal populations in transgenic mice, with particular emphasis on gonadotropin-releasing hormone (GnRH) neurons....
Krestel,Heinz Eric, Mayford,Mark, Seeburg,Peter H., Sprengel,Rolf
Doxycycline (Dox)-sensitive co-regulation of two transcriptionally coupled transgenes was investigated in the mouse. For this, we generated four independent mouse lines carrying coding regions for...
Dominance of the lurcher mutation in heteromeric kainate and AMPA receptor channels (2001)
Schwarz,Martin K., Pawlak,Verena, Osten,Pavel, Mack,Volker, Seeburg,Peter H., Köhr,Georg
Homomeric glutamate receptor (GluR) channels become spontaneously active when the last alanine residue within the invariant SYTANLAAF-motif in the third membrane segment is substituted by threonine....
Jerecic, Jasna, Schulze, Christian H., Seeburg, Peter H., Jonas, Peter, Sprengel, Rolf, Bischofsberger, Josef
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to...
Krestel, Heinz Eric, Mayford, Mark, Seeburg, Peter H., Sprengel, Rolf
Doxycycline (Dox)-sensitive co-regulation of two transcriptionally coupled transgenes was investigated in the mouse. For this, we generated four independent mouse lines carrying coding regions for...
Kuner, Thomas, Beck, Christine, Sakmann, Bert, Seeburg, Peter H.
In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and...
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice (2001)
Mack, Volker, Burnashev, Nail, Kaiser, Katharina M. M., Rozov, Andrej, Jensen, Vidar, Hvalby, Øivind, ...
Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In...
Dominance of the lurcher mutation in heteromeric kainate and AMPA receptor channels (2001)
Schwarz, Martin K., Pawlak, Verena, Osten, Pavel, Mack, Volker, Seeburg, Peter H., Köhr, Georg
Homomeric glutamate receptor (GluR) channels become spontaneously active when the last alanine residue within the invariant SYTANLAAF-motif in the third membrane segment is substituted by threonine....
Seeburg, Peter H., Single, Frank N., Kuner, Thomas, Higuchi, Miyoko, Sprengel, Rolf
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...
Spergel, Daniel J., Krüth, Ulrich, Shimshek, Derya R., Sprengel, Rolf, Seeburg, Peter H.
This review summarizes recent work on the use of reporter genes to label selected neuronal populations in transgenic mice, with particular emphasis on gonadotropin-releasing hormone (GnRH) neurons....
Vekovischeva, Olga Y., Zamanillo, Daniel, Echenko, Oxana, Seppälä, Timo, Uusi-Oukari, Mikko, Honkanen, Aapo, ...
AMPA-type glutamate receptors have been suggested to be involved in the neurobiological mechanisms of drug addiction. We have made use of two mouse lines, which both have modulated AMPA receptor...
Jerecic, Jasna, Schulze, Christian H., Seeburg, Peter H., Jonas, Peter, Sprengel, Rolf, Bischofsberger, Josef
High Ca2+ permeability and its control by voltage-dependent Mg2+ block are defining features of NMDA receptors. These features are lost if the principal NR1 subunit carries an asparagine (N) to...
Kuner, Thomas, Beck, Christine, Sakmann, Bert, Seeburg, Peter H.
In AMPA receptor channels, a single amino acid residue (Q/R site) of the M2 segment controls permeation of calcium ions, single-channel conductance, blockade by intracellular polyamines, and...
Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice (2001)
Mack, Volker, Burnashev, Nail, Kaiser, Katharina M. M., Rozov, Andrej, Jensen, Vidar, Hvalby, Øivind, ...
Plasticity of mature hippocampal CA1 synapses is dependent on L-alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In...
Seeburg, Peter H., Single, Frank N., Kuner, Thomas, Higuchi, Miyoko, Sprengel, Rolf
Glutamate receptor channels are built around an ancient pore loop structure which defines the inner channel environment and which is connected to structures for channel gating. This pore loop, which...
Bond,Chris T., Sprengel,Rolf, Bissonnette,John M., Kaufmann,Walter A., Pribnow,David, Neelands,Torben, ...
In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel...
Wollmuth,Lonnie P., Kuner,Thomas, Jatzke,Claudia, Seeburg,Peter H., Heintz,Nathaniel, Zuo,Jian
Neurodegeneration in Lurcher (Lc) mice results from constitutive activation of δ 2, a subunit of ionotropic glutamate receptors (GluRs) with unknown natural ligands and channel properties....
Wollmuth,Lonnie P., Kuner,Thomas, Jatzke,Claudia, Seeburg,Peter H., Heintz,Nathaniel, Zuo,Jian
Neurodegeneration in Lurcher (Lc) mice results from constitutive activation of δ 2, a subunit of ionotropic glutamate receptors (GluRs) with unknown natural ligands and channel properties....
Higuchi,Miyoko, Maas,Stefan, Single,Frank N., Hartner,Jochen C., Rozov,Andrej, Burnashev,Nail, ...
RNA editing by site-selective deamination of adenosine to inosine1, 2 alters codons3, 4 and splicing5 in nuclear transcripts6, and therefore protein function. ADAR2 (refs 7, 8) is a candidate...
Higuchi,Miyoko, Maas,Stefan, Single,Frank N., Hartner,Jochen C., Rozov,Andrej, Burnashev,Nail, ...
RNA editing by site-selective deamination of adenosine to inosine1, 2 alters codons3, 4 and splicing5 in nuclear transcripts6, and therefore protein function. ADAR2 (refs 7, 8) is a candidate...
Steigerwald,Frank, Schulz,Torsten W., Schenker,Leslie T., Kennedy,Mary B., Seeburg,Peter H., Köhr,Georg
NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional...
Steigerwald,Frank, Schulz,Torsten W., Schenker,Leslie T., Kennedy,Mary B., Seeburg,Peter H., Köhr,Georg
NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional...
Dysfunction in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R) (2000)
Single,Frank N., Rozov,Andrej, Burnashev,Nail, Zimmermann,Frank, Hanley,Daniel F., Forrest,Douglas, ...
NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1...
Dysfunction in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R) (2000)
Single,Frank N., Rozov,Andrej, Burnashev,Nail, Zimmermann,Frank, Hanley,Daniel F., Forrest,Douglas, ...
NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1...
Bond, Chris T., Sprengel, Rolf, Bissonnette, John M., Kaufmann, Walter A., Pribnow, David, Neelands, Torben, ...
In excitable cells, small-conductance Ca2+-activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel...
Higuchi, Miyoko, Maas, Stefan, Single, Frank N., Hartner, Jochen C., Rozov, Andrej, Burnashev, Nail, ...
RNA editing by site-selective deamination of adenosine to inosine1, 2 alters codons3, 4 and splicing5 in nuclear transcripts6, and therefore protein function. ADAR2 (refs 7, 8) is a candidate...
Kask, Kalev, Jerecic, Jasna, Zamanillo, Daniel, Wilbertz, Johannes, Sprengel, Rolf, Seeburg, Peter H.
Wollmuth, Lonnie P., Kuner, Thomas, Jatzke, Claudia, Seeburg, Peter H., Heintz, Nathaniel, Zuo, Jian
Neurodegeneration in Lurcher (Lc) mice results from constitutive activation of δ 2, a subunit of ionotropic glutamate receptors (GluRs) with unknown natural ligands and channel properties....
Steigerwald, Frank, Schulz, Torsten W., Schenker, Leslie T., Kennedy, Mary B., Seeburg, Peter H., Köhr, Georg
NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional...
Dysfunction in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R) (2000)
Single, Frank N., Rozov, Andrej, Burnashev, Nail, Zimmermann, Frank, Hanley, Daniel F., Forrest, Douglas, ...
NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1...
Higuchi, Miyoko, Maas, Stefan, Single, Frank N., Hartner, Jochen C., Rozov, Andrej, Burnashev, Nail, ...
RNA editing by site-selective deamination of adenosine to inosine1, 2 alters codons3, 4 and splicing5 in nuclear transcripts6, and therefore protein function. ADAR2 (refs 7, 8) is a candidate...
Kask, Kalev, Jerecic, Jasna, Zamanillo, Daniel, Wilbertz, Johannes, Sprengel, Rolf, Seeburg, Peter H.
Wollmuth, Lonnie P., Kuner, Thomas, Jatzke, Claudia, Seeburg, Peter H., Heintz, Nathaniel, Zuo, Jian
Neurodegeneration in Lurcher (Lc) mice results from constitutive activation of δ 2, a subunit of ionotropic glutamate receptors (GluRs) with unknown natural ligands and channel properties....
Steigerwald, Frank, Schulz, Torsten W., Schenker, Leslie T., Kennedy, Mary B., Seeburg, Peter H., Köhr, Georg
NMDA receptors interact via the extended intracellular C-terminal domain of the NR2 subunits with constituents of the postsynaptic density for purposes of retention, clustering, and functional...
Dysfunction in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R) (2000)
Single, Frank N., Rozov, Andrej, Burnashev, Nail, Zimmermann, Frank, Hanley, Daniel F., Forrest, Douglas, ...
NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1...
Beck,Christine, Wollmuth,Lonnie P., Seeburg,Peter H., Sakmann,Bert, Kuner,Thomas
In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved....
EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains (1999)
Brückner,Katja, Labrador,Juan Pablo, Scheiffele,Peter, Herb,Anne, Seeburg,Peter H., Klein,Rüdiger
Transmembrane ephrinB proteins have important functions during embryonic patterning as ligands for Eph receptor tyrosine kinases and presumably as signal-transducing receptor-like molecules....
Beck,Christine, Wollmuth,Lonnie P., Seeburg,Peter H., Sakmann,Bert, Kuner,Thomas
In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved....
Feldmeyer,Dirk, Kask,Kalev, Brusa,Rossella, Kornau,Hans Christian, Kolhekar,Rohini, Rozov,Andrej, ...
We generated mouse mutants with targeted AMPA receptor (AMPAR) GluRB subunit alleles, functionally expressed at different levels and deficient in Q/Rsite editing. All mutant lines had increased...
GABA- and glutamate-activated channels in GFP-tagged GnRH neurons in transgenic mice (1999)
Spergel,Daniel J., Krüth,Ulrich, Hanley,Daniel F., Sprengel,Rolf, Seeburg,Peter H.
Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy (1999)
Sprengel,Rolf, Higuchi,Miyoko, Monyer,Hannah, Seeburg,Peter H.
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
Zamanillo,Daniel, Sprengel,Rolf, Hvalby,Øivind, Jensen,Vidar, Burnashev,Nail, Rozov,Andrej, ...
Studies on conditional gene expression in the brain (1999)
Jerecic,Jasna, Single,Frank N., Krüth,Ulrich, Krestel,Heinz Eric, Kolhekar,Rohini, Storck,Thorsten, ...
Feldmeyer,Dirk, Kask,Kalev, Brusa,Rossella, Kornau,Hans Christian, Kolhekar,Rohini, Rozov,Andrej, ...
We generated mouse mutants with targeted AMPA receptor (AMPAR) GluRB subunit alleles, functionally expressed at different levels and deficient in Q/Rsite editing. All mutant lines had increased...
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
Zamanillo,Daniel, Sprengel,Rolf, Hvalby,Øivind, Jensen,Vidar, Burnashev,Nail, Rozov,Andrej, ...
Beck, Christine, Wollmuth, Lonnie P., Seeburg, Peter H., Sakmann, Bert, Kuner, Thomas
In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved....
EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains (1999)
Brückner, Katja, Labrador, Juan Pablo, Scheiffele, Peter, Herb, Anne, Seeburg, Peter H., Klein, Rüdiger
Transmembrane ephrinB proteins have important functions during embryonic patterning as ligands for Eph receptor tyrosine kinases and presumably as signal-transducing receptor-like molecules....
Feldmeyer, Dirk, Kask, Kalev, Brusa, Rossella, Kornau, Hans Christian, Kolhekar, Rohini, Rozov, Andrej, ...
We generated mouse mutants with targeted AMPA receptor (AMPAR) GluRB subunit alleles, functionally expressed at different levels and deficient in Q/Rsite editing. All mutant lines had increased...
GABA- and glutamate-activated channels in GFP-tagged GnRH neurons in transgenic mice (1999)
Spergel, Daniel J., Krüth, Ulrich, Hanley, Daniel F., Sprengel, Rolf, Seeburg, Peter H.
Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy (1999)
Sprengel, Rolf, Higuchi, Miyoko, Monyer, Hannah, Seeburg, Peter H.
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
Zamanillo, Daniel, Sprengel, Rolf, Hvalby, Øivind, Jensen, Vidar, Burnashev, Nail, Rozov, Andrej, ...
Studies on conditional gene expression in the brain (1999)
Jerecic, Jasna, Single, Frank N., Krüth, Ulrich, Krestel, Heinz Eric, Kolhekar, Rohini, Storck, Thorsten, ...
Beck, Christine, Wollmuth, Lonnie P., Seeburg, Peter H., Sakmann, Bert, Kuner, Thomas
In NMDA receptor channels, the M2 loop forms the narrow constriction and the cytoplasmic vestibule. The identity of an extracellular vestibule leading toward the constriction remained unresolved....
Feldmeyer, Dirk, Kask, Kalev, Brusa, Rossella, Kornau, Hans Christian, Kolhekar, Rohini, Rozov, Andrej, ...
We generated mouse mutants with targeted AMPA receptor (AMPAR) GluRB subunit alleles, functionally expressed at different levels and deficient in Q/Rsite editing. All mutant lines had increased...
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning (1999)
Zamanillo, Daniel, Sprengel, Rolf, Hvalby, Øivind, Jensen, Vidar, Burnashev, Nail, Rozov, Andrej, ...
Kask,Kalev, Zamanillo,Daniel, Rozov,Andrej, Burnashev,Nail, Sprengel,Rolf, Seeburg,Peter H.
Calcium permeability of L--amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Kask,Kalev, Zamanillo,Daniel, Rozov,Andrej, Burnashev,Nail, Sprengel,Rolf, Seeburg,Peter H.
Calcium permeability of L--amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum (1998)
Köhr,Georg, Melcher,Thorsten, Seeburg,Peter H.
RNA editing by site selective adenosine deamination changes codons in several nuclear transcripts in the mammalian brain and affects critical properties of the encoded proteins, as exemplified by the...
Differentiation of Glycine Antagonist Sites of N-Methyl-D-aspartate Receptor Subtypes (1998)
Honer,Michael, Benke,Dietmar, Laube,Bodo, Kuhse,Jochen, Heckendorn,Roland, Allgeier,Hans, ...
The binding site for the co-agonist glycine on N-methyl-D-aspartate (NMDA) receptors has been mapped to the NR1 subunit whereas binding of the principal agonist glutamate is mediated by the NR2...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel,Rolf, Suchanek,Bettina, Amico,Carla, Brusa,Rossella, Burnashev,Nail, Rozov,Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel,Rolf, Suchanek,Bettina, Amico,Carla, Brusa,Rossella, Burnashev,Nail, Rozov,Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Differentiation of Glycine Antagonist Sites of N-Methyl-D-aspartate Receptor Subtypes (1998)
Honer, Michael, Benke, Dietmar, Laube, Bodo, Kuhse, Jochen, Heckendorn, Roland, Allgeier, Hans, ...
The binding site for the co-agonist glycine on N-methyl-D-aspartate (NMDA) receptors has been mapped to the NR1 subunit whereas binding of the principal agonist glutamate is mediated by the NR2...
Kask, Kalev, Zamanillo, Daniel, Rozov, Andrej, Burnashev, Nail, Sprengel, Rolf, Seeburg, Peter H.
Calcium permeability of L--amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Candidate editases for GluR channels in single neurons of rat hippocampus and cerebellum (1998)
Köhr, Georg, Melcher, Thorsten, Seeburg, Peter H.
RNA editing by site selective adenosine deamination changes codons in several nuclear transcripts in the mammalian brain and affects critical properties of the encoded proteins, as exemplified by the...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel, Rolf, Suchanek, Bettina, Amico, Carla, Brusa, Rossella, Burnashev, Nail, Rozov, Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
Kask, Kalev, Zamanillo, Daniel, Rozov, Andrej, Burnashev, Nail, Sprengel, Rolf, Seeburg, Peter H.
Calcium permeability of L--amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) in excitatory neurons of the mammalian brain is prevented by coassembly of the GluR-B subunit, which...
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo (1998)
Sprengel, Rolf, Suchanek, Bettina, Amico, Carla, Brusa, Rossella, Burnashev, Nail, Rozov, Andrej, ...
NMDA receptors, a class of glutamate-gated cation channels with high Ca2+ conductance, mediate fast transmission and plasticity of central excitatory synapses. We show here that gene-targeted mice...
A standardized nomenclature for adenosine deaminases that act on RNA (1997)
Bass,B. L., Nishikura,K., Keller,Walter, Seeburg,Peter H., Emeson,R. B., OConnell,M. A., ...
Interaction of ion channels and receptors with PDZ domain proteins (1997)
Kornau,Hans Christian, Seeburg,Peter H., Kennedy,Mary B.
The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to...
Mittaz,Lauréane, Scott,Hamish S., Rossier,Colette, Seeburg,Peter H., Higuchi,Miyoko, Antonarakis,Stylianos E.
RED1 is a double-stranded RNA-specific editase characterized in the rat and is implicated in the editing of glutamate receptor subunit pre-mRNAs, particularly in the brain. Starting from human ESTs...
Herb,Anne, Wisden,William, Catania, Maria V., Marechal,Daniel, Dresse,Albert, Seeburg,Peter H.
A recently cloned rat brain cDNA derives from a novel gene, termed dendrin (DEN), expressed exclusively in forebrain structures, particularly in neocortex, olfactory bulb, hippocampus,...
The human growth hormone gene locus: structure, evolution, and allelic variations (1997)
Hirt,H., Kimelman,J., Birnbaum,Morris J., Chen,E. Y., Seeburg,Peter H., Eberhardt,N. L., ...
Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy (1997)
Sprengel,Rolf, Higuchi,Miyoko, Monyer,Hannah, Seeburg,Peter H.
Glutamate receptor channels, RNA editing and epilepsy (1997)
Seeburg,Peter H., Brusa,Rossella, Higuchi,Miyoko, Sprengel,Rolf
A standardized nomenclature for adenosine deaminases that act on RNA (1997)
Bass, B. L., Nishikura, K., Keller, Walter, Seeburg, Peter H., Emeson, R. B., OConnell, M. A., ...
Herb, Anne, Wisden, William, Catania, Maria V., Marechal, Daniel, Dresse, Albert, Seeburg, Peter H.
A recently cloned rat brain cDNA derives from a novel gene, termed dendrin (DEN), expressed exclusively in forebrain structures, particularly in neocortex, olfactory bulb, hippocampus,...
The human growth hormone gene locus: structure, evolution, and allelic variations (1997)
Hirt, H., Kimelman, J., Birnbaum, Morris J., Chen, E. Y., Seeburg, Peter H., Eberhardt, N. L., ...
Interaction of ion channels and receptors with PDZ domain proteins (1997)
Kornau, Hans Christian, Seeburg, Peter H., Kennedy, Mary B.
The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to...
Mittaz, Lauréane, Scott, Hamish S., Rossier, Colette, Seeburg, Peter H., Higuchi, Miyoko, Antonarakis, Stylianos E.
RED1 is a double-stranded RNA-specific editase characterized in the rat and is implicated in the editing of glutamate receptor subunit pre-mRNAs, particularly in the brain. Starting from human ESTs...
Glutamate receptor channels: A possible link between RNA editing in the brain and epilepsy (1997)
Sprengel, Rolf, Higuchi, Miyoko, Monyer, Hannah, Seeburg, Peter H.
Glutamate receptor channels, RNA editing and epilepsy (1997)
Seeburg, Peter H., Brusa, Rossella, Higuchi, Miyoko, Sprengel, Rolf
RED2, a brain specific member of the RNA specific adenosine deaminase family (1996)
Melcher,Thorsten, Maas,Stefan, Herb,Anne, Sprengel,Rolf, Higuchi,Miyoko, Seeburg,Peter H.
The mammalian RNA-specific adenosine deaminases DRADA/dsRAD (alias ADAR) and RED1 (alias ADARB1) have been implicated in the site-selective editing of brain-expressed pre-mRNAs for glutamate receptor...
Kuner,Thomas, Wollmuth,Lonnie P., Karlin,Arthur, Seeburg,Peter H., Sakmann,Bert
The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1?NR2C channels with charged sulfhydryl-specific...
Kuner,Thomas, Wollmuth,Lonnie P., Karlin,Arthur, Seeburg,Peter H., Sakmann,Bert
The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1?NR2C channels with charged sulfhydryl-specific...
1. Tyrosine kinases regulate NMDA receptor-channel activity in cultured neurons, and NMDA receptor subunits are tyrosine phosphorylated in the brain. 2. Heteromeric NMDA receptor-channels were...
Herb,Anne, Higuchi,Miyoko, Sprengel,Rolf, Seeburg,Peter H.
RNA editing by adenosine deamination in brain-expressed pre-mRNAs for glutamate receptor (GluR) subunits alters gene-specified codons for functionally critical positions, such as the channels Q/R...
Korpi,Esa R., Seeburg,Peter H., Lüddens,R.
The multisubunit gamma-aminobutyric acid type A (GABAA) receptor is heterogeneous in molecular and pharmacological aspects. We used quantitative autoradiographic techniques to generate detailed...
A candidate enzyme for RNA editing at the Q/R site in GluR-B pre-mRNA (1996)
Melcher,Thorsten, Maas,Stefan, Herb,Anne, Sprengel,Rolf, Seeburg,Peter H., Higuchi,Miyoko
Rapid construction in yeast of complex targeting vectors for gene manipulation in the mouse (1996)
Storck,Thorsten, Storck,U., Kolhekar,Rohini, Sprengel,Rolf, Seeburg,Peter H.
Targeting vectors for embryonic stem (ES) cells typically contain a mouse gene segment of >7 kb with the neo gene inserted for positive selection of the targeting event. More complex targeting...
Wollmuth,Lonnie P., Kuner,Thomas, Seeburg,Peter H., Sakmann,Bert
1. The molecular determinants for the narrow constriction of recombinant N-methyl-D-aspartate (NMDA) receptor channels composed of wild-type and mutant NR1- and NR2A-subunits were studied in Xenopus...
Wollmuth,Lonnie P., Kuner,Thomas, Seeburg,Peter H., Sakmann,Bert
1. The molecular determinants for the narrow constriction of recombinant N-methyl-D-aspartate (NMDA) receptor channels composed of wild-type and mutant NR1- and NR2A-subunits were studied in Xenopus...
Herb, Anne, Higuchi, Miyoko, Sprengel, Rolf, Seeburg, Peter H.
RNA editing by adenosine deamination in brain-expressed pre-mRNAs for glutamate receptor (GluR) subunits alters gene-specified codons for functionally critical positions, such as the channels Q/R...
Korpi, Esa R., Seeburg, Peter H., Lüddens, R.
The multisubunit gamma-aminobutyric acid type A (GABAA) receptor is heterogeneous in molecular and pharmacological aspects. We used quantitative autoradiographic techniques to generate detailed...
Kuner, Thomas, Wollmuth, Lonnie P., Karlin, Arthur, Seeburg, Peter H., Sakmann, Bert
The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1?NR2C channels with charged sulfhydryl-specific...
Köhr, Georg, Seeburg, Peter H.
1. Tyrosine kinases regulate NMDA receptor-channel activity in cultured neurons, and NMDA receptor subunits are tyrosine phosphorylated in the brain. 2. Heteromeric NMDA receptor-channels were...
RED2, a brain specific member of the RNA specific adenosine deaminase family (1996)
Melcher, Thorsten, Maas, Stefan, Herb, Anne, Sprengel, Rolf, Higuchi, Miyoko, Seeburg, Peter H.
The mammalian RNA-specific adenosine deaminases DRADA/dsRAD (alias ADAR) and RED1 (alias ADARB1) have been implicated in the site-selective editing of brain-expressed pre-mRNAs for glutamate receptor...
A candidate enzyme for RNA editing at the Q/R site in GluR-B pre-mRNA (1996)
Melcher, Thorsten, Maas, Stefan, Herb, Anne, Sprengel, Rolf, Seeburg, Peter H., Higuchi, Miyoko
Rapid construction in yeast of complex targeting vectors for gene manipulation in the mouse (1996)
Storck, Thorsten, Storck, U., Kolhekar, Rohini, Sprengel, Rolf, Seeburg, Peter H.
Targeting vectors for embryonic stem (ES) cells typically contain a mouse gene segment of >7 kb with the neo gene inserted for positive selection of the targeting event. More complex targeting...
Wollmuth, Lonnie P., Kuner, Thomas, Seeburg, Peter H., Sakmann, Bert
1. The molecular determinants for the narrow constriction of recombinant N-methyl-D-aspartate (NMDA) receptor channels composed of wild-type and mutant NR1- and NR2A-subunits were studied in Xenopus...
Kuner, Thomas, Wollmuth, Lonnie P., Karlin, Arthur, Seeburg, Peter H., Sakmann, Bert
The structure of the NMDA receptor channel M2 segment was investigated by probing the extracellular and cytoplasmic faces of cysteine-substituted NR1?NR2C channels with charged sulfhydryl-specific...
Wollmuth, Lonnie P., Kuner, Thomas, Seeburg, Peter H., Sakmann, Bert
1. The molecular determinants for the narrow constriction of recombinant N-methyl-D-aspartate (NMDA) receptor channels composed of wild-type and mutant NR1- and NR2A-subunits were studied in Xenopus...
Brusa,Rossella, Zimmermann,Frank, Feldmeyer,Dirk, Gass,Peter, Seeburg,Peter H., ...
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to...
Brusa,Rossella, Zimmermann,Frank, Feldmeyer,Dirk, Gass,Peter, Seeburg,Peter H., ...
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to...
Kornau,Hans Christian, Schenker,Leslie T., Kennedy,Mary B., Seeburg,Peter H.
The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails...
he distribution of splice variants of the NMDAR1 subunit mRNA in adult rat brain (1995)
Laurie,David J., Putzke,J., Zieglgänsberger,Walter, Seeburg,Peter H., Toelle,T. R.
Regional variation in the alternative splice forms of the NMDAR1 subunit mRNA was investigated by in situ hybridization in the adult rat brain, using radiolabelled splice-specific oligonucleotide...
Geiger,Jörg R. P., Melcher,Thorsten, Sakmann,Bert, Seeburg,Peter H., Jonas,Peter, ...
Recording of glutamate-activated currents in membrane patches was combined with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat brain slices. Analysis of...
Cellular and subcellular distribution of NMDAR1 splice variant mRNA in spinal cord of the rat (1995)
Tölle,Thomas R., Berthele,Achim, Laurie,David J., Seeburg,Peter H., Zieglgänsberger,Walter
The regional distribution of alternatively spliced messenger RNA encoding the N-methyl-D-aspartate (NMDA) receptor R1 subunit (NMDAR1) variants was examined by in situ hybridization in the rat lumbar...
Flip and Flop variants of AMPA receptors in the rat lumbar spinal cord (1995)
Tölle,Thomas R., Berthele,Achim, Zieglgänsberger,Walter, Seeburg,Peter H., Wisden,William
The expression of eight messenger RNA splice forms encoding the Flip and Flop variants of AMPA receptor subunits GluR-A to -D in the rat lumbar spinal cord was examined by in situ hybridization using...
Geiger,Jörg R. P., Melcher,Thorsten, Sakmann,Bert, Seeburg,Peter H., Jonas,Peter, ...
Recording of glutamate-activated currents in membrane patches was combined with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat brain slices. Analysis of...
Melcher,Thorsten, Maas,Stefan, Higuchi,Miyoko, Keller,Walter, Seeburg,Peter H., Major,G., ...
In neurons of the mammalian brain primary transcripts of genes encoding subunits of glutamate receptor channels can undergo RNA editing, leading to altered properties of the transmitter-activated...
Melcher,Thorsten, Maas,Stefan, Higuchi,Miyoko, Keller,Walter, Seeburg,Peter H., Major,G., ...
In neurons of the mammalian brain primary transcripts of genes encoding subunits of glutamate receptor channels can undergo RNA editing, leading to altered properties of the transmitter-activated...
Korpi,Esa R., Kuner,Thomas, Seeburg,Peter H., Lüddens,H.
Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can be...
Korpi,Esa R., Kuner,Thomas, Seeburg,Peter H., Lüddens,H.
Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can be...
Gene Structure of the Murine N-MethylD-Aspartate Receptor Subunit NR2C (1995)
Suchanek,Bettina, Seeburg,Peter H., Sprengel,Rolf
The murine N-methyl D-aspartate receptor subunit NR2C (-3) is encoded by a unique gene composed of 12 translated and three 5`-untranslated exons that spread over 20 kilobases of genomic sequence....
The NMDA receptor channel: molecular design of a coincidence detector (1995)
Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah
The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)
Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah
Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)
Seeburg,Peter H., Sprengel,Rolf, Monyer,Hannah, Higuchi,Miyoko, Kuner,Thomas, Köhr,Georg, ...
The NMDA receptor channel: molecular design of a coincidence detector (1995)
Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah
The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)
Seeburg,Peter H., Burnashev,Nail, Köhr,Georg, Kuner,Thomas, Sprengel,Rolf, Monyer,Hannah
Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)
Seeburg,Peter H., Sprengel,Rolf, Monyer,Hannah, Higuchi,Miyoko, Kuner,Thomas, Köhr,Georg, ...
Brusa, Rossella, Zimmermann, Frank, Feldmeyer, Dirk, Gass, Peter, Seeburg, Peter H., ...
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to...
Geiger, Jörg R. P., Melcher, Thorsten, Sakmann, Bert, Seeburg, Peter H., Jonas, Peter, ...
Recording of glutamate-activated currents in membrane patches was combined with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat brain slices. Analysis of...
Kornau, Hans Christian, Schenker, Leslie T., Kennedy, Mary B., Seeburg, Peter H.
The N-methyl-D-aspartate (NMDA) receptor subserves synaptic glutamate-induced transmission and plasticity in central neurons. The yeast two-hybrid system was used to show that the cytoplasmic tails...
Korpi, Esa R., Kuner, Thomas, Seeburg, Peter H., Lüddens, H.
Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can be...
he distribution of splice variants of the NMDAR1 subunit mRNA in adult rat brain (1995)
Laurie, David J., Putzke, J., Zieglgänsberger, Walter, Seeburg, Peter H., Toelle, T. R.
Regional variation in the alternative splice forms of the NMDAR1 subunit mRNA was investigated by in situ hybridization in the adult rat brain, using radiolabelled splice-specific oligonucleotide...
Melcher, Thorsten, Maas, Stefan, Higuchi, Miyoko, Keller, Walter, Seeburg, Peter H., Major, G., ...
In neurons of the mammalian brain primary transcripts of genes encoding subunits of glutamate receptor channels can undergo RNA editing, leading to altered properties of the transmitter-activated...
The NMDA receptor channel: molecular design of a coincidence detector (1995)
Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah
Gene Structure of the Murine N-MethylD-Aspartate Receptor Subunit NR2C (1995)
Suchanek, Bettina, Seeburg, Peter H., Sprengel, Rolf
The murine N-methyl D-aspartate receptor subunit NR2C (-3) is encoded by a unique gene composed of 12 translated and three 5`-untranslated exons that spread over 20 kilobases of genomic sequence....
Cellular and subcellular distribution of NMDAR1 splice variant mRNA in spinal cord of the rat (1995)
Tölle, Thomas R., Berthele, Achim, Laurie, David J., Seeburg, Peter H., Zieglgänsberger, Walter
The regional distribution of alternatively spliced messenger RNA encoding the N-methyl-D-aspartate (NMDA) receptor R1 subunit (NMDAR1) variants was examined by in situ hybridization in the rat lumbar...
Flip and Flop variants of AMPA receptors in the rat lumbar spinal cord (1995)
Tölle, Thomas R., Berthele, Achim, Zieglgänsberger, Walter, Seeburg, Peter H., Wisden, William
The expression of eight messenger RNA splice forms encoding the Flip and Flop variants of AMPA receptor subunits GluR-A to -D in the rat lumbar spinal cord was examined by in situ hybridization using...
The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)
Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah
Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)
Seeburg, Peter H., Sprengel, Rolf, Monyer, Hannah, Higuchi, Miyoko, Kuner, Thomas, Köhr, Georg, ...
Brusa, Rossella, Zimmermann, Frank, Feldmeyer, Dirk, Gass, Peter, Seeburg, Peter H., ...
The arginine residue at position 586 of the GluR-B subunit renders heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptor channels impermeable to...
Geiger, Jörg R. P., Melcher, Thorsten, Sakmann, Bert, Seeburg, Peter H., Jonas, Peter, ...
Recording of glutamate-activated currents in membrane patches was combined with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat brain slices. Analysis of...
Korpi, Esa R., Kuner, Thomas, Seeburg, Peter H., Lüddens, H.
Numerous ligands affect inhibitory gamma-aminobutyric acid (GABA)A receptors, none of them showing strict receptor subtype specificity. We report here that a cerebellar GABAA receptor subtype can be...
Melcher, Thorsten, Maas, Stefan, Higuchi, Miyoko, Keller, Walter, Seeburg, Peter H., Major, G., ...
In neurons of the mammalian brain primary transcripts of genes encoding subunits of glutamate receptor channels can undergo RNA editing, leading to altered properties of the transmitter-activated...
The NMDA receptor channel: molecular design of a coincidence detector (1995)
Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah
The NMDA Receptor Channel: Molecular design of a coincidence detector (1995)
Seeburg, Peter H., Burnashev, Nail, Köhr, Georg, Kuner, Thomas, Sprengel, Rolf, Monyer, Hannah
Glutamate Receptor Channels in CNS: Molecular and Functional Aspects (1995)
Seeburg, Peter H., Sprengel, Rolf, Monyer, Hannah, Higuchi, Miyoko, Kuner, Thomas, Köhr, Georg, ...
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing (1994)
Lomeli,H., Mosbacher,Johannes, Melcher,H., Höger,T., Geiger,Jörg R. P., Kuner,Thomas, ...
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear...
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing (1994)
Lomeli,H., Mosbacher,Johannes, Melcher,H., Höger,T., Geiger,Jörg R. P., Kuner,Thomas, ...
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear...
A molecular determinant for submillisecond desensitization in glutamate receptors (1994)
Mosbacher,Johannes, Schoepfer,Ralf, Monyer,Hannah, Burnashev,Nail, Seeburg,Peter H., Ruppersberg,J. Peter
The decay of excitatory postsynaptic currents in central neurons mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors is likely to be shaped either by receptor...
A molecular determinant for submillisecond desensitization in glutamate receptors (1994)
Mosbacher,Johannes, Schoepfer,Ralf, Monyer,Hannah, Burnashev,Nail, Seeburg,Peter H., Ruppersberg,J. Peter
The decay of excitatory postsynaptic currents in central neurons mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors is likely to be shaped either by receptor...
Hartveit,E., Brandstaetter,J. H., Sassoè-Pognetto,M., Laurie,David J., Seeburg,Peter H., Waessle,H.
The localization of the N-methyl-D-aspartate receptor subunit NR2A was studied, by using light microscopic immunocytochemistry, in the retina of adult rat, rabbit, cat, and monkey. Strong, punctate...
Korpi,Esa R., Kuner,Thomas, Kristo,P., Köhler,Martin, Herb,Anne, Lüddens,H., ...
Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction...
Korpi,Esa R., Kuner,Thomas, Kristo,P., Köhler,Martin, Herb,Anne, Lüddens,H., ...
Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction...
High-level expression of functional glutamate receptor channels in insect cells (1994)
Keinänen,Kari, Köhr,Georg, Seeburg,Peter H., Laukkanen,M. L., Oker-Blom,C.
We have expressed glutamate-gated ion channels in Spodoptera frugiperda Sf21 insect cells using a recombinant baculovirus system. Cells infected with recombinant baculoviruses encoding the...
Köhler,Martin, Kornau,Hans Christian, Seeburg,Peter H.
The murine gene encoding the GluR-B subunit of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors was characterized with respect to exon-intron organization, transcriptional start...
Jonas,Peter, Racca,Claudia, Sakmann,Bert, Seeburg,Peter H., Monyer,Hannah
Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type glutamate receptor (GluR) channels. Heterologous expression suggested that the Ca2+ permeability of these receptors...
Jonas,Peter, Racca,Claudia, Sakmann,Bert, Seeburg,Peter H., Monyer,Hannah
Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type glutamate receptor (GluR) channels. Heterologous expression suggested that the Ca2+ permeability of these receptors...
NMDA receptor channels: subtype specific potentiation by reducing agents (1994)
Köhr,Georg, Eckardt,Sigrid, Lüddens,H., Monyer,Hannah, Seeburg,Peter H.
Sulfhydryl redox agents affect NMDA receptor activity. We investigated a putative redox site in four recombinant NMDA receptors. In 293 cells expressing NR1-NR2A channels dithiothreitol (DTT) rapidly...
Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition (1994)
Laurie,David J., Seeburg,Peter H.
The ligand preferences of recombinant NR1 homomeric and NR1-NR2 heteromeric NMDA receptors were examined by homogenate binding assay. The binding affinities for most ligands were similar to those...
Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA (1994)
Laurie,David J., Seeburg,Peter H.
Developmental and regional alternative splicing of the NMDAR1 subunit gene transcript was examined by in situ hybridization in the developing and adult rat brain. NMDAR1 mRNA, barely detectable at...
Impact of β and γ variants on ligand binding properties of g-aminobutyric acidA receptors (1994)
Lüddens,H., Seeburg,Peter H., Korpi,Esa R.
We expressed in cultured cells recombinant gamma-aminobutyric acid type A (GABAA) receptors of the subunit compositions alpha 1 beta j gamma k and alpha 5 beta j gamma k (j = 1, 2, or 3 and k = 2 or...
Monyer,Hannah, Burnashev,Nail, Laurie,David J., Sakmann,Bert, Seeburg,Peter H.
An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the four NR2 transcripts...
Monyer,Hannah, Burnashev,Nail, Laurie,David J., Sakmann,Bert, Seeburg,Peter H.
An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the four NR2 transcripts...
Molecular biology of glutamate receptors (1994)
Schoepfer,Ralf, Monyer,Hannah, Sommer,B., Wisden,William, Sprengel,Rolf, Kuner,Thomas, ...
Molecular biology of glutamate receptors (1994)
Schoepfer,Ralf, Monyer,Hannah, Sommer,B., Wisden,William, Sprengel,Rolf, Kuner,Thomas, ...
Molecular biology of NMDA receptors (1994)
Seeburg,Peter H., Monyer,Hannah, Sprengel,Rolf, Burnashev,Nail
Molecular biology of NMDA receptors (1994)
Seeburg,Peter H., Monyer,Hannah, Sprengel,Rolf, Burnashev,Nail
Molecular biology of glutamate receptors (1994)
Schoepfer, Ralf, Monyer, Hannah, Sommer, B., Wisden, William, Sprengel, Rolf, Kuner, Thomas, ...
Molecular biology of glutamate receptors (1994)
Schoepfer, Ralf, Monyer, Hannah, Sommer, B., Wisden, William, Sprengel, Rolf, Kuner, Thomas, ...
Köhler, Martin, Kornau, Hans Christian, Seeburg, Peter H.
The murine gene encoding the GluR-B subunit of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors was characterized with respect to exon-intron organization, transcriptional start...
Hartveit, E., Brandstaetter, J. H., Sassoè-Pognetto, M., Laurie, David J., Seeburg, Peter H., Waessle, H.
The localization of the N-methyl-D-aspartate receptor subunit NR2A was studied, by using light microscopic immunocytochemistry, in the retina of adult rat, rabbit, cat, and monkey. Strong, punctate...
Jonas, Peter, Racca, Claudia, Sakmann, Bert, Seeburg, Peter H., Monyer, Hannah
Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type glutamate receptor (GluR) channels. Heterologous expression suggested that the Ca2+ permeability of these receptors...
High-level expression of functional glutamate receptor channels in insect cells (1994)
Keinänen, Kari, Köhr, Georg, Seeburg, Peter H., Laukkanen, M. L., Oker-Blom, C.
We have expressed glutamate-gated ion channels in Spodoptera frugiperda Sf21 insect cells using a recombinant baculovirus system. Cells infected with recombinant baculoviruses encoding the...
Korpi, Esa R., Kuner, Thomas, Kristo, P., Köhler, Martin, Herb, Anne, Lüddens, H., ...
Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction...
NMDA receptor channels: subtype specific potentiation by reducing agents (1994)
Köhr, Georg, Eckardt, Sigrid, Lüddens, H., Monyer, Hannah, Seeburg, Peter H.
Sulfhydryl redox agents affect NMDA receptor activity. We investigated a putative redox site in four recombinant NMDA receptors. In 293 cells expressing NR1-NR2A channels dithiothreitol (DTT) rapidly...
Ligand affinities at recombinant N-methyl-D-aspartate receptors depend on subunit composition (1994)
Laurie, David J., Seeburg, Peter H.
The ligand preferences of recombinant NR1 homomeric and NR1-NR2 heteromeric NMDA receptors were examined by homogenate binding assay. The binding affinities for most ligands were similar to those...
Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA (1994)
Laurie, David J., Seeburg, Peter H.
Developmental and regional alternative splicing of the NMDAR1 subunit gene transcript was examined by in situ hybridization in the developing and adult rat brain. NMDAR1 mRNA, barely detectable at...
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing (1994)
Lomeli, H., Mosbacher, Johannes, Melcher, H., Höger, T., Geiger, Jörg R. P., Kuner, Thomas, ...
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear...
Impact of β and γ variants on ligand binding properties of g-aminobutyric acidA receptors (1994)
Lüddens, H., Seeburg, Peter H., Korpi, Esa R.
We expressed in cultured cells recombinant gamma-aminobutyric acid type A (GABAA) receptors of the subunit compositions alpha 1 beta j gamma k and alpha 5 beta j gamma k (j = 1, 2, or 3 and k = 2 or...
Monyer, Hannah, Burnashev, Nail, Laurie, David J., Sakmann, Bert, Seeburg, Peter H.
An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the four NR2 transcripts...
A molecular determinant for submillisecond desensitization in glutamate receptors (1994)
Mosbacher, Johannes, Schoepfer, Ralf, Monyer, Hannah, Burnashev, Nail, Seeburg, Peter H., Ruppersberg, J. Peter
The decay of excitatory postsynaptic currents in central neurons mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors is likely to be shaped either by receptor...
Molecular biology of NMDA receptors (1994)
Seeburg, Peter H., Monyer, Hannah, Sprengel, Rolf, Burnashev, Nail
Jonas, Peter, Racca, Claudia, Sakmann, Bert, Seeburg, Peter H., Monyer, Hannah
Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type glutamate receptor (GluR) channels. Heterologous expression suggested that the Ca2+ permeability of these receptors...
Korpi, Esa R., Kuner, Thomas, Kristo, P., Köhler, Martin, Herb, Anne, Lüddens, H., ...
Sequence variation was found in cDNA coding for the extracellular domain of the rat gamma-aminobutyric acid type A (GABAA) receptor alpha 6 subunit. About 20% of polymerase chain reaction...
Control of kinetic properties of AMPA receptor channels by nuclear RNA editing (1994)
Lomeli, H., Mosbacher, Johannes, Melcher, H., Höger, T., Geiger, Jörg R. P., Kuner, Thomas, ...
AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor channels mediate the fast component of excitatory postsynaptic currents in the central nervous system. Site-selective nuclear...
Monyer, Hannah, Burnashev, Nail, Laurie, David J., Sakmann, Bert, Seeburg, Peter H.
An in situ study of mRNAs encoding NMDA receptor subunits in the developing rat CNS revealed that, at all stages, the NR1 gene is expressed in virtually all neurons, whereas the four NR2 transcripts...
A molecular determinant for submillisecond desensitization in glutamate receptors (1994)
Mosbacher, Johannes, Schoepfer, Ralf, Monyer, Hannah, Burnashev, Nail, Seeburg, Peter H., Ruppersberg, J. Peter
The decay of excitatory postsynaptic currents in central neurons mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors is likely to be shaped either by receptor...
Molecular biology of NMDA receptors (1994)
Seeburg, Peter H., Monyer, Hannah, Sprengel, Rolf, Burnashev, Nail
Higuchi,Miyoko, Single,Frank N., Köhler,Martin, Sommer,B., Sprengel,Rolf, Seeburg,Peter H.
A functionally critical position (Q/R site) of the AMPA receptor subunit GluR-B is controlled by RNA editing that operates in the nucleus, since in brain and clonal cell lines of neural origin,...
Wisden,William, Parker,Eric M., Mahle,Cathy D., Grisel,Darcy A., Nowak,Henry P., Yocca,Frank D., ...
A gene encoding a novel G protein-coupled 5-hydroxytryptamine (5-HT) receptor, termed 5-HT5B, was cloned. The ligand binding profile of this receptor is distinct from that of other cloned 5-HT...
Marti,T., Benke,Dietmar, Künzi,R., Heckendorn,Roland, Pozza,M., Allgeier,Hans, ...
Activation of N-methyl-D-aspartate (NMDA) receptors is essential for synaptic plasticity in the central nervous system and contributes to neuronal death under various pathological conditions....
Differentialsignal transduction by five splice variants of the PACAP receptor (1993)
Spengler,D., Waeber,C., Pantaloni,C., Holsboer,F., Bockaert,Joël, Seeburg,Peter H., ...
The two forms of pituitary adenylyl cyclase-activating polypeptide (PACAP-27 and -38) are neuropeptides of the secretin/glucagon/vasoactive intestinal polypeptide/growth-hormone-releasing hormone...
The unique properties of glutamate receptor channels (1993)
Sprengel,Rolf, Seeburg,Peter H.
Rapid excitatory neurotransmission in the central nervous system (CNS) is mediated predominantly by synaptically released -glutamate which activates cation selective channels with different kinetic...
Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)
Raditsch,Martin, Ruppersberg,J. Peter, Kuner,Thomas, Günther,Willy, Schoepfer,Ralf, Seeburg,Peter H., ...
Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...
Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)
Raditsch,Martin, Ruppersberg,J. Peter, Kuner,Thomas, Günther,Willy, Schoepfer,Ralf, Seeburg,Peter H., ...
Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...
Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)
Raditsch,Martin, Ruppersberg,J. Peter, Kuner,Thomas, Günther,Willy, Schoepfer,Ralf, Seeburg,Peter H., ...
Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...
Stable expression of cloned rat GABAA receptor subunits in a human kidney cell line (1993)
Hamilton,B. J., Lennon,D. J., Im,H. K., Im,W. B., Seeburg,Peter H., Carter,D. B.
A predominant form of the GABAA/benzodiazepine receptor-Cl- channel complex is believed to consist of three different 48-55 kDa subunits (α, β, γ) with unknown stoichiometry....
The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family (1993)
Lomeli,H., Sprengel,Rolf, Laurie,David J., Köhr,Georg, Herb,Anne, Seeburg,Peter H., ...
We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25%...
Bach,A. W. J., Unger,L., Sprengel,Rolf, Mengod,G., Palacios,J., Seeburg,Peter H., ...
Using polymerase chain reaction (PCR) a complementary DNA (cDNA) encoding a 5-hydroxytryptamine (5-HT) receptor was isolated from rat forebrain. The amplified cDNA specifies an open reading frame of...
Köhler,Martin, Burnashev,Nail, Sakmann,Bert, Seeburg,Peter H.
GluR6, a subunit of high affinity kainate receptor channels in the mammalian CNS, carries a glutamine (Q) or arginine (R) residue in a critical position (Q/R site) of the putative channel-forming...
Toelle,T. R., Berthele,Achim, Zieglgänsberger,Walter, Seeburg,Peter H., Wisden,William
Diverse arrays of glutamate-gated channels in the spinal cord and associated pathways are partly responsible for sensory input, for altered sensitivity to peripheral stimuli during inflammation, and...
Mammalian ionotropic glutamate receptors (1993)
Wisden,William, Seeburg,Peter H.
Exciting new milestones in glutamate receptor (GluR) channel research include the following: the cloning of N-methyl-D-aspartate (NMDA) receptors; delineation of molecular determinants for ion flow...
A complex mosaic of high-affinity kainate receptors in rat brain (1993)
Wisden,William, Seeburg,Peter H.
The significance for CNS function of glutamate-gated cation channels that exhibit high-affinity kainate sites is not understood. Such receptors, which on dorsal root ganglia and in recombinant...
Köhler,Martin, Burnashev,Nail, Sakmann,Bert, Seeburg,Peter H.
GluR6, a subunit of high affinity kainate receptor channels in the mammalian CNS, carries a glutamine (Q) or arginine (R) residue in a critical position (Q/R site) of the putative channel-forming...
Bach, A. W. J., Unger, L., Sprengel, Rolf, Mengod, G., Palacios, J., Seeburg, Peter H., ...
Using polymerase chain reaction (PCR) a complementary DNA (cDNA) encoding a 5-hydroxytryptamine (5-HT) receptor was isolated from rat forebrain. The amplified cDNA specifies an open reading frame of...
Natural point mutation reveals a behavioural correlate for a cerebellar GABAA receptor (1993)
Korpi, Esa R., Kleingoor, C., Kettenmann, H., Seeburg, Peter H.
Higuchi, Miyoko, Single, Frank N., Köhler, Martin, Sommer, B., Sprengel, Rolf, Seeburg, Peter H.
A functionally critical position (Q/R site) of the AMPA receptor subunit GluR-B is controlled by RNA editing that operates in the nucleus, since in brain and clonal cell lines of neural origin,...
Köhler, Martin, Burnashev, Nail, Sakmann, Bert, Seeburg, Peter H.
GluR6, a subunit of high affinity kainate receptor channels in the mammalian CNS, carries a glutamine (Q) or arginine (R) residue in a critical position (Q/R site) of the putative channel-forming...
The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family (1993)
Lomeli, H., Sprengel, Rolf, Laurie, David J., Köhr, Georg, Herb, Anne, Seeburg, Peter H., ...
We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25%...
Marti, T., Benke, Dietmar, Künzi, R., Heckendorn, Roland, Pozza, M., Allgeier, Hans, ...
Activation of N-methyl-D-aspartate (NMDA) receptors is essential for synaptic plasticity in the central nervous system and contributes to neuronal death under various pathological conditions....
Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)
Raditsch, Martin, Ruppersberg, J. Peter, Kuner, Thomas, Günther, Willy, Schoepfer, Ralf, Seeburg, Peter H., ...
Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...
The TiPS/TINS Lecture: The molecular biology of mammalian glutamate receptor channels (1993)
In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and pharmacological properties. Molecular cloning has...
The TINS/TiPS Lecture: The molecular biology of mammalian glutamate receptor channels (1993)
In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and pharmacological properties. Molecular cloning has...
Differentialsignal transduction by five splice variants of the PACAP receptor (1993)
Spengler, D., Waeber, C., Pantaloni, C., Holsboer, F., Bockaert, Joël, Seeburg, Peter H., ...
The two forms of pituitary adenylyl cyclase-activating polypeptide (PACAP-27 and -38) are neuropeptides of the secretin/glucagon/vasoactive intestinal polypeptide/growth-hormone-releasing hormone...
The unique properties of glutamate receptor channels (1993)
Sprengel, Rolf, Seeburg, Peter H.
Rapid excitatory neurotransmission in the central nervous system (CNS) is mediated predominantly by synaptically released -glutamate which activates cation selective channels with different kinetic...
Toelle, T. R., Berthele, Achim, Zieglgänsberger, Walter, Seeburg, Peter H., Wisden, William
Diverse arrays of glutamate-gated channels in the spinal cord and associated pathways are partly responsible for sensory input, for altered sensitivity to peripheral stimuli during inflammation, and...
Wisden, William, Parker, Eric M., Mahle, Cathy D., Grisel, Darcy A., Nowak, Henry P., Yocca, Frank D., ...
A gene encoding a novel G protein-coupled 5-hydroxytryptamine (5-HT) receptor, termed 5-HT5B, was cloned. The ligand binding profile of this receptor is distinct from that of other cloned 5-HT...
Mammalian ionotropic glutamate receptors (1993)
Wisden, William, Seeburg, Peter H.
Exciting new milestones in glutamate receptor (GluR) channel research include the following: the cloning of N-methyl-D-aspartate (NMDA) receptors; delineation of molecular determinants for ion flow...
A complex mosaic of high-affinity kainate receptors in rat brain (1993)
Wisden, William, Seeburg, Peter H.
The significance for CNS function of glutamate-gated cation channels that exhibit high-affinity kainate sites is not understood. Such receptors, which on dorsal root ganglia and in recombinant...
Stable expression of cloned rat GABAA receptor subunits in a human kidney cell line (1993)
Hamilton, B. J., Lennon, D. J., Im, H. K., Im, W. B., Seeburg, Peter H., Carter, D. B.
A predominant form of the GABAA/benzodiazepine receptor-Cl- channel complex is believed to consist of three different 48-55 kDa subunits (α, β, γ) with unknown stoichiometry....
Köhler, Martin, Burnashev, Nail, Sakmann, Bert, Seeburg, Peter H.
GluR6, a subunit of high affinity kainate receptor channels in the mammalian CNS, carries a glutamine (Q) or arginine (R) residue in a critical position (Q/R site) of the putative channel-forming...
Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)
Raditsch, Martin, Ruppersberg, J. Peter, Kuner, Thomas, Günther, Willy, Schoepfer, Ralf, Seeburg, Peter H., ...
Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...
Subunit-specific block of cloned NMDA receptors by argiotoxin636 (1993)
Raditsch, Martin, Ruppersberg, J. Peter, Kuner, Thomas, Günther, Willy, Schoepfer, Ralf, Seeburg, Peter H., ...
Cloned NMDA receptor channels of the NR1-NR2A, NR1-NR2B and NR1-NR2C type show differences in argiotoxin636 block. Mutations of an asparagine residue located at a homologous position in the TM2...
Ca2+ permeable AMPA/KA receptors in fusiform cerebellar glial cells (1992)
Burnashev,Nail, Khodorova,A., Jonas,Peter, Helm,Paul Johannes, Wisden,William, Monyer,Hannah, ...
Burnashev,Nail, Schoepfer,Ralf, Monyer,Hannah, Ruppersberg,J. Peter, Guenther,W., Seeburg,Peter H., ...
The N-methyl-D-aspartate (NMDA) receptor forms a cation-selective channel with a high calcium permeability and sensitivity to channel block by extracellular magnesium. These properties, which are...
Localization of GABAA receptors in the rat retina (1992)
Greferath,U., Müller,F., Wässle,H., Shivers,B. D., Seeburg,Peter H.
A third g subunit of the g-aminobutyric acid type A receptor family (1992)
Herb,Anne, Wisden,William, Lüddens,H., Puia,G., Vicini,V., Seeburg,Peter H.
Cloned cDNAs encoding a member of the &gamma:-aminobutyric acid type A receptor &gamma:-subunit class were isolated from rat-brain-mRNA-derived libraries. The γ3 mRNA is present in cortex,...
Laurie,David J., Wisden,William, Seeburg,Peter H.
In an effort to determine subunit compositions of in vivo GABAA receptors, the cellular localization of 13 subunit encoding mRNAs (alpha 1-alpha 6, beta 1-beta 3, gamma 2-gamma 3, delta) was...
High-affinity kainate and domoate receptors in rat brain (1992)
Lomeli,H., Wisden,William, Köhler,Martin, Keinänen,Kari, Sommer,B., Seeburg,Peter H.
Heteromeric NMDA receptors: molecular and functional distinction of subtypes (1992)
Monyer,Hannah, Sprengel,Rolf, Schoepfer,Ralf, Herb,Anne, Higuchi,Miyoko, Lomeli,H., ...
Glutamate receptor expression in the rat retina (1992)
Müller,F., Greferath,U., Wässle,H., Wisden,William, Seeburg,Peter H.
A glutamate receptor channel with high affinity for domoate and kainate (1992)
Sommer,B., Burnashev,Nail, Verdoorn,Todd A., Keinaenen,K., Sakmann,Bert, Seeburg,Peter H.
The non-NMDA family of glutamate receptors comprises a growing number of structurally related subunits (GluR-A to -D or -1 to -4; GluR-5, -6; KA-1). GluR-A to -D appear to constitute the major AMPA...
Ca2+ permeable AMPA/KA receptors in fusiform cerebellar glial cells (1992)
Burnashev,Nail, Khodorova,A., Jonas,Peter, Helm,Paul Johannes, Wisden,William, Monyer,Hannah, ...
Burnashev,Nail, Schoepfer,Ralf, Monyer,Hannah, Ruppersberg,J. Peter, Guenther,W., Seeburg,Peter H., ...
The N-methyl-D-aspartate (NMDA) receptor forms a cation-selective channel with a high calcium permeability and sensitivity to channel block by extracellular magnesium. These properties, which are...
Heteromeric NMDA receptors: molecular and functional distinction of subtypes (1992)
Monyer,Hannah, Sprengel,Rolf, Schoepfer,Ralf, Herb,Anne, Higuchi,Miyoko, Lomeli,H., ...
A glutamate receptor channel with high affinity for domoate and kainate (1992)
Sommer,B., Burnashev,Nail, Verdoorn,Todd A., Keinaenen,K., Sakmann,Bert, Seeburg,Peter H.
The non-NMDA family of glutamate receptors comprises a growing number of structurally related subunits (GluR-A to -D or -1 to -4; GluR-5, -6; KA-1). GluR-A to -D appear to constitute the major AMPA...
Ca2+ permeable AMPA/KA receptors in fusiform cerebellar glial cells (1992)
Burnashev, Nail, Khodorova, A., Jonas, Peter, Helm, Paul Johannes, Wisden, William, Monyer, Hannah, ...
Burnashev, Nail, Schoepfer, Ralf, Monyer, Hannah, Ruppersberg, J. Peter, Guenther, W., Seeburg, Peter H., ...
The N-methyl-D-aspartate (NMDA) receptor forms a cation-selective channel with a high calcium permeability and sensitivity to channel block by extracellular magnesium. These properties, which are...
Localization of GABAA receptors in the rat retina (1992)
Greferath, U., Müller, F., Wässle, H., Shivers, B. D., Seeburg, Peter H.
A third g subunit of the g-aminobutyric acid type A receptor family (1992)
Herb, Anne, Wisden, William, Lüddens, H., Puia, G., Vicini, V., Seeburg, Peter H.
Cloned cDNAs encoding a member of the &gamma:-aminobutyric acid type A receptor &gamma:-subunit class were isolated from rat-brain-mRNA-derived libraries. The γ3 mRNA is present in cortex,...
Laurie, David J., Wisden, William, Seeburg, Peter H.
In an effort to determine subunit compositions of in vivo GABAA receptors, the cellular localization of 13 subunit encoding mRNAs (alpha 1-alpha 6, beta 1-beta 3, gamma 2-gamma 3, delta) was...
High-affinity kainate and domoate receptors in rat brain (1992)
Lomeli, H., Wisden, William, Köhler, Martin, Keinänen, Kari, Sommer, B., Seeburg, Peter H.
Heteromeric NMDA receptors: molecular and functional distinction of subtypes (1992)
Monyer, Hannah, Sprengel, Rolf, Schoepfer, Ralf, Herb, Anne, Higuchi, Miyoko, Lomeli, H., ...
Glutamate receptor expression in the rat retina (1992)
Müller, F., Greferath, U., Wässle, H., Wisden, William, Seeburg, Peter H.
A glutamate receptor channel with high affinity for domoate and kainate (1992)
Sommer, B., Burnashev, Nail, Verdoorn, Todd A., Keinaenen, K., Sakmann, Bert, Seeburg, Peter H.
The non-NMDA family of glutamate receptors comprises a growing number of structurally related subunits (GluR-A to -D or -1 to -4; GluR-5, -6; KA-1). GluR-A to -D appear to constitute the major AMPA...
Ca2+ permeable AMPA/KA receptors in fusiform cerebellar glial cells (1992)
Burnashev, Nail, Khodorova, A., Jonas, Peter, Helm, Paul Johannes, Wisden, William, Monyer, Hannah, ...
Burnashev, Nail, Schoepfer, Ralf, Monyer, Hannah, Ruppersberg, J. Peter, Guenther, W., Seeburg, Peter H., ...
The N-methyl-D-aspartate (NMDA) receptor forms a cation-selective channel with a high calcium permeability and sensitivity to channel block by extracellular magnesium. These properties, which are...
Heteromeric NMDA receptors: molecular and functional distinction of subtypes (1992)
Monyer, Hannah, Sprengel, Rolf, Schoepfer, Ralf, Herb, Anne, Higuchi, Miyoko, Lomeli, H., ...
A glutamate receptor channel with high affinity for domoate and kainate (1992)
Sommer, B., Burnashev, Nail, Verdoorn, Todd A., Keinaenen, K., Sakmann, Bert, Seeburg, Peter H.
The non-NMDA family of glutamate receptors comprises a growing number of structurally related subunits (GluR-A to -D or -1 to -4; GluR-5, -6; KA-1). GluR-A to -D appear to constitute the major AMPA...
Puia,G., Vicini,S., Seeburg,Peter H., Costa,E.
gamma-Aminobutyric acid (GABA)-activated Cl- currents in neonatal rat cortical neurons and in cultured cells engineered for the expression of specific molecular forms of the GABAA receptor alpha,...
Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes (1991)
Kavanaugh,M. P., Christie,M. J., Osborne,P. B., Busch,A. E., Shen,K. Z., Wu,Y. N., ...
GABAA receptor point mutation increases the affinity of compounds for the benzodiazepine site (1991)
Pritchett,D. B., Seeburg,Peter H.
Recombinantly expressed γ - aminobutyric acid type A (GABAA) receptors consisting of α1,2, and γ2 subunits contain a binding site for benzodiazepines that differs in its properties...
Structural determinants of ion flow through recombinant glutamate receptor channels (1991)
Verdoorn,Todd A., Burnashev,Nail, Monyer,Hannah, Seeburg,Peter H., Sakmann,Bert
Voigt,Mark M., Laurie,David J., Seeburg,Peter H., Bach,Alfred
To date, there have been at least eight different receptors for the neurotransmitter serotonin (5-HT) identified in the central nervous system. These receptors fall into four pharmacological classes:...
Distribution of GABAA receptor subunit mRNAs in rat lumbar spinal cord (1991)
Wisden,William, Gundlach,A. L., Barnard,Eric A., Seeburg,Peter H., Hunt,S. P.
Cloning, pharmacological characteristics and expression pattern of GABAA receptor a4 subunit (1991)
Wisden,William, Herb,Anne, Wieland,Heike, Keinänen,Kari, Lüddens,H., Seeburg,Peter H.
Molecular biology of glutamate-gated channels: Focus on AMPA and kainate (1991)
Seeburg,Peter H., Wisden,William, Verdoorn,Todd A., Keinänen,Kari, Werner,Pia, Monyer,Hannah, ...
Structural determinants of ion flow through recombinant glutamate receptor channels (1991)
Verdoorn,Todd A., Burnashev,Nail, Monyer,Hannah, Seeburg,Peter H., Sakmann,Bert
Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes (1991)
Kavanaugh, M. P., Christie, M. J., Osborne, P. B., Busch, A. E., Shen, K. Z., Wu, Y. N., ...
GABAA receptor point mutation increases the affinity of compounds for the benzodiazepine site (1991)
Pritchett, D. B., Seeburg, Peter H.
Recombinantly expressed γ - aminobutyric acid type A (GABAA) receptors consisting of α1,2, and γ2 subunits contain a binding site for benzodiazepines that differs in its properties...
RNA editing in brain controls a determinant of ion flow in glutamate-gated channels (1991)
Sommer, B., Köhler, Martin, Sprengel, Rolf, Seeburg, Peter H.
Structural determinants of ion flow through recombinant glutamate receptor channels (1991)
Verdoorn, Todd A., Burnashev, Nail, Monyer, Hannah, Seeburg, Peter H., Sakmann, Bert
Voigt, Mark M., Laurie, David J., Seeburg, Peter H., Bach, Alfred
To date, there have been at least eight different receptors for the neurotransmitter serotonin (5-HT) identified in the central nervous system. These receptors fall into four pharmacological classes:...
Distribution of GABAA receptor subunit mRNAs in rat lumbar spinal cord (1991)
Wisden, William, Gundlach, A. L., Barnard, Eric A., Seeburg, Peter H., Hunt, S. P.
Cloning, pharmacological characteristics and expression pattern of GABAA receptor a4 subunit (1991)
Wisden, William, Herb, Anne, Wieland, Heike, Keinänen, Kari, Lüddens, H., Seeburg, Peter H.
Molecular biology of glutamate-gated channels: Focus on AMPA and kainate (1991)
Seeburg, Peter H., Wisden, William, Verdoorn, Todd A., Keinänen, Kari, Werner, Pia, Monyer, Hannah, ...
Puia, G., Vicini, S., Seeburg, Peter H., Costa, E.
gamma-Aminobutyric acid (GABA)-activated Cl- currents in neonatal rat cortical neurons and in cultured cells engineered for the expression of specific molecular forms of the GABAA receptor alpha,...
Structural determinants of ion flow through recombinant glutamate receptor channels (1991)
Verdoorn, Todd A., Burnashev, Nail, Monyer, Hannah, Seeburg, Peter H., Sakmann, Bert
Differential benzodiazepine pharmacology of recombinant GABAA receptors (1990)
Blankenfeld,G., Ymer,S., Pritchett,D. B., Sontheimer,H., Ewert,Markus, Seeburg,Peter H., ...
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+ (1990)
Draguhn,Andreas, Verdoorn,Todd A., Ewert,Markus, Seeburg,Peter H., Sakmann,Bert
A family of ionotropic AMPA selective glutamate receptors (1990)
Keinänen,Kari, Wisden,William, Sommer,B., Werner,Pia, Herb,Anne, Verdoorn,Todd A., ...
A cerebellar GABAA receptor selective for a behavioural alcohol antagonist (1990)
Lüddens,H., Pritchett,D. B., Köhler,Martin, Killisch,I., Keinänen,Kari, Monyer,Hannah, ...
Neurosteroids act on recombinant human GABAA receptors (1990)
Puia,G., Santi,M. R., Vicini,S., Pritchett,D. B., Purdy,R. H., Paul,S. M., ...
The GABAA receptor family: Molecular and functional diversity (1990)
Seeburg,Peter H., Wisden,William, Verdoorn,Todd A., Pritchett,D. B., Werner,Pia, Herb,Anne, ...
FLIP and FLOP: A cell specific functional switch in glutamate-operated channels of CNS (1990)
Sommer,B., Keinänen,Kari, Verdoorn,Todd A., Wisden,William, Burnashev,Nail, Herb,Anne, ...
Functional properties of recombinant rat GABAA receptors depend on subunit composition (1990)
Verdoorn,Todd A., Draguhn,Andreas, Ymer,S., Seeburg,Peter H., Sakmann,Bert
Purification, cloning and expression of a peripheral-type benzodiazepine receptor (1990)
Krueger,K. E., Mukhin,A. G., Antkiewicz-Michaluk,L., Santi,M. R., Grayson,D. R., Guidotti,A., ...
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+ (1990)
Draguhn,Andreas, Verdoorn,Todd A., Ewert,Markus, Seeburg,Peter H., Sakmann,Bert
A family of ionotropic AMPA selective glutamate receptors (1990)
Keinänen,Kari, Wisden,William, Sommer,B., Werner,Pia, Herb,Anne, Verdoorn,Todd A., ...
The GABAA receptor family: Molecular and functional diversity (1990)
Seeburg,Peter H., Wisden,William, Verdoorn,Todd A., Pritchett,D. B., Werner,Pia, Herb,Anne, ...
FLIP and FLOP: A cell specific functional switch in glutamate-operated channels of CNS (1990)
Sommer,B., Keinänen,Kari, Verdoorn,Todd A., Wisden,William, Burnashev,Nail, Herb,Anne, ...
Functional properties of recombinant rat GABAA receptors depend on subunit composition (1990)
Verdoorn,Todd A., Draguhn,Andreas, Ymer,S., Seeburg,Peter H., Sakmann,Bert
Differential benzodiazepine pharmacology of recombinant GABAA receptors (1990)
Blankenfeld, G., Ymer, S., Pritchett, D. B., Sontheimer, H., Ewert, Markus, Seeburg, Peter H., ...
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+ (1990)
Draguhn, Andreas, Verdoorn, Todd A., Ewert, Markus, Seeburg, Peter H., Sakmann, Bert
A family of ionotropic AMPA selective glutamate receptors (1990)
Keinänen, Kari, Wisden, William, Sommer, B., Werner, Pia, Herb, Anne, Verdoorn, Todd A., ...
A cerebellar GABAA receptor selective for a behavioural alcohol antagonist (1990)
Lüddens, H., Pritchett, D. B., Köhler, Martin, Killisch, I., Keinänen, Kari, Monyer, Hannah, ...
Penschow, J. D., Aldred, G. P., Darling, P. A., Haralambidis, J., Hammond, V. E., VanLeeuwen, B. H., ...
Neurosteroids act on recombinant human GABAA receptors (1990)
Puia, G., Santi, M. R., Vicini, S., Pritchett, D. B., Purdy, R. H., Paul, S. M., ...
The GABAA receptor family: Molecular and functional diversity (1990)
Seeburg, Peter H., Wisden, William, Verdoorn, Todd A., Pritchett, D. B., Werner, Pia, Herb, Anne, ...
FLIP and FLOP: A cell specific functional switch in glutamate-operated channels of CNS (1990)
Sommer, B., Keinänen, Kari, Verdoorn, Todd A., Wisden, William, Burnashev, Nail, Herb, Anne, ...
Functional properties of recombinant rat GABAA receptors depend on subunit composition (1990)
Verdoorn, Todd A., Draguhn, Andreas, Ymer, S., Seeburg, Peter H., Sakmann, Bert
Purification, cloning and expression of a peripheral-type benzodiazepine receptor (1990)
Krueger, K. E., Mukhin, A. G., Antkiewicz-Michaluk, L., Santi, M. R., Grayson, D. R., Guidotti, A., ...
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+ (1990)
Draguhn, Andreas, Verdoorn, Todd A., Ewert, Markus, Seeburg, Peter H., Sakmann, Bert
A family of ionotropic AMPA selective glutamate receptors (1990)
Keinänen, Kari, Wisden, William, Sommer, B., Werner, Pia, Herb, Anne, Verdoorn, Todd A., ...
The GABAA receptor family: Molecular and functional diversity (1990)
Seeburg, Peter H., Wisden, William, Verdoorn, Todd A., Pritchett, D. B., Werner, Pia, Herb, Anne, ...
FLIP and FLOP: A cell specific functional switch in glutamate-operated channels of CNS (1990)
Sommer, B., Keinänen, Kari, Verdoorn, Todd A., Wisden, William, Burnashev, Nail, Herb, Anne, ...
Functional properties of recombinant rat GABAA receptors depend on subunit composition (1990)
Verdoorn, Todd A., Draguhn, Andreas, Ymer, S., Seeburg, Peter H., Sakmann, Bert
The rat gonadotropin-releasing hormone: SH Locus: Structure and hypothalamic expression (1989)
Bond,Chris T., Hayflick,J. S., Seeburg,Peter H., Adelman,John P.
The dopamine D2 receptor: two molecular forms generated by alternative splicing (1989)
DalToso,R., Sommer,B., Ewert,Markus, Herb,Anne, Pritchett,D. B., Bach,Alfred, ...
Cloned human dopamine D2 receptor cDNA was isolated from a pituitary cDNA library and found to encode an additional 29 amino acid residues in the predicted intracellular domain between transmembrane...
The lutropin receptor: An unusual member of the G protein-coupled receptor family (1989)
McFarland,K. C., Sprengel,Rolf, Phillips,H. S., Köhler,Martin, Rosenblit,N., Nikolics,K., ...
Type I and type II GABAA /Benzodiazepine receptors produced in transfected cells (1989)
Pritchett,D. B., Lüddens,H., Seeburg,Peter H.
GABAA (gamma-aminobutyric acid A)-benzodiazepine receptors expressed in mammalian cells and assembled from one of three different alpha subunit variants (alpha 1, alpha 2, or alpha 3) in combination...
A novel GABAA receptor subunit is important for benzodiazepine pharmacology (1989)
Pritchett,D. B., Sontheimer,H., Shivers,B. D., Ymer,S., Kettenmann,H., Schofield,P. R., ...
Negative allosteric modulation of native and reconstituted GABAA receptors (1989)
Puia,G., Santi,M. R., Pritchett,D. B., Seeburg,Peter H., Costa,E.
Sequence and expression of human GABAA receptor a1 and ß1 subunits (1989)
Schofield,P. R., Pritchett,D. B., Sontheimer,H., Kettenmann,H., Seeburg,Peter H.
The gene encoding GnRH and its associated peptide GAP: some insights into hypogonadism (1989)
Seeburg,Peter H., Mason,A. J., Young III,W. S., Stewart,T. A., Nikolics,K.
Two novel GABAA receptor subunits exist in distinct neuronal subpopulations (1989)
Shivers,B. D., Killisch,I., Sprengel,Rolf, Sontheimer,H., Köhler,Martin, Schofield,P. R., ...
Functional chloride channels by mammalian cell expression of rat glycine receptor subunit (1989)
Sontheimer,H., Becker,Cord-Michael, Pritchett,D. B., Schofield,P. R., Grenningloh,G., Kettenmann,H., ...
Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor (1989)
Sprengel,Rolf, Werner,Pia, Seeburg,Peter H., Mukhin,A. G., Sonti,M. R., Grayson,D. R., ...
Prolactin-inhibiting activity of GnRH-associated peptide in cultured human pituitary cells (1989)
Wormald,P. J., Abrahamson,M. J., Seeburg,Peter H., Nikolics,K., Millar,R. P.
Sequence and expression of novel GABAA receptor a subunit (1989)
Ymer,S., Draguhn,Andreas, Köhler,Martin, Schofield,P. R., Seeburg,Peter H.
GABAA receptor b subunit heterogeneity: functional expression of cloned cDNAs (1989)
Ymer,S., Schofield,P. R., Draguhn,Andreas, Werner,Pia, Köhler,Martin, Seeburg,Peter H.
Cloned cDNAs encoding two new beta subunits of the rat and bovine GABAA receptor have been isolated using a degenerate oligonucleotide probe based on a highly conserved peptide sequence in the second...
Cloned serotonin 5HT-2 receptor: Stucture and second messenger coupling (1989)
Pritchett,D. B., Bach,Alfred, Taleb,O., DalToso,R., Seeburg,Peter H.
Sequence and expression of novel GABAA receptor a subunit (1989)
Ymer,S., Draguhn,Andreas, Köhler,Martin, Schofield,P. R., Seeburg,Peter H.
GABAA receptor b subunit heterogeneity: functional expression of cloned cDNAs (1989)
Ymer,S., Schofield,P. R., Draguhn,Andreas, Werner,Pia, Köhler,Martin, Seeburg,Peter H.
Cloned cDNAs encoding two new beta subunits of the rat and bovine GABAA receptor have been isolated using a degenerate oligonucleotide probe based on a highly conserved peptide sequence in the second...
The rat gonadotropin-releasing hormone: SH Locus: Structure and hypothalamic expression (1989)
Bond, Chris T., Hayflick, J. S., Seeburg, Peter H., Adelman, John P.
Buckle, V. J., Fujita, Naoyuki, Ryder-Cook, A. S., Derry, J. M. J., Barnard, Pene J., Lebo, R. V., ...
The dopamine D2 receptor: two molecular forms generated by alternative splicing (1989)
DalToso, R., Sommer, B., Ewert, Markus, Herb, Anne, Pritchett, D. B., Bach, Alfred, ...
Cloned human dopamine D2 receptor cDNA was isolated from a pituitary cDNA library and found to encode an additional 29 amino acid residues in the predicted intracellular domain between transmembrane...
The lutropin receptor: An unusual member of the G protein-coupled receptor family (1989)
McFarland, K. C., Sprengel, Rolf, Phillips, H. S., Köhler, Martin, Rosenblit, N., Nikolics, K., ...
Type I and type II GABAA /Benzodiazepine receptors produced in transfected cells (1989)
Pritchett, D. B., Lüddens, H., Seeburg, Peter H.
GABAA (gamma-aminobutyric acid A)-benzodiazepine receptors expressed in mammalian cells and assembled from one of three different alpha subunit variants (alpha 1, alpha 2, or alpha 3) in combination...
A novel GABAA receptor subunit is important for benzodiazepine pharmacology (1989)
Pritchett, D. B., Sontheimer, H., Shivers, B. D., Ymer, S., Kettenmann, H., Schofield, P. R., ...
Negative allosteric modulation of native and reconstituted GABAA receptors (1989)
Puia, G., Santi, M. R., Pritchett, D. B., Seeburg, Peter H., Costa, E.
Sequence and expression of human GABAA receptor a1 and ß1 subunits (1989)
Schofield, P. R., Pritchett, D. B., Sontheimer, H., Kettenmann, H., Seeburg, Peter H.
The gene encoding GnRH and its associated peptide GAP: some insights into hypogonadism (1989)
Seeburg, Peter H., Mason, A. J., Young III, W. S., Stewart, T. A., Nikolics, K.
Two novel GABAA receptor subunits exist in distinct neuronal subpopulations (1989)
Shivers, B. D., Killisch, I., Sprengel, Rolf, Sontheimer, H., Köhler, Martin, Schofield, P. R., ...
Functional chloride channels by mammalian cell expression of rat glycine receptor subunit (1989)
Sontheimer, H., Becker, Cord-Michael, Pritchett, D. B., Schofield, P. R., Grenningloh, G., Kettenmann, H., ...
Molecular cloning and expression of cDNA encoding a peripheral-type benzodiazepine receptor (1989)
Sprengel, Rolf, Werner, Pia, Seeburg, Peter H., Mukhin, A. G., Sonti, M. R., Grayson, D. R., ...
Prolactin-inhibiting activity of GnRH-associated peptide in cultured human pituitary cells (1989)
Wormald, P. J., Abrahamson, M. J., Seeburg, Peter H., Nikolics, K., Millar, R. P.
Sequence and expression of novel GABAA receptor a subunit (1989)
Ymer, S., Draguhn, Andreas, Köhler, Martin, Schofield, P. R., Seeburg, Peter H.
GABAA receptor b subunit heterogeneity: functional expression of cloned cDNAs (1989)
Ymer, S., Schofield, P. R., Draguhn, Andreas, Werner, Pia, Köhler, Martin, Seeburg, Peter H.
Cloned cDNAs encoding two new beta subunits of the rat and bovine GABAA receptor have been isolated using a degenerate oligonucleotide probe based on a highly conserved peptide sequence in the second...
Cloned serotonin 5HT-2 receptor: Stucture and second messenger coupling (1989)
Pritchett, D. B., Bach, Alfred, Taleb, O., DalToso, R., Seeburg, Peter H.
Sequence and expression of novel GABAA receptor a subunit (1989)
Ymer, S., Draguhn, Andreas, Köhler, Martin, Schofield, P. R., Seeburg, Peter H.
GABAA receptor b subunit heterogeneity: functional expression of cloned cDNAs (1989)
Ymer, S., Schofield, P. R., Draguhn, Andreas, Werner, Pia, Köhler, Martin, Seeburg, Peter H.
Cloned cDNAs encoding two new beta subunits of the rat and bovine GABAA receptor have been isolated using a degenerate oligonucleotide probe based on a highly conserved peptide sequence in the second...
Ackland,J. F., Seeburg,Peter H., Nikolics,K., Jackson,I. M. D.
We have developed RIAs using antisera directed against the cryptic peptide of the GnRH precursor (termed GnRH-associated peptide, GAP) and have used these together with a GnRH assay to characterize...
Bach,Alfred, Lan,H. C., Johnson,D. L., Abell,C. W., Bembenek,M. F., Kwan,S. W., ...
The monoamine oxidases play a vital role in the metabolism of biogenic amines in the central nervous system and in peripheral tissues. Using oligonucleotide probes derived from three sequenced...
Molecular Biology of the GABAA receptor (1988)
Barnard,Eric A., Darlison,Mark G., Fujita,Naoyuki, Glencorse,T. A., Levitan,E. S., Reale,V., ...
Structural and functional basis for GABAA receptor heterogeneity (1988)
Levitan,E. S., Schofield,P. R., Burt,David R., Rhee,L. M., Wisden,William, Köhler,Martin, ...
Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase) (1988)
Malfroy,B., Kuang,W. J., Seeburg,Peter H., Mason,A. J., Schofield,P. S.
Structure and functional expression of cloned rat serotonin 5HT-2 receptor (1988)
Pritchett,D. B., Bach,A. W. J., Wozny,M., Taleb,O., DalToso,R., Shih,J., ...
A complementary DNA (cDNA) encoding a serotonin receptor with 51% sequence identity to the 5HT-1C subtype was isolated from a rat brain cDNA library by homology screening. Transient expression of the...
Potassium channels expressed from rat brain cDNA have delayed rectifier properties (1988)
Stühmer,Walter, Stocker,Martin, Sakmann,Bert, Seeburg,Peter H., Baumann,Ariane, Grupe,A., ...
Molecular basis of human growth hormone gene deletions (1988)
Vnencak-Jones,C. L., Phillips,J. A., Chen,E. Y., Seeburg,Peter H.