Eissing, Thomas, Waldherr, Steffen, Allgöwer, Frank, Scheurich, Peter, Bullinger, Eric
Recently, a mathematical model of the mitochondrial apoptotic pathway was proposed. In that study, the robustness of different simplified signaling models with respect to parameter changes was also...
Steady state and (bi-) stability evaluation of simple protease signalling networks (2007)
Eissing, Thomas, Waldherr, Steffen, Allgöwer, Frank, Scheurich, Peter, Bullinger, Eric
Signal transduction networks are complex, as are their mathematical models. Gaining a deeper understanding requires a system analysis. Important aspects are the number, location and stability of...
Eissing, Thomas, Waldherr, Steffen, Gondro, Cedric, Bullinger, Eric, Sawodny, Oliver, Allgöwer, Frank, ...
Proc. of the IEEE Conference on Control Applications
Bistability analyses of a caspase activation model for receptor-induced apoptosis (2004)
Eissing, Thomas, Conzelmann, Holger, Gilles, Ernst Dieter, Allgöwer, Frank, Bullinger, Eric, Scheurich, Peter
Apoptosis is an important physiological process crucially involved in development and homeostasis of multicellular organisms. Although the major signaling pathways have been unraveled, a detailed...
Schäfer, Hans-Jochen, Scheurich, Peter, Rathgeber, Gabriele, Dose, Klaus
8-Azido-1,N6-etheno-ATP - a fluorescent and photoreactive ATP analog has been synthesized and characterized by elementary analysis, thin layer chromatography, infrared spectroscopy, proton resonance...
The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
Grell, Matthias, Wajant, Harald, Zimmermann, Gudrun, Scheurich, Peter
Tumor necrosis factor (TNF) can induce a variety of cellular responses at low picomolar concentrations. This is in apparent conflict with the published dissociation constants for TNF binding to TNF...
NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling
Kreuz, Sebastian, Siegmund, Daniela, Scheurich, Peter, Wajant, Harald
The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of death receptor-induced apoptosis. We found that cFLIP can be upregulated in some cell lines under critical...
Scheurich, Peter, Zimmermann, Ulrich, Schnabl, Heide
Cell fusion is induced between guard cell and mesophyll cell protoplasts of Vicia faba by electrical field application. The process of fusion is initiated by electrical breakdown of the cell...
The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
Grell, Matthias, Wajant, Harald, Zimmermann, Gudrun, Scheurich, Peter
Tumor necrosis factor (TNF) can induce a variety of cellular responses at low picomolar concentrations. This is in apparent conflict with the published dissociation constants for TNF binding to TNF...
NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling
Kreuz, Sebastian, Siegmund, Daniela, Scheurich, Peter, Wajant, Harald
The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of death receptor-induced apoptosis. We found that cFLIP can be upregulated in some cell lines under critical...
Scheurich, Peter, Zimmermann, Ulrich, Schnabl, Heide
Cell fusion is induced between guard cell and mesophyll cell protoplasts of Vicia faba by electrical field application. The process of fusion is initiated by electrical breakdown of the cell...
NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
Kreuz, Sebastian, Siegmund, Daniela, Rumpf, Jost-Julian, Samel, Dierk, Leverkus, Martin, Janssen, Ottmar, ...
Fas (APO-1/CD95) is the prototypic death receptor, and the molecular mechanisms of Fas-induced apoptosis are comparably well understood. Here, we show that Fas activates NFκB via a pathway involving...
Lazdins, Janis K., Grell, Matthias, Walker, Maja R., Woods-Cook, Kathie, Scheurich, Peter, Pfizenmaier, Klaus
Tumor necrosis factor (TNF) and lymphotoxin (LT) are highly pleiotropic cytokines that play a central role in regulating HIV-1 replication. These cytokines express their activities through two...