Scientific Commons: Philippe Gevaert

Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue (2009)

Patou, Joke, Holtappels, Gabriele, Affleck, Karen, Gevaert, Philippe, Perez-Novo, Claudina, Van Cauwenberge, Paul, ...

Abstract Background The mast cell is a crucial effector cell in allergic rhinitis and other inflammatory diseases. During the acute allergic reaction preformed mediators such as histamine, but also...

Differential expression of the interleukin 5 receptor alpha isoforms in blood and tissue eosinophils of nasal polyp patients (2009)

Gevaert, Philippe, Hellman, C., Lundblad, L., Lundahl, J., Holtappels, Gabriële, Van Cauwenberge, Paul, ...

Given the key role of interleukin-5 (IL-5) in eosinophil function, we investigated the regulated expression of the membrane-anchored (TM-IL-5R alpha) isoform, or a secreted (SOL IL-5R alpha) isoform,...

Decreased FOXP3 protein expression in patients with asthma (2009)

Provoost, Sharen, Maes, Tania, Van Durme, Yannick, Gevaert, Philippe, Bachert, Claus, Schmidt-Weber, C.B., ...

Background: T-regulatory cells (T(reg)) are important in balancing immune responses and maintaining peripheral tolerance. Current evidence suggests that asthma is characterized by a relative...

Chronic rhinosinusitis with and without nasal polyps: what is the difference? (2009)

Huvenne, Wouter, Van Bruaene, Nicholas, Zhang, Nan, VAN ZELE, THIBAUT, Patou, Joke, Gevaert, Philippe, ...

Chronic rhinosinusitis is a heterogeneous group of chronic sinus diseases that may consist of clearly different disease entities. Further investigation of the pathomechanisms of chronic...

Role of Staphylococcus Aureus Enterotoxin B in allergic sensitization (2009)

Huvenne, Wouter, Callebaut, Ina, Vanoirbeek, Jeroen, Van Cauwenberge, Paul, Gevaert, Philippe, Bachert, Claus, ...

Mepolizumab, a humanised anti-IL-5 monoclonal antibody, as treatment of severe nasal polyposis (2008)

Gevaert, Philippe, Van Bruaene, Nicholas, BLOMME, KATRIEN, SOUSA, AR, MARSHAL, RP, Bachert, Claus

Staphylococcus aureus Enterotoxin B breaks primary tolerance to ovalbumine (2008)

Huvenne, Wouter, CALLEBAUT, I, BOBIC, S, VERBINNEN, B, HENS, G, Van Cauwenberge, Paul, ...

Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients (2008)

Van Zele, Thibaut, Vaneechoutte, Mario, Holtappels, Gabriële, Gevaert, Philippe, Van Cauwenberge, Paul, Bachert, Claus

T-cell regulation in chronic paranasal sinus disease (2008)

Van Bruaene, Nicholas, Perez Novo, Claudina, BASINSKI, TM, Van Zele, Thibaut, Holtappels, Gabriële, De Ruyck, Natalie, ...

Staphylococcus aureus enterotoxin B, protein A, and lipoteichoic acid stimulations in nasal polyps (2008)

Patou, Joke, Gevaert, Philippe, VAN ZELE, THIBAUT, Holtappels, Gabriële, Van Cauwenberge, Paul, Bachert, Claus

Background: Increasing evidence points toward a modifying role of Staphylococcus aureus and its products in the pathogenesis of nasal polyposis. Objective: The aim of this study was to investigate...

Role of staphylococcal superantigens in upper airway disease (2008)

Bachert, Claus, Zhang, Nan, Patou, Joke, VAN ZELE, THIBAUT, Gevaert, Philippe

Purpose of review Chronic rhinosinusitis with nasal polyps often represents a chronic severe inflammatory disease of the upper airways and may serve as a model for lower airway diseases such as...

Remodelling in nasal polyposis is independent of TH-cell polarisation (2007)

Zhang, Nan, ZELE, TV, Gevaert, Philippe, Holtappels, Gabriële, VAN CAUWENBERGE, P, Bachert, Claus

Staphylococcus aureus enterotoxin B stimulation in nasal polyps (2007)

Patou, Joke, Van Zele, Thibaut, Holtappels, Gabriële, Gevaert, Philippe, Van Cauwenberge, Paul, Bachert, Claus

Local immunoglobulin production in nasal polyposis is modulated by superantigens (2007)

Van Zele, Thibaut, Gevaert, Philippe, Holtappels, Gabriële, Van Cauwenberge, Paul, Bachert, Claus

Role of staphylococcal superantigens in airway disease: A review. Part 2: S-aureus enterotoxins in AERD, asthma, early childhood wheezing and COPD (2007)

Bachert, Claus, Zhang, Nan, Gevaert, Philippe, Van Zele, Thibaut, Perez Novo, Claudina

Preclinical study of a novel, non-steroidal, plant-derived, anti-inflammatory compound for the treatment of airway disease (2007)

Gevaert, Philippe, Patou, Joke, Van Zele, Thibaut, Holtappels, Gabriële, DE BOSSCHER, K, Vanden Berghe, Wim, ...

Staphylococcus aureus enterotoxin B stimulation in nasal polyps (2007)

Patou, Joke, Van Zele, Thibaut, Holtappels, Gabriële, Gevaert, Philippe, Van Cauwenberge, Paul, Bachert, Claus

Staphylococcus aureus sensitization and allergic disease in early childhood: Population-based birth cohort study (2007)

SEMIC-JUSUFAGIC, A, Bachert, Claus, Gevaert, Philippe, Holtappels, Gabriële, LOWE, L, WOODCOCK, A, ...

Upper airway inflammation in chronic smoke exposed mice (2007)

Huvenne, Wouter, Holtappels, Gabriële, De Ruyck, Natalie, Perez Novo, Claudina, Gevaert, Philippe, Van Cauwenberge, Paul, ...

T cell regulation in chronic sinus disease (2007)

Van Bruaene, Nicholas, PEREZ-NOVO, C, Van Zele, Thibaut, Holtappels, Gabriële, De Ruyck, Natalie, Van Cauwenberge, Paul, ...

Staphylococcal superantigens in airway disease: A review. Part 1: The role of S-aureus enterotoxins in allergic rhinitis and nasal polyps (2007)

Bachert, Claus, Gevaert, Philippe, Zhang, Nan, Van Zele, Thibaut, Perez Novo, Claudina

Upper airway inflammation in chronic smoke exposed mice (2007)

Huvenne, Wouter, Holtappels, Gabriële, DERUYCK, N, PEREZ-NOVO, C, Gevaert, Philippe, Van Cauwenberge, Paul, ...

Aggravation of bronchial eosinophilia in mice by nasal and bronchial exposure to Staphylococcus aureus enterotoxin B (2006)

Gevaert, Philippe, ...

BACKGROUND: The role of bacterial enterotoxins like Staphylococcus aureus enterotoxin B (SEB) in allergic asthma remains unknown. We used a mouse model of airway allergy to study the effects of nasal...

Differentiation of chronic sinus diseases by measurement of inflammatory mediators (2006)

Van Zele, Thibaut, Claeys, Sofie, Gevaert, Philippe, Van Maele, Georges, Holtappels, Gabriële, Van Cauwenberge, Paul, ...

Aggravation of bronchial eosinophilia in mice by nasal and bronchial exposure to Staphylococcus aureus enterotoxin B (2006)

HELLINGS, PW, HENS, G, MEYTS, I, BULLENS, D, VANOIRBEEK, J, Gevaert, Philippe, ...

Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps (2006)

Gevaert, Philippe, LANG-LOIDOLT, D, LACKNER, A, STAMMBERGER, H, STAUDINGER, H, VAN ZELE, T, ...

Development of a rabbit model to study inflammation in nasal and paranasal cavities (2006)

Huvenne, Wouter, Gevaert, Philippe, Holtappels, Gabriële, Van Cauwenberge, Paul, Bachert, Claus

Organization of secondary lymphoid tissue and local IgE formation to Staphylococcus aureus enterotoxins in nasal polyp tissue (2005)

Gevaert, Philippe, Holtappels, Gabriële, JOHANSSON, SGO, Cuvelier, Claude, CAUWENBERGE, P, Bachert, Claus

Pharmacological management of nasal polyposis (2005)

Bachert, Claus, Watelet, Jean-Baptiste, Gevaert, Philippe, Van Cauwenberge, Paul

Nasal polyps in patients with and without cystic fibrosis: a differentiation by innate markers and inflammatory mediators (2005)

Claeys, Sofie, Van Hoecke, Helen, Holtappels, Gabriële, Gevaert, Philippe, DE BELDER, T, Verhasselt, Bruno, ...

An update on the impact of Staphylococcus aureus enterotoxins in chronic sinusitis with nasal polyposis (2005)

Zhang, Nan, Gevaert, Philippe, VAN ZELE, THIBAUT, PEREZ-NOVO, C, PATOU, JOKE, Holtappels, Gabriële, ...

Soluble interleukin-5 receptor alpha is increased in acute exacerbation of chronic obstructive pulmonary disease (2004)

ROHDE, G, Gevaert, Philippe, Holtappels, Gabriële, FRANSEN, L, BORG, I, WIETHEGE, A, ...

Collection of nasal secretions for immunological analysis (2004)

Watelet, Jean-Baptiste, Gevaert, Philippe, Holtappels, Gabriële, Van Cauwenberge, Paul, Bachert, Claus

Increased IgE-antibodies to Staphylococcus aureus enterotoxins in patients with COPD (2004)

ROHDE, G, Gevaert, Philippe, Holtappels, Gabriële, BORG, I, WIETHEGE, A, ARINIR, U, ...

Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis (2004)

Van Zele, Thibaut, Gevaert, Philippe, Watelet, Jean-Baptiste, Claeys, Cindy, Van Cauwenberge, Paul, Bachert, Claus

Macrophage mannose receptor in chronic sinus disease (2004)

Claeys, Sofie, DE BELDER, T, Holtappels, Gabriële, Gevaert, Philippe, Verhasselt, Bruno, Van Cauwenberge, Paul, ...

Aspirin sensitivity and IgE antibodies to Staphylococcus aureus enterotoxins in nasal polyposis: Studies on the relationship (2004)

PEREZ-NOVO, CA, KOWALSKI, ML, KUNA, P, PTASINSKA, A, Holtappels, Gabriële, Van Cauwenberge, Paul, ...

Transforming growth factor beta 1 in nasal remodeling: Differences between chronic rhinosinusitis and nasal polyposis (2004)

Watelet, Jean-Baptiste, Claeys, Cindy, PEREZ-NOVO, C, Gevaert, Philippe, Van Cauwenberge, Paul, Bachert, Claus

Quantitative Real Time Polymerase Chain Reaction for measurement of human Interleukin – 5 receptor alpha spliced isoforms mRNA (2003)

Pérez, Claudina, Vandesompele, Jo, Vandenbroucke, Ina, Holtappels, Gabriele, Speleman, Frank, Gevaert, Philippe, ...

Abstract Background Expression of human Interleukin-5 receptor alpha (hIL-5Rα) is controlled by alternative splicing, which generates two different transcripts encoding a membrane-anchored and a...

Interleukin 5, eosinophilic diseases and therapeutic intervention (2003)

Zabeau, Lennart, Gevaert, Philippe, Bachert, Claus, Tavernier, Jan

Quantitative Real Time Polymerase Chain Reaction for measurement of human Interleukin – 5 receptor alpha spliced isoforms mRNA (2003)

Perez Novo, Claudina, Vandesompele, Jo, Holtappels, Gabriële, Speleman, Franki, Gevaert, Philippe, Van Cauwenberge, Paul, ...

Staphylococcus aureus enterotoxins: a key in airway disease? (2002)

Bachert, Claus, Gevaert, Philippe, Van Cauwenberge, Paul

Staphylococcus aureus superantigens and airway disease. (2002)

Bachert, Claus, Gevaert, Philippe, Van Cauwenberge, Paul

Mediators in nasal polyposis. (2002)

Bachert, Claus, Gevaert, Philippe, HOLTAPPELS, G, Van Cauwenberge, Paul

Up-regulation of IL-18 in allergic rhinitis. (2002)

VERHAEGHE, B, Gevaert, Philippe, HOLTAPPELS, G, LUKAT, KF, LANGE, B, Van Cauwenberge, Paul, ...