Shigellosis: an old disease in new clothes? (2006)
BACKGROUND: The burden of shigellosis is greatest in resource-poor countries. Although this diarrheal disease has been thought to cause considerable morbidity and mortality in excess of 1,000,000...
Shigellosis: an old disease in new clothes? (2006)
BACKGROUND: The burden of shigellosis is greatest in resource-poor countries. Although this diarrheal disease has been thought to cause considerable morbidity and mortality in excess of 1,000,000...
Shigellosis: an old disease in new clothes? (2006)
BACKGROUND: The burden of shigellosis is greatest in resource-poor countries. Although this diarrheal disease has been thought to cause considerable morbidity and mortality in excess of 1,000,000...
Raqib,Rubhana, Ekberg,Caroline, Sharkar,Protim, Bardhan,Pradip K., Zychlinsky,Arturo, Sansonetti,Philippe J., ...
Shigella dysenteriae type I-induced apoptotic cell death in rectal tissues from patients infected with Shigella dysenteriae type I was studied by the terminal deoxynucleotidyltransferase- mediated...
Raqib, Rubhana, Ekberg, Caroline, Sharkar, Protim, Bardhan, Pradip K., Zychlinsky, Arturo, Sansonetti, Philippe J., ...
A prospective study of reactive arthritis triggered by shigella dysentery (1995)
Azim, Tasnim, Mitchison, N. Avrion, Sieper, Joachin, Salam, M. Abdus, Albert, M. John, Charron, Dominique, ...
Arondel, Josette, Singer, Monique, Matsukawa, Akihiro, Zychlinsky, Arturo, Sansonetti, Philippe J.
Infection by the enteric bacterial pathogen Shigella results in intense mucosal inflammation and destruction of the colonic and rectal epithelium in infected humans. Initial bacterial translocation...
François, Mathias, Le Cabec, Véronique, Dupont, Marie-Ange, Sansonetti, Philippe J., Maridonneau-Parini, Isabelle
Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to...
Parameters Underlying Successful Protection with Live Attenuated Mutants in Experimental Shigellosis
Bernardini, Maria Lina, Arondel, Josette, Martini, Irene, Aidara, Awa, Sansonetti, Philippe J.
Because the use of live attenuated mutants of Shigella spp. represents a promising approach to protection against bacillary dysentery (M. E. Etherridge, A. T. M. Shamsul Hoque, and D. A. Sack, Lab....
Rasolofo-Razanamparany, Voahangy, Cassel-Beraud, Anne-Marie, Roux, Jean, Sansonetti, Philippe J., Phalipon, Armelle
The mucosal humoral immune response elicited following Shigella flexneri infection in patients living in Antananarivo districts (Madagascar Island) was evaluated by measuring the gut-derived,...
Immunogenicity of IpaC-Hybrid Proteins Expressed in the Shigella flexneri 2a Vaccine Candidate SC602
Bârzu, Simona, Arondel, Josette, Guillot, Sophie, Sansonetti, Philippe J., Phalipon, Armelle
We have investigated the capacity of live attenuated Shigella flexneri strains to act as vectors for the induction of local and systemic antibody responses against heterologous epitopes. The S....
Vaccination against Shigellosis with Attenuated Shigella flexneri 2a Strain SC602
Coster, Trinka S., Hoge, Charles W., VanDeVerg, Lillian L., Hartman, Antoinette B., Oaks, Edwin V., Venkatesan, Malabi M., ...
The Shigella flexneri 2a SC602 vaccine candidate carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding...
Raqib, Rubhana, Ekberg, Caroline, Sharkar, Protim, Bardhan, Pradip K., Zychlinsky, Arturo, Sansonetti, Philippe J., ...
Shigella dysenteriae type 1-induced apoptotic cell death in rectal tissues from patients infected with Shigella dysenteriae type 1 was studied by the terminal deoxynucleotidyltransferase-mediated...
Hathaway, Lucy J., Griffin, George E., Sansonetti, Philippe J., Edgeworth, Jonathan D.
Shigella flexneri infection of human macrophages is followed by rapid bacterial escape into the cytosol and secretion of IpaB, which activates caspase-1 to mediate cell death and release of mature...
Niebuhr, Kirsten, Giuriato, Sylvie, Pedron, Thierry, Philpott, Dana J., Gaits, Frédérique, Sable, Julia, ...
Phosphoinositides play a central role in the control of several cellular events including actin cytoskeleton organization. Here we show that, upon infection of epithelial cells with the Gram-negative...
Mavris, Maria, Sansonetti, Philippe J., Parsot, Claude
Bacteria of Shigella spp. use a virulence plasmid-encoded type III secretion (TTS) system to invade the colonic epithelium in humans. The activity of the TTS apparatus is tightly regulated in the...
Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases
Chamaillard, Mathias, Philpott, Dana, Girardin, Stephen E., Zouali, Habib, Lesage, Suzanne, Chareyre, Fabrice, ...
CARD15 is a major susceptibility gene for a frequent multifactorial chronic inflammatory bowel disorder, Crohn disease (CD). By using NF-κB activation assays, the cytosolic CARD15 was shown to...
Kim, Dong Wook, Lenzen, Gerlinde, Page, Anne-Laure, Legrain, Pierre, Sansonetti, Philippe J., Parsot, Claude
Bacteria of Shigella spp. are responsible for shigellosis in humans. They use a type III secretion system to inject effector proteins into host cells and induce their entry into epithelial cells or...
CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
Girardin, Stephen E., Tournebize, Régis, Mavris, Maria, Page, Anne-Laure, Li, Xiaoxia, Stark, George R., ...
Epithelial cells are refractory to extracellular lipopolysaccharide (LPS), yet when presented inside the cell, it is capable of initiating an inflammatory response. Using invasive Shigella flexneri...
Shigellosis: An Old Disease in New Clothes?
Sansonetti discusses a "landmark" study of the epidemiology of shigellosis, involving over 600,000 people of all ages in six Asian countries.
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
Magalhaes, Joao Gamelas, Philpott, Dana J, Nahori, Marie-Anne, Jéhanno, Muguette, Fritz, Joerg, Bourhis, Lionel Le, ...
Tracheal cytotoxin (TCT) was originally described as the minimal effector that was able to reproduce the cytotoxic response of Bordetella pertussis on ciliated epithelial cells. This molecule...
Arondel, Josette, Singer, Monique, Matsukawa, Akihiro, Zychlinsky, Arturo, Sansonetti, Philippe J.
Infection by the enteric bacterial pathogen Shigella results in intense mucosal inflammation and destruction of the colonic and rectal epithelium in infected humans. Initial bacterial translocation...
François, Mathias, Le Cabec, Véronique, Dupont, Marie-Ange, Sansonetti, Philippe J., Maridonneau-Parini, Isabelle
Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to...
Parameters Underlying Successful Protection with Live Attenuated Mutants in Experimental Shigellosis
Bernardini, Maria Lina, Arondel, Josette, Martini, Irene, Aidara, Awa, Sansonetti, Philippe J.
Because the use of live attenuated mutants of Shigella spp. represents a promising approach to protection against bacillary dysentery (M. E. Etherridge, A. T. M. Shamsul Hoque, and D. A. Sack, Lab....
Rasolofo-Razanamparany, Voahangy, Cassel-Beraud, Anne-Marie, Roux, Jean, Sansonetti, Philippe J., Phalipon, Armelle
The mucosal humoral immune response elicited following Shigella flexneri infection in patients living in Antananarivo districts (Madagascar Island) was evaluated by measuring the gut-derived,...
Immunogenicity of IpaC-Hybrid Proteins Expressed in the Shigella flexneri 2a Vaccine Candidate SC602
Bârzu, Simona, Arondel, Josette, Guillot, Sophie, Sansonetti, Philippe J., Phalipon, Armelle
We have investigated the capacity of live attenuated Shigella flexneri strains to act as vectors for the induction of local and systemic antibody responses against heterologous epitopes. The S....
Vaccination against Shigellosis with Attenuated Shigella flexneri 2a Strain SC602
Coster, Trinka S., Hoge, Charles W., VanDeVerg, Lillian L., Hartman, Antoinette B., Oaks, Edwin V., Venkatesan, Malabi M., ...
The Shigella flexneri 2a SC602 vaccine candidate carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding...
Raqib, Rubhana, Ekberg, Caroline, Sharkar, Protim, Bardhan, Pradip K., Zychlinsky, Arturo, Sansonetti, Philippe J., ...
Shigella dysenteriae type 1-induced apoptotic cell death in rectal tissues from patients infected with Shigella dysenteriae type 1 was studied by the terminal deoxynucleotidyltransferase-mediated...
Hathaway, Lucy J., Griffin, George E., Sansonetti, Philippe J., Edgeworth, Jonathan D.
Shigella flexneri infection of human macrophages is followed by rapid bacterial escape into the cytosol and secretion of IpaB, which activates caspase-1 to mediate cell death and release of mature...
Niebuhr, Kirsten, Giuriato, Sylvie, Pedron, Thierry, Philpott, Dana J., Gaits, Frédérique, Sable, Julia, ...
Phosphoinositides play a central role in the control of several cellular events including actin cytoskeleton organization. Here we show that, upon infection of epithelial cells with the Gram-negative...
Mavris, Maria, Sansonetti, Philippe J., Parsot, Claude
Bacteria of Shigella spp. use a virulence plasmid-encoded type III secretion (TTS) system to invade the colonic epithelium in humans. The activity of the TTS apparatus is tightly regulated in the...
Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases
Chamaillard, Mathias, Philpott, Dana, Girardin, Stephen E., Zouali, Habib, Lesage, Suzanne, Chareyre, Fabrice, ...
CARD15 is a major susceptibility gene for a frequent multifactorial chronic inflammatory bowel disorder, Crohn disease (CD). By using NF-κB activation assays, the cytosolic CARD15 was shown to...
CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
Girardin, Stephen E., Tournebize, Régis, Mavris, Maria, Page, Anne-Laure, Li, Xiaoxia, Stark, George R., ...
Epithelial cells are refractory to extracellular lipopolysaccharide (LPS), yet when presented inside the cell, it is capable of initiating an inflammatory response. Using invasive Shigella flexneri...
Kim, Dong Wook, Lenzen, Gerlinde, Page, Anne-Laure, Legrain, Pierre, Sansonetti, Philippe J., Parsot, Claude
Bacteria of Shigella spp. are responsible for shigellosis in humans. They use a type III secretion system to inject effector proteins into host cells and induce their entry into epithelial cells or...
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
Magalhaes, Joao Gamelas, Philpott, Dana J, Nahori, Marie-Anne, Jéhanno, Muguette, Fritz, Joerg, Bourhis, Lionel Le, ...
Tracheal cytotoxin (TCT) was originally described as the minimal effector that was able to reproduce the cytotoxic response of Bordetella pertussis on ciliated epithelial cells. This molecule...
Shigellosis: An Old Disease in New Clothes?
Sansonetti discusses a "landmark" study of the epidemiology of shigellosis, involving over 600,000 people of all ages in six Asian countries.
PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection
Pendaries, Caroline, Tronchère, Hélène, Arbibe, Laurence, Mounier, Joelle, Gozani, Or, Cantley, Lewis, ...
The virulence factor IpgD, delivered into nonphagocytic cells by the type III secretion system of the pathogen Shigella flexneri, is a phosphoinositide 4-phosphatase generating phosphatidylinositol 5...
Bougnères, Laurence, Girardin, Stéphane E., Weed, Scott A., Karginov, Andrei V., Olivo-Marin, Jean-Christophe, Parsons, J. Thomas, ...
Shigella, the causative agent of bacillary dysentery, invades epithelial cells in a process involving Src tyrosine kinase signaling. Cortactin, a ubiquitous actin-binding protein present in...
Shigella is a Gram-negative bacterial species of the family Enterobacteriaceae that causes bacillary dysentery in humans. This acute colitis reflects the capacity of the microorganism to disrupt,...
Fullner, Karla Jean, Boucher, John C., Hanes, Martha A., Haines, G. Kenneth, Meehan, Brian M., Walchle, Cynthia, ...
The contribution of accessory toxins to the acute inflammatory response to Vibrio cholerae was assessed in a murine pulmonary model. Intranasal administration of an El Tor O1 V. cholerae strain...
Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells
Beatty, Wandy L., Méresse, Stéphane, Gounon, Pierre, Davoust, Jean, Mounier, Joëlle, Sansonetti, Philippe J., ...
Bacterial lipopolysaccharide (LPS) at the apical surface of polarized intestinal epithelial cells was previously shown to be transported from the apical to the basolateral pole of the epithelium...
Egile, Coumaran, Loisel, Thomas P., Laurent, Valérie, Li, Rong, Pantaloni, Dominique, Sansonetti, Philippe J., ...
To propel itself in infected cells, the pathogen Shigella flexneri subverts the Cdc42-controlled machinery responsible for actin assembly during filopodia formation. Using a combination of bacterial...
Sperandio, Brice, Regnault, Béatrice, Guo, Jianhua, Zhang, Zhi, Stanley, Samuel L., Sansonetti, Philippe J., ...
Antimicrobial factors are efficient defense components of the innate immunity, playing a crucial role in the intestinal homeostasis and protection against pathogens. In this study, we report that...
Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella
Jaumouillé, Valentin, Francetic, Olivera, Sansonetti, Philippe J, Tran Van Nhieu, Guy
Type III secretion (T3S) systems are largely used by pathogenic Gram-negative bacteria to inject multiple effectors into eukaryotic cells. Upon cell contact, these bacterial microinjection devices...
Mounier, Joëlle, Popoff, Michel R., Enninga, Jost, Frame, Margaret C., Sansonetti, Philippe J., Van Nhieu, Guy Tran
Shigella, the causative agent of bacillary dysentery, invades epithelial cells by locally reorganizing the actin cytoskeleton. Shigella invasion requires actin polymerization dependent on the Src...