Phillip T. Sekella

A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage.

Sekella, Phillip T, Rueda, David, Walter, Nils G

Recently, Breaker and coworkers engineered hammerhead ribozymes that rearrange from a catalytically inactive to an active conformation upon allosteric binding of a specific ligand. To monitor...

A biosensor for theophylline based on fluorescence detection of ligand-induced hammerhead ribozyme cleavage.

Sekella, Phillip T, Rueda, David, Walter, Nils G

Recently, Breaker and coworkers engineered hammerhead ribozymes that rearrange from a catalytically inactive to an active conformation upon allosteric binding of a specific ligand. To monitor...