Wagner, Nicole, Jehl-Piétri, Chantal, Lopez, Pascal, Murdaca, Joseph, Giordano, Christian, Schwartz, Chantal, ...
Aims Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors. PPARβ agonists were suggested as potential drugs for the treatment of metabolic syndrome, but...
Partisani, Mariagrazia, Favard, Cyril, Carlier, Marie-France, ...
The Arf6-specific exchange factor EFA6 coordinates membrane trafficking with actin cytoskeleton remodeling. It localizes to the plasma membrane where it catalyzes Arf6 activation and induces the...
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. (2006)
Rassoulzadegan, Minoo, Grandjean, Valérie, Gounon, Pierre, Vincent, Stéphane, Gillot, Isabelle, Cuzin, François
Paramutation is a heritable epigenetic modification induced in plants by cross-talk between allelic loci. Here we report a similar modification of the mouse Kit gene in the progeny of heterozygotes...
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. (2006)
Rassoulzadegan, Minoo, Grandjean, Valérie, Gounon, Pierre, Vincent, Stéphane, Gillot, Isabelle, Cuzin, François
Paramutation is a heritable epigenetic modification induced in plants by cross-talk between allelic loci. Here we report a similar modification of the mouse Kit gene in the progeny of heterozygotes...
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. (2006)
Rassoulzadegan, Minoo, Grandjean, Valérie, Gounon, Pierre, Vincent, Stéphane, Gillot, Isabelle, Cuzin, François
Paramutation is a heritable epigenetic modification induced in plants by cross-talk between allelic loci. Here we report a similar modification of the mouse Kit gene in the progeny of heterozygotes...
Arhets, Philippe, Olivo, Jean-Christophe, Gounon, Pierre, Sansonetti, Philippe, Guillén, Nancy
Several changes in cell morphology take place during the capping of surface receptors in Entamoeba histolytica. The amoebae develop the uroid, an appendage formed by membrane invaginations, which...
Le Bouguénec, Chantal, Lalioui, Lila, Du Merle, Laurence, Jouve, Mabel, Courcoux, Pascale, Bouzari, Saeid, ...
Operons of the afa family are expressed by pathogenic Escherichia coli strains associated with intestinal and extraintestinal infections in humans and animals. The recently demonstrated heterogeneity...
Immunochemical Analysis of UMP Kinase from Escherichia coli
Landais, Stéphanie, Gounon, Pierre, Laurent-Winter, Christine, Mazié, Jean-Claude, Danchin, Antoine, Bârzu, Octavian, ...
Mono- and polyclonal antibodies directed against UMP kinase from Escherichia coli were tested with the intact protein or with fragments obtained by deletion mutagenesis. As detected in enzyme-linked...
PpdD Type IV Pilin of Escherichia coli K-12 Can Be Assembled into Pili in Pseudomonas aeruginosa
Sauvonnet, Nathalie, Gounon, Pierre, Pugsley, Anthony P.
Escherichia coli K-12 possesses at least 16 chromosomal genes related to genes involved in the formation of type IV pili in other gram-negative bacteria. However, E. coli K-12 does not produce type...
Lalioui, Lila, Jouve, Mabel, Gounon, Pierre, Le Bouguenec, Chantal
The afa gene clusters, which encode proteins involved in adhesion to epithelial cells, from Escherichia coli strains associated with urinary and intestinal infections in humans have been...
Role of Adhesins and Toxins in Invasion of Human Tracheal Epithelial Cells by Bordetella pertussis
Bassinet, Laurence, Gueirard, Pascale, Maitre, Bernard, Housset, Bruno, Gounon, Pierre, Guiso, Nicole
Bordetella pertussis, the agent of whooping cough, can invade and survive in several types of eukaryotic cell, including CHO, HeLa 229, and HEp-2 cells and macrophages. In this study, we analyzed...
Isolation and Characterization of vicH, Encoding a New Pleiotropic Regulator in Vibrio cholerae
Tendeng, Christian, Badaut, Cyril, Krin, Evelyne, Gounon, Pierre, Ngo, Saravuth, Danchin, Antoine, ...
During the last decade, the hns gene and its product, the H-NS protein, have been extensively studied in Escherichia coli. H-NS-like proteins seem to be widespread in gram-negative bacteria. However,...
Mesnage, Stéphane, Tosi-Couture, Evelyne, Gounon, Pierre, Mock, Michèle, Fouet, Agnès
Bacillus anthracis, the etiological agent of anthrax, is a gram-positive spore-forming bacterium. Fully virulent bacilli are toxinogenic and capsulated. Two abundant surface proteins, including the...
Bernier, Christine, Gounon, Pierre, Le Bouguénec, Chantal
Enteroaggregative Escherichia coli (EAEC) is recognized as an emerging cause of diarrhea in children and adults worldwide, and recent studies have implicated EAEC in persistent diarrhea in patients...
Magdalena, Juana, Hachani, Abderrahman, Chamekh, Mustapha, Jouihri, Noureddine, Gounon, Pierre, Blocker, Ariel, ...
Type III secretion systems (TTSS) are essential virulence determinants of many gram-negative bacteria and serve, upon physical contact with target cells, to translocate bacterial proteins directly...
A novel dispersin protein in enteroaggregative Escherichia coli
Sheikh, Jalaluddin, Czeczulin, John R., Harrington, Susan, Hicks, Susan, Henderson, Ian R., Le Bouguénec, Chantal, ...
Enteroaggregative Escherichia coli (EAEC) is a diarrheal pathogen defined by its characteristic aggregative adherence (AA) to HEp-2 cells in culture. We have previously shown that EAEC strains...
Pilus formation and protein secretion by the same machinery in Escherichia coli
Sauvonnet, Nathalie, Vignon, Guillaume, Pugsley, Anthony P., Gounon, Pierre
The secreton (type II secretion) and type IV pilus biogenesis branches of the general secretory pathway in Gram-negative bacteria share many features that suggest a common evolutionary origin. Five...
Self-assembly of minimal COPII cages
Antonny, Bruno, Gounon, Pierre, Schekman, Randy, Orci, Lelio
The small G-protein Sar1 and the cytosolic complexes Sec23/24 and Sec13/31 associate sequentially on endoplasmic reticulum membranes to form a protein coat named COPII, which drives the formation of...
Arhets, Philippe, Olivo, Jean-Christophe, Gounon, Pierre, Sansonetti, Philippe, Guillén, Nancy
Several changes in cell morphology take place during the capping of surface receptors in Entamoeba histolytica. The amoebae develop the uroid, an appendage formed by membrane invaginations, which...
Le Bouguénec, Chantal, Lalioui, Lila, Du Merle, Laurence, Jouve, Mabel, Courcoux, Pascale, Bouzari, Saeid, ...
Operons of the afa family are expressed by pathogenic Escherichia coli strains associated with intestinal and extraintestinal infections in humans and animals. The recently demonstrated heterogeneity...
Immunochemical Analysis of UMP Kinase from Escherichia coli
Landais, Stéphanie, Gounon, Pierre, Laurent-Winter, Christine, Mazié, Jean-Claude, Danchin, Antoine, Bârzu, Octavian, ...
Mono- and polyclonal antibodies directed against UMP kinase from Escherichia coli were tested with the intact protein or with fragments obtained by deletion mutagenesis. As detected in enzyme-linked...
PpdD Type IV Pilin of Escherichia coli K-12 Can Be Assembled into Pili in Pseudomonas aeruginosa
Sauvonnet, Nathalie, Gounon, Pierre, Pugsley, Anthony P.
Escherichia coli K-12 possesses at least 16 chromosomal genes related to genes involved in the formation of type IV pili in other gram-negative bacteria. However, E. coli K-12 does not produce type...
Lalioui, Lila, Jouve, Mabel, Gounon, Pierre, Le Bouguenec, Chantal
The afa gene clusters, which encode proteins involved in adhesion to epithelial cells, from Escherichia coli strains associated with urinary and intestinal infections in humans have been...
Role of Adhesins and Toxins in Invasion of Human Tracheal Epithelial Cells by Bordetella pertussis
Bassinet, Laurence, Gueirard, Pascale, Maitre, Bernard, Housset, Bruno, Gounon, Pierre, Guiso, Nicole
Bordetella pertussis, the agent of whooping cough, can invade and survive in several types of eukaryotic cell, including CHO, HeLa 229, and HEp-2 cells and macrophages. In this study, we analyzed...
Isolation and Characterization of vicH, Encoding a New Pleiotropic Regulator in Vibrio cholerae
Tendeng, Christian, Badaut, Cyril, Krin, Evelyne, Gounon, Pierre, Ngo, Saravuth, Danchin, Antoine, ...
During the last decade, the hns gene and its product, the H-NS protein, have been extensively studied in Escherichia coli. H-NS-like proteins seem to be widespread in gram-negative bacteria. However,...
Mesnage, Stéphane, Tosi-Couture, Evelyne, Gounon, Pierre, Mock, Michèle, Fouet, Agnès
Bacillus anthracis, the etiological agent of anthrax, is a gram-positive spore-forming bacterium. Fully virulent bacilli are toxinogenic and capsulated. Two abundant surface proteins, including the...
Bernier, Christine, Gounon, Pierre, Le Bouguénec, Chantal
Enteroaggregative Escherichia coli (EAEC) is recognized as an emerging cause of diarrhea in children and adults worldwide, and recent studies have implicated EAEC in persistent diarrhea in patients...
Magdalena, Juana, Hachani, Abderrahman, Chamekh, Mustapha, Jouihri, Noureddine, Gounon, Pierre, Blocker, Ariel, ...
Type III secretion systems (TTSS) are essential virulence determinants of many gram-negative bacteria and serve, upon physical contact with target cells, to translocate bacterial proteins directly...
A novel dispersin protein in enteroaggregative Escherichia coli
Sheikh, Jalaluddin, Czeczulin, John R., Harrington, Susan, Hicks, Susan, Henderson, Ian R., Le Bouguénec, Chantal, ...
Enteroaggregative Escherichia coli (EAEC) is a diarrheal pathogen defined by its characteristic aggregative adherence (AA) to HEp-2 cells in culture. We have previously shown that EAEC strains...
Pilus formation and protein secretion by the same machinery in Escherichia coli
Sauvonnet, Nathalie, Vignon, Guillaume, Pugsley, Anthony P., Gounon, Pierre
The secreton (type II secretion) and type IV pilus biogenesis branches of the general secretory pathway in Gram-negative bacteria share many features that suggest a common evolutionary origin. Five...
Self-assembly of minimal COPII cages
Antonny, Bruno, Gounon, Pierre, Schekman, Randy, Orci, Lelio
The small G-protein Sar1 and the cytosolic complexes Sec23/24 and Sec13/31 associate sequentially on endoplasmic reticulum membranes to form a protein coat named COPII, which drives the formation of...
Boyer, Laurent, Doye, Anne, Rolando, Monica, Flatau, Gilles, Munro, Patrick, Gounon, Pierre, ...
The GTPase RhoA is a major regulator of the assembly of actin stress fibers and the contractility of the actomyosin cytoskeleton. The epidermal cell differentiation inhibitor (EDIN) and EDIN-like...
Gauthier, Nils C., Monzo, Pascale, Gonzalez, Teresa, Doye, Anne, Oldani, Amanda, Gounon, Pierre, ...
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are endocytosed by a clathrin- independent pathway into vesicles named GPI-AP–enriched early endosomal compartments (GEECs). We recently...
Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes
Narni-Mancinelli, Emilie, Campisi, Laura, Bassand, Delphine, Cazareth, Julie, Gounon, Pierre, Glaichenhaus, Nicolas, ...
Cytolysis, interferon γ and tumor necrosis factor (TNF) α secretion are major effector mechanisms of memory CD8+ T cells that are believed to be required for immunological protection in vivo. By...
Garry, Ambroise, Fromy, Bérengère, Blondeau, Nicolas, Henrion, Daniel, Brau, Frédéric, Gounon, Pierre, ...
The TWIK related K+ channel TREK1 is an important member of the class of two-pore-domain K+ channels. It is a background K+ channel and is regulated by hormones, neurotransmitters, intracellular pH...
Marinets, Alexandra, Zhang, Tonghai, Guillén, Nancy, Gounon, Pierre, Bohle, Barbara, Vollmann, Ute, ...
A panel of monoclonal antibodies was raised from mice immunized with a membrane preparation from Entamoeba histolytica, the pathogenic species causing invasive amebiasis in humans. Antibody EH5 gave...
Trafficking of Shigella Lipopolysaccharide in Polarized Intestinal Epithelial Cells
Beatty, Wandy L., Méresse, Stéphane, Gounon, Pierre, Davoust, Jean, Mounier, Joëlle, Sansonetti, Philippe J., ...
Bacterial lipopolysaccharide (LPS) at the apical surface of polarized intestinal epithelial cells was previously shown to be transported from the apical to the basolateral pole of the epithelium...
The Tripartite Type III Secreton of Shigella flexneri Inserts Ipab and Ipac into Host Membranes
Blocker, Ariel, Gounon, Pierre, Larquet, Eric, Niebuhr, Kirsten, Cabiaux, Véronique, Parsot, Claude, ...
Bacterial type III secretion systems serve to translocate proteins into eukaryotic cells, requiring a secreton and a translocator for proteins to pass the bacterial and host membranes. We used the...
Caillaud, Marie-Cécile, Lecomte, Philippe, Jammes, Fabien, Quentin, Michaël, Pagnotta, Sophie, Andrio, Emilie, ...
The infection of plants by obligate parasitic nematodes constitutes an interesting model for investigating plant cytoskeleton functions. Root knot nematodes have evolved the ability to manipulate...
Manneville, Jean-Baptiste, Casella, Jean-François, Ambroggio, Ernesto, Gounon, Pierre, Bertherat, Julien, Bassereau, Patricia, ...
Cytoplasmic coat proteins are required for cargo selection and budding of tubulovesicular transport intermediates that shuttle between intracellular compartments. To better understand the physical...
Bellot, Grégory, Garcia-Medina, Raquel, Gounon, Pierre, Chiche, Johanna, Roux, Danièle, Pouysségur, Jacques, ...
While hypoxia-inducible factor (HIF) is a major actor in the cell survival response to hypoxia, HIF also is associated with cell death. Several studies implicate the HIF-induced putative BH3-only...
Robert, Guillaume, Ben Sahra, Issam, Puissant, Alexandre, Colosetti, Pascal, Belhacene, Nathalie, Gounon, Pierre, ...
CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR,...