R. A. Coutinho

Details der Publikationsliste

Zeitraum

1981 - 2008

Anzahl

441

Co-Autoren

A resurgent HIV-1 epidemic among men who have sex with men in the era of potent antiretroviral therapy (2008)

Bezemer, D., Wolf, F. De, Boerlijst, M.C., Sighem, A. Van, Hollingsworth, T.D., Prins, M., ...

Objective: Reducing viral load, highly active antiretroviral therapy has the potential to limit onwards transmission of HIV-1 and thus help contain epidemic spread. However, increases in risk...

A hidden HIV epidemic among women in Vietnam (2008)

Nguyen, T.A., Oosterhoff, P., Hardon, A., Tran, H.N., Coutinho, R.A., Wright, P.

Background: The HIV epidemic in Vietnam is still concentrated among high risk populations, including IDU and FSW. The response of the government has focused on the recognized high risk populations,...

Diagnostic and clinical implications of anorectal lymphogranuloma venereum in men who have sex with men: A retrospective case-control study (2006)

Bij, A. Van Der, Spaargaren, J., Morre, S.A., Fennema, H.S.A., Mindel, A., Coutinho, R.A., ...

Background. Recently, outbreaks of anorectal lymphogranuloma venereum (LGV) have occurred among men who have sex with men (MSM). This study identifies risk factors and clinical predictors of LGV to...

Surveillance of risk profiles among new and repeat blood donors with transfusion-transmissible infections from 1995 through 2003 in the Netherlands (2006)

Bij, A. Van Der, Coutinho, R.A.

To evaluate the effectiveness of blood donor selection, this study reports risk profiles of donors with transfusion-transmissible infections as obtained by ongoing surveillance, 1995 through 2003, in...

Diversity and origin of hepatitis C virus infection among unpaid blood donors in the Netherlands (2006)

Bij, A. Van Der, Zaaijer, H.L., Cuijpers, H.T.M., ...

To improve transfusion policy and to increase understanding of the spread of hepatitis C virus (HCV) in the general population, HCV infections among voluntary Dutch blood donors were examined with...

High and persistent excretion of hepatitis A virus in immunocompetent patients (2006)

Tjon, G., Coutinho, R.A., Esman, S., Wijkmans, C.J., ...

The duration and level of virus excretion in blood and faeces of patients with. hepatitis A virus (HAV) infection were studied in relation to levels of alanine aminotransferase (ALT), disease...

Association between 'safer sex fatigue' and rectal gonorrhea is mediated by unsafe sex with casual partners among HIV-positive homosexual men (2006)

Stolte, I.G., Kolader, M., Fennema, H., Coutinho, R.A.

Objective: The objective of this study was to investigate whether and what sexual risk behavior is a mediator of associations between rectal gonorrhea (RG) and highly active antiretroviral...

Effectiveness of a hepatitis A vaccination program for migrant children in Amsterdam, The Netherlands (1992-2004) (2006)

Sonder, G.J.B., Baayen, T.D., Coutinho, R.A.

Objective: To evaluate the impact and effectiveness of risk-group vaccination against hepatitis A targeted at migrant children living in a country with low endemicity of hepatitis A. Methods:...

Decline in HIV incidence and injecting, but not in sexual risk behaviour, seen in drug users in Amsterdam: a 19-year prospective cohort study (2006)

Lindenburg, C.E.A., Krol, A., Smit, C., Buster, M.C.A., Coutinho, R.A., Prins, M.

Objective: To study temporal changes in HIV incidence, HIV transmission routes, and both injecting and sexual risk behaviour in the open Amsterdam Cohort Study (ACS) among drug users. Initiated in...

Molecular epidemiology of Neisseria gonorrhoeae in Amsterdam, The Netherlands, shows distinct heterosexual and homosexual networks (2006)

Kolader, M.E., Bij, A. Van Der, Dierdorp, M., Fennema, J.S.A., Coutinho, R.A., ...

Molecular typing, added to epidemiological data, can better identify transmission patterns of gonorrhea in Western countries, where the incidence has recently been rising. From September 2002 to...

Long-term follow-up: no effect of therapeutic vaccination with HIV-1 p17/p24:Ty virus-like particles on HIV-1 disease progression (2002)

Lindenburg, C. E. A., Stolte, I., Langendam, M. W., Miedema, F., Williams, I. G., Colebunders, R., ...

Long-term effects of therapeutic vaccination of human immunodeficiency virus (HIV)-1-infected subjects with HIV-1 p17/p24:Ty virus-like particles (p24-VLP) on progression to AIDS, death, a CD4 cell...

Pneumococcal carriage in children in The Netherlands: a molecular epidemiological study (2001)

Bogaert, D., Engelen, M.N., Timmers-Reker, A.J., Elzenaar, K.P., Peerbooms, P.G., Coutinho, R.A., ...

In 1999, Engelen and coworkers investigated colonization in Amsterdam among 259 children attending 16 day-care centers (DCCs) and among 276 children who did not attend day-care centers (NDCCs). A...

Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection (2000)

Hazenberg, Mette D., Borleffs, J.C.C., Otto, S.A. (Sigrid), Verschuren, M.C.M. (Martie), Boucher, C.A.B., ...

Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in...

Predictors of Mortality in the Amsterdam Cohort of Human Immunodeficiency Virus (HIV)-positive and HIV-negative Drug Users (1996)

Mientjes, G. H. C., Bax, J. S., Coutinho, R. A.

The impact of human immunodeficiency virus (HIV) infection and other risk factors on mortality was studied in a cohort of Dutch injection drug users and drug users who did not inject. Participants...

Large Declines in Sexual Risk Behavior with Noncommercial Partners among Heterosexual Injection Drug Users in Amsterdam, 1989-1995 (1996)

Coutinho, R. A.

Previous studies among injection drug users have reported small or nonexistent reductions in sexual risk behavior with noncommercial partners, and a large potential for further heterosexual spread of...

Validity of Self-Reported Sexually Transmitted Diseases in a Cohort of Drug-Using Prostitutes in Amsterdam: Trends from 1986 to 1992 (1995)

FENNEMA, J S A, COUTINHO, R A

Background Rates of self-reported sexually transmitted diseases (STD) among drug-using prostitutes in Amsterdam have been shown to be declining. However, self reports may provide biased estimates....

Risk Factors for the Transition from Noninjection to Injection Drug Use and Accompanying AIDS Risk Behavior in a Cohort of Drug Users (1994)

Hartgers, C., Coutinho, R. A.

Although injection drug users have been shown to reduce high-risk injection behaviors in response to the epidemic of human immunodeficiency virus (HIV) infection and ac-quired immunodeficiency...

The Harm Reduction Approach and Risk Factors for Human Immunodeficiency Virus (HIV) Seroconversion in Injecting Drug Users, Amsterdam (1992)

Coutinho, R. A.

To assess risk factors for seroconversion to human immunodeficiency virus, the authors studied a cohort of human immunodeficiency virus-seronegative injecting drug users in Amsterdam, the...

RISK FACTORS AND CHANGES IN SEXUAL BEHAVIOR IN MALE HOMOSEXUALS WHO SEROCONVERTED FOR HUMAN IMMUNODEFICIENCY VIRUS ANTIBODIES (1990)

KUIKEN, C. L., COUTINHO, R. A.

In Amsterdam, The Netherlands, a cohort of 982 homosexual and bisexual men has been studied since 1984. Of these, 238 men had antibodies to the human immunodeficiency virus at the onset of the study,...

Increasing antigenic and genetic diversity of the V3 variable domain of the human immunodeficiency virus envelope protein in the course of the AIDS epidemic.

Kuiken, C L, Zwart, G, Baan, E, Coutinho, R A, Van Den Hoek, J A, Goudsmit, J

Population-wide variation in genomic RNA of human immunodeficiency virus type 1 (HIV-1) encompassing the V3 loop of the envelope protein was studied in serum samples of 74 newly infected individuals...

Detection of Chlamydia trachomatis infection in urine samples from men and women by ligase chain reaction.

Van Doornum, G J, Buimer, M, Prins, M, Henquet, C J, Coutinho, R A, Plier, P K, ...

The suitability of urine specimens from women and men for the detection of Chlamydia trachomatis infection by a ligase chain reaction (LCR)-based assay with plasmid primers was examined with a group...

Immunoglobulin subclasses of antibodies to human T-cell leukemia/lymphoma virus I-associated antigens in acquired immune deficiency syndrome and lymphadenopathy syndrome.

Goudsmit, J, Miedema, F, Roos, M T, Schellekens, P T, Coutinho, R A, ...

Immunoglobulin G (IgG) and IgM antibodies to human T-cell leukemia/lymphoma virus-I (HTLV-I)-associated membrane antigens (HTLV-I-MA) were assayed by indirect cytospin immunofluorescence, and IgG and...

Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission.

Van't Wout, A B, Kootstra, N A, Mulder-Kampinga, G A, Scherpbier, H J, Veenstra, J, ...

Macrophage-tropic, non-syncytium-inducing, HIV-1 variants predominate in the asymptomatic phase of infection and may be responsible for establishing infection in an individual exposed to the mixture...

A prospective study of antibody responses to defined epitopes of human papillomavirus (HPV) type 16 in relationship to genital and anorectal presence of HPV DNA.

Van Doornum, G J, Prins, M, Pronk, L, Coutinho, R A, Dillner, J

The aim of this study was to investigate whether antibody responses against synthetic peptides derived from genital human papillomavirus (HPV) proteins are associated with laboratory-proven genital...

Impact of HIV antibody testing on changes in sexual behavior among homosexual men in The Netherlands.

Van Griensven, G J, De Vroome, E M, Tielman, R A, Goudsmit, J, De Wolf, F, ...

Between October 1984 and May 1986, 746 homosexual men, living in and around Amsterdam, The Netherlands, were surveyed at three consecutive six months periods regarding their sexual behavior. At the...

Risk reduction among intravenous drug users in Amsterdam under the influence of AIDS.

Van Den Hoek, J A, Van Haastrecht, H J, Coutinho, R A

We evaluated the impact of a needle/syringe exchange program among 263 drug users in the period December 1985 to April 1988. Participants in this study were asked about their risk-behavior at three...

Needle sharing and participation in the Amsterdam Syringe Exchange program among HIV-seronegative injecting drug users.

Hartgers, C, Van Ameijden, E J, Van Den Hoek, J A, Coutinho, R A

To enhance the prevention of human immunodeficiency virus infection, factors related to regular participation in the Amsterdam Syringe Exchange and the borrowing of syringes were studied in 131...

The course of the HIV epidemic among intravenous drug users in Amsterdam, The Netherlands.

Van Haastrecht, H J, Van Den Hoek, J A, Bardoux, C, Leentvaar-Kuypers, A, Coutinho, R A

To determine if behavioral changes in intravenous drug users in Amsterdam have retarded the HIV (human immunodeficiency virus) epidemic in this group in recent years, we report that: HIV-antibody...

The impact of harm-reduction-based methadone treatment on mortality among heroin users.

Langendam, M W, Van Brussel, G H, Coutinho, R A, Van Ameijden, E J

OBJECTIVES: The purpose of this study was to investigate the impact of harm-reduction-based methadone programs on mortality among heroin users. METHODS: A prospective cohort investigation was...

Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia.

De Wolf, F, Goudsmit, J, Paul, D A, Lange, J M, Hooijkaas, C, Schellekens, P, ...

One hundred and ninety eight men seropositive for human immunodeficiency virus (HIV) antibody and 58 HIV antibody seroconverters were studied for an average of 19.3 (SEM 0.5) months to assess the...

Distinct IgG recognition patterns during progression of subclinical and clinical infection with lymphadenopathy associated virus/human T lymphotropic virus.

Lange, J M, Coutinho, R A, Krone, W J, Verdonck, L F, Danner, S A, ...

Longitudinal IgG recognition patterns of viral proteins were studied in 15 men who had seroconverted for lymphadenopathy associated virus/human T lymphotropic virus (LAV/HTLV-III). Antibodies to the...

Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.

Lange, J M, Paul, D A, Huisman, H G, De Wolf, F, Coutinho, R A, ...

Sequential serum samples from 13 homosexual men who seroconverted for antibodies to human immunodeficiency virus (HIV) were tested for HIV antigen. In one of these men, who developed the acquired...

Efficacy of a heat inactivated hepatitis B vaccine in male homosexuals: outcome of a placebo controlled double blind trial.

Coutinho, R A, Lelie, N, Reerink-Brongers, E E, Stoutjesdijk, L, Dees, P, ...

The efficacy of a heat inactivated hepatitis B virus vaccine, containing 3 micrograms hepatitis B surface antigen (HBsAg), was studied in a high risk group of 800 susceptible homosexual men by a...

Prevalence and incidence of hepatitis A among male homosexuals.

Coutinho, R A, Lelie, N, Nagelkerke, N, Kuipers, H, Rijsdijk, T

In a study of 689 male homosexuals 290 (42%) were found to have antibodies to hepatitis A virus. The 399 men who did not have antibodies were followed up for up to 690 days, and 35 cases of hepatitis...

Injecting risk behavior among drug users in Amsterdam, 1986 to 1992, and its relationship to AIDS prevention programs.

Van Ameijden, E J, Van Den Hoek, A R, Coutinho, R A

OBJECTIVES. Serial, cross-sectional trends in injecting risk behavior were studied among drug users from 1986 to 1992. METHODS. From a cohort study in Amsterdam, 616 intake visits of drug users who...

Clinical symptoms associated with seroconversion for HIV-1 among misusers of intravenous drugs: comparison with homosexual seroconverters and infected and non-infected intravenous drug misusers.

Mientjes, G H, Van Ameijden, E J, Weigel, H M, Van Den Hoek, J A, Coutinho, R A

OBJECTIVE--To study the clinical symptoms associated with seroconversion for HIV-1 among misusers of intravenous drugs. DESIGN--Case-control study in cohorts of drug misusers and homosexual men....

HIV prevalence and risk behavior among injecting drug users who participate in "low-threshold" methadone programs in Amsterdam.

Hartgers, C, Krijnen, P, Coutinho, R A

INTRODUCTION. After the onset of the HIV epidemic, the hope arose that the "harm reduction" approach of the Amsterdam "low-threshold" methadone programs would have a function in controlling the...

Increasing antigenic and genetic diversity of the V3 variable domain of the human immunodeficiency virus envelope protein in the course of the AIDS epidemic.

Kuiken, C L, Zwart, G, Baan, E, Coutinho, R A, Van Den Hoek, J A, Goudsmit, J

Population-wide variation in genomic RNA of human immunodeficiency virus type 1 (HIV-1) encompassing the V3 loop of the envelope protein was studied in serum samples of 74 newly infected individuals...

Detection of Chlamydia trachomatis infection in urine samples from men and women by ligase chain reaction.

Van Doornum, G J, Buimer, M, Prins, M, Henquet, C J, Coutinho, R A, Plier, P K, ...

The suitability of urine specimens from women and men for the detection of Chlamydia trachomatis infection by a ligase chain reaction (LCR)-based assay with plasmid primers was examined with a group...

Immunoglobulin subclasses of antibodies to human T-cell leukemia/lymphoma virus I-associated antigens in acquired immune deficiency syndrome and lymphadenopathy syndrome.

Goudsmit, J, Miedema, F, Roos, M T, Schellekens, P T, Coutinho, R A, ...

Immunoglobulin G (IgG) and IgM antibodies to human T-cell leukemia/lymphoma virus-I (HTLV-I)-associated membrane antigens (HTLV-I-MA) were assayed by indirect cytospin immunofluorescence, and IgG and...

Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission.

Van't Wout, A B, Kootstra, N A, Mulder-Kampinga, G A, Scherpbier, H J, Veenstra, J, ...

Macrophage-tropic, non-syncytium-inducing, HIV-1 variants predominate in the asymptomatic phase of infection and may be responsible for establishing infection in an individual exposed to the mixture...

A prospective study of antibody responses to defined epitopes of human papillomavirus (HPV) type 16 in relationship to genital and anorectal presence of HPV DNA.

Van Doornum, G J, Prins, M, Pronk, L, Coutinho, R A, Dillner, J

The aim of this study was to investigate whether antibody responses against synthetic peptides derived from genital human papillomavirus (HPV) proteins are associated with laboratory-proven genital...

Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia.

De Wolf, F, Goudsmit, J, Paul, D A, Lange, J M, Hooijkaas, C, Schellekens, P, ...

One hundred and ninety eight men seropositive for human immunodeficiency virus (HIV) antibody and 58 HIV antibody seroconverters were studied for an average of 19.3 (SEM 0.5) months to assess the...

Distinct IgG recognition patterns during progression of subclinical and clinical infection with lymphadenopathy associated virus/human T lymphotropic virus.

Lange, J M, Coutinho, R A, Krone, W J, Verdonck, L F, Danner, S A, ...

Longitudinal IgG recognition patterns of viral proteins were studied in 15 men who had seroconverted for lymphadenopathy associated virus/human T lymphotropic virus (LAV/HTLV-III). Antibodies to the...

Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.

Lange, J M, Paul, D A, Huisman, H G, De Wolf, F, Coutinho, R A, ...

Sequential serum samples from 13 homosexual men who seroconverted for antibodies to human immunodeficiency virus (HIV) were tested for HIV antigen. In one of these men, who developed the acquired...

Impact of HIV antibody testing on changes in sexual behavior among homosexual men in The Netherlands.

Van Griensven, G J, De Vroome, E M, Tielman, R A, Goudsmit, J, De Wolf, F, ...

Between October 1984 and May 1986, 746 homosexual men, living in and around Amsterdam, The Netherlands, were surveyed at three consecutive six months periods regarding their sexual behavior. At the...

Risk reduction among intravenous drug users in Amsterdam under the influence of AIDS.

Van Den Hoek, J A, Van Haastrecht, H J, Coutinho, R A

We evaluated the impact of a needle/syringe exchange program among 263 drug users in the period December 1985 to April 1988. Participants in this study were asked about their risk-behavior at three...

Needle sharing and participation in the Amsterdam Syringe Exchange program among HIV-seronegative injecting drug users.

Hartgers, C, Van Ameijden, E J, Van Den Hoek, J A, Coutinho, R A

To enhance the prevention of human immunodeficiency virus infection, factors related to regular participation in the Amsterdam Syringe Exchange and the borrowing of syringes were studied in 131...

The course of the HIV epidemic among intravenous drug users in Amsterdam, The Netherlands.

Van Haastrecht, H J, Van Den Hoek, J A, Bardoux, C, Leentvaar-Kuypers, A, Coutinho, R A

To determine if behavioral changes in intravenous drug users in Amsterdam have retarded the HIV (human immunodeficiency virus) epidemic in this group in recent years, we report that: HIV-antibody...

The impact of harm-reduction-based methadone treatment on mortality among heroin users.

Langendam, M W, Van Brussel, G H, Coutinho, R A, Van Ameijden, E J

OBJECTIVES: The purpose of this study was to investigate the impact of harm-reduction-based methadone programs on mortality among heroin users. METHODS: A prospective cohort investigation was...

Efficacy of a heat inactivated hepatitis B vaccine in male homosexuals: outcome of a placebo controlled double blind trial.

Coutinho, R A, Lelie, N, Reerink-Brongers, E E, Stoutjesdijk, L, Dees, P, ...

The efficacy of a heat inactivated hepatitis B virus vaccine, containing 3 micrograms hepatitis B surface antigen (HBsAg), was studied in a high risk group of 800 susceptible homosexual men by a...

Prevalence and incidence of hepatitis A among male homosexuals.

Coutinho, R A, Lelie, N, Nagelkerke, N, Kuipers, H, Rijsdijk, T

In a study of 689 male homosexuals 290 (42%) were found to have antibodies to hepatitis A virus. The 399 men who did not have antibodies were followed up for up to 690 days, and 35 cases of hepatitis...

Injecting risk behavior among drug users in Amsterdam, 1986 to 1992, and its relationship to AIDS prevention programs.

Van Ameijden, E J, Van Den Hoek, A R, Coutinho, R A

OBJECTIVES. Serial, cross-sectional trends in injecting risk behavior were studied among drug users from 1986 to 1992. METHODS. From a cohort study in Amsterdam, 616 intake visits of drug users who...

Clinical symptoms associated with seroconversion for HIV-1 among misusers of intravenous drugs: comparison with homosexual seroconverters and infected and non-infected intravenous drug misusers.

Mientjes, G H, Van Ameijden, E J, Weigel, H M, Van Den Hoek, J A, Coutinho, R A

OBJECTIVE--To study the clinical symptoms associated with seroconversion for HIV-1 among misusers of intravenous drugs. DESIGN--Case-control study in cohorts of drug misusers and homosexual men....

HIV prevalence and risk behavior among injecting drug users who participate in "low-threshold" methadone programs in Amsterdam.

Hartgers, C, Krijnen, P, Coutinho, R A

INTRODUCTION. After the onset of the HIV epidemic, the hope arose that the "harm reduction" approach of the Amsterdam "low-threshold" methadone programs would have a function in controlling the...

Changes in sexual behaviour and the fall in incidence of HIV infection among homosexual men.

Van Griensven, G. J., De Vroome, E. M., Goudsmit, J., Coutinho, R. A.

To investigate the epidemiology and normal course of infection with HIV the prevalence and incidence of the infection were studied among two cohorts of homosexual men in Amsterdam in 1980-7. The...

Low T cell reactivity to combined CD3 plus CD28 stimulation is predictive for progression to AIDS: correlation with decreased CD28 expression

ROOS, M TH L, MIEDEMA, F, MEINESZ, A A P, PAKKER, N G, LANGE, J M A, ...

In 219 HIV-1-infected men of the Amsterdam cohort we measured CD4+ T cell numbers and in vitro T cell responses to CD3 MoAbs with or without CD28 costimulation and phytohaemagglutinin (PHA). The...

Introduction of lymphadenopathy associated virus or human T lymphotropic virus (LAV/HTLV-III) into the male homosexual community in Amsterdam.

Coutinho, R A, Krone, W J, Smit, L, Schaesberg, W, ...

To establish when lymphadenopathy associated virus or human T lymphotropic virus (LAV/HTLV-III) was introduced into the Netherlands, we studied a cohort of homosexual men who participated in a...

Prevalence of syphilis and hepatitis B among homosexual men in two saunas in Amsterdam.

Bleeker, A, Coutinho, R A, Bakker-Kok, J, Tio, D, De Koning, G A

In a pilot study by field-screening in two different sauna baths, a day-sauna and a night-sauna, 318 homosexual men were investigated for syphilis and hepatitis B surface antigen (HBsAg) and its...

Screening for syphilis among homosexual men in bars and saunas in Amsterdam.

Lumey, L H, Kok, J, Coutinho, R A

Serological screening of 1627 homosexual men visiting two saunas and two bars in Amsterdam showed that 32.2% were seroreactive for syphilis. The 18-month study period ended in June 1981. Follow-up...

Epidemiology of PPNG infections in Amsterdam: analysis by auxanographic typing and plasmid characterisation.

Ansink-Schipper, M C, Huikeshoven, M H, Woudstra, R K, Van Klingeren, B, De Koning, G A, Tio, D, ...

In January 1981 the incidence of penicillinase producing Neisseria gonorrhoeae (PPNG) strains in Amsterdam had increased to 18% of all new cases of gonorrhoea. Auxanographic typing in combination...

Infection with cytomegalovirus in homosexual men.

Coutinho, R A, Nagelkerke, N, Kuipers, H, ...

The prevalence and incidence of cytomegalovirus (CMV) infections were studied in a group of homosexual men. Of the 710 participants, 501 (70.6%) had complement fixing antibodies to CMV on entry to...

Influence of special surveillance programmes and AIDS on declining incidence of syphilis in Amsterdam.

Coutinho, R A, Schoonhoven, F J, Van Den Hoek, J A, Emsbroek, J A

In 1976-8 the incidence of syphilis in Amsterdam doubled from 41 to 88 per 100,000. Contact tracers identified two major risk groups, homosexual men with multiple partners and prostitutes using...

Rapid amplified enzyme linked immunosorbent assay evaluated for detecting herpes simplex virus.

Emsbroek, J A, Overdiek, P, Coutinho, R A

A new amplified enzyme linked immunosorbent assay (amplified ELISA) kit for detecting herpes simplex virus (HSV) antigen was evaluated. Duplicate swabs were taken from 180 patients with clinically...

Failure rate of condoms during anogenital intercourse in homosexual men.

Van Griensven, G J, De Vroome, E M, Tielman, R A, Coutinho, R A

Two hundred and seventy seven homosexual men participating in an AIDS study in Amsterdam, The Netherlands, were interviewed in July to December 1986 regarding their experiences with the use of...

HIV infection and STD in drug addicted prostitutes in Amsterdam: potential for heterosexual HIV transmission.

Van Den Hoek, J A, Van Haastrecht, H J, Scheeringa-Troost, B, Goudsmit, J, Coutinho, R A

To assess the potential role of drug using prostitutes in the heterosexual transmission of human immunodeficiency virus (HIV), 117 prostitutes, recruited from December 1985 to November 1987 at a...

Increase of infectious syphilis among heterosexuals in Amsterdam: its relationship to drug use and prostitution.

Van Den Hoek, J A, Van Der Linden, M M, Coutinho, R A

Since 1986, an increase in heterosexually acquired syphilis cases has been seen in Amsterdam. The proportion of syphilis patients who reported using hard drugs, increased from 7% in 1985 to 23% in...

Declining gonorrhoea rates in The Netherlands, 1976-88: consequences for the AIDS epidemic.

Van De Laar, M J, Pickering, J, Van Den Hoek, J A, Van Griensven, G J, Coutinho, R A, Van De Water, H P

The national notification gonorrhoea data are analysed over the period 1976-88 in conjunction with detailed data from the two STD clinics in Amsterdam in order to get an insight into the underlying...

Herpes simplex virus type 2 and other genital ulcerative infections as a risk factor for HIV-1 acquisition.

Keet, I P, Lee, F K, Van Griensven, G J, Lange, J M, Nahmias, A, Coutinho, R A

We studied the role of genital ulcerative infections for acquisition of human immunodeficiency virus type 1 (HIV-1) infection in a cohort of 989 homosexual men in Amsterdam between October 1984 and...

Serum beta 2-microglobulin levels in asymptomatic HIV-1-infected subjects during long-term zidovudine treatment.

Mulder, J W, Krijnen, P, Coutinho, R A, Bakker, M, Goudsmit, J, Lange, J M

beta 2-microglobulin levels were determined in the serum of 18 initially asymptomatic HIV-1 p24 antigenaemic subjects who were treated with zidovudine (+/- acyclovir) and who were followed for 2 1/2...

Evidence for a change in behaviour among heterosexuals in Amsterdam under the influence of AIDS.

Van Haastrecht, H J, Van Den Hoek, J A, Coutinho, R A

In determining the effectiveness of AIDS preventive measures among heterosexuals, trends in visits to two clinics for sexually transmitted diseases (STD) in Amsterdam between 1982 and 1989 are...

Homosexual prostitution among male drug users and its risk for HIV infection.

Van Den Hoek, J A, Van Haastrecht, H J, Coutinho, R A

OBJECTIVE--to assess whether male prostitution is an independent risk factor for HIV infection among male (intravenous and nonintravenous) drug users. DESIGN--a cross-sectional study....

The importance of ethnicity as a risk factor for STDs and sexual behaviour among heterosexuals.

Hooykaas, C, Van Der Velde, F W, Van Der Linden, M M, Van Doornum, G J, Coutinho, R A

OBJECTIVES--To study risk factors for sexually transmitted diseases (STDs) and sexual behaviour. Especially to assess whether there is a higher risk of being infected with STDs among ethnic...

Decreasing incidence of PID in Amsterdam.

Coutinho, R A, Rijsdijk, A J, Van Den Hoek, J A, Leentvaar-Kuijpers, A

OBJECTIVE--To study the incidence of pelvic inflammatory disease (PID) in Amsterdam in the period 1983-1990. METHODS--Patients diagnosed with PID based on a clinical definition were reported weekly...

HIV prevalence among clients attending a sexually transmitted diseases clinic in Amsterdam: the potential risk for heterosexual transmission.

Fennema, J S, Van Ameijden, E J, Coutinho, R A, Van Doornum, G J, Henquet, C J, Van Den Hoek, J A

INTRODUCTION--Patients attending a clinic for sexually transmitted diseases (STD) in general have engaged in at risk sexual behaviour. Therefore they are at increased risk of acquiring HIV through...

HIV prevalence and risk behaviour among prostitutes and clients in Amsterdam: migrants at increased risk for HIV infection.

Van Haastrecht, H J, Fennema, J S, Coutinho, R A, Van Der Helm, T C, Kint, J A, Van Den Hoek, J A

OBJECTIVES--To study groups of prostitutes and clients of prostitutes in order (i) to determine HIV prevalence and sexual risk behaviour, (ii) to determine differences between samples recruited...

Regional distribution and incidence of human papillomavirus infections among heterosexual men and women with multiple sexual partners: a prospective study.

Van Doornum, G J, Prins, M, Juffermans, L H, Hooykaas, C, Van Den Hoek, J A, Coutinho, R A, ...

OBJECTIVE--To assess prevalence, incidence and potential risk factors of human papillomavirus (HPV) infection among heterosexual men and women with multiple partners and to identify niches of...

Determinants of penicillinase producing Neisseria gonorrhoeae infections in heterosexuals in Amsterdam.

Prins, M, Bindels, P J, Coutinho, R A, Henquet, C J, Van Doornum, G J, Van Den Hoek, J A

BACKGROUND AND OBJECTIVES--At the STD clinic of the Municipal Health Service in Amsterdam, the annual number of infections with penicillinase-producing Neisseria gonorrhoeae (PPNG) strains remained...

Sexual behaviour and sexually transmitted diseases in Dutch marines and naval personnel on a United Nations mission in Cambodia.

Hopperus Buma, A P, Veltink, R L, Van Ameijden, E J, Tendeloo, C H, Coutinho, R A

OBJECTIVES--To determine the sexual risk behaviour and the incidence of sexually transmitted diseases (STD) among Dutch marines and naval personnel during a United Nations (UN) deployment....

Differences in clinical manifestations of genital chlamydial infections related to serovars.

Van De Laar, M J, Van Duynhoven, Y T, Fennema, J S, Ossewaarde, J M, Van Den Brule, A J, Van Doornum, G J, ...

OBJECTIVES: To study the association of serovars of Chlamydia trachomatis with clinical manifestations of genital tract infection and socio-demographic characteristics. METHODS: In 1986-88 the C...

Never injected, but hepatitis C virus-infected: a study among self-declared never-injecting drug users from the Amsterdam Cohort Studies

Kok, A, Zuure, F R, Coutinho, R A, Prins, M

The aim of this study was to gain insight in transmission routes of hepatitis C virus (HCV) infection among never-injecting drug users (DU) by studying, incidence, prevalence, determinants and...