Scientific Commons: R. Fässler

Conditional collagen VII inactivation allows analysis of anchoring fibril stability and function in vivo and reveals a major role of fibroblasts in collagen VII expression (2009)

Fritsch, A., Kern, J. S., Loeckermann, S., Velati, D., Fässler, R., Bruckner-Tuderman, L.

Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system (2009)

Pereira, J. A., Benninger, Y., Baumann, R., Goncalves, A. F., Özcelik, M., Thurnherr, T., ...

Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment (2009)

Kim, M., Ogawa, M., Fujita, Y., Yoshikawa, Y., Nagai, T., Koyama, T., ...

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma (2009)

Massoumi, R., Kuphal, S., Hellerbrand, C., Haas, B., Wild, P., Spruss, T., ...

The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase (2009)

Schlomann, U., Schwamborn, J. C., Müller, M., Fässler, R., Püschel, A. W.

Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation (2009)

Stanchi, F., Grashoff, C., Yonga, C. F. N., Grall, D., Fässler, R.

Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS (2009)

Dours-Zimmermann, M. T., Maurer, K., Rauch, U., Stoffel, W., Fässler, R., Zimmermann, D. R.

beta(1) integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity (2009)

Bauer, M., Brakebusch, C., Coisne, C., Sixt, M., Wekerle, H., Engelhardt, B., ...

Inhibiting the alpha(4) subunit of the integrin heterodimers alpha(4)beta(1) and alpha(4)beta(7) with the monoclonal antibody natalizumab is an effective treatment for multiple sclerosis (MS)....

Integrins Anchor the Invasive Machinery (2009)

Wickström, S. A., Fässler, R.

beta 1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity (2009)

Zhang, X., Mernaugh, G., Yang, D. H., Gewin, L., Srichai, M. B., Harris, R. C., ...

Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contraction (2009)

Kogata, N., Tribe, R. M., Fässler, R., Way, M., Adams, R. H.

Integrin-linked kinase is an adaptor with essential functions during mouse development (2009)

Lange, A., Wickström, S. A., Jakobson, M., Zent, R., Sainio, K., Fässler, R.

How ILK and kindlins cooperate to orchestrate integrin signaling (2009)

Böttcher, R. T., Lange, A., Fässler, R.

The Kindlin protein family: new members to the club of focal adhesion proteins (2009)

Meves, A., Stremmel, C., Gottschalk, K., Fässler, R.

alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling (2009)

Montanez, E., Wickström, S. A., Altstätter, J., Chu, H. Y., Fässler, R.

Dermal reconstitution following injury requires integrin-linked kinase (2009)

Zweers, M. C., Schmitz, M., Peters, A., Denton, C. P., Fässler, R., Gullberg, D., ...

Differential gene expression between sensory neocortical areas: Potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways (2008)

Leamey, C. A., Glendining, K. A., Kreiman, G., Kang, N. D., Wang, K. H., Fässler, R., ...

Functional role of beta 1 integrin-mediated signalling in the human hair follicle (2008)

Kloepper, J. E., Hendrix, S., Bodo, E., Tiede, S., Humphries, M. J., Philpott, M. P., ...

Cell therapy restores skin function in an immunocompetent mouse model for dystrophic epidermolysis bullosa (2008)

Kern, J. S., Lockermann, S., Fritsch, A., Fässler, R., Bruckner-Tuderman, L.

Crucial role for fibroblast integrin-linked kinase in murine wound healing (2008)

Zweers, M. C., Schmitz, M., Denton, C. P., Fässler, R., Krieg, T., Eckes, B.

Integrin beta 1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability (2008)

Abraham, S., Kogata, N., Fässler, R., Adams, R. H.

Kindlin-3 is essential for integrin activation and platelet aggregation (2008)

Moser, M., Nieswandt, B., Ussar, S., Pozgajova, M., Fässler, R.

Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage (2008)

Wang, H. V., Chang, L. W., Brixius, K., Wickström, S. A., Montanez, E., Thievessen, I., ...

Improvement of reporter activity by IRES-mediated polycistronic reporter system (2008)

Bouabe, H., Fässler, R., Heesemann, J.

Molecular analysis of mitten deformities in the collagen VII hypomorph and human RDEB reveals potential targets for therapy (2008)

Fritsch, A., Loeckermann, S., Kern, J. S., Schumann, H., Fässler, R., Bruckner-Tuderman, L.

Cell therapy restores skin function in an immunocompetent mouse model for dystrophic epidermolysis bullosa (2008)

Kern, J. S., Loeckermann, S., Fritsch, A., Muller, M. L., Fässler, R., Bruckner-Tuderman, L.

Rapid leukocyte migration by integrin-independent flowing and squeezing (2008)

Lämmermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Söldner, R., Hirsch, K., ...

beta 1 integrin expression by podocytes is required to maintain glomerular structural integrity (2008)

Pozzi, A., Jarad, G., Moeckel, G. W., Coffa, S., Zhang, X., Gewin, L., ...

Dermal reconstitution following injury requires integrin-linked kinase (2008)

Zweers, M., Schmitz, M., Peters, A., Denton, C., Fässler, R., Gullberg, D., ...

A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy (2008)

Fritsch, A., Loeckermann, S., Kern, J. S., Braun, A., Bösl, M. R., Bley, T. A., ...

Staphylococcus aureus recruits membrane microdomains upon integrin engagement (2008)

Berking, A. D., Hoffmann, C., Doderlein, T. J. L., Fässler, R., Ohlsen, K., Hauck, C. R.

Influence of beta-parvin signaling on exercise-induced adaptations of skeletal muscle (2008)

Brixius, K., Thievessen, I., Chu, H., Braun, A., Moser, M., Niehoff, A., ...

Regenerative capacity of skeletal muscle insufficiency in transgenic mice with a partial deficiency of the integrin-linked kinase (2008)

Brixius, K., Wang, H. V., Chang, L. W., Niehoff, A., Thievessen, I., Bruggemann, G. P., ...

In vivo analysis of the tight junction associated adhesion molecule ESAM (2008)

Butz, S., Petri, B., Volkery, S., Wegmann, F., Moser, C., Khandoga, A. G., ...

Genetic analysis of integrin signalling in mice (2008)

Fässler, R.

Constitutively active vinculin in a transgenic mouse model (2008)

Marg, S., Winkler, U., Himmel, M., Moser, M., Fässler, R., Ziegler, W. H.

Kindlin-2 controls bidirectional signaling of integrins (2008)

Montanez, E., Ussar, S., Schifferer, M., Bösl, M., Zent, R., Moser, M., ...

Roles of plasma fibronectin in thrombosis and hemostasis: A lesson from fibrinogen/VWF/and plasma finronectin triple knockout mice (2008)

Reheman, A., Yang, H., Spring, C., Zhu, G., Chen, P., Wagner, D., ...

The cardiac phenotype of Xin-deficient mice (2008)

Rubsteck, J., Meyer, R., Fässler, R., Furst, D. O.

beta 1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells (2008)

Taddei, I., Deugnier, M. A., Faraldo, M. M., Petit, V., Bouvard, D., Medina, D., ...

SILAC mouse for quantitative proteomics uncovers kindlin-3 as an essential factor for red blood cell function (2008)

Krüger, M., Moser, M., Ussar, S., Thievessen, I., Luber, C. A., Forner, F., ...

Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin (2008)

Kessenbrock, K., Frohlich, L., Sixt, M., Lämmermann, T., Pfister, H., Bateman, A., ...

Integrin trafficking regulated by Rab21 is necessary for cytokinesis (2008)

Pellinen, T., Tuomi, S., Arjonen, A., Wolf, M., Edgren, H., Meyer, H., ...

The involvement of the tumor suppressor gene Cyld in autoimmune brain inflammation (2008)

Hovelmeyer, N., Reissig, S., Massoumi, R., Fässler, R., Waisman, A.

The role of integrin binding sites in fibronectin matrix assembly in vivo (2008)

Leiss, M., Beckmann, K., Giros, A., Costell, M., Fässler, R.

Homing of Mouse Spermatogonial Stem Cells to Germline Niche Depends on beta 1-integrin (2008)

Kanatsu-Shinohara, M., Takehashi, M., Takashima, S., Lee, J., Morimoto, H., Chuma, S., ...

Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation (2008)

Egea, J., Erlacher, C., Montanez, E., Burtscher, I., Yamagishi, S., Hess, M., ...

Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction (2008)

Salmenpera, P., Kankuri, E., Bizik, J., Siren, V., Virtanen, I., Takahashi, S., ...

Solid Tumor Proteome and Phosphoproteome Analysis by High Resolution Mass Spectrometry (2008)

Zanivan, S., Gnad, F., Wickström, S. A., Geiger, T., Macek, B., Cox, J., ...

Conditional Deletion of Fibronectin Results in a Scoliosis-Like Phenotype (2008)

Chen, Q., Zhao, H., Zhao, J., Pacicca, D. M., Fässler, R., Dallas, S. L.

Basement Membrane and VEGF Synergistically Activate Cdc42 and Rac1 to Promote Endothelial Cell Migration and Survival during Vasculogenesis from Embryonic Stem Cells (2008)

Liu, J., Graham, A. M., Han, Y. L., Brakebusch, C., Fässler, R., Li, S. H.

Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction (2008)

Ussar, S., Moser, M., Widmaier, M., Rognoni, E., Harrer, C., Genzel-Boroviczeny, O., ...

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts (2007)

Song, L. Y., Fässler, R., Mishina, Y., Jiao, K., Baldwin, H. S.

Intronic insertion of a neomycin-phosphotransferase expression cassette suppresses synthesis of collagen VII and generates a viable mouse model for dystrophic epidermolysis bullosa (2007)

Fritsch, A., Lockermann, S., Braun, A., Bösl, M., Hausser, I., ...

Kindlin-1 is a migfilin-binding protein which associates with kindlin-2 at focal contacts (2007)

Lai-Cheong, J., Ussar, S., Arita, K., Fässler, R., Hart, I., McGrath, J. A.

ESAM supports neutrophil emigration into inflamed tissue, activation of Rho, and VEGF-induced vascular permeability (2007)

Butz, S., Wegmann, F., Petri, B., Volkery, S., Khandoga, A. G., Moser, C., ...

Beta1 integrin and collecting system development (2007)

Zent, R., Zhang, X., Mernaugh, G., Coffa, S., Fässler, R., Pozzi, A.

Effect of apolipoprotein M on modulation of HDL in APOM transgenic and APOM deficient mice (2007)

Christoffersen, C., Jauhiainen, M., Moser, M., Porse, B., Ehnholm, C., Fässler, R., ...

Integrin-linked kinase is required for epidermal and hair follicle morphogenesis (2007)

Lorenz, K., Grashoff, C., Torka, R., Sakai, T., Langbein, L., Bloch, W., ...

Integrin-linked kinase controls Notch1 signaling by down-regulation (2007)

Mo, J. S., Kim, M. Y., Han, S. O., Kim, I. S., Ann, E. J., Lee, K. S., ...

Defective osteoblast function in ICAP-1-deficient mice (2007)

Bouvard, D., Aszodi, A., Kostka, G., Block, M. R., Albiges-Rizo, C., Fässler, R.

The RGD motif in fibronectin is essential for development but dispensable for fibril assembly (2007)

Takahashi, S., Leiss, M., Moser, M., Ohashi, T., Kitao, T., Heckmann, D., ...

Increased tumor cell dissemination and cellular senescence in the absence of beta(1)-integrin function (2007)

Kren, A., Baeriswyl, V., Lehembre, F., Wunderlin, C., Strittmatter, K., Antoniadis, H., ...

Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo (2007)

Nieswandt, B., Moser, M., Pleines, I., Varga-Szabo, D., Monkley, S., Critchley, D., ...

Trpsl regulates proliferation and apoptosis of chondrocytes through Stat3 signaling (2007)

Suemoto, H., Muragaki, Y., Nishioka, K., Sato, M., Ooshima, A., Itoh, S., ...

Ena/VASP is required for endothelial barrier function in vivo (2007)

Furman, C., Sieminski, A. L., Kwiatkowski, A. V., Rubinson, D. A., Vasile, E., Bronson, R. T., ...

Ablation of integrin-linked kinase in fibroblasts: Altered mechanical properties resulting in disturbed wound healing (2007)

Eckes, B., Zweers, M. C., Peters, A., Denton, C. P., Fässler, R., Krieg, T.

The collagen VII hypomorph, a viable mouse model for dystrophic epidermolysis bullosa, allows testing of molecular therapies (2007)

Fritsch, A., Loeckermann, S., Kern, J. S., Fässler, R., Bruckner-Tuderman, L.

Conditional deletion of beta(1)-Integrin in astroglia causes partial reactive gliosis (2007)

Robel, S., Mori, T., Rite, I., Zoubaa, S., Schlegel, J., Nave, K. A., ...

Conditional deletion of fibronectin in osteoblasts reveals distinct roles in orchestrating assembly of bone ECM proteins and in osteoblast differentiation (2007)

Chen, Q., Zhao, J., Dallas, M. R., Pacicca, D. M., Fässler, R., Dallas, S. L.

Distinct Target-Derived Signals Organize Formation, Maturation, and Maintenance of Motor Nerve Terminals (2007)

Fox, M.A., Sanes, J.R., Eswarakumar, V.P., Fässler, R., Hudson, B.G., ...

Staphylococcus aureus fibronectin binding protein-A induces motile attachment sites and complex actin remodeling in living endothelial cells (2006)

Schröder, A., Schröder, B., Roppenser, B., Linder, S., Sinha, B., Fässler, R., ...

ESAM supports neutrophil extravasation, activation of Rho and VEGF-induced vascular permeability (2006)

Butz, S., Wegmann, F., Petri, B., Khandoga, A. G., Moser, C., Khandoga, A., ...

What mouse mutants teach us about extracellular matrix function (2006)

Aszodi, A., Legate, K. R., Nakchbandi, I., Fässler, R.

γ-parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response (2006)

Chu, H. Y., Thievessen, I., Sixt, M., Lämmermann, T., Waisman, A., Braun, A., ...

ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability (2006)

Wegmann, F., Petri, B., Khandoga, A. G., Moser, C., Khandoga, A., Volkery, S., ...

Local call: from integrins to actin assembly (2006)

Wiesner, S., Lange, A., Fässler, R.

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-κB signaling (2006)

Massoumi, R., Chmielarska, K., Hennecke, K., Pfeifer, A., Fässler, R.

Lack of β1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype (2006)

Breau, M. A., Pietri, T., Eder, O., Blanche, M., Brakebusch, C., Fässler, R., ...

Cylindroma as tumor of hair follicle origin (2006)

Massoumi, R., Podda, M., Fässler, R., Paus, R.

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation (2006)

Ferby, I., Reschke, M., Kudlacek, O., Knyazev, P., Pante, G., Amann, K., ...

Regulation of integrin activity by MIA (2006)

Bauer, R., Humphries, M., Fässler, R., Winklmeier, A., Craig, S. E., Bosserhoff, A. K.

The vascular basement membrane: A niche for insulin gene expression and beta cell proliferation (2006)

Nikolova, G., Jabs, N., Konstantinova, I., Domogatskaya, A., Tryggvason, K., Sorokin, L., ...

Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes (2006)

Ruotsalainen, H., Sipila, L., Vapola, M., Sormunen, R., Salo, A. M., Uitto, L., ...

Determining the origin of articular chondrocytes by lineage tracing (2006)

Dover, S. L., Hyde, G., Aszodi, A., Fässler, R., Wallis, G. A., Boot-Handford, R. P.

Elimination of epiplakin by gene targeting results in acceleration of keratinocyte migration in mice (2006)

Goto, M., Sumiyoshi, H., Sakai, T., Fässler, R., Ohashi, S., Adachi, E., ...

ILK, PINCH and parvin: the tIPP of integrin signalling (2006)

Legate, K. R., Montanez, E., Kudlacek, O., Fässler, R.

The Kindlins: Subcellular localization and expression during murine development (2006)

Ussar, S., Wang, H. V., Linder, S., Fässler, R., Moser, M.

β1 integrins: zip codes and signaling relay for blood cells (2006)

Sixt, M., Bauer, M., Lammermann, T., Fässler, R.

Genetic analysis of β1 integrin "activation motifs" in mice (2006)

Czuchra, A., Meyer, H., Legate, K. R., Brakebusch, C., Fässler, R.

Chondroitin sulfate perlecan enhances collagen fibril formation - Implications for perlecan chondrodysplasias (2006)

Kvist, A. J., Johnson, A. E., Morgelin, M., Gustafsson, E., Bengtsson, E., Lindblom, K., ...

Beta1 integrin is required for ureteric bud branching development (2006)

Zhang, X., Mernaugh, G., Coffa, S., Moeckel, G., Brakebusch, C., Fässler, R., ...

Integrin-fibronectin interactions in vivo (2006)

Fässler, R.

Reduced perlecan results in skeletal dysplasia: A new mouse model (2006)

Rodgers, K. D., Sasaki, T., Aszodi, A., Fässler, R., Jacenko, O.

Fibronectin is not the only important molecule required for fibrinogen/VWF-independent platelet aggregation: Study of thrombosis in a new strain of triple deficient mice. (2006)

Reheman, A., Hong, Y., Spring, C. M., Chen, P., Wagner, D. D., Fässler, R., ...

ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability (2006)

Wegmann, F., Petri, B., Khandoga, A. G., Moser, C., Khandoga, A., Volkery, S., ...

Indentation-Type Scanning Force Microscopy, a Versatile Tool for Imaging, Measuring and Manipulating Soft Biological Tissues, for Example, Normal, Diseased and Engineered Cartilage (2006)

Stolz, M., Raiteri, R., Gottardi, R., Wirz, D., Daniels, A. U., VanLandingham, M. R., ...

Consequences of loss of PINCH2 expression in mice (2005)

Stanchi,F., Bordoy,R., Kudlacek,O., Braun,A., Pfeifer,A., Moser,M., ...

Fibronectin is required for integrin alpha v beta 6-mediated activation of latent TGF-beta complexes containing LTBP-1 (2005)

Fontana,L., Chen,Y., Prijateli,P., Sakai,T., Fässler,R., Sakai,L. Y., ...

ADAM 12-mediated focal adhesion formation is differently regulated by beta 1 and beta 3 integrins (2005)

Thodeti,C. K., Frohlich,C., Nielsen,C. K., Takada,Y., Fässler,R., Albrechtsen,R., ...

PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage (2005)

Li,S. H., Bordoy,R., Stanchi,F., Moser,M., Braun,A., Kudlacek,O., ...

The role of chondrocyte-matrix attachment complexes in skeletal development (2005)

Aszodi,A., Nicolae,C., Raducanu,A., Grashoff,C., Fässler,R.

Regulation of neural progenitor proliferation and survival by beta 1 integrins (2005)

Leone,D. P., Relvas,J. B., Campos,L. S., Hemmi,S., Brakebusch,C., Fässler,R., ...

Integrin-actin interactions (2005)

Wiesner,S., Legate,K. R., Fässler,R.

Integrin-actin interactions (2005)

Wiesner,S., Legate,K. R., Fässler,R.

Loss of alpha 10 beta 1 integrin expression leads to moderate dysfunction of growth plate chondrocytes (2005)

Bengtsson,T., Aszodi,A., Nicolae,C., Hunziker,E. B., Lundgren-Akerlund,E., Fässler,R.

Type IX collagen knock-out mouse shows progressive hearing loss (2005)

Suzuki,N., Asamura,K., Kikuchi,Y., Takumi,Y., Abe,S., Imamura,Y., ...

No synthase interacting protein is indispensable for embryonic development (2005)

Oess,S., Gemhard,S., Moser,M., Graf,S., Schilling,K., Fässler,R., ...

Tenomodulin is necessary for tenocyte proliferation and tendon maturation (2005)

Docheva,D., Hunziker,E. B., Fässler,R., Brandau,O.

Tenomodulin is necessary for tenocyte proliferation and tendon maturation (2005)

Docheva, D., Hunziker, E. B., Fässler, R., Brandau, O.

Type IX collagen knock-out mouse shows progressive hearing loss (2005)

Suzuki, N., Asamura, K., Kikuchi, Y., Takumi, Y., Abe, S., Imamura, Y., ...

ADAM 12-mediated focal adhesion formation is differently regulated by beta 1 and beta 3 integrins (2005)

Thodeti, C. K., Frohlich, C., Nielsen, C. K., Takada, Y., Fässler, R., Albrechtsen, R., ...

Consequences of loss of PINCH2 expression in mice (2005)

Stanchi, F., Bordoy, R., Kudlacek, O., Braun, A., Pfeifer, A., Moser, M., ...

Fibronectin is required for integrin alpha v beta 6-mediated activation of latent TGF-beta complexes containing LTBP-1 (2005)

Fontana, L., Chen, Y., Prijateli, P., Sakai, T., Fässler, R., Sakai, L. Y., ...

Integrin-actin interactions (2005)

Wiesner, S., Legate, K. R., Fässler, R.

Loss of alpha 10 beta 1 integrin expression leads to moderate dysfunction of growth plate chondrocytes (2005)

Bengtsson, T., Aszodi, A., Nicolae, C., Hunziker, E. B., Lundgren-Akerlund, E., Fässler, R.

No synthase interacting protein is indispensable for embryonic development (2005)

Oess, S., Gemhard, S., Moser, M., Graf, S., Schilling, K., Fässler, R., ...

PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage (2005)

Li, S. H., Bordoy, R., Stanchi, F., Moser, M., Braun, A., Kudlacek, O., ...

Regulation of neural progenitor proliferation and survival by beta 1 integrins (2005)

Leone, D. P., Relvas, J. B., Campos, L. S., Hemmi, S., Brakebusch, C., Fässler, R., ...

The role of chondrocyte-matrix attachment complexes in skeletal development (2005)

Aszodi, A., Nicolae, C., Raducanu, A., Grashoff, C., Fässler, R.

Type IX collagen is crucial for normal hearing (2005)

Asamura, K., Abe, S., Imamura, Y., Aszodi, A., Suzuki, N., Hashimoto, S., ...

beta 1 integrin function in vivo: Adhesion, migration and more (2005)

Brakebusch, C., Fässler, R.

beta(1) integrins are not required for the maintenance of lymphocytes within intestinal epithelia (2005)

Marsal, J., Brakebusch, C., Bungartz, G., Fässler, R., Agace, W. W.

Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta 1 integrin-null cells (2004)

Kikkawa,Y., Yu,H., Genersch,E., Sanzen,N., Sekiguchi,K., Fässler,R., ...

Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system (2004)

Menzies,A. S., Aszodi,A., Williams,S. E., Pfeifer,A., Wehman,A. M., Goh,K. L., ...

Conditional beta 1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system (2004)

Pietri,T., Eder,O., Breau,M. A., Topilko,P., Blanche,M., Brakebusch,C., ...

beta 1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance (2004)

Campos,L. S., Leone,D. P., Relvas,J. B., Brakebusch,C., Fässler,R., Suter,U., ...

Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface (2004)

Herzog,C., Has,C., Franzke,C. W., Echtermeyer,F. G., Schlotzer-Schrehardt,U., Kröger,S., ...

Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes (2004)

Nyberg,P., Sakai,T., Cho,K. H., Caparon,M. G., Fässler,R., Bjorck,L.

Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities (2004)

Bjarnegard,M., Enge,M., Norlin,J., Gustafsdottir,S., Fredriksson,S., Abramsson,A., ...

Laminin: the crux of basement membrane assembly (2004)

Sasaki,T., Fässler,R., Hohenester,E.

Modulation of Ca2+ sensitivity by cyclic mucleotides in smooth muscle from protein kinase G-deficient mice (2004)

Bonnevier,J., Fässler,R., Somlyo,A. P., Somlyo,A. V., Arner,A.

Conditional β1-integrin gene deletion in nneural crest cells causes severe developmental alterations of th peripheral nervous system. (2004)

Pietri,T., Eder,O., Breau,M., Topilko,P., Blanche,M., Brakebusch,C., ...

Analysis of integrin function by gene targeting in mice (2004)

Brandau,O., Fässler,R.

Integrin-linked kinase: integrin's mysterious partner (2004)

Grashoff,C., Thievessen,I., Lorenz,K., Ussar,S., Fässler,R.

Lentiviral transgene vectors - Green light for efficient production of transgenic farm animals (2004)

Fässler, R.

Modulation of Ca2+ sensitivity by cyclic mucleotides in smooth muscle from protein kinase G-deficient mice (2004)

Bonnevier, J., Fässler, R., Somlyo, A. P., Somlyo, A. V., Arner, A.

Conditional beta 1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system (2004)

Pietri, T., Eder, O., Breau, M. A., Topilko, P., Blanche, M., Brakebusch, C., ...

Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface (2004)

Herzog, C., Has, C., Franzke, C. W., Echtermeyer, F. G., Schlotzer-Schrehardt, U., Kröger, S., ...

Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities (2004)

Bjarnegard, M., Enge, M., Norlin, J., Gustafsdottir, S., Fredriksson, S., Abramsson, A., ...

Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes (2004)

Nyberg, P., Sakai, T., Cho, K. H., Caparon, M. G., Fässler, R., Bjorck, L.

Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of beta 1 integrin-null cells (2004)

Kikkawa, Y., Yu, H., Genersch, E., Sanzen, N., Sekiguchi, K., Fässler, R., ...

Laminin: the crux of basement membrane assembly (2004)

Sasaki, T., Fässler, R., Hohenester, E.

Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system (2004)

Menzies, A. S., Aszodi, A., Williams, S. E., Pfeifer, A., Wehman, A. M., Goh, K. L., ...

beta 1 integrins activate a MAPK signalling pathway in neural stem cells that contributes to their maintenance (2004)

Campos, L. S., Leone, D. P., Relvas, J. B., Brakebusch, C., Fässler, R., Suter, U., ...

Conditional β1-integrin gene deletion in nneural crest cells causes severe developmental alterations of th peripheral nervous system. (2004)

Pietri, T., Eder, O., Breau, M., Topilko, P., Blanche, M., Brakebusch, C., ...

Analysis of integrin function by gene targeting in mice (2004)

Brandau, O., Fässler, R.

Integrin-linked kinase: integrin's mysterious partner (2004)

Grashoff, C., Thievessen, I., Lorenz, K., Ussar, S., Fässler, R.

β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis (2003)

Aszodi,A., Hunziker,E. B., Brakebusch,C., Fässler,R.

Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity (2003)

Yi,M., Sakai,T., Fässler,R., Ruoslahti,E.

Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets (2003)

Bekku,Y., Su,W. D., Hirakawa,S., Fässler,R., Ohtsuka,A., Kang,J. S., ...

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain (2003)

Zhou,X. H., Brandau,O., Feng,K., Oohashi,T., Ninomiya,Y., Rauch,U., ...

Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration (2003)

Steiling,H., Wustefeld,T., Bugnon,P., Brauchle,M., Fässler,R., Teupser,D., ...

The integrin-actin connection, an eternal love affair (2003)

Brakebusch,C., Fässler,R.

Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease...

The role of laminin in embryonic cell polarization and tissue organization (2003)

Li,S. H., Edgar,D., Fässler,R., Wadsworth,W., Yurchenco,P. D.

PINCH2 is a new five LIM domain protein, homologous to PINCH and localized to focal adhesions (2003)

Braun,A., Bordoy,R., Stanchi,F., Moser,M., Kostka,G., Ehler,E., ...

PINCH is a five LIM domain protein involved in the regulation of integrin-mediated cell adhesion. It has been shown that PINCH interacts with integrin-linked kinase and Nck2. Here we describe a new...

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation (2003)

Sakai,T., Li,S. H., Docheva,D., Grashoff,C., Sakai,K., Kostka,G., ...

Integrin-mediated cell-matrix interactions are essential for development, tissue homeostasis, and repair. Upon ligand binding, integrins are recruited into focal adhesions (FAs). Integrin-linked...

Integrin-linked kinase regulates chondrocyte shape and proliferation (2003)

Grashoff,C., Aszodi,A., Sakai,T., Hunziker,E. B., Fässler,R.

The interaction of chondrocytes with the extracellular-matrix environment is mediated mainly by integrins. Ligated integrins are recruited to focal adhesions (FAs) together with scaffolding proteins...

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon (2003)

Altrock,W. D., Dieck,S. T., Sokolov,M., Meyer,A. C., Sigler,A., Brakebusch,C., ...

Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of...

Plasma fibronectin promotes thrombus growth and stability in injured arterioles (2003)

Ni,H. Y., Yuen,P. S. T., Papalia,J. M., Trevithick,J. E., Sakai,T., Fässler,R., ...

Mice lacking both of the best-known platelet ligands, von Willebrand factor and fibrinogen, can still form occlusive thrombi in injured arterioles. The platelets of these animals accumulate excessive...

Plasma fibronectin promotes thrombus growth and stability in injured arterioles (2003)

Ni, H, Yuen, PS, Papalia, JM, Trevithick, JE, Sakai, T, Fässler, R, ...

Mice lacking both of the best-known platelet ligands, von Willebrand factor and fibrinogen, can still form occlusive thrombi in injured arterioles. The platelets of these animals accumulate excessive...

Disruption of focal adhesions by integrin cytoplasmic domain- associated protein-1 alpha (2003)

Bouvard,D., Vignoud,L., Dupe-Manet,S., Abed,N., Fournier,H. N., Vincent-Monegat,C., ...

Regulation of integrin affinity and clustering plays a key role in the control of cell adhesion and migration. The protein ICAP-1alpha (integrin cytoplasmic domain-associated protein- 1alpha) binds...

None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion (2003)

He,Z. Y., Brakebusch,C., Fässler,R., Kreidberg,J. A., Primakoff,P., Myles,D. G.

Antibody inhibition and alpha6beta1 ligand binding experiments indicate that the egg integrin alpha6beta1 functions as a receptor for sperm during gamete fusion; yet, eggs null for the alpha6...

Complementary roles of platelet glycoprotein VI and integrin α2 β1 in collagen-induced thrombus formation in flowing whole blood ex vivo (2003)

Kuijpers,M. J. E., Schulte,V., Bergmeier,W., Lindhout,T., Brakebusch,C., Offermanns,S., ...

Platelets interact vigorously with subendothelial collagens that are exposed by injury or pathological damage of a vessel wall. The collagen-bound platelets trap other platelets to form aggregates,...

Role of collagen type II and perlecan in skeletal development (2003)

Gustafsson,E., Aszodi,A., Ortega,N., Hunziker,E. B., Denker,H. W., Werb,Z., ...

The integrin-actin connection, an eternal love affair (2003)

Brakebusch, C., Fässler, R.

Integrin receptors connect the extracellular matrix to the actin cytoskeleton. This interaction can be viewed as a cyclical liaison, which develops again and again at new adhesion sites only to cease...

Integrin-linked kinase regulates chondrocyte shape and proliferation (2003)

Grashoff, C., Aszodi, A., Sakai, T., Hunziker, E. B., Fässler, R.

The interaction of chondrocytes with the extracellular-matrix environment is mediated mainly by integrins. Ligated integrins are recruited to focal adhesions (FAs) together with scaffolding proteins...

PINCH2 is a new five LIM domain protein, homologous to PINCH and localized to focal adhesions (2003)

Braun, A., Bordoy, R., Stanchi, F., Moser, M., Kostka, G., Ehler, E., ...

PINCH is a five LIM domain protein involved in the regulation of integrin-mediated cell adhesion. It has been shown that PINCH interacts with integrin-linked kinase and Nck2. Here we describe a new...

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation (2003)

Sakai, T., Li, S. H., Docheva, D., Grashoff, C., Sakai, K., Kostka, G., ...

Integrin-mediated cell-matrix interactions are essential for development, tissue homeostasis, and repair. Upon ligand binding, integrins are recruited into focal adhesions (FAs). Integrin-linked...

None of the integrins known to be present on the mouse egg or to be ADAM receptors are essential for sperm-egg binding and fusion (2003)

He, Z. Y., Brakebusch, C., Fässler, R., Kreidberg, J. A., Primakoff, P., Myles, D. G.

Antibody inhibition and alpha6beta1 ligand binding experiments indicate that the egg integrin alpha6beta1 functions as a receptor for sperm during gamete fusion; yet, eggs null for the alpha6...

Disruption of focal adhesions by integrin cytoplasmic domain- associated protein-1 alpha (2003)

Bouvard, D., Vignoud, L., Dupe-Manet, S., Abed, N., Fournier, H. N., Vincent-Monegat, C., ...

Regulation of integrin affinity and clustering plays a key role in the control of cell adhesion and migration. The protein ICAP-1alpha (integrin cytoplasmic domain-associated protein- 1alpha) binds...

Complementary roles of platelet glycoprotein VI and integrin α2 β1 in collagen-induced thrombus formation in flowing whole blood ex vivo (2003)

Kuijpers, M. J. E., Schulte, V., Bergmeier, W., Lindhout, T., Brakebusch, C., Offermanns, S., ...

Platelets interact vigorously with subendothelial collagens that are exposed by injury or pathological damage of a vessel wall. The collagen-bound platelets trap other platelets to form aggregates,...

Plasma fibronectin promotes thrombus growth and stability in injured arterioles (2003)

Ni, H. Y., Yuen, P. S. T., Papalia, J. M., Trevithick, J. E., Sakai, T., Fässler, R., ...

Mice lacking both of the best-known platelet ligands, von Willebrand factor and fibrinogen, can still form occlusive thrombi in injured arterioles. The platelets of these animals accumulate excessive...

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon (2003)

Altrock, W. D., Dieck, S. T., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., ...

Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of...

Antiangiogenic proteins require plasma fibronectin or vitronectin for in vivo activity (2003)

Yi, M., Sakai, T., Fässler, R., Ruoslahti, E.

Fibroblast growth factor receptor signalling is crucial for liver homeostasis and regeneration (2003)

Steiling, H., Wustefeld, T., Bugnon, P., Brauchle, M., Fässler, R., Teupser, D., ...

Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets (2003)

Bekku, Y., Su, W. D., Hirakawa, S., Fässler, R., Ohtsuka, A., Kang, J. S., ...

Role of collagen type II and perlecan in skeletal development (2003)

Gustafsson, E., Aszodi, A., Ortega, N., Hunziker, E. B., Denker, H. W., Werb, Z., ...

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain (2003)

Zhou, X. H., Brandau, O., Feng, K., Oohashi, T., Ninomiya, Y., Rauch, U., ...

The role of laminin in embryonic cell polarization and tissue organization (2003)

Li, S. H., Edgar, D., Fässler, R., Wadsworth, W., Yurchenco, P. D.

β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis (2003)

Aszodi, A., Hunziker, E. B., Brakebusch, C., Fässler, R.

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon (2003)

Altrock, W. D., Tom Dieck, S., Sokolov, M., Meyer, A. C., Sigler, A., Brakebusch, C., ...

Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of...

Brevican-deficient mice display impaired hippocampal CA1 long- term potentiation but show no obvious deficits in learning and memory (2002)

Brakebusch,C., Seidenbecher,C. I., Asztely,F., Rauch,U., Matthies,H., Meyer,H., ...

Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has...

Chondromodulin-I is dispensable during enchondral ossification and eye development (2002)

Brandau,O., Aszodi,A., Hunziker,E. B., Neame,P. J., Vestweber,D., Fässler,R.

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy (2002)

Enge,M., Bjarnegard,M., Gerhardt,H., Gustafsson,E., Kalen,M., Asker,N., ...

Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to...

All four members of the Ten-m/Odz family of transmembrane proteins form dimers (2002)

Feng,K., Zhou,X. H., Oohashi,T., Morgelin,M., Lustig,A., Hirakawa,S., ...

Ten-m/Odz/teneurins are a new family of four distinct type II transmembrane molecules. Their extracellular domains are composed of an array of eight consecutive EGF modules followed by a large...

Role of the beta 1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia (2002)

Gustavsson,A., Armulik,A., Brakebusch,C., Fässler,R., Johansson,S., Fällman,M.

Invasin of Yersinia pseudotuberculosis binds to beta1-integrins on host cells and triggers internalization of the bacterium. To elucidate the mechanism behind the beta1-integrin-mediated...

Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation (2002)

Li,S., Harrison,D., Carbonetto,S., Fässler,R., Smyth,N., Edgar,D., ...

Laminin-1 is essential for early embryonic basement membrane assembly and differentiation. Several steps can be distinguished, i.e., the expression of laminin and companion matrix components, their...

A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair (2002)

Grose,R., Hutter,C., Bloch,W., Thorey,I., Watt,F. M., Fässler,R., ...

Integrins are ubiquitous transmembrane receptors that play crucial roles in cell-cell and cell-matrix interactions. In this study, we have determined the effects of the loss of beta1 integrins in...

Defective Rac-mediated proliferation and survival after targeted mutation of the beta(1) integrin cytodomain (2002)

Hirsch,E., Barberis,L., Brancaccio,M., Azzolino,O., Xu,D. Z., Kyriakis,J. M., ...

Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of beta(1) integrin leads to defective proliferation and...

Integrins in invasive growth (2002)

Brakebusch,C., Bouvard,D., Stanchi,F., Saki,T., Fässler,R.

beta 1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response (2002)

Brakebusch,C., Fillatreau,S., Potocnik,A. J., Bungartz,G., Wilhelm,P., Svensson,M., ...

Several experimental evidences suggested that beta1 integrin- mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of...

Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis (2002)

Braun,A., Aszodi,A., Hellebrand,H., Berna,A., Fässler,R., Brandau,O.

Profilins are small, widely expressed actin binding proteins, thought to be key regulators of actin dynamics in living cells. So far, three profilin-genes have been described: profilin-I (PFNI),...

COMP deficient mice have a normal skeletal development (2002)

Svensson,L., Aszódi,A., Fässler,R., Heinegard,D., Hunziker,E. B., Reinholt,F. P., ...

Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice (2002)

Moser,M., Hunziker,E. B., Sandell,L., Fässler,R., Buettner,R.

Abnormal migration of the neural crest and transposition of great arteries in perlecan-null mice embryos. Circulation Res., 91: 158-164 (2002)

Costell,M., Carmona,R., Gustafsson,E., González-Iriarte,M., Fässler,R., Muñoz-Chápuli,R.

Cartilage oligomeric matrix protein-deficient mice have normal skeletal development (2002)

Svensson,L., Aszodi,A., Heinegard,D., Hunziker,E. B., Reinholt,F. P., Fässler,R., ...

Targeted disruption of the murine zyxin gene (2002)

Hoffman,L. M., Nix,D. A., Benson,B., Boot-Hanford,R., Gustafsson,E., Jamora,C., ...

The fibrobronectin-binding integrins alpha-5beta-1 and alpha-vbeta-3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibrobronectin fibrillogenesis (2002)

Danen,E. H. J., Sonneveld,P., Brakebusch,C., Fässler,R., Sonnenberg,A.

Defective Rac-mediated proliferation and survival after targeted mutation of the beta(1) integrin cytodomain (2002)

Hirsch, E., Barberis, L., Brancaccio, M., Azzolino, O., Xu, D. Z., Kyriakis, J. M., ...

Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of beta(1) integrin leads to defective proliferation and...

Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation (2002)

Li, S., Harrison, D., Carbonetto, S., Fässler, R., Smyth, N., Edgar, D., ...

Laminin-1 is essential for early embryonic basement membrane assembly and differentiation. Several steps can be distinguished, i.e., the expression of laminin and companion matrix components, their...

Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis (2002)

Braun, A., Aszodi, A., Hellebrand, H., Berna, A., Fässler, R., Brandau, O.

Profilins are small, widely expressed actin binding proteins, thought to be key regulators of actin dynamics in living cells. So far, three profilin-genes have been described: profilin-I (PFNI),...

Integrins in invasive growth (2002)

Brakebusch, C., Bouvard, D., Stanchi, F., Saki, T., Fässler, R.

A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair (2002)

Grose, R., Hutter, C., Bloch, W., Thorey, I., Watt, F. M., Fässler, R., ...

Integrins are ubiquitous transmembrane receptors that play crucial roles in cell-cell and cell-matrix interactions. In this study, we have determined the effects of the loss of beta1 integrins in...

Brevican-deficient mice display impaired hippocampal CA1 long- term potentiation but show no obvious deficits in learning and memory (2002)

Brakebusch, C., Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., ...

Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has...

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy (2002)

Enge, M., Bjarnegard, M., Gerhardt, H., Gustafsson, E., Kalen, M., Asker, N., ...

Loss of pericytes from the capillary wall is a hallmark of diabetic retinopathy, however, the pathogenic significance of this phenomenon is unclear. In previous mouse gene knockout models leading to...

All four members of the Ten-m/Odz family of transmembrane proteins form dimers (2002)

Feng, K., Zhou, X. H., Oohashi, T., Morgelin, M., Lustig, A., Hirakawa, S., ...

Ten-m/Odz/teneurins are a new family of four distinct type II transmembrane molecules. Their extracellular domains are composed of an array of eight consecutive EGF modules followed by a large...

Role of the beta 1-integrin cytoplasmic tail in mediating invasin-promoted internalization of Yersinia (2002)

Gustavsson, A., Armulik, A., Brakebusch, C., Fässler, R., Johansson, S., Fällman, M.

Invasin of Yersinia pseudotuberculosis binds to beta1-integrins on host cells and triggers internalization of the bacterium. To elucidate the mechanism behind the beta1-integrin-mediated...

beta 1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response (2002)

Brakebusch, C., Fillatreau, S., Potocnik, A. J., Bungartz, G., Wilhelm, P., Svensson, M., ...

Several experimental evidences suggested that beta1 integrin- mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of...

COMP deficient mice have a normal skeletal development (2002)

Svensson, L., Aszódi, A., Fässler, R., Heinegard, D., Hunziker, E. B., Reinholt, F. P., ...

Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice (2002)

Moser, M., Hunziker, E. B., Sandell, L., Fässler, R., Buettner, R.

Abnormal migration of the neural crest and transposition of great arteries in perlecan-null mice embryos. Circulation Res., 91: 158-164 (2002)

Costell, M., Carmona, R., Gustafsson, E., González-Iriarte, M., Fässler, R., Muñoz-Chápuli, R.

Cartilage oligomeric matrix protein-deficient mice have normal skeletal development (2002)

Svensson, L., Aszodi, A., Heinegard, D., Hunziker, E. B., Reinholt, F. P., Fässler, R., ...

Chondromodulin-I is dispensable during enchondral ossification and eye development (2002)

Brandau, O., Aszodi, A., Hunziker, E. B., Neame, P. J., Vestweber, D., Fässler, R.

Targeted disruption of the murine zyxin gene (2002)

Hoffman, L. M., Nix, D. A., Benson, B., Boot-Hanford, R., Gustafsson, E., Jamora, C., ...

The fibrobronectin-binding integrins alpha-5beta-1 and alpha-vbeta-3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibrobronectin fibrillogenesis (2002)

Danen, E. H. J., Sonneveld, P., Brakebusch, C., Fässler, R., Sonnenberg, A.

Short arm region of laminin-5 gamma 2 chain: Structure, mechanism of processing and binding to heparin and proteins (2001)

Sasaki,T., Göhring,W., Mann,K., Brakebusch,C., Yamada,Y., Fässler,R., ...

Laminin-5 is a typical component of several epithelial tissues and contains a unique gamma2 chain which can be proteolytically processed by BMP-1. This occurs in the N-terminal half of the gamma2...

Short arm region of laminin-5 gamma 2 chain: Structure, mechanism of processing and binding to heparin and proteins (2001)

Sasaki, T., Göhring, W., Mann, K., Brakebusch, C., Yamada, Y., Fässler, R., ...

Laminin-5 is a typical component of several epithelial tissues and contains a unique gamma2 chain which can be proteolytically processed by BMP-1. This occurs in the N-terminal half of the gamma2...

Skin wounds and severed nerves heal normally in mice lacking tenascin-C.

Forsberg, E, Hirsch, E, Fröhlich, L, Meyer, M, Ekblom, P, Aszodi, A, ...

A large number of functions have been demonstrated for tenascin-C by antibody perturbation assays and in vitro cell culture experiments. However, these results contrast sharply with the lack of any...

Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.

Fässler, R, Schnegelsberg, P N, Dausman, J, Shinya, T, Muragaki, Y, McCarthy, M T, ...

Type IX collagen is a nonfibrillar collagen composed of three gene products, alpha 1(IX), alpha 2(IX), and alpha 3(IX). Type IX molecules are localized on the surface of type II-containing fibrils...

Defective smooth muscle regulation in cGMP kinase I-deficient mice.

Pfeifer, A, Klatt, P, Massberg, S, Ny, L, Sausbier, M, Hirneiss, C, ...

Regulation of smooth muscle contractility is essential for many important biological processes such as tissue perfusion, cardiovascular haemostasis and gastrointestinal motility. While an increase in...

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.

Aszódi, A, Pfeifer, A, Ahmad, M, Glauner, M, Zhou, X H, Ny, L, ...

The vasodilator-stimulated phosphoprotein (VASP) is associated with actin filaments and focal adhesions, which form the interface between the cytoskeleton and the extracellular matrix. VASP is...

Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C.

Svineng, G, Fässler, R, Johansson, S

A new splice variant of the human integrin subunit beta1 has been identified and designated beta1C-2. It differs from the previously reported beta1C (in this report designated beta1C-1) by 18...

Skin wounds and severed nerves heal normally in mice lacking tenascin-C.

Forsberg, E, Hirsch, E, Fröhlich, L, Meyer, M, Ekblom, P, Aszodi, A, ...

A large number of functions have been demonstrated for tenascin-C by antibody perturbation assays and in vitro cell culture experiments. However, these results contrast sharply with the lack of any...

Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.

Fässler, R, Schnegelsberg, P N, Dausman, J, Shinya, T, Muragaki, Y, McCarthy, M T, ...

Type IX collagen is a nonfibrillar collagen composed of three gene products, alpha 1(IX), alpha 2(IX), and alpha 3(IX). Type IX molecules are localized on the surface of type II-containing fibrils...

Defective smooth muscle regulation in cGMP kinase I-deficient mice.

Pfeifer, A, Klatt, P, Massberg, S, Ny, L, Sausbier, M, Hirneiss, C, ...

Regulation of smooth muscle contractility is essential for many important biological processes such as tissue perfusion, cardiovascular haemostasis and gastrointestinal motility. While an increase in...

The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.

Aszódi, A, Pfeifer, A, Ahmad, M, Glauner, M, Zhou, X H, Ny, L, ...

The vasodilator-stimulated phosphoprotein (VASP) is associated with actin filaments and focal adhesions, which form the interface between the cytoskeleton and the extracellular matrix. VASP is...

Identification of beta1C-2, a novel variant of the integrin beta1 subunit generated by utilization of an alternative splice acceptor site in exon C.

Svineng, G, Fässler, R, Johansson, S

A new splice variant of the human integrin subunit beta1 has been identified and designated beta1C-2. It differs from the previously reported beta1C (in this report designated beta1C-1) by 18...

R. Fässler

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