Davies, S N, Goldsmith, G E, Hellon, R F, Mitchell, D
The dynamic responses in a thermal afferent pathway to rates of temperature change have been studied in anaesthetized cats. Recordings were made in the caudal trigeminal nucleus from neurones with a...
Facial thermal input in the caudal trigeminal nucleus of rats reared at 30 degrees C.
Dawson, N J, Hellon, R F, Herington, J G, Young, A A
1. Rats reared from birth in air at 30 degrees C showed a decreased ability to maintain colonic temperature when exposed to 10 degrees C as compared with rats reared at 20 degrees C. This difference...
Intraventricular injections of drugs which inhibit phospholipase A2 suppress fever in rabbits.
Cranston, W I, Hellon, R F, Mitchell, D, Townsend, Y
Injection of two chemically dissimilar inhibitors of phospholipase A2 (mepacrine and parabromophenacylbromide) into the cerebral ventricles of rabbits inhibited the febrile response to endogenous...
Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.
Cranston, W I, Hellon, R F, Townsend, Y
1. Anisomycin has been given into the cerebral ventricles of rabbits. The inhibitory action of a range of doses on fever and on [14C]leucine incorporation into hypothalamic protein has been studied....
Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits.
Cannon, M, Cranston, W I, Hellon, R F, Townsend, Y
1. To test further the hypothesis that brain protein synthesis is necessary for fever, three structurally similar trichothecene antibiotics were injected into the cerebral ventricles of rabbits. They...
An analysis of a thermal afferent pathway in the rat
Hellon, R. F., Taylor, David C. M.
1. Single unit activity has been recorded in the thalamic, hypothalamic and raphe magnus nuclei of rats anaesthetized with Urethane.
The representation of facial temperature in the caudal trigeminal nucleus of the cat.
1. In cats anaesthetized with urethane, extracellular micro-electrode recordings were made in the marginal layer of the trigeminal nucleus caudalis between the level of the obex and the Cl rootlets....
Thermal stimulation of intra-abdominal veins in conscious rabbits.
Cranston, W I, Hellon, R F, Townsend, Y
1. Infusions of hot and cold Hartmann's solution were given into the hepatic portal vein and inferior vena cava of conscious rabbits. Similar infusions were given into an ear vein as controls. The...
Suppression of fever in rabbits by a protein synthesis inhibitor, anisomycin.
Cranston, W I, Hellon, R F, Townsend, Y
1. The protein synthesis inhibitor, anisomycin, was given into the cerebral ventricles of rabbits as a priming dose followed by a continuous infusion. Doses of 100, 200 and 300 microgram followed by...
Evidence that brain prostaglandin synthesis is not essential in fever.
Cranston, W I, Duff, G W, Hellon, R F, Mitchell, D, Townsend, Y
1. We have tested the hypothesis that a fever caused by pyrogen depends upon the synthesis of prostaglandin E in the brain and that the prostaglandin in turn acts on the hypothalamus to produce...
Thermoregulation in rabbits during fever.
Cranston, W I, Duff, G W, Hellon, R F, Mitchell, D
1. We have studied the effect of fever on the efficacy of the thermoregulatory control system in conscious rabbits. 2. The control system was challenged by a series of systemic thermal loads produced...
Thermal receptors in the scrotum of the rat.
Hellon, R F, Hensel, H, Schäfer, K
1. The technique of single fibre dissection has been used to study the warm and cold thermoreceptors in the rat scrotum. 2. The warm receptors showed dynamic activity during increases of scrotal...
Convergence in a thermal afferent pathway in the rat.
1. In anaesthetized rats, unit activity was recorded in the afferent somatosensory pathway leading from the scrotum. Recording sites were in the dorsal horn near the entry zone of the scrotal nerve,...
Is brain prostaglandin synthesis involved in responses to cold?
Cranston, W I, Hellon, R F, Mitchell, D
1. Experiments with rats have suggested that prostaglandin synthesis in the C.N.S. may mediate thermoregulatory reactions to cold. This possibility was investigated in cats using two types of...
Hypothalamic endogenous noradrenaline and thermoregulation in the cat and rabbit
Cranston, W. I., Hellon, R. F., Luff, R. H., Rawlins, M. D.
1. The imino-dibenzyl drugs, imipramine and desipramine, which inhibit the uptake by neurones of noradrenaline, were injected into the lateral cerebral ventricles of cats and rabbits: changes in body...
A dissociation between fever and prostaglandin concentration in cerebrospinal fluid.
Cranston, W I, Hellon, R F, Mitchell, D
1. Sustained fever has been induced in conscious rabbits by I.V. injection and infusion of endogenous pyrogen. 2. Cerebrospinal fluid (e.s.f.) was sampled from the cisterna magna at hourly intervals....
Neurones in the dorsal horn of the rat responding to scrotal skin temperature changes
1. Micro-electrode recordings have been made from single neurones in the dorsal horn of male rats anaesthetized with urethane. Scrotal temperature was altered within the range 13-43° C by means of a...
1. In rats the scrotal temperature was raised or lowered with a water-perfused thermode while micro-electrode recordings were made of unit activity in the ventrobasal complex of the thalamus. The...
Neurones in the somatosensory cortex of the rat responding to scrotal skin temperature changes
Hellon, R. F., Misra, N. K., Provins, K. A.
1. In rats the scrotal temperature was raised or lowered with a water-perfused thermode while micro-electrode recordings were made of unit activity in the somatosensory (SI) cortex. The electrodes...
Are there functionally important temperature sensors in the right heart or lungs?
Cranston, W I, Hellon, R F, Townsend, Y
1. In conscious rabbits, paired hot or cold infusions were given into the left atrium or jugular vein. For each pair of infusions the volume and temperature of the fluid was identical. The time...
Natural and artifical acclimatization to hot environments
Hellon, R. F., Jones, R. M., Macpherson, R. K., Weiner, J. S.
Feldberg, W., Hellon, R. F., Lotti, V. J.
1. In dogs the effects on rectal temperature of noradrenaline, adrenaline, 5-hydroxytryptamine (5-HT) and of the monoamine oxidase inhibitor tranylcypromine were studied following their injection...
Thermal stimulation of hypothalamic neurones in unanaesthetized rabbits
1. A technique has been devised for recording unit activity in the anterior hypothalamus of conscious rabbits during the controlled displacement of local temperature by 1-2° C. The region at 1 and 2...
Observations on the mechanism of salicylate-induced antipyresis
Cranston, W. I., Hellon, R. F., Luff, R. H., Rawlins, M. D., Rosendorff, C.
1. Fever has been produced in conscious rabbits, first, by injection of leucocyte pyrogen into the lateral cerebral ventricle and, second, by local cooling of the hypothalamus.
Effects on temperature of monoamines injected into the cerebral ventricles of anaesthetized dogs
Feldberg, W., Hellon, R. F., Myers, R. D.
1. In dogs anaesthetized with pentobarbitone sodium an injection of adrenaline or noradrenaline into the cerebral ventricles through a cannula implanted into the left lateral ventricle caused a fall...
Davies, S N, Goldsmith, G E, Hellon, R F, Mitchell, D
The dynamic responses in a thermal afferent pathway to rates of temperature change have been studied in anaesthetized cats. Recordings were made in the caudal trigeminal nucleus from neurones with a...
Facial thermal input in the caudal trigeminal nucleus of rats reared at 30 degrees C.
Dawson, N J, Hellon, R F, Herington, J G, Young, A A
1. Rats reared from birth in air at 30 degrees C showed a decreased ability to maintain colonic temperature when exposed to 10 degrees C as compared with rats reared at 20 degrees C. This difference...
Intraventricular injections of drugs which inhibit phospholipase A2 suppress fever in rabbits.
Cranston, W I, Hellon, R F, Mitchell, D, Townsend, Y
Injection of two chemically dissimilar inhibitors of phospholipase A2 (mepacrine and parabromophenacylbromide) into the cerebral ventricles of rabbits inhibited the febrile response to endogenous...
Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.
Cranston, W I, Hellon, R F, Townsend, Y
1. Anisomycin has been given into the cerebral ventricles of rabbits. The inhibitory action of a range of doses on fever and on [14C]leucine incorporation into hypothalamic protein has been studied....
Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits.
Cannon, M, Cranston, W I, Hellon, R F, Townsend, Y
1. To test further the hypothesis that brain protein synthesis is necessary for fever, three structurally similar trichothecene antibiotics were injected into the cerebral ventricles of rabbits. They...
An analysis of a thermal afferent pathway in the rat
Hellon, R. F., Taylor, David C. M.
1. Single unit activity has been recorded in the thalamic, hypothalamic and raphe magnus nuclei of rats anaesthetized with Urethane.
The representation of facial temperature in the caudal trigeminal nucleus of the cat.
1. In cats anaesthetized with urethane, extracellular micro-electrode recordings were made in the marginal layer of the trigeminal nucleus caudalis between the level of the obex and the Cl rootlets....
Thermal stimulation of intra-abdominal veins in conscious rabbits.
Cranston, W I, Hellon, R F, Townsend, Y
1. Infusions of hot and cold Hartmann's solution were given into the hepatic portal vein and inferior vena cava of conscious rabbits. Similar infusions were given into an ear vein as controls. The...
Suppression of fever in rabbits by a protein synthesis inhibitor, anisomycin.
Cranston, W I, Hellon, R F, Townsend, Y
1. The protein synthesis inhibitor, anisomycin, was given into the cerebral ventricles of rabbits as a priming dose followed by a continuous infusion. Doses of 100, 200 and 300 microgram followed by...
Evidence that brain prostaglandin synthesis is not essential in fever.
Cranston, W I, Duff, G W, Hellon, R F, Mitchell, D, Townsend, Y
1. We have tested the hypothesis that a fever caused by pyrogen depends upon the synthesis of prostaglandin E in the brain and that the prostaglandin in turn acts on the hypothalamus to produce...
Thermoregulation in rabbits during fever.
Cranston, W I, Duff, G W, Hellon, R F, Mitchell, D
1. We have studied the effect of fever on the efficacy of the thermoregulatory control system in conscious rabbits. 2. The control system was challenged by a series of systemic thermal loads produced...
Thermal receptors in the scrotum of the rat.
Hellon, R F, Hensel, H, Schäfer, K
1. The technique of single fibre dissection has been used to study the warm and cold thermoreceptors in the rat scrotum. 2. The warm receptors showed dynamic activity during increases of scrotal...
Convergence in a thermal afferent pathway in the rat.
1. In anaesthetized rats, unit activity was recorded in the afferent somatosensory pathway leading from the scrotum. Recording sites were in the dorsal horn near the entry zone of the scrotal nerve,...
Is brain prostaglandin synthesis involved in responses to cold?
Cranston, W I, Hellon, R F, Mitchell, D
1. Experiments with rats have suggested that prostaglandin synthesis in the C.N.S. may mediate thermoregulatory reactions to cold. This possibility was investigated in cats using two types of...
Hypothalamic endogenous noradrenaline and thermoregulation in the cat and rabbit
Cranston, W. I., Hellon, R. F., Luff, R. H., Rawlins, M. D.
1. The imino-dibenzyl drugs, imipramine and desipramine, which inhibit the uptake by neurones of noradrenaline, were injected into the lateral cerebral ventricles of cats and rabbits: changes in body...
A dissociation between fever and prostaglandin concentration in cerebrospinal fluid.
Cranston, W I, Hellon, R F, Mitchell, D
1. Sustained fever has been induced in conscious rabbits by I.V. injection and infusion of endogenous pyrogen. 2. Cerebrospinal fluid (e.s.f.) was sampled from the cisterna magna at hourly intervals....
Neurones in the dorsal horn of the rat responding to scrotal skin temperature changes
1. Micro-electrode recordings have been made from single neurones in the dorsal horn of male rats anaesthetized with urethane. Scrotal temperature was altered within the range 13-43° C by means of a...
1. In rats the scrotal temperature was raised or lowered with a water-perfused thermode while micro-electrode recordings were made of unit activity in the ventrobasal complex of the thalamus. The...
Neurones in the somatosensory cortex of the rat responding to scrotal skin temperature changes
Hellon, R. F., Misra, N. K., Provins, K. A.
1. In rats the scrotal temperature was raised or lowered with a water-perfused thermode while micro-electrode recordings were made of unit activity in the somatosensory (SI) cortex. The electrodes...
Are there functionally important temperature sensors in the right heart or lungs?
Cranston, W I, Hellon, R F, Townsend, Y
1. In conscious rabbits, paired hot or cold infusions were given into the left atrium or jugular vein. For each pair of infusions the volume and temperature of the fluid was identical. The time...
Natural and artifical acclimatization to hot environments
Hellon, R. F., Jones, R. M., Macpherson, R. K., Weiner, J. S.
Feldberg, W., Hellon, R. F., Lotti, V. J.
1. In dogs the effects on rectal temperature of noradrenaline, adrenaline, 5-hydroxytryptamine (5-HT) and of the monoamine oxidase inhibitor tranylcypromine were studied following their injection...
Thermal stimulation of hypothalamic neurones in unanaesthetized rabbits
1. A technique has been devised for recording unit activity in the anterior hypothalamus of conscious rabbits during the controlled displacement of local temperature by 1-2° C. The region at 1 and 2...
Observations on the mechanism of salicylate-induced antipyresis
Cranston, W. I., Hellon, R. F., Luff, R. H., Rawlins, M. D., Rosendorff, C.
1. Fever has been produced in conscious rabbits, first, by injection of leucocyte pyrogen into the lateral cerebral ventricle and, second, by local cooling of the hypothalamus.
Effects on temperature of monoamines injected into the cerebral ventricles of anaesthetized dogs
Feldberg, W., Hellon, R. F., Myers, R. D.
1. In dogs anaesthetized with pentobarbitone sodium an injection of adrenaline or noradrenaline into the cerebral ventricles through a cannula implanted into the left lateral ventricle caused a fall...
Design and Evaluation of a Ventilated Garment for Use in Temperatures up to 200°C
Crockford, G. W., Hellon, R. F.
The protection of personnel against high air and radiant temperatures is a problem that has been confronting industry for many years now, and for many industrial situations it still has not been...
Are single-unit recordings useful in understanding thermoregulation?
The data which have emerged from single-unit recordings of thermally sensitive neurons in the hypothalamus are reviewed. Although these neurons may be important components in the central control of...
Mitchell, D., Laburn, H. P., Cooper, K. E., Hellon, R. F., Cranston, W. I., Townsend, Y.
We have reviewed the evidence in favor of a prostaglandin mediator of the thermal responses in fever and found that PGE injected into the hypothalamus does not always cause fever, that cerebrospinal...