Neuronal activity and tonotopy in the auditory system visualized by c-fos gene expression (2009)
N/A
Guglielmetti, F., Fischer, R., Dose, V.
A probabilistic technique for the joint estimation of background and sources with the aim of detecting faint and extended celestial objects is described. Bayesian probability theory is applied to...
Molecular farming of human tissue transglutaminase in tobacco plants (2009)
Sorrentino, A., Schillberg, S., Fischer, R., Porta, R., Mariniello, L.
In this study we have utilized Nicotiana tabacum with a molecular farming purpose in attempt of producing transgenic plants expressing the human tissue transglutaminase (htTG). Three plant expression...
Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa (2009)
Scholz, M., Lipinski, M., Leupold, M., Luftmann, H., Harig, L., Ofir, R., ...
Hydroponically cultivated Nigella sativa L. plants treated with methyl jasmonate (MeJA) showed a twelvefold increase in levels of the monodesmosidic triterpene saponins alpha-hederin and...
Lipinski, M., Scholz, M., Pieper, K., Fischer, R., Prüfer, D., Müller, K.J.
Squalene epoxidase catalyzes the formation of 2,3-oxidosqualene from squalene and in plants is the last enzyme common to all biosynthetic pathways leading to an array of triterpene derivatives like...
Main chamber high recycling on ASDEX Upgrade (2009)
McCormick, K., Dux, R., Fischer, R., Scarabosio, A., ASDEX Upgrade Team
H-Mode Threshold and Confinement in Helium and Deuterium in ASDEX Upgrade (2009)
Ryter, F., Pütterich, T., Reich, M., Scarabosio, A., Wolfrum, E., Fischer, R., ...
Epstein-Barr virus BDLF2-BMRF2 complex affects cellular morphology (2009)
Di Fiore, S., Ritter, K., Fischer, R., Kleines, M.
Herpesvirus glycoproteins often form specific heterodimers that can fulfil functions that cannot be carried out by either of the partners acting alone. This study showed that interactions between the...
MS-specific noise model reveals the potential of iTRAQ in quantitative proteomics (2009)
Hundertmark, C., Fischer, R., Reinl, T., May, S., Klawonn, F., Jänsch, L.
Motivation: Mass spectrometry (MS) data are impaired by noise similar to many other analytical methods. Therefore, proteomics requires statistical approaches to determine the reliability of...
Overview of ASDEX Upgrade results (2009)
Zohm, H., Adamek, J., Angioni, C., Antar, G., Atanasiu, C. V., Balden, M., ...
Polyphenoloxidase silencing affects latex coagulation in taraxacum species (2009)
Wahler, D., Schulze Gronover, C., Richter, C., Foucu, F., Twyman, R.M., Moerschbacher, B.M., ...
Latex is the milky sap that is found in many different plants. It is produced by specialized cells known as laticifers and can comprise a mixture of proteins, carbohydrates, oils, secondary...
Lipid dip-pen nanolithography. (2009)
Lenhert, S., Sekula, S., Wang, Y., Giam, L., Schelb, M., Siebenbrock, J., ...
CFN Summer School on Nano-Biology, Bad Herrenalb, September 8-11, 2009
Protein templating and cell culture on lipid nanoarrays. (2009)
Sekula-Neuner, S., Fuchs, J., Weg-Remers, S., Ellmark, P., Borrebaeck, C.A.K., Siebenbrock, J., ...
CFN Summer School on Nano-Biology, Bad Herrenalb, September 8-11, 2009
Electron Density Profiles from the Probabilistic Analysis of the Lithium Beam at JET (2009)
Dodt, T., Fischer, R., Korotkov, A., McDonald, D. C., JET-EFDA Contributors
Multiple diagnostic data analysis of density and temperature profiles in ASDEX Upgrade (2009)
Fischer, R., Burckhart, A., Hicks, N., Kurzan, B., Wolfrum, E., ASDEX Upgrade Team
Ranft, K., Thepen, T., Fischer, R., Barth, S., Stöcker, M.
Bispecific molecules (BSMs) facilitate the targeting of immune effector cells to tumor cells. Here we describe the construction and characterization of a recombinant BSM comprising two single chain...
Implementation and Application of EMC3-EIRENE at ASDEX Upgrade (2009)
Lunt, T., Feng, Y., Coster, D., Wischmeier, M., Wolfrum, E., Fischer, R., ...
Confinement enhancement in ASDEX Upgrade improved H-mode discharges with nitrogen seeding (2009)
Tardini, G., Fischer, R., Igochine, V., Kallenbach, A., Maggi, C. F., Neu, R., ...
Bebrone, C., Delbrück, H., Kupper, M.B., Schlömer, P., Willmann, C., ...
Bacteria can defend themselves against beta-lactam antibiotics through the expression of class B beta-lactamases, which cleave the beta-lactam amide bond and render the molecule harmless. There are...
Visual Physics Analysis (VISPA) - Concepts and First Applications (2008)
Actis, O., Erdmann, M., Fischer, R., Hinzmann, A., Kirsch, M., Klimkovich, T., ...
VISPA is a novel development environment for high energy physics analyses, based on a combination of graphical and textual steering. The primary aim of VISPA is to support physicists in prototyping,...
Mandated by the Rivers and Harbors Act and Clean Water Act, the Corps of Engineers is (2008)
J. Anderson, R. Fischer, C. Smith, S. Webb, J. Dennis, ...
• Contributing Authors: (in alphabetical order) (2008)
Phillip Regalia, Erdal Arıkan, Yonina Eldar, Robert Fischer, Walid Hachem, Emmanouil Kalantzis, ...
Integrating diagnostic data analysis for W7-AS using Bayesian graphical models, Rev (2008)
J Svensson, A Dinklage, J Geiger, A Werner, R Fischer
Analysis of diagnostic data in fusion experiments is usually dealt with separately for each diagnostic, in spite of the existence of a large number of interdependencies between global physics...
Integrated Interpretative Transport Modelling (2008)
A. Dinklage, C. D. Beidler, R. Fischer, H. Maaßberg, J. Svensson, Yu. A. Turkin
Integrated analysis of fusion data Usually, diagnostic data and modelling results are dealt with separately in the analysis of fusion data, i.e., experimental results are passed to modelling codes...
DOI 10.1007/s00216-002-1505-6 SPECIAL ISSUE PAPER (2008)
R. Fischer, Depth Profiles, Resolution Limits
Abstract A ubiquitous problem in solid state analysis is the determination of the elemental composition of a sample as a function of the depth. The determination of the depth profiles from ion-beam...
Bayesian Experimental Design – Studies for Fusion Diagnostics (2008)
Abstract. The design of fusion diagnostics is essential for the physics program of future fusion devices. The goal is to maximize the information gain of a future experiment with respect to various...
Investigation of the hydrogen ¯uxes in the plasma edge of (2008)
U. Langer, E. Taglauer, R. Fischer, W-as Team
W7-AS during H-mode discharges
Analysis of Mixtures in Physical Spectra (2008)
Abstract: A reversible jump Markov chain Monte Carlo technique is applied to estimate the number and parameters of peaks in ubiquitous physical problems in the framework of Bayesian probability...
BAYESIAN METHODS FOR INTEGRATED DATA ANALYSIS (2008)
A. Dinklage, R. Fischer, J. Svensson
A brief introduction to Bayesian probability theory is given with emphasis on data analysis. The analysis of Thomson scattering data is discussed. Capabilities for assessing diagnostic set-ups are...
Bayesian Experimental Design -- (2008)
Studies For Fusion, R. Fischer
The design of fusion diagnostics is essential for the physics program of future fusion devices. The goal is to maximize the information gain of a future experiment with respect to various...
Integrated Data Analysis of Spectroscopic Data (2008)
Dodt, D., Dinklage, A., Fischer, R., Bartschat, K., Zatsarinny, O.
Eukaryotic expression and secretion of EGFP-labeled annexin A5 (2008)
Stöcker, M., Pardo, A., Hetzel, C., Reutelingsperger, C., Fischer, R., Barth, S.
Hetzel, C., Bachran, C., Fischer, R., Fuchs, H., Barth, S., Stocker, M.
The most potent immunotoxins (ITs) developed to date contain bacterial or plant cytotoxic components. As these are potentially immunogenic in man, human proteins are preferred for the long-term...
Probalistic lithium beam data analysis (2008)
Fischer, R., Wolfrum, E., Schweinzer, J., ASDEX Upgrade Team
Probabilistic lithium beam data analysis (2008)
Fischer, R., Wolfrum, E., Schweinzer, J., ASDEX Upgrade Team
Divertor power and particle fluxes between and during type-I ELMs in the ASDEX Upgrade (2008)
Kallenbach, A., Dux, R., Eich, T., Fischer, R., Giannone, L., Harhausern, J., ...
Design and Calibration of a Polychromator for the Thomson Scattering at Wendelstein 7-X (2008)
Schmuck, S., Dinklage, A., Fischer, R., Knauer, J. P., Kurzan, B., ...
Integrated Data Analysis for Fusion: A Bayesian Tutorial for Fusion Diagnosticians (2008)
Dinklage, A., Dreier, H., Fischer, R., Gori, S., Preuss, R., Von Toussaint, U.
Zhang, M.Y., Zimmermann, S., Fischer, R., Schillberg, S.
This study investigated whether single-chain antibodies (scFvs) specific for a viral movement protein could accumulate in the plant cell cytosol and restrict viral systemic infection in plants. Nine...
Stahnke, B., Thepen, T., Stöcker, M., Rosinke, R., Jost, E., Fischer, R., ...
Acute myeloid leukemia (AML) cells of subtypes M4 and M5 show enhanced expression of CD64 (Fc gamma RI), the high-affinity receptor for IgG, which is normally expressed at high levels only on...
Bayesian experimental design of a multichannel interferometer for Wendelstein 7-X (2008)
Dreier, H., Dinklage, A., Fischer, R., Hirsch, M., Kornejew, P.
Reconstruction of an electron energy distribution function using integrated data analysis (2008)
Dodt, D., Dinklage, A., Fischer, R., Bartschat, K., Zatsarinny, O., Loffhagen, D.
Studies of edge MHD modes in H-mode discharges in ASDEX Upgrade using reflectometry (2008)
Da Graca, S., Conway, G. D., Maraschek, M., Silva, A., Wolfrum, E., Fischer, R., ...
Platis, D., Drossard, J., Fischer, R., Ma, J.K.-C., Labrou, N.E.
Affinity chromatography on immobilized Protein A is the current method of choice for the Purification of monoclonal antibodies (mAbs). Despite its widespread use it presents certain drawbacks, such...
Chung, W.Y., Sack, M., Carter, R., Spiegel, H., Fischer, R., Hirst, T.R., ...
Previously we have described studies on in vitro pentamer assembly of Escherichia coli (E. coli) derived heat-labile enterotoxin B subunit (EtxB) using conventional monoclonal antibodies (Amin et...
Dhonukshe, P., Grigoriev, I., Fischer, R., Tominaga, M., Robinson, D.G., Hašek, J., ...
Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs),...
Nölke, G., Schneider, B., Agdour, S., Drossard, J., Fischer, R., Schillberg, S.
Ornithine decarboxylase (ODC) is a cytosolic enzyme that catalyses the direct decarboxylation of L-ornithine to putrescine, one of the rate-limiting steps of polyamine biosynthesis in plants. We...
Bo Zhang, J., Shi, R.P., Huang, T., Fischer, R., Liao, Y.C.
Fusarium head blight (FHB) or scab of wheat is a devastating disease in warm and humid regions at wheat-flowering periods worldwide. Natural resistance against FHB pathogens is inadequate and the...
Modifizerite Kohlenstoff-Nanopartikel, Verfahren zu deren Herstellung und deren Verwendung. (2008)
Balaban, M.C., Balaban, T.S., Fischer, R., Hennrich, F., Kappes, M.M., Malik, S.
Biomimetic membrane and protein microarrays by dip-pen nanolithography. (2008)
Sekula, S., Fuchs, J., Weg-Remers, S., Siebenbrock, J., Seibold, P., Schunck, T., ...
NanoBio Europe : Internat.Congress and Exhibition on Nanobiotechnology, Barcelona, E, June 9-13, 2008
Fischer, R., Schimmel, T., Richter, W., Wenzel, W.
Symp.Biomaterialien/Biokompatibilität, Tübingen, 10.April 2008
Schebek, L., [Hrsg.], Gößling-Reisemann, S., Gleich, A.von, Ruth, M., Fischer, R., ...
Projektbericht im Rahmen des Forschungsvorhabens FKZ 01 RN 0401 (Oktober 2007)
Parallelisation Efficiency, M. Ast, C. Barrado, J. Cela, R. Fischer, J. Labarta, ...
The simulated models and requirements of engineering programs like computational fluids dynamics and structural mechanics grow more rapidly than single processor performance. Automatic...
Analysis of Mixtures in Physical Spectra (2007)
A reversible jump Markov chain Monte Carlo technique is applied to estimate the number and parameters of peaks in ubiquitous physical problems in the framework of Bayesian probability theory. For...
A. Dinklage, R. Fischer, G. Kühner, H. Maaßberg, E. Pasch, J. Svensson
Aspects of the integration of different data sources are discussed with respect to improvement of reliability and significance of experimental results. Thomson scattering data have been analysed by...
Major Results from Wendelstein 7-AS Stellarator (2007)
F. Wagner, R. Burhenn, F. Gadelmeier, J. Geiger, M. Hirsch, H. P. Laqua, ...
island divertor operation and the modelling of the results with the EMC3/EIRENE code- confinement issues with emphasis on the differences to tokamaks (isotope effect, density scaling, lack of profile...
ABSTRACT AN OPERATIONAL RICE FIELD MAPPING TOOL USING SPACEBORNE SAR DATA (2007)
F. Holecz, E. Dwyer, S. Monaco, B. Schmid, U. Frei, R. Fischer
Rice is of significant importance for many tropical countries, both as a staple food and as an agricultural product for international trading. Crucial parameters for yield forecasting are the area of...
Bayesian Background Estimation (2007)
R. Fischer, V. Dose, K. M. Hanson, W. Von, Der Linden
The ubiquitous problem of estimating the background of a measured spectrum is solved with Bayesian probability theory. A mixture model is used to capture the defining characteristics of the problem,...
Topics and methods for steady-state data validation (2007)
A. Dinklage, R. Fischer, J. Svensson
Steady –state fusion devices, such as Wendelstein 7-X require new approaches for data analysis. These efforts are motivated both by physics and technical requirements of steady-state operation. The...
Island divertor experiments on the Wendelstein 7-AS stellarator (2007)
K. Mccormick, P. Grigull, R. Burhenn, R. Brakel, H. Ehmler, Y. Feng, ...
A new generation SQUID biosusceptometer (2007)
Starr Fischer Ewing, T. N. Starr, R. Fischer, T. Ewing, F. Longo, R. Engelhardt, ...
Introduction Iron overload from genetic disorders and/or regular blood transfusions is a serious health problem in many regions of the world. As liver and spleen iron stores account for more than 70...
An Integrated Data Analysis Model for the W7-AS Stellarator (2007)
Svensson Dinklage Geiger, J. Svensson, A. Dinklage, J. Geiger, R. Fischer
This paper describes the first implementation of a new diagnostic analysis model in which a number of previously separate diagnostic models are integrated into a single comprehensive model. The...
Physical Mixture Modeling with Unknown Number of Components (2007)
Measured physical spectra often comprise an unknown number of components of known parametric family. A reversible jump Markov chain Monte Carlo (RJMCMC) technique is applied to the problem of...
Biomagnetic Liver Susceptometry in Long-Term Survivors After Bone Marrow (2007)
Or Stem Cell, R. Engelhardt, M. Dürken, P. Nielsen, F. Neubauer, M. Haberhausen, ...
Introduction Patients with major hematologic malignancy or aplastic anemia were treated with bone marrow (BMT) or stem cell transplantation. Additional transfusion of erythrocyte concentrates during...
HOW TO SEPARATE THE SIGNAL FROM THE BACKGROUND (2007)
W. Von, Der Linden, V. Dose, R. Fischer
Abstract. In many applications like radio astronomy and electron spectroscopy three sources contribute to the measured signal: the desired image, the noise, and an unknown slowly varying background....
V. Dose, R. Fischer, W. Von, Der Linden
Deconvolution of experimental measurements in e.g. electron or ion scattering can result in considerable resolution enhancement. It is usually assumed that the apparatus function which we wish to...
Abstract. Bayesian probability theory allows to infer an image given data constraints, prior knowledge, and background information. One ingredient of the background information is usually paid little...
BAYESIAN ANALYSIS OF ION BEAM DIAGNOSTICS (2007)
U. V. Toussaint, R. Fischer, V. Dose
Abstract. Ion beam diagnostics are routinely used for quantitative analysis of the surface composition of mixture materials up to a depth of a few m. Unfortunately, advantageous properties of the...
ABSTRACT. The ubiquitous spectroscopic problem of decomposing overlapping lines is solved for ion scattering spectroscopy employing MaximumEntropy. The chosen example of Pd adsorption on a Ru surface...
Probabilistic Evaluation of Growth Models Based on Time Dependent Auger Signals (2007)
V. Dose, N. Memmel, R. Fischer
The time-dependent Auger intensity measured during epitaxial growth of ultra-thin films is routinely used to study the growth process. The Auger signal yields integrated information about the...
Depth profile reconstruction from rutherford backscattering data (2007)
U. V. Toussaint, K. Krieger, R. Fischer, V. Dose
Abstract. An adaptive kernel method in the Bayesian framework together with a new simulation program for Rutherford backscattering spectroscopy (RBS) have been applied to the analysis of RBS data....
W. Von, Der Linden, R. Fischer, V. Dose
Abstract. Evidence integrals are a key ingredient of quantified maximum entropy (QME). They allow to evaluate hyper-parameters which in turn determine the amount of regularization, the noise level,...
Shrestha, R., Fischer, R., Sillanpää, M.
In most mining areas, significant concentrations of metals such as Pb, Cu, Cr, Zn, Cd, Fe, Mn, Co, Ni, Hg, Ar, halogenated organic compounds and radionuclides are found. Of those, Cr is one of the...
Nichtlineares Vorcodierungsverfahren fuer einen digitalen Broadcastkanal (2007)
Fischer, R., Windpassinger, C.
WO2005011219 A UPAB: 20050311 NOVELTY - The non-linear precoding method uses a modulo arithmetic calculation for pre-equalizing of the broadcast channel (BC), with virtual division of the latter for...
Immunodetection of Venturia inaequalis ascospores with phage antibodies (2007)
Ribbert, M., Wolters, A., Barth, S., Stöcker, M., Schaeffer, A., Fischer, R., ...
We describe the bacterial expression of single chain variable fragment (scFv) antibodies that bind specifically to the ascospores of Venturia inaequalis (Cooke). A scFv phage display library was...
Genetic stability of recombinant potato virus X virus vectors presenting foreign epitopes (2007)
Uhde-Holzem, K., Fischer, R., Commandeur, U.
We investigated the genetic stability of recombinant potato virus X vectors presenting beet necrotic yellow vein virus (BNYVV) epitopes. Following N-terminal PVX coat protein (CP) fusion of the BNYVV...
MacIean, J., Koekemoer, M., Oliver, A.J., Stewart, D., Hitzeroth, I. I., Rademacher, T., ...
Virus-like particle-based vaccines for high-risk human papillomaviruses (HPVs) appear to have great promise; however, cell culture-derived vaccines will probably be very expensive. The optimization...
Sack, M., Paetz, A., Kunert, R., Bomble, M., Hesse, F., Stiegler, G., ...
We report the production of an important human therapeutic antibody in plant cell suspension cultures and the functional analysis of that antibody, including a comparison with the same antibody...
Segers, K., Sperandio, O., Sack, M., Fischer, R., Miteva, M.A., Rosing, J., ...
Most orally bioavailable drugs on the market are competitive inhibitors of catalytic sites, but a significant number of targets remain undrugged, because their molecular functions are believed to be...
R. Shrestha, R. Fischer, M. Sillanpää
In most mining areas, significant concentrations of metals such as Pb, Cu, Cr, Zn, Cd, Fe, Mn, Co, Ni, Hg, Ar, halogenated organic compounds and radionuclides are found. Of those, Cr is one of the...
Noll, G.A., Fontanellaz, M.E., Rüping, B., Ashoub, A., Fischer, R., ...
Forisomes are protein aggregates found uniquely in the sieve elements of Fabaceaen plants. Upon wounding they undergo a reversible, calcium-dependent conformational switch which enables them to act...
Neu, R., Balden, M., Bobkov, V., Dux, R., Gruber, O., Herrmann, A., ...
Assessing potential impact to ground water in the EU and member state registration procedures (2007)
Jones, R.L., Fischer, R., Gottesbüren, B., Hanze, K., Huber, A., ...
A comprehensive model for the cellular uptake of cationic cell-penetrating peptides. (2007)
Duchardt, F, Fotin-Mleczek, M., Schwarz, Heinz, Fischer, R, Brock, R.
The plasma membrane represents an impermeable barrier for most macromolecules. Still some proteins and so-called cell-penetrating peptides enter cells efficiently. It has been shown that endocytosis...
Experimental determination of the NBI power deposition and consequences for NBI current drive (2007)
Ryter, F., Tardini, G., Horton, L.D., Schneider, W., Suttrop, W., Fischer, R., ...
Probabilistic Lithium beam data analysis (2007)
Fischer, R., Wolfrum, E., Schweinzer, J., ASDEX Upgrade Team
Impact of a static magnetic field on high-order harmonic spectra (2007)
Fischer, R., Keitel, C. H., Jung, R., Pretzler, G., Willi, O.
Facing the future with pharmaceuticals from plants (2007)
Fischer, R., Twyman, R.M., Hellwig, S., Drossard, J., Schillberg, S.
Accessory stimuli modulate effeccts of nonconscious priming (2007)
Fischer, R., Schubert, Torsten, Liepelt, Roman
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Plasma wall interaction and its implication in an all tungsten divertor tokamak (2007)
NEU, R, BALDEN, M, BOBKOV, V, DUX, R, GRUBER, O, HERRMANN, A, ...
Overview of ASDEX Upgrade Results (2007)
GRUBER, O, ANGIONI, C, ATANASIU, C, BALDEN, M, BECKER, G, BECKER, W, ...
Nonlinear spectral-spatial control and localization of supercontinuum radiation (2007)
Neshev, D, Sukhorukov, A, Dreishuh, A, Fischer, R, Ha, S, Bolger, J, ...
We present the first observation of spatiospectral control and localization of supercontinuum light through the nonlinear interaction of spectral components in extended periodic structures. We use an...
Polyacylation of single- and multi-wall carbon nanotubes under Friedel-Crafts conditions. (2007)
Balaban, T.S., Balaban, M.C., Malik, S., Hennrich, F., Fischer, R., Rösner, H., ...
233rd Nat.Meeting of the American Chemical Society, Chicago, Ill., March 25-29, 2007
Heterogeneous phospholipid and protein nanostructures generated by dip-pen nanolithography. (2007)
Sekula, S., Fuchs, J., Weg-Remers, S., Siebenbrock, J., Seibold, P., Schunck, T., ...
CFN Summer School on Nano-Electronics, Bad Herrenalb, August 28-31, 2007
Jester, S.S., Kiowski, O., Lebedkin, S., Hennrich, F., Fischer, R., Stürzl, N., ...
physica status solidi (b), 244(2007) S.3973-77
Optical lattices as nonlinear photonic crystals (2007)
Neshev, D, Sukhorukov, A, Mitchell, A, Rosberg, C, Fischer, R, Dreishuh, A, ...
We review our experimental development in the field of optical lattices, emphasizing their unique properties for control of linear and nonlinear propagation of light. We draw some important links...
Observation of polychromatic gap solitons generated by supercontinuum light (2007)
Neshev, D, Sukhorukov, A, Dreishuh, A, Fischer, R, Ha, S, Krolikowski, W, ...
We present the first observation of simultaneous spatio-spectral localization and formation of a supercontinuum gap soliton in an optical waveguide array, demonstrating new possibilities for tunable...
The New SQUID Biosusceptometer at Oakland: First Year of Experience (2006)
EB Fung, R Fischer, Z Pakbaz, RL Fagaly, E Vichinsky, TN Starr, ...
Liver iron measurements using biosusceptometers have been validated on two low-TC SQUID (Superconducting Quantum Interference Device) systems (New York and Hamburg) built in the 1980’s. Recently,...
Interaction of Artificial Metallic Objects with Biosusceptometric Measurements (2006)
R Engelhardt, EB Fung, P Kelly, TR Biehl, Z Pakbaz, P Nielsen, ...
In human subjects, metallic objects cause distortions of the magnetic fields used by magnetic resonance imaging (0.5 – 3.0 T) or by SQUID biomagnetic liver susceptometry (0.1 – 30 mT) and may...
Interaction of Artificial Metallic Objects with Biosusceptometric Measurements (2006)
R Engelhardt, EB Fung, P Kelly, TR Biehl, Z Pakbaz, P Nielsen, ...
In human subjects, metallic objects cause distortions of the magnetic fields used by magnetic resonance imaging (0.5 – 3.0 T) or by SQUID biomagnetic liver susceptometry (0.1 – 30 mT) and may...
The New SQUID Biosusceptometer at Oakland: First Year of Experience (2006)
EB Fung, R Fischer, Z Pakbaz, RL Fagaly, E Vichinsky, TN Starr, ...
Liver iron measurements using biosusceptometers have been validated on two low-TC SQUID (Superconducting Quantum Interference Device) systems (New York and Hamburg) built in the 1980’s. Recently,...
The New SQUID Biosusceptometer at Oakland: First Year of Experience (2006)
EB Fung, R Fischer, Z Pakbaz, RL Fagaly, E Vichinsky, TN Starr, ...
Liver iron measurements using biosusceptometers have been validated on two low-TC SQUID (Superconducting Quantum Interference Device) systems (New York and Hamburg) built in the 1980’s. Recently,...
Interaction of Artificial Metallic Objects with Biosusceptometric Measurements (2006)
R Engelhardt, EB Fung, P Kelly, TR Biehl, Z Pakbaz, P Nielsen, ...
In human subjects, metallic objects cause distortions of the magnetic fields used by magnetic resonance imaging (0.5 – 3.0 T) or by SQUID biomagnetic liver susceptometry (0.1 – 30 mT) and may...
Interaction of Artificial Metallic Objects with Biosusceptometric Measurements (2006)
R Engelhardt, EB Fung, P Kelly, TR Biehl, Z Pakbaz, P Nielsen, ...
In human subjects, metallic objects cause distortions of the magnetic fields used by magnetic resonance imaging (0.5 – 3.0 T) or by SQUID biomagnetic liver susceptometry (0.1 – 30 mT) and may...
The New SQUID Biosusceptometer at Oakland: First Year of Experience (2006)
EB Fung, R Fischer, Z Pakbaz, RL Fagaly, E Vichinsky, TN Starr, ...
Liver iron measurements using biosusceptometers have been validated on two low-TC SQUID (Superconducting Quantum Interference Device) systems (New York and Hamburg) built in the 1980’s. Recently,...
Patchen, M. L., Fischer, R., MacVittie, T. J., Seiler, F. R., Williams, D. E.
In the presence of hemopoietic cytokines such as granulocyte- macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3), mast cell growth factor (MGF; also known as steel factor, stem...
Patchen, M. L., Fischer, R., Schmauder-Chock, E. A., Williams, D. E.
Based on in vitro studies, mast cell growth factor (MGF; also known as steel factor, stem cell factor, and c-kit ligand) has been implicated as an important hematopoietic regulator, especially in the...
Patchen, M. L., Fischer, R., Macvittie, T. J., Seiler, F., Williams, D. E.
One of the most recent cytokines implicated in hematopoietic regulation is c-kit ligand, also known as mast cell growth factor (MGF), steel factor (SLF), and stem cell factor (SCF) (1-3). The c-kit...
Reactions to geovisualization: An experience from a European project (2006)
Andrienko, G., Andrienko, N., Fischer, R., Mues, V., Schuck, A.
The paper is written jointly by two parties, computer scientists specializing in geovisualization and experts in forestry, who cooperated within a joint project. The authors tell a story about an...
Müller, K.J., Lin, J., Fischer, R., Prüfer, D.
The tobacco knox1 genes tokn1 and tokn2 were isolated and their neomorphic capacities were tested while expressed in tobacco and potato. In addition, their neomorphic capacities were compared to...
The potential of plant virus vectors for vaccine production (2006)
Yusibov, V., Rabindran, S., Commandeur, U., Twyman, R.M., Fischer, R.
The intracellular fate of a recombinant protein is tissue-dependent (2006)
Drakakaki, G., Marcel, S., Arcalis, E., Altmann, F., Gonzalez-Melendi, P., Fischer, R., ...
Bayesian Design of Diagnostics: Case Studies for WENDELSTEIN 7-X (2006)
Dreier, H., Dinklage, A., Fischer, R., Hirsch, M., Kornejew, P., Pasch, E.
Design of Diagnostics: Case Studies for Wendelstein 7–X (2006)
Dreier, H., Dinklage, A., Fischer, R., Hirsch, M., Kornejew, P., Pasch, E.
Bayesian Design of Plasma Diagnostics (2006)
Dreier, H., Dinklage, A., Fischer, R., Hirsch, M., Kornejew, P.
Bayesian design of a multichannel interferometer (2006)
Dreier, H., Dinklage, A., Fischer, R., Hirsch, M., Kornejew, P.
Edge transport barrier characteristics of improved H-modes in ASDEX Upgrade (2006)
Horton, L.D., Brambilla, M., Fischer, R., Konz, C., Kurzan, B., ...
Optimization of Plasma Diagnostics using Bayesian Probability Theory (2006)
Dreier, H., Dinklage, A., Fischer, R., Hirsch, M., Kornejew, P.
Polychromatic nonlinear surface modes generated by supercontinuum light (2006)
Sukhorukov, A, Neshev, D, Dreishuh, A, Fischer, R, Ha, S, Krolikowski, W, ...
We study propagation of polychromatic light near the edge of a nonlinear waveguide array. We describe simultaneous spatial and spectral beam reshaping associated with power and wavelength-dependent...
Balaban, T.S., Balaban, M.C., Malik, S., Hennrich, F., Fischer, R., Rösner, H., ...
Advanced Materials, 18(2006) S.2763-67
Spatio-spectral control of supercontinuum light (2006)
Neshev, D, Sukhorukov, A, Dreishuh, A, Fischer, R, Han, S, Rosberg, C, ...
We present the first observation of spatio-spectral control and tunable spectral filtering of supercontinuum light in an array of LiNbO3 nonlinear waveguides.
Plant-derived pharmaceuticals - the road forward (2005)
Ma, JKC, Chikwamba, R, Sparrow, P, Fischer, R, Mahoney, R, Twyman, RM
Plant-derived pharmaceuticals are poised to become the next major commercial development in biotechnology. The advantages they offer in terms of production scale and economy, product safety, ease of...
Plant-derived pharmaceuticals - the road forward (2005)
Ma, JKC, Chikwamba, R, Sparrow, P, Fischer, R, Mahoney, R, Twyman, RM
Plant-derived pharmaceuticals are poised to become the next major commercial development in biotechnology. The advantages they offer in terms of production scale and economy, product safety, ease of...
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, Antonio, Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, A., Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, Antonio, Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
Single-pion production and the structure of the weak neutral current (2005)
The restrictions of the structure of the weak neutral current imposed by single pion production cross sections on single nucleons are investigated. A general vector (V), axial-vector (A) neutral...
Bayesian reconstruction of surface roughness and depth profiles (2005)
Mayer,M., Fischer,R., Lindig,S., Von Toussaint,U., Stark,R. W., Dose,V.
Bayesian reconstruction of surface roughness and depth profiles (2005)
Mayer,M., Fischer,R., Lindig,S., Von Toussaint,U., Stark,R. W., Dose,V.
Searching Faint and Extended Sources in the X-ray Universe (2005)
Guglielmetti,F., Fischer,R., Rosati,P., Mainieri,V., Dose,V.
Bayesian reconstruction of surface roughness and depth profiles (2005)
Mayer, M., Fischer, R., Lindig, S., Von Toussaint, U., Stark, R. W., Dose, V.
Komplexbildung zur Stabilisierung und Reinigung eines Proteins von Interesse (2005)
Sack, M., Vaquero-Martin, C., Fischer, R.
EP 1529844 A UPAB: 20050608 NOVELTY - Altering properties and/or generating novel properties such as accumulation ability, stability or integrity, etc., of a natural or a recombinant target protein,...
Bruell, D., Bruns, C.J., Yezhelyev, M., Huhn, M., Müller, J., Ischenko, I., ...
Pancreatic carcinoma is the fifth leading cause of: cancer-related deaths in North America and Europe. Major reasons for the high mortality rate include the inability to detect pancreatic cancer at...
Uhde, K., Fischer, R., Commandeur, U.
We describe the construction of recombinant Potato virus X (PVX) vectors expressing two different epitopes, ep4 and ep6, from Beet necrotic yellow vein virus (BNYVV). The seven-amino-acid epitopes...
Transgenic plants in the biopharmaceutical market (2005)
Twyman, R.M., Schillberg, S., Fischer, R.
Many of our 'small-molecule-drugs' are natural products from plants, or are synthetic compounds based on molecules found naturally in plants. However, the vast majority of the protein therapeutics...
Recent progress in plantibody technology (2005)
Stoger, E., Sack, M., Nicholson, L., Fischer, R., Christou, P.
Antibodies are an important class of proteins that can be used for the prevention, treatment and diagnosis of many diseases. Consequently, there is an intense and growing demand for recombinant...
Sowing the seeds of success. Pharmaceutical proteins from plants (2005)
Stoger, E., Ma, J.K.-C., Fischer, R., Christou, P.
Among the many plant-based production systems that have been developed for pharmaceutical proteins, seeds have the useful advantage of accumulating proteins in a relatively small volume and in a...
Antigen-specific targeting and elimination of EBV-transformed B cells by allergen toxins (2005)
Stöcker, M., Klockenbring, T., Huhn, M., Nachreiner, T., Wicklein, D., Petersen, A., ...
Background: With the exception of antigen-specific immunotherapy, current treatments for atopic diseases provide only symptomatic relief. Because of the increasing incidence of such diseases, the...
Sorrentino, A., Schillberg, S., Fischer, R., Rao, R., Porta, R., Mariniello, L.
Human tissue transglutaminase (htTG) is one of the most important member within the transglutaminase family, enzymes that for their capacity of catalyzing post-translational modifications of proteins...
Schillberg, S., Twyman, R.M., Fischer, R.
Plants are now gaining widespread acceptance as a general platform for the large-scale production of recombinant proteins. The principle has been demonstrated by the success of a diverse repertoire...
Four-dimensional imaging of transvacuolar strand dynamics in tobacco BY-2 cells (2005)
Ruthardt, N., Gulde, N., Spiegel, H., Fischer, R., Emans, N.
The vacuole is a characteristic organelle of plant cells and fulfills several important functions related to metabolism and growth of the cell. To shed light on the details of vacuolar structural...
Recombinant soluble human Fc(gamma) receptor I with picomolar affinity for immunoglobulin G (2005)
Paetz, A., Sack, M., Thepen, T., Tur, M.K., Brüll, D., Finnern, R., ...
Nölke, G., Schneider, B., Fischer, R., Schillberg, S.
Ornithine decarboxylase (ODC) is a cytosolic enzyme that catalyses the direct decarboxylation of l-ornithine to putrescine, one of the rate-limiting steps of polyamine biosynthesis in plants. In the...
Nicholson, L., Gonzalez-Melendi, P., Dolleweerd, C. Van, Tuck, H., Perrin, Y., Ma, J.K.-C., ...
To investigate the role of subunit assembly in the intracellular deposition of multimeric recombinant proteins, we expressed a partially humanized secretory immunoglobulin in rice endosperm cells and...
Ma, J.K.-C., Barros, E., Bock, R., Christou, P., Dale, P.J., Dix, P.J., ...
Plant-derived pharmaceuticals - the road forward (2005)
Ma, J.K.-C., Chikwamba, R., Sparrow, P., Fischer, R., Mahoney, R., Twyman, R.M.
Plant-derived pharmaceuticals are poised to become the next major commercial development in biotechnology. The advantages they offer in terms of production scale and economy, product safety, ease of...
Drakakaki, G., Marcel, S., Glahn, R.P., Lund, E.K., Pariagh, S., Fischer, R., ...
We have generated transgenic maize plants expressing Aspergillus phytase either alone or in combination with the iron-binding protein ferritin. Our aim was to produce grains with increased amounts of...
Schinkel, H., Schiermeyer, A., Soeur, R., Fischer, R., Schillberg, S.
Thrombomodulin is a membrane-bound protein that plays an active role in the blood coagulation system by binding thrombin and initiating the protein C anticoagulant pathway. Solulin (TM) is a...
DURCH MOLEKULARES PATHOGENICID VERMITTELTE KRANKHEITSRESISTENZ IN PFLANZEN (2005)
Fischer, R., Schillberg, S., Naehring, J., Sack, M., Monecke, M., Liao, Y., ...
Searching Faint and Extended Sources in the X-ray Universe (2005)
Guglielmetti, F., Fischer, R., Rosati, P., Mainieri, V., Dose, V.
Integrated Bayesian Experimental Design (2005)
Fischer, R., Dreier, H., Dinklage, A., Kurzan, B., Pasch, E.
Beerenwinkel, N., Sing, T., Lengauer, T., Rahnenfuhrer, J., Roomp, K., Savenkov, I., ...
The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure exerted...
Sequencing of Aspergillus nidulans and comparative analysis with A-fumigatus and A-oryzae (2005)
Galagan, J. E., Calvo, S. E., Cuomo, C., Ma, L. J., Wortman, J. R., Batzoglou, S., ...
The Aspergillus nidulans phytochrome FphA represses sexual development in red light (2005)
Blumenstein, A., Vienken, K., Tasler, R., Purschwitz, J., Veith, D., Frankenberg-Dinkel, N., ...
Searching faint and extended sources in the X-ray universe (2005)
Guglielmetti, F., Fischer, R., Rosati, P., Mainieri, V., Dose, V.
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus (2005)
Nierman, W. C., Pain, A., Anderson, M. J., Wortman, J. R., Kim, H. S., Arroyo, J., ...
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, A., Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, Antonio, Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
National character does not reflect mean personality trait levels in 49 cultures (2005)
TERRACCIANO, A, ABDEL-KHALEK, AM, ADAM, N, ADAMOVOVA, L, AHN, C, AHN, HN, ...
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, Antonio, Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, Antonio, Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, Antonio, Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
Raman spectroscopy of individual single-walled carbon nanotubes from various sources. (2005)
Hennrich, F., Krupke, R., Lebedkin, S., Arnold, K., Fischer, R., Resasco, D.E., ...
Journal of Physical Chemistry B, 109(2005) S.10567-73
National Character Does Not Reflect Mean Personality Trait Levels in 49 Cultures (2005)
Terracciano, Antonio, Abdel-Khalek, A. M., Adam, N., Adamovova, L., Ahn, C., Ahn, H., ...
Most people hold beliefs about personality characteristics typical of members of their own and others' cultures. These perceptions of national character may be generalizations from personal...
Integrated Interpretative Transport Modelling (2004)
Dinklage,A., Beidler,C. D., Fischer,R., Maaßberg,H., Svensson,J., Turkin,Yu. A.
Zeff from spectroscopic bremsstrahlung measurements at ASDEX Upgrade and JET (2004)
Meister,H., Fischer,R., Horton,L. D., Maggi,C. F., Nishijima,D., ...
Zeff from spectroscopic bremsstrahlung measurements at ASDEX Upgrade and JET (2004)
Meister,H., Fischer,R., Horton,L. D., Maggi,C. F., Nishijima,D., ...
Zeff from spectroscopic bremsstrahlung measurements at ASDEX Upgrade and JET (2004)
Meister,H., Fischer,R., Horton,L. D., Maggi,C. F., Nishijima,D., ...
Integrated Interpretative Transport Modelling (2004)
Dinklage,A., Beidler,C. D., Fischer,R., Maaßberg,H., Svensson,J., Turkin,Yu. A.
Bayesian group analysis of plasma-enhanced chemical vapour deposition data (2004)
A ubiquitous goal in plasma-enhanced chemical vapour deposition (PECVD) is to describe the correlation between film properties and categorical and quantitative input variables. The correlations...
Integrating diagnostic DATA analyses for W7-AS using Bayesian graphical models (2004)
Svensson, J., Dinklage, A., Geiger, J., Fischer, R., Werner, A.
m22(scFv)-ETA', a new recombinant anti-CD64 immunotoxin for specific elimination of AML cells (2004)
Tur, M.K., Huhn, M., Thepen, T., Stöcker, M., Krohn, R., Vogel, S., ...
Antigen-specific targeting and elimination of EBV-transformed B cells by allergen-toxins (2004)
Klockenbring, T., Stöcker, M., Huhn, M., Petersen, A., Bauer, R., Goerlich, R., ...
Vogt, U., Pelissier, T., Pütz, A., Razvi, F., Fischer, R., Wassenegger, M.
Viroid infection is associated with the production of short interfering RNAs (siRNAs), a hallmark of post-transcriptional gene silencing (PTGS). However, viroid RNAs autonomously replicating in the...
Sriraman, R., Bardor, M., Sack, M., Vaquero, C., Faye, L., Fischer, R., ...
Plant-based expression systems are attractive for the large-scale production of pharmaceutical proteins. However, glycoproteins require particular attention as inherent differences in the...
Peschen, D., Fischer, R., Kreuzaler, F., Liao, Y.C.
In planta expression of recombinant antibodies recognizing pathogen-specific antigens has been proposed as a strategy for crop protection. We report the expression of fusion proteins comprising a...
Over-expression and production of plant allergens by molecular farming strategies (2004)
Obermeyer, G., Gehwolf, R., Sebesta, W., Hamilton, N., Gadermaier, G., Ferreira, F., ...
Antibody-based pathogen resistance in plants (2004)
Nölke, G., Fischer, R., Schillberg, S.
Genetic engineering can be used to create plants with enhanced resistance to disease. Several strategies have been developed and tested, including expression of pathogen-derived sequences, the...
Measurement of antibody-membrane interactions by surface plasmon resonance (2004)
Klimka, A., Tur, M.K., Huhn, M., Bierfreund, U., Terrada, E., Fischer, R., ...
Due to problems of immobilizing functional tumor antigens in their natural conformation on surfaces for immunoassays, it is often difficult to evaluate the binding of antibodies derived from phage...
Plant cell cultures for the production of recombinant proteins (2004)
Hellwig, S., Drossard, J., Twyman, R.M., Fischer, R.
The use of whole plants for the synthesis of recombinant proteins has received a great deal of attention recently because of advantages in economy, scalability and safety compared with traditional...
Preliminary x-ray analysis of a human VH fragment at 1.8 Å resolution (2004)
Gaur, R.K., Kupper, M.B., Fischer, R., Hoffmann, K.M.V.
Small antibody fragments are more useful than full-size antibodies for achieving efficient biodistribution. As a first step towards the design of a clinically desirable antibody fragment, the...
Improvement of grapevine using current biotechnology (2004)
Fischer, R., Nölke, G., Orecchia, M., Schillberg, S., Twyman, R.M.
Di Fiore, S., Hoppmann, V., Fischer, R., Schillberg, S.
We developed a transient expression assay for Madagascar periwinkle (Catharanthus roseus [L.] G. Don.) that is based on vacuum infiltration of intact leaves with recombinant Agrobacterium...
Arcalis, E., Marcel, S., Altmann, F., Kolarich, D., Drakakaki, G., Fischer, R., ...
Protein transport within cereal endosperm cells is complicated by the abundance of endoplasmic reticulum (ER)-derived and vacuolar protein bodies. For wheat storage proteins, two major transport...
Plant-based production of biopharmaceuticals (2004)
Fischer, R., Stoger, E., Schillberg, S., Christou, P., Twyman, R.M.
Plants are now gaining widespread acceptance as a general platform for the large-scale production of recombinant proteins. The first plant-derived recombinant pharmaceutical proteins are reaching the...
Antibody production in transgenic plants (2004)
Stoger, E., Schillberg, S., Twyman, R.M., Fischer, R., Christou, P.
Antibodies bind with great affinity and specificity to their target antigens, allowing them to be exploited in research, medicine, agriculture, and industry. It is estimated that more than 1,000...
Vesikel mit chimaeren Rezeptoren zur Induktion einer gerichteten T-Zellantwort in vivo (2004)
Barth, S.D., Finnern, R., Klockenbring, T., Fischer, R., Paetz, A.
EP 1407765 A UPAB: 20040907 NOVELTY - New vesicles (A) carry on the outer side a binder molecule (I) which is anchored to the membrane and includes: (i) a first domain (D1) having a binding site for...
Integrated Interpretative Transport Modelling (2004)
Dinklage, A., Beidler, C.D., Fischer, R., Maaßberg, H., Svensson, J., Turkin, Yu.A.
Integrated approaches in fusion data analysis (2004)
Dinklage, A., Fischer, R., Dreier, H., Svensson, J., Turkin, Yu.
Source detection with Bayesian inference on ROSAT all-sky survey data sample (2004)
Guglielmetti, F., Fischer, R., Dose, V., Voges, W., Boese, G.
Zeff from spectroscopic bremsstrahlung measurements at ASDEX Upgrade and JET (2004)
Meister, H., Fischer, R., Horton, L. D., Maggi, C. F., Nishijima, D., ASDEX Upgrade Team, ...
Integrating diagnostic data analysis for W7-AS using bayesian graphical models (2004)
Svensson, J., Dinklage, A., Geiger, J., Werner, A., Fischer, R.
Zeff from spectroscopic bremsstrahlung measurements at ASDEX Upgrade and JET (2004)
Meister, H., Fischer, R., Horton, L. D., Maggi, C. F., Nishijima, D., ASDEX Upgrade Team, ...
Integrating diagnostic data analysis for W7-AS using Bayesian graphical models (2004)
Svensson, J., Dinklage, A., Geiger, J., Werner, A., Fischer, R.
Integrated approaches in fusion data analysis (2004)
Dinklage, A., Fischer, R., Dreier, H., Svensson, J., Turkin, Yu.
Integrated Interpretative Transport Modelling (2004)
Dinklage, A., Beidler, C. D., Fischer, R., Maaßberg, H., Svensson, J., Turkin, Yu. A.
Source Detection and Background Estimation with Bayesian Inference (2004)
Guglielmetti, F., Fischer, R., Voges, W., Boese, G., Dose, V.
Integrating diagnostic data analysis for W7-AS using Bayesian graphical models (2004)
Svensson, J., Dinklage, A., Geiger, J., Werner, A., Fischer, R.
Bayesian Reconstruction of Surface Roughness and Depth Profiles (2004)
M. Mayer, R. Fischer, S. Lindig, U. Von Toussaint, R.W. Stark, V. Dose
Bayesian data analysis provides a consistent probabilistic theory for the extraction of sample parameters from spectra measured with MeV ion beam analysis methods. The application of Bayesian data...
Integrated Approaches in Fusion Data Analysis (2004)
Dinklage Fischer Dreier, A. Dinklage, R. Fischer, H. Dreier, J. Svensson, Yu. Turkin
The concept of integrated data analysis in nuclear fusion requires the linkage of data and physical information. Summarizing the key steps for the analysis of transport in the core plasma, benefits...
Repertoire analysis of anergic B cells from patients with systemic lupus erythematosus (2003)
Longo, NS, Fischer, R, Daruwalla, J, Grammer, AC, Lipsky, PE
No abstract available.
Grammer, A, Fischer, R, Slota, R, Longo, N, Sohn, H, Yarboro, C, ...
No abstract available.
'Molecular farming' of antibodies in plants. (2003)
Schillberg, S., Fischer, R., Emans, N.
'Molecular farming' is the production of valuable recombinant proteins in transgenic organisms on an agricultural scale. While plants have long been used as a source of medicinal compounds, molecular...
The biosafety of molecular farming in plants. (2003)
Commandeur, U., Twyman, R. M., Fischer, R.
Molecular farming in plants provides an inexpensive and convenient way to produce biopharmaceutical molecules and other valuable proteins on a large scale. Proof of principle has been demonstrated...
Island divertor experiments on the Wendelstein 7-AS stellarator (2003)
McCormick,K., Grigull,P., Burhenn,R., Brakel,R., Ehmler,H., Feng,Y., ...
A promising new operational regime on the Wendelstein stellarator W7-AS has been discovered, fulfilling the conditions of optimal core behavior in combination with edge parameters suitable for...
Major results from Wendelstein 7-AS stellarator (2003)
Wagner,F., Burhenn,R., Gadelmeier,F., Geiger,J., Hirsch,M., Laqua,H. P., ...
W7-AS operates with an island divertor, which utilises the natural edge islands of the low-shear stellarator configuration to divert the plasma. High densities (up to 4×1020m-3) and partly detached...
Bayesian modelling of fusion diagnostics (2003)
Fischer,R., Dinklage,A., Pasch,E.
Integrated data analysis of fusion diagnostics is the combination of different, heterogeneous diagnostics in order to improve physics knowledge and reduce the uncertainties of results. One example is...
From Off-line to Real-time Analysis: Accelerating Bayesian Analysis Codes (2003)
Dinklage,A., Fischer,R., Geiger,J., Kühner,G., Maassberg,H., Svensson,J., ...
Island divertor experiments on the Wendelstein 7-AS stellarator (2003)
McCormick,K., Grigull,P., Burhenn,R., Brakel,R., Ehmler,H., Feng,Y., ...
Major results from Wendelstein 7-AS stellarator (2003)
Wagner,F., Burhenn,R., Gadelmeier,F., Geiger,J., Hirsch,M., Laqua,H. P., ...
Island divertor experiments on the Wendelstein 7-AS stellarator (2003)
McCormick, K., Grigull, P., Burhenn, R., Brakel, R., Ehmler, H., Feng, Y., ...
A promising new operational regime on the Wendelstein stellarator W7-AS has been discovered, fulfilling the conditions of optimal core behavior in combination with edge parameters suitable for...
Major results from Wendelstein 7-AS stellarator (2003)
Wagner, F., Burhenn, R., Gadelmeier, F., Geiger, J., Hirsch, M., Laqua, H. P., ...
W7-AS operates with an island divertor, which utilises the natural edge islands of the low-shear stellarator configuration to divert the plasma. High densities (up to 4×1020m-3) and partly detached...
From Off-line to Real-time Analysis: Accelerating Bayesian Analysis Codes (2003)
Dinklage, A., Fischer, R., Geiger, J., Kühner, G., Maassberg, H., Svensson, J., ...
Using plants as a production system for N-Glycosylated proteins of therapeutic relevance (2003)
Hellwig, S., Sack, M., Spiegel, H., Drossard, J., Fischer, R.
Tur, M.K., Huhn, M., Thepen, T., Stocker, M., Krohn, R., Vogel, S., ...
CD64, the high affinity receptor for IgG (FcgammaRI) is expressed on acute myeloid leukemia blast cells and has recently been described as a specific target for immunotherapy. To generate a...
Molecular farming in plants: Host systems and expression technology (2003)
Twyman, R.M., Stoger, E., Schillberg, S., Christou, P., Fischer, R.
Plants provide an inexpensive and convenient system for the large-scale production of valuable recombinant proteins. This principle has been demonstrated by the commercial success of several...
Production of therapeutic antibodies in plants: Vaccines & antibodies (2003)
Nölke, G., Fischer, R., Schillberg, S.
Antibodies are versatile tools for the diagnosis and treatment of many diseases. Their use has increased dramatically with the advent of recombinant antibody (rAb) technology, allowing the production...
Production of antibodies in plants and their use for global health (2003)
Fischer, R., Twyman, R.M., Schillberg, S.
Recombinant antibodies can be used to diagnose, treat and prevent disease by exploiting their specific antigen-binding activities. A large number of drugs currently in development are recombinant...
Molecular farming of recombinant antibodies in plants (2003)
Schillberg, S., Fischer, R., Emans, N.
Antibodies represent a large proportion of therapeutic drugs currently in development. In most cases, they are produced in mammalian cell lines or transgenic animals because these have been shown to...
'Molecular farming' of antibodies in plants (2003)
Schillberg, S., Fischer, R., Emans, N.
'Molecular farming' is the production of valuable recombinant proteins in transgenic organisms on an agricultural scale. While plants have long been used as a source of medicinal compounds, molecular...
Tur, M.K., Rothe, A., Huhn, M., Goerres, U., Klimka, A., Stocker, M., ...
Isolation of cell-surface specific antibodies prerequisites the functional expressing of antigens on intact cells, which are maintained routinely by cell culturing. However, long-term culturing of...
Verfahren und Vorrichtung zur Sortierung kleiner Einheiten (2003)
Barth, S., Vogel, S., Fischer, R., Gillner, A., Wehner, M.
DE 10246088 A UPAB: 20030616 NOVELTY - Process for sorting small units (1) such as cells, particles or molecules comprises producing a liquid stream containing the small units; and accelerating the...
Abele, H., Dreher, C., Eggers, T., Fischer, R., Hummel, V., Sautter, A.
Die gemeinsame Studie der Fraunhofer Institute IPA und ISI deckt neue Entwicklungstendenzen im Mittelstand auf und belegt, dass die im Fraktal-Konzept, im E-Business, in der Netzwerkbildung und in...
The biosafety of molecular farming in plants (2003)
Commandeur, U., Twyman, R.M., Fischer, R.
Molecular farming in plants provides an inexpensive and convenient way to produce biopharmaceutical molecules and other valuable proteins on a large scale. Proof of principle has been demonstrated...
Jaag, H.M., Kawchuk, L., Rohde, W., Fischer, R., Emans, N., Prüfer, D.
Potato leafroll polerovirus (PLRV) genomic RNA acts as a polycistronic mRNA for the production of proteins P0, P1, and P2 translated from the T-proximal half of the genome. Within the P1 coding...
Bruell, D., Stöcker, M., Huhn, M., Redding, N., Küpper, M., Schumacher, P., ...
Pancreatic carcinoma still has the highest mortality rate in comparison to any other malignancy. Major reasons are late detection of disease, highly aggressive tumor growth and the early formation of...
Island divertor experiments on the Wendelstein 7-AS stellarator (2003)
McCormick, K., Grigull, P., Burhenn, R., Brakel, R., Ehmler, H., Feng, Y., ...
The condition of forests in Europe, Executive report 2003 (2003)
Fischer, R., Beuker, E., Calatayud, V., Furst, A., Haberle, K.H., ...
From Off-line to Real-time Analysis: Accelerating Bayesian Analysis Codes (2003)
A. Dinklage, R. Fischer, J. Geiger, S. Kühner, H. Maaßberg, H. Svensson, ...
Capabilities of real time performance of a Bayesian analysis codes are explored.
Increasing the Significance of Thomson Scattering Data by Bayesian Modelling (2003)
A. Dinklage, R. Fischer, M. Hirsch, E. Pasch, A. Weller
Introduction: The Integration of Diagnostics Results Data analysis employing a full statistical diagnostics model increases the significance of measurements and allows for the quantification of the...
Antibody molecular farming in plants and plant cells (2002)
Schillberg, S., Emans, N., Fischer, R.
`Molecular Farming' is a novel approach to the production of pharmaceuticals, where valuable recombinant proteins can be produced in transgenic organisms on an agricultural scale. Plants have been...
Folded Acoustic and Quantized Optic Phonons in Semiconductor Superlattices, (2002)
Colvard,C., Gant,T. A., Klein,M. V., Merlin,R., Fischer,R.
Raman scattering studies of a variety of MBE-grown (GaAl)As superlattices are presented. Folded acoustic phonons appear as doublets in the Raman spectra. Their frequencies are accurately predicted by...
Depth profiles and resolution limits in accelerator-based solid state analysis (2002)
A ubiquitous problem in solid state analysis is the determination of the elemental composition of a sample as a function of the depth. The determination of the depth profiles from ion-beam...
Sack, M., Vaquero, C., Finnern, R., Fischer, R.
Plant-based expression systems are becoming increasingly popular and have been proposed for economical production of a large variety of biopharmaceuticals. Detailed characterisation of the plant...
Spiegel, H., Sack, M., Finnern, R., Fischer, R.
The murine mAb Guy 13 binds to the surface protein SAI/II of S.mutans, the major cause of dental caries. Used in topical immunotherapy this mAb prevents recolonisation of the tooth surfaces by...
Stoger, E., Sack, M., Fischer, R., Christou, P.
Diverses stratégies ont été mises au point pour exploiter les plantes en tant que bioréacteurs pour la production d'anticorps. Les recherches s'intéressent aux systèmes d'expression et à la...
Sack, M., Vaquero, C., Finnern, R., Fischer, R.
Plant-based expression systems are becoming increasingly popular and have been proposed for economical production of a large variety of biopharmaceuticals. Detailed characterisation of the plant...
Spiegel, H., Sack, M., Finnern, R., Fischer, R.
The murine mAb Guy 13 binds to the surface protein SAI/II of S.mutans, the major cause of dental caries. Used in topical immunotherapy this mAb prevents recolonisation of the tooth surfaces by...
Antibody expression in plants (2002)
Verch, T., Lewandowski, D., Schillberg, S., Yusibov, V., Koprowski, H., Fischer, R.
In the past two decades, advances in plant molecular biology and recombinant antibody engineering have provided new tools for plant biotechnology. Plants are emerging as a safer alternative to...
Gene expression strategies of RNA viruses (2002)
Commandeur, U., Rohde, W., Fischer, R., Prüfer, D.
Plant viral genomes encode a limited set of proteins that are required for viral replication, particle formation, movement of the virus or its RNA from cell to cell, polyprotein maturation, and...
Molecular Farming. Produktion hochwertiger Proteine in Pflanzen (2002)
Mavituna, M., Schillberg, S., Fischer, R.
Als Molecular Farming bezeichnet man die Produktion von hochwertigen Proteinen in Pflanzen. Neben Molecular Farming werden auch die Begriffe Gen-Farming, Bio-Pharming oder Molecular Pharming...
Antibody molecular farming in plants and plant cells (2002)
Schillberg, S., Emans, N., Fischer, R.
"Molecular Framing" is a novel approach to the production of pharmaceuticals, where valuable recombinant proteins can be produced in transgenic organisms on an agricultural scale. Plants have been...
Di Fiore, S., Li, Q., Leech, M.J., Schuster, F., Emans, N., Fischer, R., ...
Tryptophan decarboxylase (TDC) is a cytosolic enzyme that catalyzes an early step of the terpenoid indole alkaloid biosynthetic pathway by decarboxylation of L-tryptophan to produce the protoalkaloid...
Hoppmann, V., Di Fiore, S., Zimmermann, S., Emans, N., Rademacher, T., Fischer, R., ...
The chloroplast targeting transit sequence from potato granule bound starch synthase (gbss) was used to direct the accumulation of recombinant proteins to the plastid stroma. The potato gbss transit...
Efficacy of plant-produced recombinant antibodies against HCG (2002)
Kathuria, S., Sriraman, R., Nath, R., Sack, M., Pal, R., Artsaenko, O., ...
BACKGROUND: Antibody engineering facilitates the construction of different antibody formats [single chain variable fragment (scFv), diabody, full-size chimeric monoclonal antibody] with ease....
A carcinoembryonic antigen-specific diabody produced in tobacco (2002)
Vaquero, C., Sack, M., Schuster, F., Finnern, R., Drossard, J., Schumann, D., ...
The feasibility of using tobacco for production of a recombinant antibody (T84.66/GS8 diabody) directed against the carcinoembryonic antigen (CEA) and used for tumor imaging was investigated. Two...
Practical considerations for pharmaceutical antibody production in different crop systems (2002)
Stoger, E., Sack, M., Perrin, Y., Vaquero, C., Torres, E., Twyman, R. M., ...
The potential of plant cells to produce functional recombinant antibodies has been demonstrated in a number of different plant systems. We present a comparative study of a well-defined target...
Plantibodies. Applications, advantages and bottlenecks (2002)
Stoger, E., Sack, M., Fischer, R., Christou, P.
Various strategies have been developed to exploit plants as bioreactors for the production of pharmaceutical antibodies, to engineer antibody-mediated pathogen resistance or to alter the plant...
Fraktal+ Status quo der Studie "Vernetzte E-Wertschöpfung" (2002)
Im Rahmen des Vortrages wurde die Studie »Auswirkungen der vernetzten E-Wertschöpfung im produzierenden Mittelstand« vorgestellt. Der Inhalt der Studie befasst sich mit der Thematik in welchem...
Fischer, R., Mueller-Schulte, D.
DE 10035953 A UPAB: 20020521 NOVELTY - Preparation of spherical, magnetic silica particles (A) by; (i) mixing a silica hydrosol (B) with a magnetic colloid or ferrofluid, or with magnetic particles;...
Meng, F., Stassen, M.H.W., Schillberg, S., Fischer, R., Baets, M.H. De
Pathogenic anti-acetylcholine receptor (AChR) antibodies in myasthenia gravis (MG) and the corresponding animal model, experimental autoimmune myasthenia gravis (EAMG), principally recognize the main...
Uptake of a fluorescent marker in plant cells is sensitive to brefeldin A and wortmannin (2002)
Emans, N., Zimmermann, S., Fischer, R.
We assessed FM1-43 [N-(3-triethylammoniumpropyl)-4-(4-[dibutylamino]styryl)pyridinium dibromide] as a fluorescent endocytosis marker in intact, walled plant cells. At 4 deg C, FM1-43 stained the...
Functional recombinant antibodies against human chorionic gonadotropin expressed in plants (2002)
Kathuria, S.R., Nath, R., Pal, R., Singh, O., Fischer, R., Lohiya, N.K., ...
Single-chain variable fragments, diabodies and chimeric antibodies (mouse variable domains and human immunoglobulin constant domains) were engineered by DNA recombinant technique and expressed...
Efficacy of plant-produced recombinant antibodies against HCG (2002)
Kathuria, S., Sriraman, R., Nath, R., Sack, M., Pal, R., Artsaenko, O., ...
BACKGROUND: Antibody engineering facilitates the construction of different antibody formats [single chain variable fragment (scFv), diabody, full-size chimeric monoclonal antibody] with...
Molecular farming of medicines: a field of growing promise. (2001)
Fischer, R., Schillberg, S., Emans, N.
The benefits and techniques of molecular farming (processes involved in the production of recombinant proteins in transgenic plants) are briefly described in this article with emphasis on the use of...
High-resolution elastic recoil detection utilizing Bayesian probability theory (2001)
Neumaier,P., Dollinger,G., Bergmaier,A., Genchev,I., Görgens,L., Fischer,R., ...
Hellwig, S., Emde, F., Raven, N.P.G., Henke, M., Logt, P. Van Der, Fischer, R.
In the last few years the Pichia pastoris expression system has been gaining more and more interest for the expression of recombinant proteins. Many groups have employed fermentation technology in...
Molecular farming of medicines. A field of growing promise (2001)
Fischer, R., Schillberg, S., Emans, N.
Man has been using plants as a source of medicines for millennia. From the earliest stages of civilization, herbs and plant extracts have been sought that ease suffering and cure disease. In the last...
Tomato Ve disease resistance genes encode cell surface-like receptors (2001)
Kawchuk, L., Hachey, J., Lynch, D.R., Kulcsar, F., Rooijen, G. Van, Waterer, D.R., ...
In tomato, Ve is implicated in race-specific resistance to infection by Verticillium species causing crop disease. Characterization of the Ve locus involved positional cloning and isolation of two...
Zhang, M.Y., Schillberg, S., Zimmermann, S., Liao, Y.C., Breuer, G., Fischer, R.
Glutathione S-transferase (GST) fusion proteins are used frequently for investigating protein-protein and protein-DNA interactions. The present study demonstrates that the use of GST fusion proteins...
Holzem, A., Nähring, J., Fischer, R.
This study describes the identification of the epitope recognized by the tobacco mosaic virus (TMV) coat protein (CP)-specific monoclonal antibody 29 (MAb29) by displaying a CP gene-fragment library...
Antibody-based resistance to plant pathogens (2001)
Schillberg, S., Zimmermann, S., Zhang, M.Y., Fischer, R.
Plant diseases are a major threat to the world food supply, as up to 15 per cent of production is lost to pathogens. In the past, disease control and the generation of resistant plant lines protected...
Achieving plant disease resistance by antibody expression (2001)
Fischer, R., Emans, N., Schillberg, S.
Molecular biotechnology has provided powerful new measures for the control of crop disease. Crops can now be engineered to be resistant through creation of transgenic plants producing recombinant...
Transgene Pflanzen als orale Impfstoffe. Grüne Revolution in der Medizin? (2001)
Mit den Methoden der molekularen Biotechnologie lassen sich heute bereits therapeutisch wirksame Proteine in Pflanzen herstellen, unter anderen die, die als so genannte essbare Vakzine sowohl zur...
Torres, E., Gonzalez-Melendi, P., Stöger, E., Shaw, P., Twyman, R. M., Nicholson, L., ...
We compared the subcellular distribution of native and artificial reticuloplasmins in endosperm, callus, and leaf tissues of transgenic rice (Oryza sativa) to determine the distribution of these...
Polypeptid-Tag's fuer den Nachweis und die Aufreinigung von Polypeptiden (2001)
Fischer, R., Helgers, Y., Hoffmann, K., Holzem, A., Monecke, M., Naehring, J., ...
EP 1092769 A UPAB: 20010522 NOVELTY - Polypeptide with tag sequence (I) or a sequence derived from (I) by replacement of one or more amino acids (aa), provided the three-dimensional/tertiary...
High-resolution elastic recoil detection utilizing Bayesian probability theory (2001)
Neumaier, P., Dollinger, G., Bergmaier, A., Genchev, I., Görgens, L., Fischer, R., ...
Swaak, A.J., Moutsopoulos, H.M., Dratwianka, B., Kalden, J.R., Tosi, S., Marchesoni, A., ...
OBJECTIVE: Patients characterized with antinuclear antibodies (ANA) and disease symptoms related to one organ system can be described as having incomplete systemic lupus erythematosus (SLE). The aim...
Swaak, A. J. G., Smeenk, R. J. T., Manger, K., Kalden, J. R., Tosi, S., ...
Objective. Patients characterized with antinuclear antibodies (ANA) and disease symptoms related to one organ system can be described as having incomplete systemic lupus erythematosus...
Schillberg, S., Zimmermann, S., Findley, K., Fischer, R.
We tested the hypothesis that membrane-anchored anti-viral antibodies can confer viral resistance to transgenic plants. A heterologous expression system was developed for plasma membrane targeting of...
Perrin, Y., Vaquero, C., Gerrard, I., Sack, M., Drossard, J., Stöger, E., ...
Field pea (Pisum sativum L.) appears well suited for the production of high-value molecules such as recombinant antibodies, with well-established agricultural practices world-wide and seeds that are...
Molecular farming of pharmaceutical proteins (2000)
Molecular farming is the production of pharmaceutically important and commercially valuable proteins in plants. Its purpose is to provide a safe and inexpensive means for the mass production of...
Investigations into the Assembly of Multi-CCD Prism Beamsplitters for TV-Cameras (2000)
Tittelbach, G., Guyenot, V., Palme, M, Fischer, R., Otto, E., Sarbach, U.
3-CCD color cameras which incorporate an imager consisting of a dichroic beamsplitter prism and 3 attached black-and-white CCD chips provide the best resolution and light sensitivity as well as true...
Cereal crops as viable production and storage systems for pharmaceutical scFv antibodies (2000)
Stöger, E., Vaquero, C., Torres, E., Sack, M., Nicholson, L., Drossard, J., ...
This report describes the stable expression of a medically important antibody in the staple cereal crops rice and wheat. We successfully expressed a single-chain Fv antibody (ScFvT84.66) against...
Transient transformation of the rust fungus Puccinia graminis f. sp. tritici (2000)
Schillberg, S., Tiburzy, R., Fischer, R.
The biotrophic rust fungus Puccinia graminis f sp. tritici (Pgt) was transformed by particle bombardment. The promoter from the Pgt translation elongation factor 1 alpha(EF-1 alpha) gene was fused to...
Prüfer, D., Kawchuk, L., Monecke, M., Nowok, S., Fischer, R., Rohde, W.
Mono- and polyclonal antibodies directed against different domains of the potato leafroll luteovirus (PLRV) P1 (ORF1) protein were applied to the analysis of P1 expression during PLRV replication in...
Vaquero, C., Sack, M., Chandler, J., Drossard, J., Schuster, F., Monecke, M., ...
To evaluate the expression of different forms of a tumor-specific antibody in plants, we adapted a recently described Agrobacterium-mediated transient expression system. A recombinant single-chain Fv...
Towards molecular farming in the future: using plant-cell-suspension cultures as bioreactors (1999)
Fischer, R., Emans, N., Schuster, F., Hellwig, S., Drossard, J.
Plant-suspension cells are an in vitro system that can be used for recombinant protein production under carefully controlled certified conditions. Plant-suspension cells can be grown in shake flasks...
Towards molecular farming in the future: transient protein expression in plants (1999)
Fischer, R., Vaquero-Martin, C., Sack, M., Drossard, J., Emans, N., Commandeur, U.
Molecular farming in plants can be achieved by stable or transient expression of a recombinant protein. Transient expression of recombinant proteins in plants can rapidly provide large amounts of the...
Fischer, R., Drossard, J., Emans, N., Commandeur, U., Hellwig, S.
This review article focuses on the use of the methylotrophic yeast Pichia pastoris as a recombinant protein-expression system. P. pastoris is a useful system for the expression of milligram-to-gram...
Torres, E., Vaquero, C., Nicholson, L., Sack, M., Stöger, E., Drossard, J., ...
We investigated the suitability of transformed rice cell lines as a system for the production of therapeutic recombinant antibodies. Expression constructs encoding a single-chain Fv fragment...
Production of carcinoembryonic antigen (CEA) N-A3 domain in Pichia pastoris by fermentation (1999)
Hellwig, S., Robin, F., Drossard, J., Raven, N.P.G., Vaquero-Martin, C., Shively, J.E., ...
Carcinoembryonic antigen (CEA) is a 180-kDa glycoprotein found on the surface of normal colon and malignant human adenocarcinomas. Recently, a fusion protein containing two of the seven Ig-like...
Fischer, R., Liao, Y.C., Drossard, J.
A TMV-specific full-size murine IgG-2b/kappa antibody (mAb24) was expressed in a Nicotiana tabacum cv. Petite Havana SR1 suspension culture (P9s), which was derived from a stably transformed...
Fischer, R., Drossard, J., Commandeur, U., Schillberg, S., Emans, N.
Molecular Farming of pharmaceuticals in plants has the potential to provide almost unlimited amounts of recombinant proteins for use in disease diagnosis and therapy. Transgenic plants are attracting...
Zhang, M.Y., Schillberg, S., Prins, M., Fischer, R.
The present data demonstrate that fusion to a C-terminal affinity purification tag using the IMAPCTÖ system is a suitable method for expression of intact and soluble NSM protein in E. coli. This...
Molecular farming of recombinant antibodies in plants (1999)
Fischer, R., Liao, Y.C., Hoffmann, K., Schillberg, S., Emans, N.
"Molecular farming" is the production of recombinant proteins in plants. It is intended to harness the power of agriculture to cultivate and harvest transgenic plants producing recombinant...
Laserinduzierte Modifikationen an Holzoberflächen (1999)
Wust, H., Beyer, E., Morgenthal, L., Panzner, M., Wiedemann, G., Fischer, R., ...
This contribution presents first results of thorough investigations concerning the effect of laser irradiation on wood. It has been found that the structure of a surface layer can be modified in a...
Fischer, R., Schumann, D., Zimmermann, S., Drossard, J., Sack, M., Schillberg, S.
We describe the expression of the bispecific antibody biscFv2429 in transgenic suspension culture cells and tobacco plants. biscFv2429 consists of two single chain antibodies, scFv24 and scFv29,...
Bauteil aus Holz sowie Verfahren zur Herstellung und Anwendung des Verfahrens (1999)
Fischer, R., Haller, P., Wiedemann, G., Panzner, M., Wust, H.
NOVELTY - The wood construction component, with a geometric shape, has zones of different characteristics from hardened molten wood materials. USE - The method is for the alteration of wood...
Schillberg, S., Zimmermann, S., Voss, A., Fischer, R.
We compared the expression of a functional recombinant TMV-specific full-size antibody (rAb29) in both the apoplast and cytosol of tobacco plants and a single chain antibody fragment (scFv29),...
Accumulation of antibody fusion proteins in the cytoplasm and ER of plant cells (1999)
Spiegel, H., Schillberg, S., Sack, M., Holzem, A., Nähring, J., Monecke, M., ...
To test whether the accumulation of cytoplasmically targeted recombinant antibodies could be improved by fusion to a cytoplasmic protein, we generated a series of single chain antibody-fusion...
R. Fischer, W. Jacob, W. Von, Der Linden, V. Dose
Abstract. Low-pressure plasmas are nowadays widely used for technical applications of plasma-surface interactions, such as plasma etching, material deposition, sputtering, etc. For a thorough...
Depth Profile Determination with Confidence Intervals from Rutherford Backscattering Data (1999)
U V Toussaint, R Fischer, K Krieger, V Dose
A new simulation program for Rutherford backscattering spectroscopy (RBS) together with an adaptive kernel method in the Bayesian probability theory framework was applied to the analysis of RBS data....
The Adaptive Resolution Concept in Form-Free Distribution Estimation (1999)
The ubiquitous ill-posed inverse problem of estimating a form-free distribution and the respective reliability given a set of noisy or incomplete data is solved with Bayesian probability theory by...
Swaak, A. J. G., Van Den Brink, H. G., Smeenk, R. J. T., Manger, K., Kalden, J. R., Tosi, S., ...
Objective. Most information available about the disease course of patients with systemic lupus erythematosus (SLE) is restricted to the first 5 yr after disease onset. Data about the disease course...
Depth Profile Reconstruction from Rutherford Backscattering Data (1998)
Toussaint, U. V., Krieger, K., Fischer, R., Dose, V.
An adaptive kernel method in the Bayesian framework together with a new simulation program for Rutherford backscattering spectroscopy (RBS) have been applied to the analysis of RBS data. Even in the...
Observation of X-Ray Generation in a Proof-of-Principle Laser Synchrotron Source Experiment. (1998)
Ting, A., Fischer, R., Fisher, A., Krall, J., Esarey, E.
A Laser Synchrotron Source (LSS) was proposed to generate short-pulsed, tunable x-rays by Thomson scattering of laser photons from a relativistic electron beam. A proof-of-principle (p.o.p)...
Grun, J., Fischer, R., Manka, C. K., Wenzel, R. F., Cozzens, R.
One-inch diameter samples of various materials, such as stainless steel, painted and unpainted aluminum, fused silica, and fiberglass composites, were irradiated by a train of picosecond-duration...
RADIATIVE RECOMBINATION IN AMORPHOUS SEMICONDUCTORS. (1998)
Author is with Dept. of Physics.
Bayesian techniques and the principle of maximum entropy in ion-beam analysis applications (1998)
Prozesky,V. M., Padayachee,J., Fischer,R., Dose,V., Weller,A.
Hall measurements on La2/3Ca1/3MnO3-δ and Nd2/3Sr1/3MnO3-δ-a comparative study. (1998)
Poddar, A., Muruguraj, P., Fischer, R., Gmelin, E., Bärner, K., Haupt, L., ...
Heat diffusivity of Nd1-xSrxMnO3-δ and La1-xCaxMnO3-δ compounds. (1998)
Liebe, J., Kang, H., Haupt, L., Mandal, P., Medvedeva, I. V., Rao, G. H., ...
Surface modification of wood by laser irradiation (1998)
Fischer, R., Haller, P., Panzner, M., Wust, H., Wiedemann, G.
Experimental investigation of the laser ablation process on wood surfaces (1998)
Panzner, M., Wiedemann, G., Henneberg, K., Fischer, R., Witke, T., Dietsch, R.
Processing of wood by conventional mechanical tools like saws or planes leaves behind a layer of squeezed wood only slightly adhering to the solid wood surface. Laser ablation of this layer could...
Transgenic plants as bioreactors for the expression of recombinant antibodies (1998)
Fischer, R., Drossard, J., Hellwig, S., Emans, N., Schillberg, S.
Bayesian techniques and the principle of maximum entropy in ion-beam analysis applications (1998)
Prozesky, V. M., Padayachee, J., Fischer, R., Dose, V., Weller, A.
The use of maximum entropy and Bayesian techniques in nuclear microprobe applications (1997)
Prozesky,V. M., Padayachee,J., Fischer,R., Dose,V., Ryan,C. G.
The use of maximum entropy and Bayesian statistics in ion-beam applications (1997)
Prozesky,V. M., Padayachee,J., Fischer,R., Dose,V., Ryan,C. G.
Klassifikation von unterschiedlichen Holzqualitäten durch Farbtextur (1997)
Am Erlanger Fraunhofer-Institut für Integrierte Schaltungen wird derzeit ein echtzeifähiges System zur Klassifikation von Fehlern in gehobelten und sägerauhen Brettern implementiert. Hierbei...
The use of maximum entropy and Bayesian techniques in nuclear microprobe applications (1997)
Prozesky, V. M., Padayachee, J., Fischer, R., Dose, V., Ryan, C. G.
The use of maximum entropy and Bayesian statistics in ion-beam applications (1997)
Prozesky, V. M., Padayachee, J., Fischer, R., Dose, V., Ryan, C. G.
Adaptive kernels and occam's razor in inversion problems (1996)
Following the adaptive-kernel methods in density estimation theory we extend the quantified maximum entropy concept by locally varying correlations. The smoothing property of the adaptive kernels are...
On the importance of ff marginalization in maximum entropy (1996)
R. Fischer, W. Von, Der Linden, V. Dose
Abstract. The correct entropic prior, computed by marginalization over the regularization parameter ff, is used to invert photoemission data and to restore the famous "Susie "...
Fischer, R., Baukloh, V., Naether, O.G.J., Schulze, W., Salzbrunn, A., Benson, D.M.
The case report illustrates the successful application of a new method of sperm extraction from a frozen-thawed testicular biopsy specimen within an established programme of intracytoplasmic sperm...
Rowland, I.R., Bearne, C.A., Fischer, R., Pool-Zobel, B.L.
Nutrition and Cancer, 26(1996) Nr.1, S.37-46
Fischer, R., Fuchs, I., Heisel, U., Westkämper, E.
Die deutsche Forschungslandschaft auf dem Gebiet der Holzbe- und -verarbeitung ist im wesentlichen nur ausgesprochenen Insidern aus der Holzindustrie und dem Holzbearbeitungsmaschinenbau bekannt. Die...
Diehl, V., Loeffler, M., Pfreundschuh, M., Ruehl, U., Hasenclever, D., Nisters-Backes, H., ...
Objective It was the aim of this prospective randomized multicenter study to compare chemotherapy and radiotherapy as consolidation treatments in patients achieving complete remission (CR) after 6...
Biepitaxial Josephson junctions and SuFET technology for the preparation of HTS-JoFETs (1994)
Petersen, K., Walkenhorst, A., Stölzel, C., Wilkens, W., Krimmer, C., Söllner, J., ...
Biepitaxial Josephson junctions and superconducting field effect transistors (SuFET) were fabricated in order to combine both techniques to a Josephson junction field effect transistor (JoFET). The...
Die Logistik-Kooperation zwischen Dienstleister und verladendem Unternehmen stellt kein ad-hoc-Gebilde dar; sie ist Ergebns eines Prozesses, der zu durchlaufen ist. Welche Aufgaben und Interaktionen...
Verfahren und Einrichtung zur Behandlung von Saatgut (1994)
Panzer, S., Mueller, P., Pflaumbaum, J., Scholze, F., Lange, M., Mueller, R., ...
Mehrwegtransportverpackungen - Einfluß auf die interne Logistik (1994)
Die Diskussion um den Einsatz der MTV fokussiert auf externe Gesichtspunkte; unberücksichtigt bleiben fast regelmäßig unternehmensinterne Sachverhalte. Um diesem Manko zu begegnen, werden am...
Analysis-aided geometric design based on constrained parametric structures (1994)
Fischer, R., Vieira, A.S., Rix, J.
In this paper, an investigation into the nature of the integration of analysis tools in early stages of the design process is performed, followed by the specification of a series of requirements on...
Biepitaxial Josephson junctions and SuFET technology for the preparation of HTS-JoFETs (1994)
Petersen, K., Walkenhorst, A., Stölzel, C., Wilkens, W., Krimmer, C., Söllner, J., ...
Biepitaxial Josephson junctions and superconducting field effect transistors (SuFET) were fabricated in order to combine both techniques to a Josephson junction field effect transistor (JoFET). The...
Biepitaxial Josephson junctions and SuFET technology for the preparation of HTS-JoFETs (1994)
Petersen, K., Walkenhorst, A., Stölzel, C., Wilkens, W., Krimmer, C., Söllner, J., ...
Biepitaxial Josephson junctions and superconducting field effect transistors (SuFET) were fabricated in order to combine both techniques to a Josephson junction field effect transistor (JoFET). The...
Sharkov, A. V., Kryukov, I. V., Khoroshilov, E. V., Kryukov, P. G., Fischer, R., Scheer, Hugo, ...
Polarization pump-probe femtosecond spectroscopy was used to investigate photoinduced optical density changes in allophycocyanin (APC) trimers at 635–690 nm after excitation with 230-fs pulses at...
Naether, O.G.J., Baukloh, V., Fischer, R., Kowalczyk, T.
In recent publications we have demonstrated that laparoscopic electrocautery of the ovarian surface (LEOS) is an effective method to reduce serum androgen concentrations, normalizing ovarian cycle...
Späth, M. M., Pavensrädt, H., Fischer, R., Schlunck, G., Wanner, C., Schollmeyer, P.
The effect of histamine on the phosphoinositide turnover and intracellular free calcium activity [Ca2+]i was examined in human glomerular epithelial cells in culture. Addition of histamine to...
Schlank ohne Magersucht - Logistik - Ganzheitlich handeln (1993)
Unternehmenslogistik ist nicht nur Voraussetzung, sondern zugleich zentraler Baustein des Lean-Management. Damit die Logistik die ihr zugewiesene Aufgabe erfüllen kann, bedarf sie einer...
Förster energy transfer between neighbouring chromophores in C-phycocyanin trimers (1993)
Gillbro, T., Sharkov, A. V., Kryukov, I. V., Khoroshilov, E. V., Kryukov, P. G., Fischer, R., ...
The excitation-energy transfer in C-phycocyanin (C-PC) trimers and monomers isolated from phycobilisomes of Mastigocladus laminosus has been studied by polarization femtosecond laser spectroscopy....
Femtosecond excitation transfer processes in biliprotein trimers (1993)
Sharkov, A. V., Khoroshilov, E. V., Kryukov, I. V., Palsson, L. O., Kryukov, P. G., Fischer, R., ...
Femtosecond Förster energy transfer over 20 A in Phycoerythrocyanin (PEC) trimers (1993)
Palsson, L. O., Gillbro, T., Sharkov, A. V., Fischer, R., Scheer, Hugo
Femtosecond excitation transfer in allophycocyanin (1993)
Sharkov, A. V., Khoroshilov, E. V., Kryukov, I. V., Kryukov, P. G., Gillbro, T., Fischer, R., ...
`2`0`5Bi/`2`0`6Bi cyclotron production from Pb-isotopes for absorption studies in humans. (1993)
Fischer, R., Wendel, J., Dresow, B., Bechtold, V., Heinrich, H.C.
Applied Radiation Isotopes, 44(1993) S.1467-72
Dresow, B., Fischer, R., Gabbe, E.E., Heinrich, H.C.
Pajares, J.M. [Hrsg.]
Bestimmung potentieller Bereiche für die Make-or-buy-Untersuchung (1992)
Der Entscheid für die Auswahl eines Untersuchungsbereiches für die Make-or-Buy - Analyse besitzt allzu häufig ad-hoc - Charakter. Die plausible Nachvollziehbarkeit für die am Prozeß Beteiligten...
Dissociating effect of chromophore modifications on C-phycocyanin heterohexamers (1992)
The bilin chromophores of the α or β subunit of C-phycocyanin (PC) from Mastigocladus laminosus were modified, and subsequently recombined with the respective complementary unmodified chromophores....
Femtosecond energy transfer processes in allophycocyanin and C-phycocyanin trimers (1992)
Khoroshilov, E. V., Kryukov, I. V., Kryukov, P. G., Sharkov, A. V., Gillbro, T., Fischer, R., ...
Femtosecond energy transfer between chromophores in allophycocyanin trimers (1992)
Sharkov, A. V., Kryukov, I. V., Khoroshilov, E. V., Kryukov, P. G., Fischer, R., Scheer, Hugo, ...
Ultrafast energy-transfer processes in allophycocyanin (APC) trimers from Mastigocladus laminosus have been examined by a femtosecond absorption technique. Isotropic absorption recovery kinetics with...
Bernhards, J., Fischer, R., Hübner, K., Georgii, A.
Diagnostic biopsies of 1,140 previously untreated patients with Hodgkin's lymphoma from the German Hodgkin Therapy Trial were evaluated by a panel of 4 histopathologists. Each case was classified by...
Dresow, B., Fischer, R., Gabbe, E.E., Wendel, J., Heinrich, H.C.
Scandinavian Journal of Gastroenterology, 27(1992) S.333-36
Dresow, B., Nielsen, P., Fischer, R., Wendel, J., Gabbe, E.E., Heinrich, H.C.
Archives of Toxicology, 65(1991) S.646-50
The DELPHI detector at LEP (1991)
Aarnio, P., Abie, H., Abreu, P., Adam, W., Adrianos, P., Adye, T., ...
The DELPHI detector at LEP (1991)
Aarnio, P., Abie, H., Abreu, P., Adam, W., Adrianos, P., Adye, T., ...
Logistik - Optimierte Neugestaltung (1991)
Die Bandbreite unternehmerischer Erfolgsfaktoren ist um die Dimension des vertikalen Integrationsgrades zu erweitern; dieser bringt- vereinfacht dargestellt- das Verhältnis der eigenerstellten zu...
Picosecond time-resolved fluorescence of phycobiliproteins (1990)
Fischer, R., Gottstein, J., Scheer, Hugo, Geiselhart, P., Schneider, Siegfried
The α- and β-subunits of C-phycocyanin from Mastigocladus laminosus were prepared according to revised procedures. Both subunits are isolated as dimers, which can be dissociated into monomers with...
The DELPHI detector at LEP (1990)
DELPHI Collaboration, Aarnio, PA, Abie, H, Abreu, P, Adam, W, Adrianos, P, ...
Wertschöpfungskette - Logistik optimieren (1990)
Eine der wichtigsten Fragestellungen des strategischen Logistikmanagement ist die optimale Gestaltung der Wertschöpfungskette. Anlalog zur Gestaltung der Fertigungstiefe ist auch hier zu fragen,...
Heuberger, A., Fallmann, W., Paschke, F., Stangl, G., Chalupka, A., ...
Experiments performed with a research type Ion Projector show electronic alignment in X, Y, and rotation with 0.1 Mym accuracy for 2 mm*2 mm chip fields obtained at 9* ionoptical reduction. The fine...
Fourier-transform Raman spectroscopy applied to photobiological systems. (1990)
Sawatzki, J., Fischer, R., Scheer, Hugo, Siebert, F.
Fluorescence and initiation of photoreactions are problems frequently encountered with resonance Raman spectroscopy of photobiological systems. These problems can be circumvented with...
PHOTOCHEMISTRY OF PHYCOBILIPROTEINS (1989)
Siebzehnrübl, S., Fischer, R., Kufer, Werner, Scheer, Hugo
Native PEC from the cyanobacterium, Mastigocladus laminosus, and its isolated α-subunit show photoreversibly photochromic reactions with difference-maxima around 502 and 570 nm in the spectral...
Sandström, A., Gillbro, T., Sundström, V., Fischer, R., Scheer, Hugo
We have investigated by picosecond absorption experiments how the size of C-phycocyanin aggregates from Mastigocladus laminosus influences the excitation energy transfer kinetics. Going from...
Eisenreich, N., Fabry, C., Fischer, R., Geissler, A., Kugler, H., Sinn, S.
In the uniaxial tensile test force, longitudinal and transversal elongation must be measured simultaneously. Recently we presented a non instrusive method to measure both elongations in one...
Bouvier, A., Bouvier, A.J., Fischer, R.
Tunable V.U.V. radiation has been generated by non-resonant fifth-harmonic generation in xenon in the domain 1135-1170 Å using amplified dye laser beams. In the case of the (2m + 1)th harmonic, in...
Eisenreich, N., Fabry, C., Fischer, R., Geissler, A., Kugler, H., Sinn, S.
In the uniaxial tensile test force, longitudinal and transversal elongation must be measured simultaneously. Recently we presented a non instrusive method to measure both elongations in one...
Bouvier, A., Bouvier, A.J., Fischer, R.
Tunable V.U.V. radiation has been generated by non-resonant fifth-harmonic generation in xenon in the domain 1135-1170 Å using amplified dye laser beams. In the case of the (2m + 1)th harmonic, in...
Eisenreich, N., Fabry, C., Fischer, R., Geissler, A., Kugler, H., Sinn, S.
In the uniaxial tensile test force, longitudinal and transversal elongation must be measured simultaneously. Recently we presented a non instrusive method to measure both elongations in one...
Bouvier, A., Bouvier, A.J., Fischer, R.
Tunable V.U.V. radiation has been generated by non-resonant fifth-harmonic generation in xenon in the domain 1135-1170 Å using amplified dye laser beams. In the case of the (2m + 1)th harmonic, in...