Borrelia burgdorferi is clonal: implications for taxonomy and vaccine development.
Dykhuizen, D E, Polin, D S, Dunn, J J, Wilske, B, Preac-Mursic, V, Dattwyler, R J, ...
The chromosomal genes fla and p93 and the ospA gene from a linear plasmid were sequenced from up to 15 isolates of Borrelia burgdorferi, which causes Lyme borreliosis in man. Comparison of the gene...
Clarithromycin in treatment of early Lyme disease: a pilot study.
Dattwyler, R J, Grunwaldt, E, Luft, B J
Forty-one patients with erythema migrans were enrolled in an open-labelled pilot study of oral clarithromycin, 500 mg twice daily for 21 days, for the treatment of early Lyme disease. Immediately...
Borrelia burgdorferi HSP70 homolog: characterization of an immunoreactive stress protein.
Anzola, J, Luft, B J, Gorgone, G, Dattwyler, R J, Soderberg, C, Lahesmaa, R, ...
The gene encoding an immunoreactive Borrelia burgdorferi HSP70 homolog was isolated and characterized. The predicted amino acid sequence of this spirochetal protein confirms that this gene encodes a...
The 93-kilodalton protein of Borrelia burgdorferi: an immunodominant protoplasmic cylinder antigen.
Luft, B J, Mudri, S, Jiang, W, Dattwyler, R J, Gorevic, P D, Fischer, T, ...
Using immunoblots, we identified proteins of Borrelia burgdorferi recognized by sera from 62 patients with either acute or chronic Lyme disease. In all groups studied, the 41-kDa flagellar protein...
Schubach, W H, Mudri, S, Dattwyler, R J, Luft, B J
The major outer surface membrane protein of Borrelia burgdorferi, OspA, is one of several antigens recognized by sera from some patients in the chronic phase of Lyme borreliosis. We have expressed...
Biochemical and immunological characterization of the surface proteins of Borrelia burgdorferi.
Luft, B J, Jiang, W, Munoz, P, Dattwyler, R J, Gorevic, P D
The immunodominant proteins and glycoproteins of Borrelia burgdorferi were analyzed by one-dimensional (1D) and 2D gel electrophoresis. More than 100 polypeptide species could be detected on...
Mapping the major antigenic domains of the native flagellar antigen of Borrelia burgdorferi.
Jiang, W, Luft, B J, Schubach, W, Dattwyler, R J, Gorevic, P D
Purified flagellar protein (p41) of Borrelia burgdorferi (strain B31) was subjected to chemical cleavage with hydroxylamine or proteolysis with V8 protease, endoproteinase Asp-N, or...
Jiang, W, Gorevic, P D, Dattwyler, R J, Dunn, J J, Luft, B J
The major outer surface protein, OspA, of Borrelia burgdorferi is a lipoprotein which is a particular interest because of its potential as a vaccine candidate. However, serotypic and genetic analysis...
Borrelia burgdorferi is clonal: implications for taxonomy and vaccine development.
Dykhuizen, D E, Polin, D S, Dunn, J J, Wilske, B, Preac-Mursic, V, Dattwyler, R J, ...
The chromosomal genes fla and p93 and the ospA gene from a linear plasmid were sequenced from up to 15 isolates of Borrelia burgdorferi, which causes Lyme borreliosis in man. Comparison of the gene...
Clarithromycin in treatment of early Lyme disease: a pilot study.
Dattwyler, R J, Grunwaldt, E, Luft, B J
Forty-one patients with erythema migrans were enrolled in an open-labelled pilot study of oral clarithromycin, 500 mg twice daily for 21 days, for the treatment of early Lyme disease. Immediately...
Borrelia burgdorferi HSP70 homolog: characterization of an immunoreactive stress protein.
Anzola, J, Luft, B J, Gorgone, G, Dattwyler, R J, Soderberg, C, Lahesmaa, R, ...
The gene encoding an immunoreactive Borrelia burgdorferi HSP70 homolog was isolated and characterized. The predicted amino acid sequence of this spirochetal protein confirms that this gene encodes a...
The 93-kilodalton protein of Borrelia burgdorferi: an immunodominant protoplasmic cylinder antigen.
Luft, B J, Mudri, S, Jiang, W, Dattwyler, R J, Gorevic, P D, Fischer, T, ...
Using immunoblots, we identified proteins of Borrelia burgdorferi recognized by sera from 62 patients with either acute or chronic Lyme disease. In all groups studied, the 41-kDa flagellar protein...
Schubach, W H, Mudri, S, Dattwyler, R J, Luft, B J
The major outer surface membrane protein of Borrelia burgdorferi, OspA, is one of several antigens recognized by sera from some patients in the chronic phase of Lyme borreliosis. We have expressed...
Biochemical and immunological characterization of the surface proteins of Borrelia burgdorferi.
Luft, B J, Jiang, W, Munoz, P, Dattwyler, R J, Gorevic, P D
The immunodominant proteins and glycoproteins of Borrelia burgdorferi were analyzed by one-dimensional (1D) and 2D gel electrophoresis. More than 100 polypeptide species could be detected on...
Mapping the major antigenic domains of the native flagellar antigen of Borrelia burgdorferi.
Jiang, W, Luft, B J, Schubach, W, Dattwyler, R J, Gorevic, P D
Purified flagellar protein (p41) of Borrelia burgdorferi (strain B31) was subjected to chemical cleavage with hydroxylamine or proteolysis with V8 protease, endoproteinase Asp-N, or...
Jiang, W, Gorevic, P D, Dattwyler, R J, Dunn, J J, Luft, B J
The major outer surface protein, OspA, of Borrelia burgdorferi is a lipoprotein which is a particular interest because of its potential as a vaccine candidate. However, serotypic and genetic analysis...