R. O. C. Oreffo

The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells (2009)

Biggs, M.J.P., Richards, R.G., Gadegaard, N., Wilkinson, C.D.W., Oreffo, R.O.C., Dalby, M.J.

The physiochemical characteristics of a material with in vivo applications are critical for the clinical success of the implant and regulate both cellular adhesion and differentiated cellular...

Differential in-gel electrophoresis (DIGE) analysis of human bone marrow osteoprogenitor cell contact guidance (2009)

Kantawong, F., Burchmore, R.J.S., Wilkinson, C.D.W., Oreffo, R.O.C., Dalby, M.J.

We have used a recent comparative proteomics technique, differential in-gel electrophoresis (DIGE), to study osteoprogenitor cell response to contact guidance in grooves. In order to increase protein...

Formation of a human-derived fat tissue layer in PDLLGA hollow fibre scaffolds for adipocyte tissue engineering (2009)

Morgan, S M, Ainsworth, B J, Kanczler, J. M., Babister, J. C., Chaudhuri, Julian B, Oreffo, R. O. C.

Development of adipose tissue-engineering strategies, where human bone marrow stromal cells (HBMSC) are combined with three-dimensional scaffolds, is likely to prove valuable for soft tissue...

Whole proteome analysis of osteoprogenitor differentiation induced by disordered nanotopography and mediated by ERK signalling (2009)

Kantawong, F., Burgess, K.E.V., Jayawardena, K., Hart, A., Burchmore, R.J., Gadegaard, N., ...

Topographic features can modulate cell behaviours such as proliferation, migration, differentiation and apoptosis. Biochemical mechanotransduction implies the conversion of mechanical forces (e.g....

Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells (2009)

Sjostrom, T., Dalby, M.J., Hart, A., Tare, R., Oreffo, R.O.C., Su, B.

Surface nanotopography is known to influence the interaction of human skeletal (mesenchymal) stem cells (hMSC) with a material 14 surface. While most surface nanopatterning has been performed on...

Proteomic analysis of human osteoprogenitor response to disordered nanotopography (2008)

Kantawong, F., Burchmore, R.J.S., Gadegaard, N., Oreffo, R.O.C., Dalby, M.J.

Previous studies have shown that microgroove-initiated contact guidance can induce bone formation in osteoprogenitor cells (OPGs) and produce changes in the cell proteome. For proteomic analysis,...

The influence of early nutritional compromise on bone structure and strength (2008)

Pollintine, P., Cooper, I., Anderson, H.L., Green, L.R., Cooper, C., Lanham, S.A., ...

Interactions with nanoscale topography: adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage (2008)

Biggs, M.J.P., Richards, R.G., Gadegaard, N., McMurray, R.J., Affrosman, S., Wilkinson, C.D.W., ...

Polymeric medical devices widely used in orthopedic surgery play key roles in fracture fixation and orthopedic implant design. Topographical modification and surface micro-roughness of these devices...

The effect of an admix of bone morphogenetic proteins on human osteoprogenitor activity in vitro and in vivo (2006)

Yang, X.B., Green, D.W., Roach, H. I., Anderson, H.C., Howdle, S.M., Shakesheff, K.M., ...