Scientific Commons: R. Paus

Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche (2008)

Kloepper, J. E., Tiede, S., Brinckmann, J., Reinhardt, D. P., Meyer, W., Faessler, R., ...

Evidence that the bulge region is a site of relative immune privilege in human hair follicles (2008)

Meyer, K. C., Klatte, J. E., Dinh, H. V., Harries, M. J., Reithmayer, K., Meyer, W., ...

Overexpression of mIGF-1 in Keratinocytes Improves Wound Healing and Accelerates Hair Follicle Formation and Cycling in Mice (2008)

Semenova, E., Koegel, H., Hasse, S., Klatte, J. E., Slonimsky, E., Bilbao, D., ...

Hair follicle stem cells: Walking the maze (2007)

Tiede, S., Kloepper, J.E., Bodo, E., Tiwari, S., Kruse, C., Paus, R.

The discovery of epithelial stem cells (eSCs) in the bulge region of the outer root sheath of hair follicles in mice and man has encouraged research into utilizing the hair follicle as a therapeutic...

TRP channels as novel players in the pathogenesis and therapy of itch (2007)

T. Bíró, B. I. Tóth, N. Dobrosi, T. Géczy, R. Paus, Marincsák Rita (1979-) (fogszakorvos)

Distinct mechanisms underlie pattern formation in the skin and skin appendages (2006)

Widelitz, R B, Baker, R E, Plikus, M, Lin, C, Maini, P K, Paus, R, ...

Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangement. There are different physiological and pathological mechanisms that lead to the formation of...

Distinct mechanisms underlie pattern formation in the skin and skin appendages (2006)

Widelitz, R. B., Baker, Ruth E., Plikus, M., Lin, C., Maini, P. K., Paus, R., ...

Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangement. There are different physiological and pathological mechanisms that lead to the formation of...

What is the biological basis of pattern formation of skin lesions? (2006)

Chuong, C M, Dhouailly, D, Gilmore, S, Forest, L, Shelly, W B, Stenn, K S, ...

Pattern recognition is at the heart of clinical dermatology and dermatopathology. Yet, while every practitioner of the art of dermatological diagnosis recognizes the supreme value of diagnostic cues...

What is the biological basis of pattern formation of skin lesions? (2006)

Chuong, C. M., Dhouailly, D., Gilmore, S., Forest, L., Shelly, W. B., Stenn, K. S., ...

Pattern recognition is at the heart of clinical dermatology and dermatopathology. Yet, while every practitioner of the art of dermatological diagnosis recognizes the supreme value of diagnostic cues...

Cylindroma as tumor of hair follicle origin (2006)

Massoumi, R., Podda, M., Fässler, R., Paus, R.

Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin (2006)

Wu, X. W., Quondamatteo, F., Lefever, T., Czuchra, A., Meyer, H., Chrostek, A., ...

Towards the development of a pragmatic technique for isolating and differentiating nestin-positive cells from human scalp skin into neuronal and glial cell populations: Generating neurons from human skin? (2006)

Kruse, C., Bodo, E., Petschnik, A.E., Danner, S., Tiede, S., Paus, R.

Nestin+ hair follicle-associated cells of murine skin can be isolated and differentiated in vitro into neuronal and glial cells. Therefore, we have asked whether human skin also contains nestin+...

Neurotrophin-3 regulates mast cell functions in neonatal mouse skin (2006)

Botchkareva, N.V., Botchkarev, Vladimir A., Paus, R., Tobin, Desmond J.

No

Neurotrophin-3 regulates mast cell functions in neonatal mouse skin (2006)

Botchkareva, N.V., Botchkarev, V.A., Paus, R., Tobin, Desmond J.

No

NGF and its precursor proNGF differentially regulate human hair growth (2005)

Peters, E, Liezman, C, Hansen, M, Overall, R, Arck, P, Klapp, B, ...

Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor (2004)

Peters, E.M.J., Handjiski, B., Kuhlmei, A., Hagen, E., Bielas, H., Braun, A., ...

Recently, we have revealed the existence of a "brain-hair follicle axis" in murine skin and have identified the neuropeptide substance P (SP) as a key mediator of stress-induced hair growth...

The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. (2002)

Tobin, Desmond J., Foitzik, K., Reinheckel, T.T., Hecklenberg, L., Botchkarev, Vladimir A., Peters, S.C., ...

No

Guidelines and techniques for the accurate classification of chemotherapy-induced hair follicle dystrophy (2001)

Handjiski, B, Mueller-Roever, S, Peters, E, Paus, R

Choleratoxin but not isoproterenol inhibits human hair follicle growth in vitro (2001)

Peters, E, Moll, I, Alt, V, Loffler, D, Paus, R

NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. (2000)

Schmidt-Ullrich, R., Tobin, Desmond J., Lenhard, D., Schneider, P, Paus, R., Scheidereit, C.

No

A new role for neurotrophins: Involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control (1999)

Botchkarev, V.A., Botchkareva, N.V., Welker, P., Metz, M., Lewin, G.R., Subramaniam, A., ...

Neurotrophins exert many biological effects not directly targeted at neurons, including modulation of keratinocyte proliferation and apoptosis in vitro. Here we exploit the cyclic growth and...

Abundant production of brain-derived neurotrophic factor by adult visceral epithelia: Implications for paracrine and target-derived neurotrophic functions (1999)

Lommatzsch, M., Braun, A., Mannsfeldt, A., Botchkarev, V.A., Botchkareva, N.V., Paus, R., ...

Brain-derived neurotrophic factor (BDNF) plays a crucial role for the survival of visceral sensory neurons during development. However, the physiological sources and the function of BDNF in the adult...

BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin (1998)

Botchkarev, V.A., Botchkareva, N.V., Lommatzsch, M., Peters, E.M., Lewin, G.R., Subramaniam, A., ...

Besides their recognized dependence on nerve growth factor (NGF) during development, the dependence of mature sympathetic ganglion neurons on other neurotrophins is still unclear. Here, we have...

Hair shaft elongation, follicle growth, and spontaneous regression in long-term, gelatin sponge-supported histoculture of human scalp skin.

Li, L, Margolis, L B, Paus, R, Hoffman, R M

In order to better understand the molecular mechanisms of human hair growth control and to test hair growth-modulatory drugs, appropriate in vitro models are required. Here, we report the long-term...

Hypothesis: possible role for the melatonin receptor in vitiligo: discussion paper.

Slominski, A, Paus, R, Bomirski, A

A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a...

Hair shaft elongation, follicle growth, and spontaneous regression in long-term, gelatin sponge-supported histoculture of human scalp skin.

Li, L, Margolis, L B, Paus, R, Hoffman, R M

In order to better understand the molecular mechanisms of human hair growth control and to test hair growth-modulatory drugs, appropriate in vitro models are required. Here, we report the long-term...

Hypothesis: possible role for the melatonin receptor in vitiligo: discussion paper.

Slominski, A, Paus, R, Bomirski, A

A new unifying hypothesis for the aetiology of vitiligo is proposed, in which we postulate that the final destruction of melanocytes in vitiligo results from a cascade of reactions initiated by a...

Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia.

Maurer, M., Handjiski, B., Paus, R.

Selected immunophilin ligands (IPLs) are not only potent immunosuppressants but also modulate hair growth. Their considerable side effects, however, justify at best topical applications of these...

Analysis of apoptosis during hair follicle regression (catagen)

Lindner, G., Botchkarev, V. A., Botchkareva, N. V., Ling, G., Paus, R.

Keratinocyte apoptosis is a central element in the regulation of hair follicle regression (catagen), yet the exact location and the control of follicular keratinocyte apoptosis remain obscure. To...

Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone.

Paus, R., Handjiski, B., Eichmüller, S., Czarnetzki, B. M.

We introduce cyclophosphamide-induced alopecia (CYP-IA) in C57BL-6 mice as a clinically relevant model for studying the biology of chemotherapy-induced alopecia and for developing anti-alopecia...

The psoriatic epidermal lesion and anagen hair growth may share the same "switch-on" mechanism.

Paus, R., Link, R. E.

Based on striking parallels between the cell kinetics in the epidermal lesion of psoriasis and the proliferation of hair matrix keratinocytes during the anagen phase of the hair growth cycle, the...

Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?

Paus, R., Slominski, A., Czarnetzki, B. M.

The etiology of alopecia areata (AA), a putative autoimmune disease characterized by sudden hair loss, has remained obscure. It is not understood, how the characteristic inflammatory infiltrate that...

R. Paus

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