Virtual reality-based simulator for training in regional anaesthesia (2009)
Grottke, O., Ntouba, A., Ullrich, S., Liao, W., Fried, E., Prescher, A., ...
BackgroundThe safe performance of regional anaesthesia (RA) requires theoretical knowledge and good manual skills. Virtual reality (VR)-based simulators may offer trainees a safe environment to learn...
Coburn, M., Kunitz, O., Apfel, C. C., Hein, M., Fries, M., Rossaint, R.
Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type...
Xenon or propofol anaesthesia for patients at cardiovascular risk in non-cardiac surgery (2008)
Hein, M., Hecker, K. E., Satlow, S., Neef, P., Rossaint, R.
Background The results of two European multi-centre trials on xenon anaesthesia led to the hypothesis that a xenon-based anaesthetic would keep left ventricular (LV) and circulatory function more...
Rex, S., Meyer, P. T., Rossaint, R., Fries, M., Büll, U., ...
Background The effects of xenon on regional cerebral blood flow (rCBF) are controversial. Moreover, the precise sites of action at which xenon exerts its effects in the human brain remain to be...
Coburn, M., Roertgen, D., Thiel, V., Fries, M., Hein, M., ...
Background Postoperative cognitive impairment after general anaesthesia, especially in the elderly, is a well-recognized problem. Xenon, known to be an N-methyl-d-aspartate antagonist, may be...
Autonomic cardiac control with xenon anaesthesia in patients at cardiovascular risk (2007)
Hein, M., Hecker, K. E., Satlow, S., Schnoor, J., Rossaint, R.
Background The cardiovascular stability found with xenon anaesthesia may be caused by absence of circulatory depression. Xenon may also act directly on autonomic cardiovascular control. Methods In a...
Coburn, M., Henzler, D., Fimm, B., Drüke, B., Rossaint, R.
Background. The aim of this study is to test the hypothesis that a standard 30-min break in a routine 7.5 h period of work makes a difference in cognitive function. Methods. In a double-blinded,...
Schälte, G., Janz, H., Busse, J., Jovanovic, V., Rossaint, R., Kuhlen, R.
Six hours after an uncomplicated extended resection of ovarian cancer, postoperative arterial bleeding led to life-threatening blood loss in a 44-yr-old Jehovah's Witness who refused blood...
Coburn, M., Kunitz, O., Hecker, K., Haaf, S., Zühlsdorff, A., ...
Background. There is limited clinical experience with xenon in a large number of patients. We present intra- and postoperative haemodynamic and recovery data comparing xenon and total intravenous...
Coagulopathy and blood component transfusion in trauma (2005)
Trauma is a serious global health problem, accounting for approximately one in 10 deaths worldwide. Uncontrollable bleeding accounts for 39% of trauma-related deaths and is the leading cause of...
Effects of xenon anaesthesia on the circulatory response to hypoventilation (2005)
Hecker, K. E., Hein, M., Reyle-Hahn, M., Horn, N. A., Rossaint, R.
Background. Circulatory response to hypoventilation is aimed at eliminating carbon dioxide and maintaining oxygen delivery (DO2) by increasing cardiac output (CO). The hypothesis that this increase...
Schälte, G., Janz, H., Busse, J., Jovanovic, V., Rossaint, R., Kuhlen, R.
Six hours after an uncomplicated extended resection of ovarian cancer, postoperative arterial bleeding led to life-threatening blood loss in a 44-yr-old Jehovah's Witness who refused blood...
Haemodynamic effects of haemorrhage during xenon anaesthesia in pigs (2005)
Hecker, K. E., Hein, M., Reyle-Hahn, S. M., Horn, N. A., Rossaint, R.
Background. It was hypothesized that xenon would stabilize mean arterial pressure (MAP) in haemorrhagic shock, recovery, and volume resuscitation, because a higher MAP has been observed with xenon,...
Effects of xenon anaesthesia on the circulatory response to hypoventilation (2005)
Hecker, K. E., Hein, M., Reyle-Hahn, M., Horn, N. A., Rossaint, R.
Background. Circulatory response to hypoventilation is aimed at eliminating carbon dioxide and maintaining oxygen delivery (DO2) by increasing cardiac output (CO). The hypothesis that this increase...
Coagulopathy and blood component transfusion in trauma (2005)
Trauma is a serious global health problem, accounting for approximately one in 10 deaths worldwide. Uncontrollable bleeding accounts for 39% of trauma-related deaths and is the leading cause of...
Minimum alveolar concentration (MAC) of xenon in intubated swine (2004)
Hecker, K. E., Horn, N., Baumert, J. H., Reyle-Hahn, S. M., Heussen, N., Rossaint, R.
Background. The minimum alveolar concentration (MAC) is a traditional index of the hypnotic potency of an inhalational anaesthetic. To investigate the anaesthetic as well as the unwanted effects of...
Effects of xenon anaesthesia on intestinal oxygenation in acutely instrumented pigs{dagger} (2004)
Vagts, D. A., Hecker, K., Iber, T., Roesner, J. P., Spee, A., Otto, B., ...
Background. Xenon is a narcotic gas that might be able to replace volatile anaesthetics or nitrous oxide due to its favourable pharmacological properties, such as providing haemodynamic stability....
Prediction of fluid responsiveness in patients during cardiac surgery (2004)
Rex, S., Brose, S., Metzelder, S., Hüneke, R., Schälte, G., Autschbach, R., ...
Background. Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are...
Coburn, M., Kunitz, O., Hecker, K., Haaf, S., Zühlsdorff, A., ...
Background. There is limited clinical experience with xenon in a large number of patients. We present intra- and postoperative haemodynamic and recovery data comparing xenon and total intravenous...
Minimum alveolar concentration (MAC) of xenon in intubated swine (2004)
Hecker, K. E., Horn, N., Baumert, J. H., Reyle-Hahn, S. M., Heussen, N., Rossaint, R.
Background. The minimum alveolar concentration (MAC) is a traditional index of the hypnotic potency of an inhalational anaesthetic. To investigate the anaesthetic as well as the unwanted effects of...
Prediction of fluid responsiveness in patients during cardiac surgery (2004)
Rex, S., Brose, S., Metzelder, S., Hüneke, R., Schälte, G., Autschbach, R., ...
Background. Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are...
Effects of xenon anaesthesia on intestinal oxygenation in acutely instrumented pigs (2004)
Vagts, D. A., Hecker, K., Iber, T., Roesner, J. P., Spee, A., Otto, B., ...
Background. Xenon is a narcotic gas that might be able to replace volatile anaesthetics or nitrous oxide due to its favourable pharmacological properties, such as providing haemodynamic stability....
Minimum alveolar concentration (MAC) of xenon in intubated swine (2004)
Hecker, K. E., Horn, N., Baumert, J. H., Reyle-Hahn, S. M., Heussen, N., Rossaint, R.
Background. The minimum alveolar concentration (MAC) is a traditional index of the hypnotic potency of an inhalational anaesthetic. To investigate the anaesthetic as well as the unwanted effects of...
Effects of xenon anaesthesia on intestinal oxygenation in acutely instrumented pigs{dagger} (2004)
Vagts, D. A., Hecker, K., Iber, T., Roesner, J. P., Spee, A., Otto, B., ...
Background. Xenon is a narcotic gas that might be able to replace volatile anaesthetics or nitrous oxide due to its favourable pharmacological properties, such as providing haemodynamic stability....
Prediction of fluid responsiveness in patients during cardiac surgery (2004)
Rex, S., Brose, S., Metzelder, S., Hüneke, R., Schälte, G., Autschbach, R., ...
Background. Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are...
Coburn, M., Kunitz, O., Hecker, K., Haaf, S., Zühlsdorff, A., ...
Background. There is limited clinical experience with xenon in a large number of patients. We present intra- and postoperative haemodynamic and recovery data comparing xenon and total intravenous...
Reyle-Hahn, M., Hecker, K., Tenbrinck, R., Kuhlen, R., Rossaint, R.
Background. In this study we investigated the effects of the physical properties of xenon on respiratory mechanisms in pigs. Methods. With institutional approval, 10 female pigs (mean 25.2 (sd 2.5)...