Pulmonary Biology Of Anti-interleukin 5 Antibodies (1997)
Egan, R.W., Athwahl, D., Chou, C-C., Chapman, R.W., Emtage, S., Jenh, C-H., ...
Interleukin 5 (IL-5) is a critical cytokine for the maturation of eosinophil precursors to eosinophils in the bone marrow and those eosinophils then accumulate in the lungs during asthma. We have...
M. Minnicozzi, W. N. Durán, D. Kim, G. J. Gleich, J. Wagner, R. W. Egan
Interleukin-5 (IL-5) is a cytokine that preferentially effects the development and function of eosinophils, and is considered important in the pathophysiology of allergic inflammation. In this study,...
Role of prostaglandin endoperoxide PGG2 in inflammatory processes (1977)
F. A. KUEHL, J. L. HUMES, R. W. EGAN, E. A. HAM, G. C. BEVERIDGE, C. G. VAN ARMAN
Garsetti, D, Holtsberg, F, Steiner, M R, Egan, R W, Clark, M A
Treatment of HL-60 cells with 0.5 mM-butyric acid resulted in morphological changes, including the formation of cytoplasmic granules, nuclear condensation and segmentation. These differentiated cells...
Presence in human eosinophils of a lysophospholipase similar to that found in the pancreas.
Holtsberg, F W, Ozgur, L E, Garsetti, D E, Myers, J, Egan, R W, Clark, M A
The supernatant fraction from lysed human eosinophils, when separated by gel-filtration chromatography, contains a protein with lysophospholipase activity of approximate molecular mass 74 kDa. This...
Anthes, J C, Zhan, Z, Gilchrest, H, Egan, R W, Siegel, M I, Billah, M M
The effects of interferon-alpha (IFN-alpha) on the interleukin-6 (IL-6) receptor in a multiple myeloma cell line, U266, have been examined. IFN-alpha inhibits [3H]thymidine incorporation in U266...
She, H S, Garsetti, D E, Steiner, M R, Egan, R W, Clark, M A
A novel fluorescence assay for quantifying lysophospholipase activity is described which utilizes a commercially available acrylodated intestinal fatty-acid-binding protein (ADIFAB) and...
Garsetti, D, Holtsberg, F, Steiner, M R, Egan, R W, Clark, M A
Treatment of HL-60 cells with 0.5 mM-butyric acid resulted in morphological changes, including the formation of cytoplasmic granules, nuclear condensation and segmentation. These differentiated cells...
Presence in human eosinophils of a lysophospholipase similar to that found in the pancreas.
Holtsberg, F W, Ozgur, L E, Garsetti, D E, Myers, J, Egan, R W, Clark, M A
The supernatant fraction from lysed human eosinophils, when separated by gel-filtration chromatography, contains a protein with lysophospholipase activity of approximate molecular mass 74 kDa. This...
Anthes, J C, Zhan, Z, Gilchrest, H, Egan, R W, Siegel, M I, Billah, M M
The effects of interferon-alpha (IFN-alpha) on the interleukin-6 (IL-6) receptor in a multiple myeloma cell line, U266, have been examined. IFN-alpha inhibits [3H]thymidine incorporation in U266...
She, H S, Garsetti, D E, Steiner, M R, Egan, R W, Clark, M A
A novel fluorescence assay for quantifying lysophospholipase activity is described which utilizes a commercially available acrylodated intestinal fatty-acid-binding protein (ADIFAB) and...
Bolser, D C, DeGennaro, F C, O'Reilly, S, Chapman, R W, Kreutner, W, Egan, R W, ...
1. The GABA-B receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APPi) have antitussive activity in the cat and guinea pig. The purpose of this study was to investigate the sites of...
Hey, J. A., Del Prado, M., Egan, R. W., Kreutner, W., Chapman, R. W.
1. The effect of (R)-alpha-methylhistamine, a selective H3-histamine receptor agonist, was examined on the neurogenic hypertension and tachycardia that is induced by stimulation of areas in the...
Antitussive effects of GABAB agonists in the cat and guinea-pig.
Bolser, D. C., Aziz, S. M., DeGennaro, F. C., Kreutner, W., Egan, R. W., Siegel, M. I., ...
1. GABAB agonists inhibit neuronal processes which are important in the pathogenesis of airway disease, such as bronchospasm. Cough is a prominent symptom of pulmonary disease, but the effects of...
Tissue eosinophilia induced by recombinant human interleukin-5 in the hamster cheek pouch membrane
Minnicozzi, M., Durán, W. N., Kim, D., Gleich, G. J., Wagner, J., Egan, R. W.
Interleukin-5 (IL-5) is a cytokine that preferentially effects the development and function of eosinophils, and is considered important in the pathophysiology of allergic inflammation. In this study,...