Junker, Andreas, Krumbholz, Markus, Eisele, Sylvia, Mohan, Hema, Augstein, Florian, Bittner, Robert, ...
We established microRNA profiles from active and inactive multiple sclerosis lesions. Using laser capture microdissection from multiple sclerosis lesions to pool single cells and in vitro cultures,...
Multiple sclerosis: T-cell receptor expression in distinct brain regions (2007)
Junker, Andreas, Ivanidze, Jana, Malotka, Joachim, Eiglmeier, Ingrid, Lassmann, Hans, Wekerle, Hartmut, ...
Multiple sclerosis (MS) is an inflammatory demyelinating disease where T cells attack the brain and the spinal cord. It is known that often particular T-cell clones are expanded in the target tissue,...
Krumbholz, Markus, Theil, Diethilde, Cepok, Sabine, Hemmer, Bernhard, Kivisäkk, Pia, Ransohoff, Richard M., ...
Understanding the mechanisms of immune cell migration to multiple sclerosis lesions offers significant therapeutic potential. This study focused on the chemokines CXCL12 (SDF-1) and CXCL13 (BCA-1),...
Krumbholz, Markus, Theil, Diethilde, Cepok, Sabine, Hemmer, Bernhard, Kivisäkk, Pia, Ransohoff, Richard M., ...
Understanding the mechanisms of immune cell migration to multiple sclerosis lesions offers significant therapeutic potential. This study focused on the chemokines CXCL12 (SDF-1) and CXCL13 (BCA-1),...
Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo (2004)
Weber, Martin S., Starck, Michaela, Wagenpfeil, Stefan, Meinl, Edgar, Hohlfeld, Reinhard, Farina, Cinthia
It is widely assumed that glatiramer acetate (GA), an approved agent for the immunomodulatory treatment of multiple sclerosis, acts primarily as an antigen for T lymphocytes. Recent studies, however,...
Pellkofer, Hannah, Schubart, Anna S., Höftberger, Romana, Schutze, Nadine, Pagany, Maria, Schüller, Martina, ...
Summary Antibodies directed against onconeuronal antigens provide a specific diagnostic marker for paraneoplastic neurological syndromes (PNS) and suggest that these autoantigens are targeted during...
Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo (2004)
Weber, Martin S., Starck, Michaela, Wagenpfeil, Stefan, Meinl, Edgar, Hohlfeld, Reinhard, Farina, Cinthia
It is widely assumed that glatiramer acetate (GA), an approved agent for the immunomodulatory treatment of multiple sclerosis, acts primarily as an antigen for T lymphocytes. Recent studies, however,...
Distinct responses of monocytes to Toll-like receptor ligands and inflammatory cytokines (2004)
Farina, Cinthia, Theil, Diethilde, Semlinger, Barbara, Hohlfeld, Reinhard, Meinl, Edgar
In this study we compared the activation of monocytes by different bacterial products via Toll‐like receptors (TLR), and by different proinflammatory mediators. In response to TLR‐2,...
Pellkofer, Hannah, Schubart, Anna S., Höftberger, Romana, Schutze, Nadine, Pagany, Maria, Schüller, Martina, ...
Antibodies directed against onconeuronal antigens provide a specific diagnostic marker for paraneoplastic neurological syndromes (PNS) and suggest that these autoantigens are targeted during disease...
Distinct responses of monocytes to Toll-like receptor ligands and inflammatory cytokines (2004)
Farina, Cinthia, Theil, Diethilde, Semlinger, Barbara, Hohlfeld, Reinhard, Meinl, Edgar
In this study we compared the activation of monocytes by different bacterial products via Toll-like receptors (TLR), and by different proinflammatory mediators. In response to TLR-2, -4 and -5...
Multiple sclerosis: glatiramer acetate inhibits monocyte reactivity in vitro and in vivo (2004)
Weber, Martin S., Starck, Michaela, Wagenpfeil, Stefan, Meinl, Edgar, Hohlfeld, Reinhard, Farina, Cinthia
It is widely assumed that glatiramer acetate (GA), an approved agent for the immunomodulatory treatment of multiple sclerosis, acts primarily as an antigen for T lymphocytes. Recent studies, however,...
Pellkofer, Hannah, Schubart, Anna S., Höftberger, Romana, Schutze, Nadine, Pagany, Maria, Schüller, Martina, ...
Summary Antibodies directed against onconeuronal antigens provide a specific diagnostic marker for paraneoplastic neurological syndromes (PNS) and suggest that these autoantigens are targeted during...
Wiendl, Heinz, Mitsdoerffer, Meike, Hofmeister, Valeska, Wischhusen, Joerg, Weiss, Elisabeth H., Dichgans, Johannes, ...
HLA‐G is a non‐classical MHC class I molecule with highly limited tissue distribution which has been attributed chiefly immune‐regulatory functions. We previously have reported that...
Wiendl, Heinz, Mitsdoerffer, Meike, Schneider, Dagmar, Melms, Arthur, Lochmuller, Hanns, Hohlfeld, Reinhard, ...
Inducible co‐stimulator ligand (ICOSL), a member of the B7 family of co‐stimulatory molecules related to B7.1/2, regulates CD4 as well as CD8 T‐cell responses via interaction with its...
Ziemssen, Tjalf, Kümpfel, Tania, Klinkert, Wolfgang E. F., Neuhaus, Oliver, Hohlfeld, Reinhard
The clinical effects of glatiramer acetate (GA), an approved therapy for multiple sclerosis, are thought to be largely mediated by a T‐helper 1 (TH1) to T‐helper 2 (TH2) shift of...
Stadelmann, Christine, Kerschensteiner, Martin, Misgeld, Thomas, Brück, Wolfgang, Hohlfeld, Reinhard, Lassmann, Hans
Recent immunohistological and imaging studies emphasize the crucial role of axonal injury in determining the extent of permanent neurological deficits in patients with multiple sclerosis. We have...
Farina, Cinthia, Then Bergh, Florian, Albrecht, Holger, Meinl, Edgar, Yassouridis, Alexander, Neuhaus, Oliver, ...
Copolymer-1 (Copaxone or COP) inhibits experimental allergic encephalomyelitis and has beneficial effects in multiple sclerosis. There is presently no practical in vitro assay for monitoring the...
Derfuss, Tobias, Gürkov, Robert, Then Bergh, Florian, Goebels, Norbert, Hartmann, Matthias, Barz, Corinna, ...
Chronic intrathecal immunoglobulin (Ig) production is a hallmark of multiple sclerosis characterized by the presence of oligoclonal IgGs and, in addition, polyspecific recognition of different...
Goebels, Norbert, Hofstetter, Harald, Schmidt, Stephan, Brunner, Christoph, Wekerle, Hartmut, Hohlfeld, Reinhard
Autoantigen-specific T-lymphocytes are present in patients with autoimmune disease and in normal subjects. Little is currently known about the temporal variation (dynamics) of the immune repertoire...
Lindert, Ralf-Björn, Haase, Claus G., Brehm, Uschi, Linington, Christopher, Wekerle, Hartmut, Hohlfeld, Reinhard
We report a comparative study of the B- and T-cell responses to the extracellular immunoglobulin (Ig)-like domain of human myelin–oligodendrocyte glycoprotein (MOGIgd) in the blood of patients with...
Meinl, Edgar, Hart, Bert A. 't, Bontrop, Ronald E., Hoch, Rudolf M., Iglesias, Antonio, De Waal Malefyt, René, ...
This study addresses the capacity of peripheral blood mononuclear cells (PBMC) from rhesus monkeys (Macaca mulatta) to present myelin basic protein (MBP), a candidate auto-antigen for multiple...
Multiple sclerosis Immunomodulatory effects of human astrocytes on T cells (1994)
Meinl, Edgar, Aloisi, Francesca, Ertl, Birgit, Weber, Frank, Malefyt, Rene De Waal, Wekerle, Hartmut, ...
Using a human culture system, we have previously shown that interferon-γ-and tumour necrosis factor-α-stimulated astrocytes are capable of presenting antigens to T lymphocytes, but do not support...
Weber, Frank, Meinl, Edgar, Aloisi, Francesca, Nevinny-Stickel, Claudia, Albert, Ekkehard, Wekerle, Hartmut, ...
Highly purified astrocyte cultures from human embryonic brain were examined for their capacity to present antigen to human leukocyte antigen (HLA) class II compatible, cytotytic CD4+ T...
Effektormechanismen und Immunregulation der Myasthenia gravis. (1986)
Düsseldorf, Univ., Diss., 1986.
Derfuss, Tobias, Parikh, Khyati, Velhin, Sviataslau, Braun, Magdalena, Mathey, Emily, Krumbholz, Markus, ...
Gray matter pathology is increasingly recognized as an important feature of multiple sclerosis (MS), but the nature of the immune response that targets the gray matter is poorly understood. Starting...