Richard Desper

Comparative methods in R hackathon (2008)

Brian O'Meara, Michael Alfaro, Charles Bell, Benjamin Bolker, Marguerite Butler, Peter Cowan, ...

The R statistical analysis package has emerged as a popular platform for implementation of powerful comparative methods to understand the evolution of organismal traits and diversification. A...

Distance-based Phylogeny Reconstruction (Optimal Radius), **1999, Atteson; 2005, Elias, Lagergren (2008)

Desper, Richard, Gascuel, Olivier

Synonyms and Index Terms: phylogeny reconstruction, distance methods, performance analysis, robustness, safety radius approach, optimal radius

Distance-based Phylogeny Reconstruction (Optimal Radius), **1999, Atteson; 2005, Elias, Lagergren (2008)

Desper, Richard, Gascuel, Olivier

Synonyms and Index Terms: phylogeny reconstruction, distance methods, performance analysis, robustness, safety radius approach, optimal radius

From (2008)

Sung-ho Goh, Y T Lee, Natarajan V Bhanu, Margaret C Cam, Richard Desper, Brian M Martin, ...

doi:10.1182/blood-2005-03-0948 A newly discovered human alpha globin gene

Distance-based Phylogeny Reconstruction (Optimal Radius), **1999, Atteson; 2005, Elias, Lagergren (2008)

Desper, Richard, Gascuel, Olivier

Synonyms and Index Terms: phylogeny reconstruction, distance methods, performance analysis, robustness, safety radius approach, optimal radius

Distance-based Phylogeny Reconstruction (Optimal Radius), **1999, Atteson; 2005, Elias, Lagergren (2008)

Desper, Richard, Gascuel, Olivier

Synonyms and Index Terms: phylogeny reconstruction, distance methods, performance analysis, robustness, safety radius approach, optimal radius

Rutgers University (2007)

Richard Desper, Feng Jiang, Cancer Genetics Branch, Holger Moch, Christos H. Papadimitriou, Alejandro A. Schaffer

Comparative genome hybridization (CGH) is a laboratory method to measure gains and losses of chromosomal regions in tumor cells. It is believed that DNA gains and losses in tumor cells do not occur...

Theoretical Foundation of the Balanced Minimum Evolution Method of Phylogenetic Inference and Its Relationship to Weighted Least-Squares Tree Fitting (2004)

Desper, Richard, Gascuel, Olivier

Due to its speed, the distance approach remains the best hope for building phylogenies on very large sets of taxa. Recently (R. Desper and O. Gascuel, J. Comp. Biol. 9:687–705, 2002), we introduced...

Theoretical Foundation of the Balanced Minimum Evolution Method of Phylogenetic Inference and Its Relationship to Weighted Least-Squares Tree Fitting (2003)

Desper, Richard, Gascuel, Olivier

Due to its speed, the distance approach remains the best hope for building phylogenies on very large sets of taxa. Recently (Desper and Gascuel 2002), we introduced a new "balanced" minimum evolution...

Theoretical Foundation of the Balanced Minimum Evolution Method of Phylogenetic Inference and Its Relationship to Weighted Least-Squares Tree Fitting (2003)

Desper, Richard, Gascuel, Olivier

Due to its speed, the distance approach remains the best hope for building phylogenies on very large sets of taxa. Recently (Desper and Gascuel 2002), we introduced a new "balanced" minimum evolution...

Inferring Tree Models for Oncogenesis from Comparative Genome Hybridization Data (2002)

Richard Desper, Feng Jiang, Olli-P. Kallioniemi, Cancer Genetics Branch, Holger Moch, Christos H. Papadimitriou, ...

Comparative genome hybridization (CGH) is a laboratory method to measure gains and losses of chromosomal regions in tumor cells. It is believed that DNA gains and losses in tumor cells do not occur...

Fast and Accurate Phylogeny Reconstruction Algorithms Based on the Minimum-Evolution Principle (2002)

Richard Desper, Olivier Gascuel

The Minimum Evolution (ME) approach to phylogeny estimation has been shown to be statistically consistent when it is used in conjunction with ordinary least-squares (OLS) fitting of a metric to a...

Fast and Accurate Phylogeny Reconstruction Algorithms Based on the Minimum-Evolution Principle (2002)

Richard Desper, Olivier Gascuel

This paper investigates the standard ordinary least-squares version [24] and the balanced version [20] of the minimum evolution principle. For the standard version, we provide a greedy construction...

Fast and Accurate Phylogeny Reconstruction Algorithms Based on the Minimum-Evolution Principle (2002)

Richard Desper, Olivier Gascuel

The Minimum Evolution (ME) approach to phylogeny estimation has been shown to be statistically consistent when it is used in conjunction with ordinary least-squares (OLS) fitting of a metric to a...

Construction of evolutionary tree models for renal cell carcinoma from comparative genomic hybridization data (2000)

Feng Jiang, Richard Desper, Christos H. Papadimitriou, Ro A. Schäffer, Olli-p. Kallioniemi, Jan Richter, ...

Renal cell carcinoma is characterized by an accumulation of complex chromosomal alterations during tumor progression. Chromosome 3p deletions are known to occur early in the carcinogenesis, but the...

Tight Bounds on the Learnability of Evolution (1999)

Andris Ambainis, Richard Desper, Martin Farach-colton, Sampath Kannan

Evolution is often modeled as a stochastic process which modifies DNA. One of the most popular such processes are the Cavender-Farris (CF) trees, which are represented as edge weighted trees. The...

The Set-Maxima Problem: an Overview (1998)

Richard Desper

Sorting problems have long been one of the foundations of theoretical computer science. Sorting problems attempt to learn properties of an unknown total order of a known set. We test the order by...

Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus

Kainu, Tommi, Juo, Suh-Hang Hank, Desper, Richard, Schäffer, Alejandro A., Gillanders, Elizabeth, Rozenblum, Ester, ...

A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for breast cancer by using...

A comprehensive continuous-time model for the appearance of CGH signal due to chromosomal missegregations during mitosis

Desper, Richard, Difilippantonio, Michael J., Ried, Thomas, Schäffer, Alejandro A.

Aneuploidy, the gain or loss of large regions of the genome, is a common feature in cancer cells. Irregularities in chromosomal copy number caused by missegregations of chromosomes during mitosis can...

Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus

Kainu, Tommi, Juo, Suh-Hang Hank, Desper, Richard, Schäffer, Alejandro A., Gillanders, Elizabeth, Rozenblum, Ester, ...

A significant proportion of familial breast cancers cannot be explained by mutations in the BRCA1 or BRCA2 genes. We applied a strategy to identify predisposition loci for breast cancer by using...

Evaluation of the Clonal Relationship between Primary and Metastatic Renal Cell Carcinoma by Comparative Genomic Hybridization

Bissig, Heidi, Richter, Jan, Desper, Richard, Meier, Verena, Schraml, Peter, Schäffer, Alejandro A., ...

The outcome of patients with renal cell carcinoma is limited by the development of metastasis after nephrectomy. To evaluate the genetic basis underlying metastatic progression of human renal cell...

A newly discovered human α-globin gene

Goh, Sung-Ho, Lee, Y. Terry, Bhanu, Natarajan V., Cam, Margaret C., Desper, Richard, Martin, Brian M., ...

A previously undefined transcript with significant homology to the pseudo-α2 region of the α-globin locus on human chromosome 16 was detected as part of an effort to better define the...