Robert N. Cole

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, Albena T., Holtzclaw, W. David, Cole, Robert N., Itoh, Ken, Wakabayashi, Nobunao, Katoh, Yasutake, ...

Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently with thiols...

The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency

Baumgartner, Matthias R., Almashanu, Shlomo, Suormala, Terttu, Obie, Cassandra, Cole, Robert N., Packman, Seymour, ...

Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase (MCC) deficiency is an autosomal recessive disorder of leucine catabolism that appears to be the most frequent organic aciduria detected in...

THE OPPORTUNISTIC PATHOGEN TOXOPLASMA GONDII DEPLOYS A DIVERSE LEGION OF INVASION AND SURVIVAL PROTEINS

Zhou, Xing W., Kafsack, Björn F. C., Cole, Robert N., Beckett, Phil, Shen, Rong F., Carruthers, Vern B.

Host cell invasion is an essential step during infection by Toxoplasma gondii, an intracellular protozoan that causes the severe opportunistic disease toxoplasmosis in humans. Recent evidence...

Detection of Norovirus Capsid Protein in Authentic Standards and in Stool Extracts by Matrix-Assisted Laser Desorption Ionization and Nanospray Mass Spectrometry

Colquhoun, David R., Schwab, Kellogg J., Cole, Robert N., Halden, Rolf U.

Mass spectrometry (MS) represents a rapid technique for the identification of microbial monocultures, and its adaptation to the detection of pathogens in real-world samples is a public health and...

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, Albena T., Holtzclaw, W. David, Cole, Robert N., Itoh, Ken, Wakabayashi, Nobunao, Katoh, Yasutake, ...

Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants. All inducers react covalently with thiols...

The molecular basis of human 3-methylcrotonyl-CoA carboxylase deficiency

Baumgartner, Matthias R., Almashanu, Shlomo, Suormala, Terttu, Obie, Cassandra, Cole, Robert N., Packman, Seymour, ...

Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase (MCC) deficiency is an autosomal recessive disorder of leucine catabolism that appears to be the most frequent organic aciduria detected in...

Detection of Norovirus Capsid Protein in Authentic Standards and in Stool Extracts by Matrix-Assisted Laser Desorption Ionization and Nanospray Mass Spectrometry

Colquhoun, David R., Schwab, Kellogg J., Cole, Robert N., Halden, Rolf U.

Mass spectrometry (MS) represents a rapid technique for the identification of microbial monocultures, and its adaptation to the detection of pathogens in real-world samples is a public health and...

iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease

Martin, Bronwen, Brenneman, Randall, Becker, Kevin G., Gucek, Marjan, Cole, Robert N., Maudsley, Stuart

Alzheimer's disease (AD) is characterized by progressive cognitive impairment associated with accumulation of amyloid β-peptide, synaptic degeneration and the death of neurons in the hippocampus,...

Barrier-to-Autointegration Factor Proteome Reveals Chromatin-Regulatory Partners

Montes De Oca, Rocío, Shoemaker, Christopher J., Gucek, Marjan, Cole, Robert N., Wilson, Katherine L.

Nuclear lamin filaments and associated proteins form a nucleoskeletal (“lamina”) network required for transcription, replication, chromatin organization and epigenetic regulation in metazoans....