Evolution of raltegravir resistance during therapy (2009)
Sichtig, Nadine, Sierra, Saleta, Kaiser, Rolf, Däumer, Martin, Reuter, Stefan, Schülter, Eugen, ...
Objectives We investigated the prevalence of raltegravir resistance-associated mutations at baseline and their evolution during raltegravir therapy in patients infected with different HIV-1 subtypes....
ABSTRACT Learning Multiple Evolutionary Pathways from Cross-sectional Data (2008)
Niko Beerenwinkel, Jörg Rahnenführer, Martin Däumer, Daniel Hoffmann, Rolf Kaiser, Joachim Selbig, ...
We introduce a mixture model of trees to describe evolutionary processes that are characterized by the accumulation of permanent genetic changes. The basic building block of the model is a directed...
The EuResist approach for predicting response to anti HIV-1 therapy (2008)
Altmann, Andre, Rosen-Zvi, Michal, Prosperi, Mattia, Aharoni, Ehud, Neuvirth, Hani, Schülter, Eugen, ...
Obermeier, Martin, Berg, Thomas, Sichtig, Nadine, Braun, Patrick, Däumer, Martin, Walter, Hauke, ...
Obermeier, Martin, Sichtig, Nadine, Braun, Patrick, Däumer, Martin, Walter, Hauke, Noah, Christian, ...
Selecting anti-HIV therapies based on a variety of genomic and clinical factors (2008)
Rosen-Zvi, Michal, Altmann, Andre, Prosperi, Mattia, Aharoni, Ehud, Neuvirth, Hani, Sönnerborg, Anders, ...
Rosen-Zvi, Michal, Schülter, Eugen, Altmann, Andre, Sierra-Aragon, Saleta, Zazzi, Maurizio, Sönnerborg, Anders, ...
Genotypic Analysis of HIV Co-Receptor Usage (2008)
Sierra, Saleta, Kaiser, Rolf, Thielen, Alexander, Sander, Oliver, Lengauer, Thomas
Thielen, Alexander, Harrigan, P Richard, Low, Andrew J., Moores, A, Altmann, Andre, Bozek, Kasia, ...
Relevance of HIV gag cleavage site mutations in failures of protease inhibitor therapies (2008)
Verheyen, Jens, Altmann, Andre, Knops, Elena, Schülter, Eugen, Sichtig, Nadine, Reuter, Stefan, ...
Comparison of Classifier Fusion Methods for Predicting Response to Anti HIV-1 Therapy (2008)
Altmann, Andre, Rosen-Zvi, Michal, Prosperi, Mattia, Aharoni, Ehud, Neuvirth, Hani, Sönnerborg, Anders, ...
Selecting anti-HIV therapies based on a variety of genomic and clinical factors (2008)
Rosen-Zvi, Michal, Altmann, Andre, Prosperi, Mattia, Aharoni, Ehud, Neuvirth, Hani, Sönnerborg, Anders, ...
Motivation: Optimizing HIV therapies is crucial since the virus rapidly develops mutations to evade drug pressure. Recent studies have shown that genotypic information might not be sufficient for the...
Bioinformatics prediction of HIV coreceptor usage (2007)
Thomas Lengauer, Oliver Sander, Saleta Sierra, Alexander Thielen, Rolf Kaiser
Trends of prevalence of primary HIV drug resistance in Germany (2007)
Sagir, Abdurrahman, Oette, Mark, Kaiser, Rolf, Däumer, Martin, Fätkenheuer, Gerd, Rockstroh, Jürgen Kurt, ...
Background Primary HIV drug resistance (PDR) is associated with poor treatment outcome of first-line highly active antiretroviral therapy (HAART). The aim of the study was to observe the trend of...
Bioinformatics prediction of HIV coreceptor usage (2007)
Lengauer, Thomas, Sander, Oliver, Sierra, Saleta, Thielen, Alexander, Kaiser, Rolf
Ahlenstiel, Golo, Roomp, Kirsten, Däumer, Martin, Nattermann, Jacob, Vogel, Martin, Rockstroh, Jürgen K., ...
Predicting HIV coreceptor usage on the basis of genetic and clinical covariates (2007)
Sing, Tobias, Low, Andrew J., Beerenwinkel, Niko, Sander, Oliver, Cheung, Peter K., Domingues, Francisco S., ...
Genotypic coreceptor analysis (2007)
Sierra, Saleta, Kaiser, Rolf, Thielen, Alexander, Lengauer, Thomas
HIV infects target cells by binding of its envelope gp120 protein to CD4 and a coreceptor on the cell surface. In vivo, the different HIV-strains use either CCR5 or CXCR4 as coreceptor. CCR5-using...
Altmann, Andre, Beerenwinkel, Niko, Sing, Tobias, Savenkov, Igor, Däumer, Martin, Kaiser, Rolf, ...
Background: The outcome of antiretroviral combination therapy depends on many factors involving host, virus, and drugs. We investigate prediction of treatment response from the applied drug...
Stable coreceptor usage of HIV in patients with ongoing treatment failure on {HAART} (2006)
Lehmann, Clara, Däumer, Martin, Bousaad, Ibrahim, Sing, Tobias, Beerenwinkel, Niko, Lengauer, Thomas, ...
Background Disease progression in HIV infection has been associated with switch of viral coreceptor usage from CCR5 to CXCR4. Objectives To investigate the relationship between HIV-coreceptor tropism...
Arevir: A Secure Platform for Designing Personalized Antiretroviral Therapies Against HIV (2006)
Roomp, Kirsten, Beerenwinkel, Niko, Sing, Tobias, Schülter, Eugen, Büch, Joachim, Sierra-Aragon, Saleta, ...
Despite the availability of antiretroviral combination therapies, success in drug treatment of HIV-infected patients is limited. One reason for therapy failure is the development of drug-resistant...
Beerenwinkel, Niko, Sing, Tobias, Lengauer, Thomas, Rahnenführer, Jörg, Roomp, Kirsten, Savenkov, Igor, ...
Mtreemix: a software package for learning and using mixture models of mutagenetic trees (2005)
Beerenwinkel, Niko, Rahnenführer, Jörg, Kaiser, Rolf, Hoffmann, Daniel, Selbig, Joachim, Lengauer, Thomas
Learning multiple evolutionary pathways from cross-sectional data (2005)
Beerenwinkel, Niko, Rahnenführer, Jörg, Däumer, Martin, Hoffmann, Daniel, Kaiser, Rolf, Selbig, Joachim, ...
Estimating HIV evolutionary pathways and the genetic barrier to drug resistance (2005)
Beerenwinkel, Niko, Däumer, Martin, Sing, Tobias, Rahnenführer, Jörg, Lengauer, Thomas, Selbig, Joachim, ...
Stable coreceptor usage of HIV-1 in patients with ongoing treatment failure on HAART (2005)
Kaiser, Rolf, Boussaad, Ibo, Lehmann, C., Däumer, Martin, Sing, Tobias, Schmeisser, N., ...
Mtreemix: a software package for learning and using mixture models of mutagenetic trees (2005)
Beerenwinkel, Niko, Rahnenführer, Jörg, Kaiser, Rolf, Hoffmann, Daniel, Selbig, Joachim, Lengauer, Thomas
Summary: Mixture models of mutagenetic trees constitute a class of probabilistic models for describing evolutionary processes that are characterized by the accumulation of permanent genetic changes....
Mtreemix: a software package for learning and using mixture models of mutagenetic trees (2005)
Beerenwinke, Niko, Rahnenführer, Jörg, Kaiser, Rolf, Hoffmann, Daniel, Selbig, Joachim, Lengauer, Thomas
Summary: Mixture models of mutagenetic trees constitute a class of probabilistic models for describing evolutionary processes that are characterized by the accumulation of permanent genetic changes....
Mtreemix: a software package for learning and using mixture models of mutagenetic trees (2005)
Beerenwinkel, Niko, Rahnenführer, Jörg, Kaiser, Rolf, Hoffmann, Daniel, Selbig, Joachim, Lengauer, Thomas
Summary: Mixture models of mutagenetic trees constitute a class of probabilistic models for describing evolutionary processes that are characterized by the accumulation of permanent genetic changes....
Beerenwinkel, Niko, Sing, Tobias, Lengauer, Thomas, Rahnenführer, Jörg, Roomp, Kirsten, Savenkov, Igor, ...
Motivation: The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective...
Beerenwinkel, Niko, Sing, Tobias, Lengauer, Thomas, Rahnenführer, Jörg, Roomp, Kirsten, Savenkov, Igor, ...
Summary: The development of drug resistance is a major obstacle to successful treatment of HIV infection. The extraordinary replication dynamics of HIV facilitates its escape from selective pressure...
Learning multiple evolutionary pathways from cross-sectional data (2004)
Beerenwinkel,Niko, Rahnenführer,Jörg, Däumer,Martin, Hoffmann,Daniel, Kaiser,Rolf, Selbig,Joachim, ...
Learning multiple evolutionary pathways from cross-sectional data (2004)
Beerenwinkel, Niko, Rahnenführer, Jörg, Däumer, Martin, Hoffmann, Daniel, Kaiser, Rolf, Selbig, Joachim, ...
Methoden zur Interpretation genotypischer Resistenztests (2004)
Beerenwinkel, Niko, Oette, Mark, Kaiser, Rolf, Häussinger, Dieter
Das Arevir-Projekt : neue Wege zur Optimierung von Anti-HIV-Therapien (2004)
Beerenwinkel, Niko, Oette, Mark, Kaiser, Rolf, Häussinger, Dieter
Das Arevir-Projekt : neue Wege zur Optimierung von Anti-HIV-Therapien (2004)
Beerenwinkel, Niko, Oette, Mark, Kaiser, Rolf, Häussinger, Dieter
Methoden zur Interpretation genotypischer Resistenztests (2004)
Beerenwinkel, Niko, Oette, Mark, Kaiser, Rolf, Häussinger, Dieter
Learning multiple evolutionary pathways from cross-sectional data (2004)
Beerenwinkel, Niko, Rahnenführer, Jörg, Däumer, Martin, Hoffmann, Daniel, Kaiser, Rolf, Selbig, Joachim, ...
Tenofovir resistance and resensitization (2003)
Wolf, Katharina ; JFA; CORA, Walter, Hauke, Beerenwinkel, Niko, Keulen, Wilco, Kaiser, Rolf, Hoffmann, Daniel, ...
Human immunodeficiency viruses in 321 samples from tenofovir-naïve patients were retrospectively evaluated for resistance to this nucleotide analogue. All virus strains with insertions between amino...
Bioinformatikmethoden für die Optimierung antiviraler Kombinationstherapien (2003)
Beerenwinkel,Niko, Däumer,Martin, Hoffmann,Daniel, Kaiser,Rolf, Selbig,Joachim, Lengauer,Thomas
Estimating effective drug combinations against drug-resistant mutants from genotypes (2003)
Beerenwinkel,Niko, Däumer,Martin, Kaiser,Rolf, Walter,Hauke, Korn,Klaus, Hoffmann,Daniel, ...
Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes (2003)
Beerenwinkel,Niko, Däumer,Martin, Oette,Mark, Korn,Klaus, Hoffmann,Daniel, Kaiser,Rolf, ...
Methods for optimizing antiviral combination therapies (2003)
Beerenwinkel,Niko, Lengauer,Thomas, Däumer,Martin, Kaiser,Rolf, Walter,Hauke, Korn,Klaus, ...
Tree models for the evolution of drug resistance (2003)
Beerenwinkel,Niko, Kaiser,Rolf, Rahnenführer,Jörg, Däumer,Martin, Hoffmann,Daniel, Selbig,Joachim, ...
Tenofovir resistance and resensitization (2003)
Wolf,Katharina, Walter,Hauke, Beerenwinkel,Niko, Keulen,Wilco, Kaiser,Rolf, Hoffmann,Daniel, ...
Bioinformatikmethoden für die Optimierung antiviraler Kombinationstherapien (2003)
Beerenwinkel, Niko, Däumer, Martin, Hoffmann, Daniel, Kaiser, Rolf, Selbig, Joachim, Lengauer, Thomas
Estimating effective drug combinations against drug-resistant mutants from genotypes (2003)
Beerenwinkel, Niko, Däumer, Martin, Kaiser, Rolf, Walter, Hauke, Korn, Klaus, Hoffmann, Daniel, ...
Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes (2003)
Beerenwinkel, Niko, Däumer, Martin, Oette, Mark, Korn, Klaus, Hoffmann, Daniel, Kaiser, Rolf, ...
Methods for optimizing antiviral combination therapies (2003)
Beerenwinkel, Niko, Lengauer, Thomas, Däumer, Martin, Kaiser, Rolf, Walter, Hauke, Korn, Klaus, ...
Tree models for the evolution of drug resistance (2003)
Beerenwinkel, Niko, Kaiser, Rolf, Rahnenführer, Jörg, Däumer, Martin, Hoffmann, Daniel, Selbig, Joachim, ...
Tenofovir resistance and resensitization (2003)
Wolf, Katharina, Walter, Hauke, Beerenwinkel, Niko, Keulen, Wilco, Kaiser, Rolf, Hoffmann, Daniel, ...
Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes (2003)
Beerenwinkel, Niko, Däumer, Martin, Oette, Mark, Korn, Klaus, Hoffmann, Daniel, Kaiser, Rolf, ...
Therapeutic success of anti-HIV therapies is limited by the development of drug resistant viruses. These genetic variants display complex mutational patterns in their pol gene, which codes for...
Methods for optimizing antiviral combination therapies (2003)
Beerenwinkel, Niko, Lengauer, Thomas, Däumer, Martin, Kaiser, Rolf, Walter, Hauke, Korn, Klaus, ...
Motivation: Despite some progress with antiretroviral combination therapies, therapeutic success in the management of HIV-infected patients is limited. The evolution of drug-resistant genetic...
Geno2pheno is predictive of short-term virological response (2002)
Beerenwinkel,Niko, Lengauer,Thomas, Däumer,Martin, Sierra,S., Schmidt,Barbara, Walter,Hauke, ...
Quantitative phenotype prediction by support vector machines (2002)
Beerenwinkel,Niko, Lengauer,Thomas, Schmidt,Barbara, Walter,Hauke, Kaiser,Rolf, Hoffmann,Daniel, ...
Beerenwinkel,Niko, Schmidt,Barbara, Walter,Hauke, Kaiser,Rolf, Lengauer,Thomas, Hoffmann,Daniel, ...
Geno2pheno is predictive of short-term virological response (2002)
Beerenwinkel, Niko, Lengauer, Thomas, Däumer, Martin, Sierra, S., Schmidt, Barbara, Walter, Hauke, ...
Quantitative phenotype prediction by support vector machines (2002)
Beerenwinkel, Niko, Lengauer, Thomas, Schmidt, Barbara, Walter, Hauke, Kaiser, Rolf, Hoffmann, Daniel, ...
Beerenwinkel, Niko, Schmidt, Barbara, Walter, Hauke, Kaiser, Rolf, Lengauer, Thomas, Hoffmann, Daniel, ...
Conditionally averaged turbulent structure in a stratified flow wind tunnel (1998)
Michioku, Kohji, Plate, Erich, Rau, Matthias, Kaiser, Rolf, Thater, Johannes
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Windkanalstudie konvektiver Grenzschichtströmungen mit angehobener Temperaturinversion / (1996)
Zugl.: Karlsruhe, Univ., Diss., 1996.
Erscheinungsjahr auf der Haupttitels.: 1993
Veränderungen im Elektrokardiogramm nach Exstirpation des Ganglion stellatum bei Causalgie. (1944)
Tübingen, Med. F., Diss., 1944 (Nicht f. d. Austausch).
Beerenwinkel, Niko, Schmidt, Barbara, Walter, Hauke, Kaiser, Rolf, Lengauer, Thomas, Hoffmann, Daniel, ...
Drug resistance testing has been shown to be beneficial for clinical management of HIV type 1 infected patients. Whereas phenotypic assays directly measure drug resistance, the commonly used...
Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes
Beerenwinkel, Niko, Däumer, Martin, Oette, Mark, Korn, Klaus, Hoffmann, Daniel, Kaiser, Rolf, ...
Therapeutic success of anti-HIV therapies is limited by the development of drug resistant viruses. These genetic variants display complex mutational patterns in their pol gene, which codes for...
Tenofovir Resistance and Resensitization
Wolf, Katharina, Walter, Hauke, Beerenwinkel, Niko, Keulen, Wilco, Kaiser, Rolf, Hoffmann, Daniel, ...
Human immunodeficiency viruses in 321 samples from tenofovir-naïve patients were retrospectively evaluated for resistance to this nucleotide analogue. All virus strains with insertions between amino...
Beerenwinkel, Niko, Schmidt, Barbara, Walter, Hauke, Kaiser, Rolf, Lengauer, Thomas, Hoffmann, Daniel, ...
Drug resistance testing has been shown to be beneficial for clinical management of HIV type 1 infected patients. Whereas phenotypic assays directly measure drug resistance, the commonly used...
Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes
Beerenwinkel, Niko, Däumer, Martin, Oette, Mark, Korn, Klaus, Hoffmann, Daniel, Kaiser, Rolf, ...
Therapeutic success of anti-HIV therapies is limited by the development of drug resistant viruses. These genetic variants display complex mutational patterns in their pol gene, which codes for...
Tenofovir Resistance and Resensitization
Wolf, Katharina, Walter, Hauke, Beerenwinkel, Niko, Keulen, Wilco, Kaiser, Rolf, Hoffmann, Daniel, ...
Human immunodeficiency viruses in 321 samples from tenofovir-naïve patients were retrospectively evaluated for resistance to this nucleotide analogue. All virus strains with insertions between amino...
Ahlenstiel, Golo, Roomp, Kirsten, Däumer, Martin, Nattermann, Jacob, Vogel, Martin, Rockstroh, Jürgen K., ...
The objective of this study was a comprehensive analysis of the immune-driven evolution of viruses of human immunodeficiency virus type 1 (HIV-1) clade B in a large patient cohort treated at a single...
Comparison of Classifier Fusion Methods for Predicting Response to Anti HIV-1 Therapy
Altmann, André, Rosen-Zvi, Michal, Prosperi, Mattia, Aharoni, Ehud, Neuvirth, Hani, Schülter, Eugen, ...
Paar, Christian, Palmetshofer, Christina, Flieger, Karin, Geit, Maria, Kaiser, Rolf, Stekel, Herbert, ...
A sequencing assay for detection of mutations conferring resistance to human immunodeficiency virus type 1 (HIV-1) integrase inhibitors raltegravir and elvitegravir was developed using the automated...
Selecting anti-HIV therapies based on a variety of genomic and clinical factors
Rosen-Zvi, Michal, Altmann, Andre, Prosperi, Mattia, Aharoni, Ehud, Neuvirth, Hani, Sönnerborg, Anders, ...
Motivation: Optimizing HIV therapies is crucial since the virus rapidly develops mutations to evade drug pressure. Recent studies have shown that genotypic information might not be sufficient for the...
Bozek, Katarzyna, Thielen, Alexander, Sierra, Saleta, Kaiser, Rolf, Lengauer, Thomas
The V3 loop of human immunodeficiency virus type 1 (HIV-1) is critical for coreceptor binding and is the main determinant of which of the cellular coreceptors, CCR5 or CXCR4, the virus uses for cell...