Dupuis, Josée, Langenberg, Claudia, Prokopenko, Inga, Saxena, Richa, Soranzo, Nicole, Jackson, Anne U, ...
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Josée Dupuis, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, Anne U Jackson, ...
Bressler, Jan, Fornage, Myriam, Hanis, Craig L, Kao, Wen, Lewis, Cora E, McPherson, Ruth, ...
Abstract Background In a genome-wide association study performed in the Framingham Offspring Cohort, individuals homozygous for the rs7566605 C allele located upstream of insulin-induced gene 2 (...
Hua Ling, Dawn M. Waterworth, Heide A. Stirnadel, Toni I. Pollin, Philip J. Barter, Y. Antero Kesäniemi, ...
Calton, Melissa A., Ersoy, Baran A., Zhang, Sumei, Kane, John P., Malloy, Mary J., Pullinger, Clive R., ...
Functionally significant heterozygous mutations in the Melanocortin-4 receptor (MC4R) have been implicated in 2.5% of early onset obesity cases in European cohorts. The role of mutations in this gene...
Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, ...
Tumor suppressor candidate 5 (TUSC5) is a gene expressed abundantly in white adipose tissue (WAT), brown adipose tissue (BAT), and peripheral afferent neurons. Strong adipocyte expression and...
Medical Sequencing at the Extremes of Human Body Mass REPORT (2008)
Nadav Ahituv, Nihan Kavaslar, Wendy Schackwitz, Anna Ustaszewska, Joel Martin, Sybil Hébert, ...
Body weight is a quantitative trait with significant heritability in humans. To identify potential genetic contributors to this phenotype, we resequenced the coding exons and splice junctions of 58...
BMC Medical Genetics BioMed Central (2008)
Jan Bressler, Myriam Fornage, Craig L Hanis, Wen Hong, Linda Kao, Cora E Lewis, ...
Research article The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
Kristi B. Adamo, Robert Dent, Carl D. Langefeld, Miranda Cox, Kathryn Williams, Kevin M. Carrick, ...
A common allele on chromosome 9 associated with coronary heart disease (2007)
McPherson, Ruth, Pertsemlidis, Alexander, Kavaslar, Nihan, Stewart, Alexandre, Roberts, Robert, Cox, David R., ...
Medical Sequencing at the extremes of Human Body Mass (2006)
Ahituv, Nadav, Kavaslar, Nihan, Schackwitz, Wendy, Ustaszewski, Anna, Martin, Joes, Hebert, Sybil, ...
Body weight is a quantitative trait with significant heritability in humans. To identify potential genetic contributors to this phenotype, we resequenced the coding exons and splice junctions of 58...
A PYY Q62P variant linked to human obesity (2006)
Ahituv, Nadav, Kavaslar, Nihan, Schackwitz, Wendy, Ustaszewska, Anna, Collier, John Michael, Hébert, Sybil, ...
Peptide YY (PYY) has been implicated in the control of food intake through functional studies in rodents and humans. To investigate whether genetic alterations within this gene result in abnormal...
Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity (2005)
Michael M. Swarbrick, Björn Waldenmaier, Len A. Pennacchio, Denise L. Lind, Martha M. Cavazos, Frank Geller, ...
A large genetic study involving multiple populations is not able to replicate previous findings linking variation in the GAD2 gene to susceptibility to obesity.
Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity (2005)
Michael M. Swarbrick, Björn Waldenmaier, Len A. Pennacchio, Denise L. Lind, Martha M. Cavazos, Frank Geller, ...
The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these...
A PYY Q62P variant linked to human obesity (2005)
Ahituv, Nadav, Kavaslar, Nihan, Schackwitz, Wendy, Ustaszewska, Anna, Collier, John Michael, Hebert, Sybil, ...
Members of the pancreatic polypeptide family and their receptors have been implicated in the control of food intake in rodents and humans. To investigate whether nucleotide changes in these candidate...
A PYY Q62P variant linked to human obesity (2005)
Ahituv, Nadav, Kavaslar, Nihan, Schackwitz, Wendy, Ustaszewska, Anna, Collier, John Michael, Hébert, Sybil, ...
Peptide YY (PYY) has been implicated in the control of food intake through functional studies in rodents and humans. To investigate whether genetic alterations within this gene result in abnormal...
Lack of MEF2A mutations in coronary artery disease (2004)
Weng, Li, Kavaslar, Nihan, Ustaszewska, Anna, Doelle, Heather, Schackwitz, Wendy, Hebert, Sybil, ...
Mutations in MEF2A have been implicated in an autosomal dominant form of coronary artery disease (adCAD1). In this study we sought to determine whether severe mutations in MEF2A might also explain...
Lack of Support for the Association Between GAD2 Polymorphisms and Severe Human Obesity (2004)
Swarbrick, Michael M., Waldenmaier, Bjorn, Pennacchio, Len A., Lind, Denise L., Cavazos, Martha M., Geller, Frank, ...
Demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention and treatment of these...
Lipid screening to prevent coronary artery disease: a quantitative evaluation of evolving guidelines
Grover, Steven A., Dorais, Marc, Paradis, Gilles, Fodor, J. George, Frohlich, Jiri J., McPherson, Ruth, ...
The analysis by Manuel and colleagues creates controversy with headlines, not data
Genest, Jacques, McPherson, Ruth, Frohlich, Jiri, Fodor, George
Lack of MEF2A mutations in coronary artery disease
Weng, Li, Kavaslar, Nihan, Ustaszewska, Anna, Doelle, Heather, Schackwitz, Wendy, Hébert, Sybil, ...
Mutations in MEF2A have been implicated in an autosomal dominant form of coronary artery disease (adCAD1). In this study we sought to determine whether severe mutations in MEF2A might also explain...
Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity
Swarbrick, Michael M, Waldenmaier, Björn, Pennacchio, Len A, Lind, Denise L, Cavazos, Martha M, Geller, Frank, ...
The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these...
Lipid screening to prevent coronary artery disease: a quantitative evaluation of evolving guidelines
Grover, Steven A., Dorais, Marc, Paradis, Gilles, Fodor, J. George, Frohlich, Jiri J., McPherson, Ruth, ...
The analysis by Manuel and colleagues creates controversy with headlines, not data
Genest, Jacques, McPherson, Ruth, Frohlich, Jiri, Fodor, George
Lack of MEF2A mutations in coronary artery disease
Weng, Li, Kavaslar, Nihan, Ustaszewska, Anna, Doelle, Heather, Schackwitz, Wendy, Hébert, Sybil, ...
Mutations in MEF2A have been implicated in an autosomal dominant form of coronary artery disease (adCAD1). In this study we sought to determine whether severe mutations in MEF2A might also explain...
Lack of Support for the Association between GAD2 Polymorphisms and Severe Human Obesity
Swarbrick, Michael M, Waldenmaier, Björn, Pennacchio, Len A, Lind, Denise L, Cavazos, Martha M, Geller, Frank, ...
The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these...
Costford, Sheila R., Kavaslar, Nihan, Ahituv, Nadav, Chaudhry, Shehla N., Schackwitz, Wendy S., Dent, Robert, ...
Medical Sequencing at the Extremes of Human Body Mass
Ahituv, Nadav, Kavaslar, Nihan, Schackwitz, Wendy, Ustaszewska, Anna, Martin, Joel, Hébert, Sybil, ...
Body weight is a quantitative trait with significant heritability in humans. To identify potential genetic contributors to this phenotype, we resequenced the coding exons and splice junctions of 58...
LDL-cholesterol concentrations: a genome-wide association study
Sandhu, Manjinder S, Waterworth, Dawn M, Debenham, Sally L, Wheeler, Eleanor, Papadakis, Konstantinos, Zhao, Jing Hua, ...
McPherson, Ruth, Frohlich, Jiri, Fodor, George, Genest, Jacques
Since the last publication of the recommendations for the management and treatment of dyslipidemia, new clinical trial data have emerged that support a more vigorous approach to lipid lowering in...
Moride, Yola, Hegele, Robert A, Langer, Anatoly, McPherson, Ruth, Miller, David B, Rinfret, Stéphane
Peer-reviewed, evidence-based recommendations for statin use in primary prevention of cardiovascular events are limited. A narrative review of published randomized controlled trials and meta-analyses...
Bressler, Jan, Fornage, Myriam, Hanis, Craig L, Kao, Wen Hong Linda, Lewis, Cora E, McPherson, Ruth, ...
Identifying genes for coronary artery disease: An idea whose time has come
Roberts, Robert, Stewart, Alexandre FR, Wells, George A, Williams, Kathryn A, Kavaslar, Nihan, McPherson, Ruth
Genetic contributors to obesity
Genetic and environmental factors interact to regulate body weight. Overall, the heritability of obesity is estimated at 40% to 70%. More than 244 genes have been found to strongly affect adiposity...
A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
Richards, J. Brent, Waterworth, Dawn, O'Rahilly, Stephen, Hivert, Marie-France, Loos, Ruth J. F., Perry, John R. B., ...
The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide...
Knotts, Trina A., Lee, Hyun Woo, Kim, Jae Bum, Oort, Pieter J., McPherson, Ruth, Dent, Robert, ...
Tumor suppressor candidate 5 (TUSC5) is a gene expressed abundantly in white adipose tissue (WAT), brown adipose tissue (BAT), and peripheral afferent neurons. Strong adipocyte expression and...
Calton, Melissa A., Ersoy, Baran A., Zhang, Sumei, Kane, John P., Malloy, Mary J., Pullinger, Clive R., ...
Functionally significant heterozygous mutations in the Melanocortin-4 receptor (MC4R) have been implicated in 2.5% of early onset obesity cases in European cohorts. The role of mutations in this gene...