Hauser, N.C., Dukalska, M., Fellenberg, K., Rupp, S.
Transcript profiling by microarray analysis offers a great opportunity to reveal unknown effects in a comprehensive context. To be able to interpret the data, some basic issues in experimental...
The cell wall of Candida glabrata: A comprehensive gene deletion study (2009)
Stevens, R., Hiller, E., Dorflinger, M., Gabaldon, T., Marcet-Houben, M., Schwarzmüller, T., ...
Identification of novel antifungal compounds using a HTS activity-selectivity assay (2009)
Keller, P., Burger-Kentischer, A., Finkelmeier, D., Kleymann, G., Wiesmüller, K.H., Lemuth, K., ...
Bareiss, P.M., Metzger, M., Sohn, K., Rupp, S., Frick, J.S., Autenrieth, I.B., ...
Together with animal experiments, organotypical cell cultures are important models for analyzing cellular interactions of the mucosal epithelium and pathogenic mechanisms in the gastrointestinal...
Efficient large scale image stitching for virtual microscopy (2008)
Steckhan, D., Bergen, T., Wittenberg, T., Rupp, S.
We describe a weighted least squares based global registration method for creating virtual slides. In microscopy a large number of fields of view is required to capture a complete slide. These fields...
Lämmle, K., Zipper, H., Breuer, M., Hauer, B., Buta, C., Brunner, H., ...
Metagenome cloning has become a powerful tool to exploit the biocatalytic potential of microbial communities for the discovery of novel biocatalysts. In a novel variant of direct expression cloning,...
Verfahren und Vorrichtung zur Vermessung eines transparenten Objekts (2007)
Muenzenmayer, C., Rupp, S., Spinnler, K., Flachmann, M., Couronne, R.
DE 102005052044 A1 UPAB: 20070822 NOVELTY - The device has a first profile line (54) at a front surface (28a, 28c) of a transparent object (24) and a second profile line at a rear surface (28b) with...
Weisensel, S., Winter, C., Wittenberg, T., Rupp, S.
DE 102006004006 B3 UPAB: 20070817 NOVELTY - The method involves generating a sequence of low resolution images based on the intensity image. The low resolution image information is produced for the...
Verfahren und Vorrichtung zum Erzeugen einer strukturfreien fiberskopischen Aufnahme (2007)
Daum, V., Spinnler, K., Couronn, R., Elter, M., Rupp, S., Winter, C.
DE 102006011707 A1 UPAB: 20071002 NOVELTY - The method involves providing display parameters of a light guide (106), where the parameters describe geometric characteristics of an intensity curve that...
Wilson, D., Tutulan-Cunita, A., Jung, W., Hauser, N.C., Hernandez, R., Williamson, T., ...
Previously, we have shown that PDE2 is required for hyphal development and cell wall integrity in Candida albicans. In the present study, we have investigated the effects of its deletion by...
Interactions of the fungal pathogen Candida albicans with the host (2007)
Fungal infections represent a serious health problem in industrialized countries. In particular, multimorbid patients are highly susceptible to life-threatening infections by opportunistic fungi,...
Hiller, E., Heine, S., Brunner, H., Rupp, S.
The SUN gene family has been defined in Saccharomyces cerevisiae and comprises a fungus-specific family of proteins which show high similarity in their C-terminal domains. Genes of this family are...
Robust estimation of camera parameters using combinatorial optimization (2007)
Rupp, S., Elter, M., Winter, C.
The estimation of the parameters of the visual system is an indispensable step for augmented reality or image guided applications where quantitative information should be derived from the images....
Wittenberg, T., Cesnjevar, R., Rupp, S., Weyand, M., Kondruweit, M.
Heart valve prosthesis and related re¬con¬struction develop problems during cli¬ni¬cal course in patients, due to calcification. To analyse and quantify these effects, heart val¬ves of pigs are...
Impact of undistortion and interpolation on fiber optic tracking (2007)
Fiber optics are commonly used for image transmission in image guides of flexible endoscopes which are utilized in various medical and industrial tasks. Many existing algorithms for video coding like...
Beleuchtungsvorrichtung fuer eine Bilderfassungseinrichtung am distalen Ende eines Endoskops (2007)
Spinnler, K., Arnold, C., Kuleschow, A., Rupp, S., Wittenberg, T., Couronn, R.
DE 102007015492 A1 UPAB: 20080903 NOVELTY - The illumination device has an illumination carrier (60), which is attached to the distal end (20) of an endoscope (10) and a number of micro-light...
Segmentierung von Mikroverkalkungen in einer Mammographieaufnahme (2007)
Elter, M., Steckhan, D., Rupp, S., Schlarb, T.
WO 2009071282 A2 UPAB: 20090629 NOVELTY - The device has a band-pass filter (120) for band-pass filtering of a mammogram image (110) in order to obtain a filtered mammogram image (130). A marking...
Avramov, I.D., Länge, K., Rupp, S., Rapp, B., Rapp, M.
IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control, 54(2007) S.157-66
New sensing materials for SAW sensors using polymer-silicate composites. (2007)
IEEE Sensors 2007 Conf., Atlanta, Ga., October 28-31, 2007
Verbessertes elektrophoretisches Trennverfahren fuer die Analyse der Genexpression (2006)
DE1004048334 A UPAB: 20060502 NOVELTY - Quantitative or qualitative analysis of the gene expression of a biological material comprises extracting at least one messenger RNA from the biological...
3-D reconstruction of the sphenoid sinus from monocular endoscopic views: First results (2006)
Wittenberg, T., Winter, C., Scholz, I., Rupp, S., Stamminger, M., Bumm, K., ...
For intervention at the pituitary gland, the shortest and most subtle method is an operation through the paranasal sinuses and especially through the sphenoid sinus. To avoid dangerous interference...
Design and implementation aspects for plugin-based software frameworks (2006)
Applications of computer vision and signal processing are often based on a set of basic and commonly accepted ideas and algorithms. Thus, when developing new approaches, reuse plays a decisive role....
Camera calibration from fiberscopic views with accuracy evaluation (2006)
Rupp, S., Winter, C., Wittenberg, T.
In many medical applications glass-fiber endoscopes are used to acquire images from complex hollows for diagnostic and interventional purposes. For a complete exploration and understanding of an...
Automatic adaptive enhancement for images obtained with fiberscopic endoscopes (2006)
Winter, C., Rupp, S., Elter, M., Münzenmayer, C., Gerhäuser, H., Wittenberg, T.
Modern techniques for medical diagnostics and therapy in keyhole surgery scenarios as well as technical inspection make use of flexible endoscopes. Their characteristic bendable image conductor...
Auflösungssteigerung von fiberskopischen Bildsequenzen im Ortsraum (2006)
Winter, C., Weisensel, S., Rupp, S., Wittenberg, T.
Die visuelle Begutachtung spielt eine wichtige Rolle in der medizinischen Diagnose und Therapie. Für schwierige Zugänge werden Endoskope mit flexiblem Bildleiter (sog. Fiberskope) eingesetzt, die...
Dynamic resolution enhancement for fiber optics (2006)
Winter, C., Elter, M., Rupp, S., Wittenberg, T.
Visual inspection of antrums and hollows plays a decisive role in medical diagnosis and therapy. For complex ac cess, the use of endoscopes with flexible image guide is in dispensable. Besides...
A flexible, component-based software framework for signal and image processing algorithms (2006)
Rupp, S., Daum, V., Winter, C.
Applications of computer vision and signal processing often share ideas and algorithms. Thus the modules required for implementation show a high degree of similarity, so that reuse plays an important...
Physically motivated reconstruction of fiberscopic images (2006)
Elter, M., Rupp, S., Winter, C.
Flexible endoscopes are applied in modern techniques for technical inspection as well as medical diagnostic and therapy in keyhole-surgery-scenarios. Their characteristic bendable image conductor...
Disentangling information flow in the Ras-cAMP signaling network (2006)
Carter, G.W., Rupp, S., Fink, G.R., Galitski, T.
The perturbation of signal-transduction molecules elicits genomic-expression effects that are typically neither restricted to a small set of genes nor uniform. Instead there are broad, varied, and...
Getting in touch with Candida albicans: The cell wall of a fungal pathogen (2006)
Sohn, K., Schwenk, J., Urban, C., Lechner, J., Schweikert, M., Rupp, S.
The cell wall of fungi is a highly complex structure consisting of a network of polysaccharides ill which a plethora of different proteins are embedded. It is one of the major organelles of the cell...
Sohn, K., Senyürek, I., Fertey, J., Königsdorfer, A., Joffroy, C., Hauser, N., ...
Adhesion to mammalian epithelia is one of the prerequisites that are essential to accomplish pathogenesis of Candida albicans in the mammalian host. In this context C. albicans is able to adhere to a...
Hauser, N.C., Martinez, R., Jacob, A., Rupp, S., Hoheisel, J.D., Matysiak, S.
L-DNA is the perfect mirror-image form of the naturally occurring d-conformation of DNA. Therefore, L-DNA duplexes have the same physical characteristics in terms of solubility, duplex stability and...
NANOCYTES®-based protein-biochip. Mass-sensing device for diagnostic purposes (2006)
Borchers, K., Hiller, E., Weber, A., Rupp, S., Tovar, G.E.M.
Nanoparticle-based diagnostic 3D-protein-biochip for Candida albicans (2006)
Borchers, K., Hiller, E., Urban, C., Weber, A., Rupp, S., Tovar, G.E.M.
Isoliertes naturidentisches Kollagen (2006)
Xiong, X., Mertsching, H., Rupp, S., Brunner, H.
DE 102006026591 A1 UPAB: 20080102 NOVELTY - Isolating collagen from tissue comprises isolating collagen-containing fibers from the tissue, extracting collagen from the fibers by incubation with a...
De Rop, L, Exler, S, Rupp, S, ...
We investigated the role in cell morphogenesis and pathogenicity of the Candida albicans GPR1 gene, encoding the G protein-coupled receptor Gpr1. Deletion of C. albicans GPR1 has only minor effects...
The transcriptional response in C. albicans during adhesion to mammalian epithelia (2005)
Sohn, K., Senyürek, I., Hauser, N., Zelt, G., Brunner, H., ...
Identification of covalently-linked proteins in the cell wall of C. albicans (2005)
Hiller, E., Sohn, K., Urban, C., Gnau, V., Nordheim, A., Brunner, H., ...
Thioredoxin-Peroxidase von C. albicans als virulenzspezifischer Marker (2005)
Urban, C., Sohn, K., Brunner, H., Rupp, S.
WO2004101612 A UPAB: 20041216 NOVELTY - Characterizing and/or detecting the differentiation stages of Candida cells (A), is new. DETAILED DESCRIPTION - Method for characterizing and/or detecting the...
Urban, C., Sohn, K., Schröppel, K., Brunner, H., Rupp, S.
Candida albicans is one of the most common fungal pathogens in humans. The cell wall is the first contact site between host and pathogen and thus is critical for colonization and infection of the...
Sohn, K., Röhm, M., Urban, C., Saunders, N., Rothenstein, D., Lottspeich, F., ...
We applied two-dimensional gel electrophoresis to identify downstream effectors of CPH1 and EFG1 under hypha-inducing conditions in Candida albicans. Among the proteins that were expressed in...
Maidan, M., Rop, L. De, Serneels, J., Exler, S., Rupp, S., Tournu, H., ...
We investigated the role in cell morphogenesis and pathogenicity of the Candida albicans GPR1 gene, encoding the G protein-coupled receptor Gpr1. Deletion of C. albicans GPR1 has only minor effects...
In Vitro-Gewebetestsystem (2005)
Dieterich, C., Rupp, S., Noll, M., Gräve, T.
WO 200192476 A UPAB: 20020418 NOVELTY - Preparation of a single-layered, human or animal in vitro tissue test system (A) comprises seeding human or animal cells (B) into a three-dimensional, gel-like...
Verfahren zur Charakterisierung von technischen Oberflaechen (2005)
Schiestel, T., Rupp, S., Brunner, H.
EP 1574859 A UPAB: 20051024 NOVELTY - In a process to characterise a surface nano-domain, biosensors incorporating immobilised affinity molecules on nanoparticles are incubated on a surface...
Adaptive Rasterreduktion in Aufnahmen von flexiblen Endoskopen durch spektrale Maskierung (2005)
Winter, C., Rupp, S., Münzenmayer, C., Spinnler, K., Gerhäuser, H., Wittenberg, T.
Neue Verfahren in der medizinischen Diagnose und Therapie machen den Einsatz von Fiberskopen mittlerweile unverzichtbar. Diese Endoskope zeichnen sich aus durch einen flexiblen Bildleiter, der...
Reconstruction of tubes from monocular fiberscopic images - application and first results (2005)
Winter, C., Scholz, I., Rupp, S., Wittenberg, T.
In many industrial and medical applications, glass-fiber endoscopes are used to acquire images from complex hollows for diagnostic and interventional purposes. For a complete exploration and...
New nano-porous coatings as functional layers in microacoustic systems for gas detection. (2005)
Rapp, M., Rupp, S., Lubert, H., Voigt, A.
Hannover-Messe, Hannover, 11.-15.April 2005
Proteomics on its way to study host-pathogen interaction in Candida albicans (2004)
Candida albicans is a common fungal pathogen of humans, but also exists as a commensal in the population. Proteomics of C. albicans has been used since the early 1980s, however, only the recent...
Lotz, H., Sohn, K., Brunner, H., Mühlschlegel, F.A., Rupp, S.
The transcription factor Rim101p of Candida albicans has been shown to play a major role in pH-dependent gene regulation. Rim101p is involved in cell wall biosynthesis, since it regulates PHR1 and...
Identification of cell surface determinants in Candida albicans. (2003)
Urban,C., Sohn,K., Lottspeich,F., Schweikert,M., Brunner,H., Rupp,S.
Urban,C., Sohn,K., Lottspeich,F., Brunner,H., Rupp,S.
To identify cell surface proteins of Candida albicans, the predominant fungal pathogen in humans, we have established an approach using a membrane impermeable biotin derivative in combination with...
Topological Quantum Numbers of Relativistic Two-Particle Mixtures (2003)
Pruss-Hunzinger, S., Rupp, S., Sorg, M.
The relativistic two-particle quantum mixtures are studied from the topological point of view. The mixture field variables can be transformed in such a way that a kinematical decoupling of both...
Urban, C., Sohn, K., Lottspeich, F., Brunner, H., Rupp, S.
To identify cell surface proteins of Candida albicans, the predominant fungal pathogen in humans, we have established an approach using a membrane impermeable biotin derivative in combination with...
Identification of cell surface determinants in Candida albicans. (2003)
Urban, C., Sohn, K., Lottspeich, F., Schweikert, M., Brunner, H., Rupp, S.
Rottmann, M., Dieter, S., Brunner, H., Rupp, S.
Morphogenesis in Saccharomyces cerevisiae and the pathogenic yeast Candida albicans is governed in part by the same molecular circuits. In S. cerevisiae, FLO11 MUC1 expression has been shown to be...
Biochips mit Dimorphismus-spezifischen Faktoren aus Candida albicans (2003)
Sohn, K., Rupp, S., Brunner, H.
DE 10142743 A UPAB: 20030522 NOVELTY - Nucleotide chip (A) comprises a solid carrier on which is fixed at least one nucleic acid (NA) suitable for identifying a transcript of a gene that encodes a...
Identification of cell surface determinants in Candida albicans (2003)
Urban, C., Sohn, K., Lottspeich, F., Schweikert, M., Brunner, H., Rupp, S.
Urban, C., Sohn, K., Lottspeich, F., Brunner, H., Rupp, S.
To identify cell surface proteins of Candida albicans, the predominant fungal pathogen in humans, we have established an approach using a membrane impermeable biotin derivative in combination with...
Dieterich,C., Schandar,M., Noll,M., Johannes,F. J., Brunner,H., Graeve,T., ...
The individual and synergistic contributions of two transcription factors, EFG1 and CPH1, have been characterized with regard to adhesion to, and invasion of, human epithelia by Candida albicans. For...
Dieterich, C., Schandar, M., Noll, M., Johannes, F. J., Brunner, H., Graeve, T., ...
The individual and synergistic contributions of two transcription factors, EFG1 and CPH1, have been characterized with regard to adhesion to, and invasion of, human epithelia by Candida albicans. For...
Das C. albicans TEC1 GEN(CaTEC1) und das kodierte Tec1p Protein (2002)
Rupp, S., Schroeppel, K., Taylor, B.N., Schweizer, A.
Die vorliegende Erfindung betrifft Nukleotidsequenzen, die die Virulenz pathogener Pilzstaemme modulierende Proteine codieren, Vektoren, die diese Sequenzen enthalten, Wirtszellen, die diese...
Dieterich, C., Schandar, M., Noll, M., Brunner, H., Graeve, T., ...
The individual and synergistic contributions of two transcription factors, EFG1 and CPH1, have been characterized with regard to adhesion to, and invasion of, human epithelia by Candida albicans. For...
Protein kinase C (PKC)eta-mediated PKCmu activation modulates ERK and JNK signal pathways (2002)
Brändlin, I., Hübner, S., Eiseler, T., Martinez-Moya, M., Horschinek, A., Hausser, A., ...
Protein kinase C (PKC), a family of lipid-activated serine kinases, is involved in multiple functions in the regulation of growth control. The PKC-related isoform PKCmu/PKD has been implicated in...
Hyphenspezifische Faktoren aus Candida albicans (2001)
Rupp, S., Johannes, F., Sohn, K.
WO 200185989 A UPAB: 20020204 NOVELTY - A nucleotide chip (A1) comprises a solid support carrying a nucleotide sequence (I) for identifying and transcribing genes (II) that encode hyphae-specific...
Sohn, K., Urban, C., Brunner, H., Rupp, S.
Cell wall dynamics in C. albicans, the most common fungal pathogen in man, underlie regulatory processes during the yeast- to-hyphae transition. To analyze this regulation on the transcriptional...
Schweizer, A. S., Rupp, S., Taylor, B. N., Roellinghoff, M., Schroeppel, K.
The temporal and spatial expression of stage-specific genes during morphological development of fungi and higher eukaryotes is controlled by transcription factors. In this study, we report the...
A microarray enzyme-linked immunosorbent assay for autoimmune diagnostics (2000)
Joos, T.O., Schrenk, M., Hopfl, P., Kroger, K., Chowdhury, U., Stoll, D., ...
Schweizer, A. S., Rupp, S., Taylor, B. N., Roellinghoff, M., Schroeppel, K.
The temporal and spatial expression of stage-specific genes during morphological development of fungi and higher eukaryotes is controlled by transcription factors. In this study, we report the...
Schweizer, A. S., Rupp, S., Taylor, B. N., Roellinghoff, M., Schroeppel, K.
The temporal and spatial expression of stage-specific genes during morphological development of fungi and higher eukaryotes is controlled by transcription factors. In this study, we report the...
cAMP mediated gene expression in S.Cerevisae (1999)
Rupp, S., Galitski, T., Fink, G.R.
cAMP is a central signaling molecule involved in a plethora of cellular regulation processes, e.g. stress response, nutrient response and pseudohyphal growth. In order to identify transcriptional...
Aufgrund der komplizierten Geometrie ist zur Pruefung der Stege oder Stutzeneinschweissungen sowohl eine ortsabhaengige Variation des Einschallwinkels als auch des Schielwinkels noetig. Mit...
Rupp, S, Summers, E, Lo, H J, Madhani, H, Fink, G
In Saccharomyces cerevisiae, two major signal transduction pathways, the Kss1 MAPK pathway and the cAMP-regulated pathway, are critical for the differentiation of round yeast form cells to...
Sohn, K., Roehm, M., Urban, C., Saunders, N., Rothenstein, D., Lottspeich, F., ...
We applied two-dimensional gel electrophoresis to identify downstream effectors of CPH1 and EFG1 under hypha-inducing conditions in Candida albicans. Among the proteins that were expressed in...
Rupp, S, Summers, E, Lo, H J, Madhani, H, Fink, G
In Saccharomyces cerevisiae, two major signal transduction pathways, the Kss1 MAPK pathway and the cAMP-regulated pathway, are critical for the differentiation of round yeast form cells to...
Sohn, K., Roehm, M., Urban, C., Saunders, N., Rothenstein, D., Lottspeich, F., ...
We applied two-dimensional gel electrophoresis to identify downstream effectors of CPH1 and EFG1 under hypha-inducing conditions in Candida albicans. Among the proteins that were expressed in...