S. Schreiber

Details der Publikationsliste

Zeitraum

1989 - 2009

Anzahl

366

Co-Autoren

Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARγ2 P12A polymorphism: a double blind, randomized, controlled cross-over study (2009)

Herrmann, J, Rubin, D, Häsler, R, Helwig, U, Pfeuffer, M, Auinger, A, ...

Abstract Background Peroxisome proliferator-activated receptor (PPAR)γ is a key regulator in adipose tissue. The rare variant Pro12Ala of PPARγ2 is associated with a decreased risk of insulin...

Adalimumab for the treatment of fistulas in patients with Crohn's disease (2009)

Schwartz, D. A, Sandborn, W. J, Kamm, M. A, ...

Objective: To evaluate the efficacy of adalimumab in the healing of draining fistulas in patients with active Crohn's disease (CD).

The TESLA Detector (2008)

S. Schreiber

this report, the principle design and layout of the proposed detector with emphasis on the TESLA version is reviewed. Examples of reference reactions studied to demonstrate the detector performance...

The use of reconstructed human epidermis for skin absorption testing: Results of the validation study (2008)

Schäfer-Korting, M., Bock, U., Diembeck, W., Gamer, A., Haltner-Ukomadu, E., ...

A formal validation study was performed, in order to investigate whether the commercially available reconstructed human epidermis (RHE) models, EPISKIN (R), EpiDerm (TM) and SkinEthic (R), are...

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23. (2008)

Tomlinson, I.P.M., Webb, E., Carvajal-Carmona, L., Broderick, P., Howarth, K., Pittman, A.M., ...

To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313...

The Tesla Linear Collider Project (2007)

Schreiber Deutsches, S. Schreiber

this report, the TESLA project is briefly described and some aspects of a possible e

Operation of a free electron laser from the extreme ultraviolet to the water window (2007)

Ackermann, W., Asova, G., Ayvazyan, V., Azima, A., Baboi, N., Bähr, J., ...

We report results on the performance of a free electron laser operating at a wavelength of 13.7 nm where unprecedented peak and average powers for a coherent EUV radiation source have been measured....

Operation of a free electron laser from the extreme ultraviolet to the water window (2007)

Ackermann, W., Asova, G., Ayvazyan, V., Azima, A., Baboi, N., Bähr, J., ...

We report results on the performance of a free electron laser operating at a wavelength of 13.7 nm where unprecedented peak and average powers for a coherent EUV radiation source have been measured....

Audio-Visual Processing in Meetings: Seven Questions and Current AMI Answers (2007)

Al-Hamas, M., Hain, T., Cernocky, J., Schreiber, S., Poel, M., Müller, R., ...

The project Augmented Multi-party Interaction (AMI) is concerned with the development of meeting browsers and remote meeting assistants for instrumented meeting rooms – and the required component...

Precision Electroweak Measurements on the Z Resonance (2006)

Schael, S, Abbiendi, G, Ainsley, C, Åkesson, P F, Alexander, G, Allison, J, ...

We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17...

Precision Electroweak Measurements on the Z Resonance (2006)

Schael, S, Abbiendi, G, Ainsley, C, Åkesson, P F, Alexander, G, Allison, J, ...

We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17...

First operation of a free-electron laser generating GW power radiation at 32 nm wavelength (2006)

Ayvazyan, V., Baboi, N., Bähr, J., Balandin, V., Beutner, B., Brandt I., A., ...

Many scientific disciplines ranging from physics, chemistry and biology to material sciences, geophysics and medical diagnostics need a powerful X-ray source with pulse lengths in the femtosecond...

First operation of a free-electron laser generating GW power radiation at 32 nm wavelength (2006)

Ayvazyan, V., Baboi, N., Bähr, J., Balandin, V., Beutner, B., Brandt I., A., ...

Many scientific disciplines ranging from physics, chemistry and biology to material sciences, geophysics and medical diagnostics need a powerful X-ray source with pulse lengths in the femtosecond...

Flexible integration of layout planning and adaptive assembly systems in digital enterprises (2006)

Constantinescu, C., Heinkel, U., Le Blond, J., Schreiber, S., Mitschang, B., Westkämper, E.

The agility and adaptability of an enterprise becomes more and more a desired feature and a key factor of success. Especially manufacturing enterprises have to be able to respond quickly to both...

Echtzeitfähiges Fabrik-Cockpit für den produzierenden Mittelstand (2006)

Kapp, R., Le Blond, J., Schreiber, S., Pfeffer, M., Westkämper, E.

This technical contribution presents a digital planning environment for an integrated facility layout and logistics planning. The aim is a noticeable reduction of time and effort for middle- and...

Verbesserte Ressourcenausnutzung in der Montage: Planung und Optimierung von Montagesystemen im wandlungsfähigen Unternehmen (2006)

Westkämper, E., Schreiber, S.

Today businesses need to deal with a turbulent environment. As a result they should have transformable structures in their production and assembly systems. Transformability of assembly is supported...

Beam Profile Measurements and Simulations of the PETRA Laser-Wire (2005)

Carter, J., Agapov, I., Blair, G. A., Boorman, G., Driouichi, C., Poirier, F., ...

The Laser-wire will be an essential diagnostic tool at the International Linear Collider. It uses a finely focussed laser beam to measure the transverse profile of electron bunches by detecting the...

Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease (2005)

Wortel, C H, Hogezand, R A, Schreiber, S, Goldin, E, ...

BACKGROUND: The ligation of CD40 by CD154 is a critical step in the interaction between APC and T cells. In animals, antagonizing CD40L-CD40 has been shown to reduce the severity of several...

Status and First Results from the Upgraded PITZ Facility (2005)

Oppelt, A., Abrahamyan, K., Asova, G., Bähr, J., Dimitrov, G., Gensch, U., ...

Since December 2004, the photo injector test facility at DESY in Zeuthen (PITZ) has been upgraded. A normal conducting copper booster cavity has been installed and the diagnostics beamline has been...

Status and First Results from the Upgraded PITZ Facility (2005)

Oppelt, A., Abrahamyan, K., Asova, G., Bähr, J., Dimitrov, G., Gensch, U., ...

Since December 2004, the photo injector test facility at DESY in Zeuthen (PITZ) has been upgraded. A normal conducting copper booster cavity has been installed and the diagnostics beamline has been...

Flexible integration of layout planning and adaptive assembly systems in digital enterprises (2005)

Constantinescu, C., Heinkel, U., Le Blond, J., Schreiber, S., Mitschang, B., Westkämper, E.

The agility and adaptability of an enterprise becomes more and more a desired feature and a key factor of success. Especially manufacturing enterprises have to be able to respond quickly to both...

Status and First Results from the Upgraded PITZ Facility (2005)

Oppelt, A., Abrahamyan, K., Asova, G., Bähr, J., Dimitrov, G., Gensch, U., ...

Since December 2004, the photo injector test facility at DESY in Zeuthen (PITZ) has been upgraded. A normal conducting copper booster cavity has been installed and the diagnostics beamline has been...

Fourier methods for quasi-periodic oscillations (2005)

Schilder, F, Vogt, W, Schreiber, S, Osinga, HM

Quasi-periodic oscillations and invariant tori play an important role in the study of forced or coupled oscillators. This paper presents two new numerical methods for the investigation of...

Status and First Results from the Upgraded PITZ Facility (2005)

Oppelt, A., Abrahamyan, K., Asova, G., Bähr, J., Dimitrov, G., Gensch, U., ...

Since December 2004, the photo injector test facility at DESY in Zeuthen (PITZ) has been upgraded. A normal conducting copper booster cavity has been installed and the diagnostics beamline has been...

The Photon Collider at Tesla (2004)

Badelek, B, Blochinger, C, Blumlein, J, Boos, E, Brinkmann, R, Burkhardt, H, ...

High energy photon colliders $(\gamma\gamma,\gamma e)$ are based on $e^- e^-$ linear colliders where high energy photons are produced using Comptonscattering of laser light on high energy electrons...

The Photon Collider at Tesla (2004)

Badelek, B, Blochinger, C, Blumlein, J, Boos, E, Brinkmann, R, Burkhardt, H, ...

High energy photon colliders $(\gamma\gamma,\gamma e)$ are based on $e^- e^-$ linear colliders where high energy photons are produced using Comptonscattering of laser light on high energy electrons...

Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease (2004)

Pender, S.L.F., Croucher, P.J., Mascheretti, S., Prothero, J.D., Fisher, S.A., MacDonald, T.T., ...

Crohn’s disease (MIM 266600) and ulcerative colitis (MIM 191390) are the major forms of inflammatory bowel disease (MIM 601458), the prevalence of Crohn’s disease being more than 1/1000 in the...

Interferon beta-1a in ulcerative colitis: a placebo controlled, randomised, dose escalating study (2003)

Fedorak, R, Steinhart, A H, Wild, G E, Theuer, D, ...

BACKGROUND: and aims: Administration of interferon (IFN)-beta may represent a rational approach to the treatment of ulcerative colitis through its immunomodulatory and anti-inflammatory effects. The...

Two-color FEL amplifier for femtosecond-resolution pump-probe experiments with GW-scale X-ray and optical pulses (2003)

Feldhaus, J., Koerfer, M., Moeller, T., Pflueger, J., Saldin, E. L., Schneidmiller, E. A., ...

Pump-probe experiments combining pulses from a X-ray FEL and an optical femtosecond laser are very attractive for sub-picosecond time-resolved studies. Since the synchronization between the two...

Review article: the expanding role of biological agents in the treatment of inflammatory bowel disease - focus on selective adhesion molecule inhibition (2003)

Van Deventer, S, Schreiber, S

Inflammatory bowel disease presents in various forms. Its increasing incidence indicates that modern lifestyle triggers disease in genetically susceptible individuals. We present a model for...

Experimental observation of breakdowns in the Fermilab RF Gun G4 (2003)

Carneiro Edwards Gonin, D. Edwards, I. Gonin, S. Schreiber

This paper describes the dependency of the breakdowns measured at DESY on G4 with respect to the RF pulse length, forward power and repetition rate. A part of the work presented in this paper is also...

Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial (2002)

Feagan, Brian G, Lichtenstein, Gary R, Mayer, Lloyd F, Schreiber, S, Colombel, Jean Frederic, ...

BACKGROUND: We did a randomised controlled trial to assess the benefit of maintenance infliximab therapy in patients with active Crohn's disease who respond to a single infusion of infliximab....

Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma (2002)

Van Montfrans, C, Kaser, A, Schreiber, S, ...

BACKGROUND: Interleukin 10 (IL-10) exerts anti-inflammatory actions by counteracting many biological effects of interferon gamma (IFN-gamma). AIMS: To investigate this in humans, we studied the...

Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group (2000)

Gangl, A, Elson, C O, Schreiber, S, Wild, G, ...

BACKGROUND & AIMS: Interleukin 10 (IL-10) is an anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation. This study evaluated the safety, tolerance, and efficacy of...

First observation of self-amplified spontaneous emission in a free-electron laser at 109 nm wavelength (2000)

Andruszkow, J., Aune, B., Ayvazian, V., Baboi, N., Bakker, R., Balakin, V., ...

We present the first observation of self-amplified spontaneous emission (SASE) in a free-electron laser (FEL) in the vacuum ultraviolet regime at 109 nm wavelength (11 eV). The observed free-electron...

First observation of self-amplified spontaneous emission in a free-electron laser at 109 nm wavelength (2000)

Andruszkow, J., Aune, B., Ayvazian, V., Baboi, N., Bakker, R., Balakin, V., ...

We present the first observation of self-amplified spontaneous emission (SASE) in a free-electron laser (FEL) in the vacuum ultraviolet regime at 109 nm wavelength (11 eV). The observed free-electron...

First observation of self-amplified spontaneous emission in a free-electron laser at 109 nm wavelength (2000)

Andruszkow, J., Aune, B., Ayvazian, V., Baboi, N., Bakker, R., Balakin, V., ...

We present the first observation of self-amplified spontaneous emission (SASE) in a free-electron laser (FEL) in the vacuum ultraviolet regime at 109 nm wavelength (11 eV). The observed free-electron...

First observation of self-amplified spontaneous emission in a free-electron laser at 109 nm wavelength (2000)

Andruszkow, J., Aune, B., Ayvazian, V., Baboi, N., Bakker, R., Balakin, V., ...

We present the first observation of self-amplified spontaneous emission (SASE) in a free-electron laser (FEL) in the vacuum ultraviolet regime at 109 nm wavelength (11 eV). The observed free-electron...

First observation of self-amplified spontaneous emission in a free-electron laser at 109 nm wavelength (2000)

Andruszkow, J., Aune, B., Ayvazian, V., Baboi, N., Bakker, R., Balakin, V., ...

We present the first observation of self-amplified spontaneous emission (SASE) in a free-electron laser (FEL) in the vacuum ultraviolet regime at 109 nm wavelength (11 eV). The observed free-electron...

Results from the CLIC Test Facility (1996)

Braun, H, Aulenbacher, K, Bossart, Rudolf, Chautard, F, Corsini, R, Delahaye, J P, ...

In order to study the principle of the Compact Linear Collider (CLIC) based on the Two Beam Acceleration (TBA) scheme at high frequency, a CLIC Test Facility (CTF) has been set-up at CERN. After four...

Fast polar decomposition of an arbitrary matrix (1990)

Nicholas J. Higham, S. Schreiber

Abstract. The polar decomposition of an m x n matrix A of full rank, where rn n, can be computed usingaquadraticallyconvergentalgorithmofHigham SIAMJ. Sci. Statist. Comput.,7 (1986), pp. 1160-1174]....

Proposing a laser based beam size monitor for the future linear collider

Blair, G A, Frisch, J, Honhavaara, K, Kamps, T, Poirier, F, Ross, I N, ...

Proc 2001 Particle Accelerator Conference, vol 2, 1339-1341, publ IEEE, Piscataway, NJ, USA (2001)

Monomeric IgG2a promotes maturation of bone-marrow macrophages and expression of the mannose receptor.

Schreiber, S, Blum, J S, Stenson, W F, MacDermott, R P, Stahl, P D, Teitelbaum, S L, ...

The macrophage mannose receptor, a 172-kDa lineage-specific glycoprotein, partakes in nonopsonin-mediated phagocytosis by recognition of terminal mannose residues on targeted particles. Because...

High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors.

Gupta, P, Mellors, J, Kingsley, L, Riddler, S, Singh, M K, Schreiber, S, ...

Seminal viral load is likely to be directly related to the sexual transmissibility of human immunodeficiency virus type 1 (HIV-1). However, it is not clear whether the level of HIV-1 in semen varies...

Prostaglandin E specifically upregulates the expression of the mannose-receptor on mouse bone marrow-derived macrophages.

Schreiber, S, Blum, J S, Chappel, J C, Stenson, W F, Stahl, P D, Teitelbaum, S L, ...

The macrophage mannose receptor (MMR) facilitates the binding and internalization of microorganisms and glycoproteins with terminal mannose residues. The receptor is progressively upregulated as bone...

Enhancement of macrophage candidacidal activity by interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors.

Maródi, L, Schreiber, S, Anderson, D C, MacDermott, R P, Korchak, H M, Johnston, R B

In contrast to its macrophage-activating capacity, IFN-gamma downregulates expression of the macrophage mannose receptor (MMR), which mediates uptake of Candida and other microorganisms. We found...

Stochastic simulation of hemagglutinin-mediated fusion pore formation.

Schreiber, S, Ludwig, K, Herrmann, A, Holzhütter, H G

Studies on fusion between cell pairs have provided evidence that opening and subsequent dilation of a fusion pore are stochastic events. Therefore, adequate modeling of fusion pore formation requires...

A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort.

Hampe, J, Schreiber, S, Shaw, S H, Lau, K F, Bridger, S, Macpherson, A J, ...

Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on the basis of clinical...

Monomeric IgG2a promotes maturation of bone-marrow macrophages and expression of the mannose receptor.

Schreiber, S, Blum, J S, Stenson, W F, MacDermott, R P, Stahl, P D, Teitelbaum, S L, ...

The macrophage mannose receptor, a 172-kDa lineage-specific glycoprotein, partakes in nonopsonin-mediated phagocytosis by recognition of terminal mannose residues on targeted particles. Because...

High viral load in semen of human immunodeficiency virus type 1-infected men at all stages of disease and its reduction by therapy with protease and nonnucleoside reverse transcriptase inhibitors.

Gupta, P, Mellors, J, Kingsley, L, Riddler, S, Singh, M K, Schreiber, S, ...

Seminal viral load is likely to be directly related to the sexual transmissibility of human immunodeficiency virus type 1 (HIV-1). However, it is not clear whether the level of HIV-1 in semen varies...

Prostaglandin E specifically upregulates the expression of the mannose-receptor on mouse bone marrow-derived macrophages.

Schreiber, S, Blum, J S, Chappel, J C, Stenson, W F, Stahl, P D, Teitelbaum, S L, ...

The macrophage mannose receptor (MMR) facilitates the binding and internalization of microorganisms and glycoproteins with terminal mannose residues. The receptor is progressively upregulated as bone...

Enhancement of macrophage candidacidal activity by interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors.

Maródi, L, Schreiber, S, Anderson, D C, MacDermott, R P, Korchak, H M, Johnston, R B

In contrast to its macrophage-activating capacity, IFN-gamma downregulates expression of the macrophage mannose receptor (MMR), which mediates uptake of Candida and other microorganisms. We found...

Stochastic simulation of hemagglutinin-mediated fusion pore formation.

Schreiber, S, Ludwig, K, Herrmann, A, Holzhütter, H G

Studies on fusion between cell pairs have provided evidence that opening and subsequent dilation of a fusion pore are stochastic events. Therefore, adequate modeling of fusion pore formation requires...

A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort.

Hampe, J, Schreiber, S, Shaw, S H, Lau, K F, Bridger, S, Macpherson, A J, ...

Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation, typically starting in early adulthood. IBD is subdivided into two subtypes, on the basis of clinical...

Palindromic rheumatism with rheumatoid nodules: a case report with ultrastructural studies.

Schreiber, S, Schumacher, H R, Cherian, P V

Rheumatoid nodules developed on the finger tips of a patient with palindromic rheumatism. The patient had no bone cysts or erosions and had no rheumatoid factor. A light microscopic and...

Treatment with tumour necrosis factor inhibitor oxpentifylline does not improve corticosteroid dependent chronic active Crohn's disease.

Bauditz, J, Haemling, J, Ortner, M, Lochs, H, Raedler, A, Schreiber, S

BACKGROUND: In Crohn's disease, inflammation is presumably sustained by an increased production of proinflammatory cytokines, in particular tumour necrosis factor alpha (TNF alpha) and interleukin 1...

Renal tubular dysfunction in patients with inflammatory bowel disease treated with aminosalicylate.

Schreiber, S, Hämling, J, Zehnter, E, Howaldt, S, Daerr, W, Raedler, A, ...

BACKGROUND: An increasing number of case reports indicate potential nephrotoxicity of 5-aminosalicylic acid (5-ASA), which shares similarities with the chemical structures of both phenacetin and...

Increased in vitro release of soluble interleukin 2 receptor by colonic lamina propria mononuclear cells in inflammatory bowel disease.

Schreiber, S, Raedler, A, Conn, A R, Rombeau, J L, MacDermott, R P

Increased concentrations of the soluble form of the interleukin 2 receptor have been observed in the sera of Crohn's disease and ulcerative colitis patients. In this study we have observed the...

Oral 4-aminosalicylic acid versus 5-aminosalicylic acid slow release tablets. Double blind, controlled pilot study in the maintenance treatment of Crohn's ileocolitis.

Schreiber, S, Howaldt, S, Raedler, A

4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance...

Activation of nuclear factor κB in inflammatory bowel disease

Schreiber, S, Nikolaus, S, Hampe, J

Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany

Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation

Nikolaus, S, Bauditz, J, Gionchetti, P, Witt, C, Lochs, H, Schreiber, S

a Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany, b Clinica Media I, Policlinico S. Orsola, University of Bologna, Italy, c Charité University...

Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease

Hampe, J, Lynch, N, Daniels, S, Bridger, S, Macpherson, A, Stokkers, P, ...

BACKGROUND AND AIMS—Genetic predisposition for inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic linkage studies. Genetic linkage of IBD to chromosome 3 has...

Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses

Kruis, W, Schreiber, S, Theuer, D, Brandes, J, Schutz, E, Howaldt, S, ...

BACKGROUND—Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug. Its efficacy in comparison with standard mesalazine therapy and the optimum dose for maintaining remission of...

Increased expression of IL-16 in inflammatory bowel disease

Seegert, D, Rosenstiel, P, Pfahler, H, Pfefferkorn, P, Nikolaus, S, Schreiber, S

BACKGROUND—Inflammatory bowel disease (IBD) is characterised by infiltration of inflamed mucosal regions with CD4+ T lymphocytes and other mononuclear cells. Interleukin (IL)-16 exerts a strong...

Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon γ

Tilg, H, Van Montfrans, C, Kaser, A, Schreiber, S, ...

Background: Interleukin 10 (IL-10) exerts anti-inflammatory actions by counteracting many biological effects of interferon γ (IFN-γ).

Activation of signal transducer and activator of transcription (STAT) 1 in human chronic inflammatory bowel disease

Schreiber, S, Rosenstiel, P, Hampe, J, Nikolaus, S, Groessner, B, Schottelius, A, ...

Background: Increased expression of proinflammatory cytokines, including tumour necrosis factor α, interleukin 6, and interferon γ, as well as activation of proinflammatory signalling molecules...

Infliximab in moderately severe glucocorticoid resistant ulcerative colitis: a randomised controlled trial

Probert, C S J, Hearing, S D, Schreiber, S, Kühbacher, T, Ghosh, S, Arnott, I D R, ...

Background: Tumour necrosis factor production is increased in the mucosa of patients with active ulcerative colitis. The benefits of infliximab in Crohn’s disease are established. We investigated...

Interferon β-1a in ulcerative colitis: a placebo controlled, randomised, dose escalating study

Nikolaus, S, Rutgeerts, P, Fedorak, R, Steinhart, A H, Wild, G E, Theuer, D, ...

Background and aims: Administration of interferon (IFN)-β may represent a rational approach to the treatment of ulcerative colitis through its immunomodulatory and anti-inflammatory effects. The...

Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis

Mimura, T, Rizzello, F, Helwig, U, Poggioli, G, Schreiber, S, Talbot, I C, ...

Background: Ten to 15% of patients with pouchitis experience refractory or recurrent disease. The aim of this study was to evaluate the effectiveness of a single daily high dose probiotic preparation...

Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

Ott, S J, Musfeldt, M, Wenderoth, D F, Hampe, J, Brant, O, Fölsch, U R, ...

Background and aims: The intestinal bacterial microflora plays an important role in the aetiology of inflammatory bowel disease (IBD). As most of the colonic bacteria cannot be identified by culture...

Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease.

Reinecker, H C, Steffen, M, Witthoeft, T, Pflueger, I, Schreiber, S, MacDermott, R P, ...

The perpetuation of inflammation in ulcerative colitis and Crohn's disease may be regulated in part by an increased secretion of proinflammatory cytokines due to either an appropriate response to...

Human rib bone marrow mononuclear cells spontaneously synthesize and secrete IgE in vitro.

MacDermott, R P, Jendrisak, G A, Nash, G S, Schreiber, S, Bertovich, M J, Nahm, M, ...

We have examined spontaneous secretion of IgE by human rib bone marrow mononuclear cells (MNC). Bone marrow MNC from nine out of 12 rib specimens synthesized and secreted substantial amounts of IgE...

Phenotype and functional properties of Vicia villosa agglutinin (VVA) binding T cells in patients with Crohn's disease: detection of contrasuppressor activity in patients lacking extra-intestinal manifestations, abscesses and fistulas.

Raedler, A, Lenz, H J, Sandgren, K, De Weerth, A, Enversen, S, Schreiber, S, ...

Patients with active Crohn's disease (CD) have significantly increased numbers of T cells binding the Vicia villosa agglutinin (VVA). In patients with CD these VVA+ T cells express either the CD4 or...

Increased spontaneous secretion of rheumatoid factor by intestinal lamina propria mononuclear cells from Crohn's disease but not ulcerative colitis patients.

MacDermott, R P, Schreiber, S, Nash, G S, Koopman, W J

Increased levels of rheumatoid factors (RF) have been observed in the serum of Crohn's disease but not ulcerative colitis patients, and have been proposed to relate to an increased state of...

Genetic variants in the CCR gene cluster and spontaneous viral elimination in hepatitis C-infected patients

MASCHERETTI, S, HINRICHSEN, H, ROSS, S, BUGGISCH, P, HAMPE, J, FOELSCH, U R, ...

Hepatitis C virus (HCV) infection results in chronic hepatitis in more than 80% of infected patients while 10–20% of patients recover spontaneously. Host genetic factors may influence the ability...

Production of IL-12 in gastritis relates to infection with Helicobacter pylori

Bauditz, J, Ortner, M, Bierbaum, M, Niedobitek, G, Lochs, H, Schreiber, S

Increased production of proinflammatory cytokines, including tumour necrosis factor-alpha (TNF-α), IL-1β, IL-6 and IL-8, has been demonstrated in Helicobacter pylori-associated gastric mucosal...

Activation of signal-transducer and activator of transcription 1 (STAT1) in pouchitis

Kühbacher, T, Gionchetti, P, Hampe, J, Helwig, U, Rosenstiel, P, Campieri, M, ...

Activation of signal transducer and activator of transcription 1 (STAT1) is a hallmark of IFN-γ receptor signal transduction but is also part of the signalling pathway of other cytokines/growth...

Internal jugular vein valve incompetence and intracranial venous anatomy in transient global amnesia

Schreiber, S, Doepp, F, Klingebiel, R, Valdueza, J

Background: Recently a causal relation between internal jugular vein valve incompetence (IJVVI) and transient global amnesia (TGA) has been suggested. IJVVI is postulated to provoke a transient...

Slipping the barrier: how variants in CARD15 could alter permeability of the intestinal wall and population health

Schreiber, S

The increased intestinal permeability in Crohn's disease is associated with the presence of variants in the CARD15 gene that are regarded as causative for Crohn's disease, suggesting a genetic rather...

Clic Test Facility Developments And Results

Bossart Braun Chautard, R. Bossart, H. Braun, F. Chautard, M. Comunian, J. P. Delahaye, ...

INTRODUCTION The objectives of the CLIC Test Facility (CTF) are to study the generation of short intense electron bunches using a laser driven photocathode in an RF gun, to generate 30 GHz RF power...

Study of Toll-like receptor gene loci in sarcoidosis

Schürmann, M, Kwiatkowski, R, Albrecht, M, Fischer, A, Hampe, J, Müller-Quernheim, J, ...

Sarcoidosis is a multi-factorial systemic disease of granulomatous inflammation. Current concepts of the aetiology include interactions of unknown environmental triggers with an inherited...

Subthreshold Membrane-Potential Resonances Shape Spike-Train Patterns in the Entorhinal Cortex

Engel, T. A., Schimansky-Geier, L., Herz, A.V.M., Schreiber, S., Erchova, I.

Many neurons exhibit subthreshold membrane-potential resonances, such that the largest voltage responses occur at preferred stimulation frequencies. Because subthreshold resonances are known to...