Siegel, Gabriele, Obernosterer, Gregor, Fiore, Roberto, Oehmen, Martin, Bicker, Silvia, Christensen, Mette, ...
Worm, Jesper, Stenvang, Jan, Petri, Andreas, Frederiksen, Klaus Stensgaard, Obad, Susanna, Elmén, Joacim, ...
microRNA-155 (miR-155) has been implicated as a central regulator of the immune system, but its function during acute inflammatory responses is still poorly understood. Here we show that exposure of...
Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140 (2008)
Nicolas, Francisco Esteban, Pais, Helio, Schwach, Frank, Lindow, Morten, Kauppinen, Sakari, Moulton, Vincent, ...
MicroRNAs (miRNAs) are short noncoding RNA molecules regulating the expression of mRNAs. Target identification of miRNAs is computationally difficult due to the relatively low homology between miRNAs...
MicroRNA expression in the adult mouse central nervous system (2008)
Bak, Mads, Silahtaroglu, Asli, Møller, Morten, Christensen, Mette, Rath, Martin F., Skryabin, Boris, ...
microRNAs are ∼22 nucleotide endogenous noncoding RNAs that post-transcriptionally repress expression of protein-coding genes by base-pairing with the 3′-untranslated regions of the target mRNAs....
Elmén, Joacim, Lindow, Morten, Silahtaroglu, Asli, Bak, Mads, Christensen, Mette, Lind-Thomsen, Allan, ...
MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty acid and cholesterol metabolism as well as hepatitis C viral replication. Here, we report that a systemically...
miR-200b mediates post-transcriptional repression of ZFHX1B (2007)
Christoffersen, Nanna Rønbjerg, Silahtaroglu, Asli, Ørom, Ulf Andersson, Kauppinen, Sakari, Lund, Anders H.
MicroRNAs have important functions during animal development and homeostasis through post-transcriptional regulation of their cognate mRNA targets. ZFHX1B is a transcriptional repressor involved in...
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain (2006)
NELSON, PETER T., BALDWIN, DON A., KLOOSTERMAN, WIGARD P., KAUPPINEN, SAKARI, PLASTERK, RONALD H.A., MOURELATOS, ZISSIMOS
microRNAs (miRNAs) are small (~22 nucleotide) regulatory RNAs which play fundamental roles in many biological processes. Recent studies have shown that the expression of many miRNAs is altered in...
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain (2005)
NELSON, PETER T., BALDWIN, DON A., KLOOSTERMAN, WIGARD P., KAUPPINEN, SAKARI, PLASTERK, RONALD H.A., MOURELATOS, ZISSIMOS
microRNAs (miRNAs) are small (~22 nucleotide) regulatory RNAs which play fundamental roles in many biological processes. Recent studies have shown that the expression of many miRNAs is altered in...
Jacobsen, Nana, Nielsen, Peter Stein, Jeffares, Daniel Charlton, Eriksen, Jens, Ohlsson, Helle, Arctander, Peter, ...
LNA oligonucleotides constitute a class of bicyclic RNA analogues having an exceptionally high affinity for their complementary DNA and RNA target molecules. We here report a novel method for highly...
Válóczi, Anna, Hornyik, Csaba, Varga, Nóra, Burgyán, József, Kauppinen, Sakari, Havelda, Zoltán
We describe here a new method for highly efficient detection of microRNAs by northern blot analysis using LNA (locked nucleic acid)-modified oligonucleotides. In order to exploit the improved...
Tolstrup, Niels, Nielsen, Peter S., Kolberg, Jens G., Frankel, Annett M., Vissing, Henrik, Kauppinen, Sakari
We report the development of new software, OligoDesign, which provides optimal design of LNA (locked nucleic acid) substituted oligonucleotides for functional genomics applications. LNAs constitute a...
LNA-enhanced detection of single nucleotide polymorphisms in the apolipoprotein E (2002)
Jacobsen, Nana, Bentzen, Joan, Meldgaard, Michael, Jakobsen, Mogens Havsteen, Fenger, Mogens, Kauppinen, Sakari, ...
Genotyping of single nucleotide polymorphisms (SNPs) in large populations presents a great challenge, especially if the SNPs are embedded in GC‐rich regions, such as the codon 112 SNP in the...
Thesis (Ph. D.)--University of Oulu, 1999.
Diss. -- Oulun yliopisto.
Dansk resumé.
Teeri, Tuula, Lehtovaara, Päivi, Kauppinen, Sakari, Salovuori, Irma, Knowles, Jonathan
Gene Vol.51 Nr.1, 43 - 52
Evolution of a fungal cellulase gene family and gene structure (1986)
Lehtovaara, Päivi, Teeri, Tuula, Kauppinen, Sakari, Penttilä, Merja, Knowles, Jonathan
NOMBA Nordforsk symp. Gene technology in basic and applied research. Nyborg, DK, 27 - 30 April 1986, 8
Elmén, Joacim, Lindow, Morten, Silahtaroglu, Asli, Bak, Mads, Christensen, Mette, Lind-Thomsen, Allan, ...
MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty acid and cholesterol metabolism as well as hepatitis C viral replication. Here, we report that a systemically...
Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase
Langkilde, Annette, Kristensen, Søren M., Lo Leggio, Leila, Mølgaard, Anne, Jensen, Jan H., Houk, Andrew R., ...
The short hydrogen bonds in rhamnogalacturonan acetylesterase have been investigated by structure determination of an active-site mutant, 1H NMR spectra and computational methods. Comparisons are...
MicroRNA expression in the adult mouse central nervous system
Bak, Mads, Silahtaroglu, Asli, Møller, Morten, Christensen, Mette, Rath, Martin F., Skryabin, Boris, ...
microRNAs are ∼22 nucleotide endogenous noncoding RNAs that post-transcriptionally repress expression of protein-coding genes by base-pairing with the 3′-untranslated regions of the target mRNAs....
Hébert, Sébastien S., Horré, Katrien, Nicolaï, Laura, Papadopoulou, Aikaterini S., Mandemakers, Wim, Silahtaroglu, Asli N., ...
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well established, fairly little is known about the molecular mechanisms affecting Aβ generation in sporadic AD....
Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140
Nicolas, Francisco Esteban, Pais, Helio, Schwach, Frank, Lindow, Morten, Kauppinen, Sakari, Moulton, Vincent, ...
MicroRNAs (miRNAs) are short noncoding RNA molecules regulating the expression of mRNAs. Target identification of miRNAs is computationally difficult due to the relatively low homology between miRNAs...
MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction
Kocerha, Jannet, Faghihi, Mohammad Ali, Lopez-Toledano, Miguel A., Huang, Jia, Ramsey, Amy J., Caron, Marc G., ...
N-methyl-d-aspartate (NMDA) glutamate receptors are regulators of fast neurotransmission and synaptic plasticity in the brain. Disruption of NMDA-mediated glutamate signaling has been linked to...
Worm, Jesper, Stenvang, Jan, Petri, Andreas, Frederiksen, Klaus Stensgaard, Obad, Susanna, Elmén, Joacim, ...
microRNA-155 (miR-155) has been implicated as a central regulator of the immune system, but its function during acute inflammatory responses is still poorly understood. Here we show that exposure of...